|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Obstructive vs nonobstructive dilatation of the renal collecting system in children: Distinction with duplex sonography显示文摘 | Kessler RM Quevedo H Lankau CA | 1993 | A JR1993，160，： | 1 |
| 4 | The safety and efficacy of B-domain deleted recombinant factor VIII concentrate in patients with severe haemophilia A 显示文摘 | Lusher M Lee CA Kessler CM | 2003 | Haemophilia2003，9，1： | 1 |
| 5 | Influence of assay method differences on multiple of the median distributions: maternal serum alpha - fetoprotein as an example 显示文摘 | Parvin CA Gray DL Kessler G | 1991 | Clin Chem1991，37，5： | 1 |
| 6 | Determination of preload-recruitable stroke work and elastance by the relationship of arterial blood flow velocity to left ventricular area显示文摘 | Broscheit JA Greim CA Kessler M | 2004 | J Cardiothorac Vasc Anesth2004，18，4： | 1 |
| 7 | Progesterone - dependent decidualizafion of the human endometrium is mediated by camp显示文摘 | Brat AK Frank GR Kessler CA | 1997 | Endocrine1997，6，3： | 1 |
| 8 | Obstructive vs nonobstructive dilatation of the renal collecting system in children:distinction with duplex sonography显示文摘 | Kessler RM Quevedo H Lankau CA | 1993 | AJR Am J Roentgenol1993，160，2： | 1 |
| 9 | TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells显示文摘 | Kessler CA Bachurski CJ Schroeder J Stanek J Handwerger S | 2008 | Mol Cell Endocrinol2008，295，12： | 1 |
| 10 | ldentlfication of a deciduas-speciilc enhancer on the human prolactin gene with two critical activator protein 1 (AP- 1)binding sites显示文摘 | Watanabe K Kessler CA Bachurski CJ | 2001 | Mol Endocrinal2001，15，： | 1 |
| 11 | TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells显示文摘 | Kessler CA Bachurski CJ Schroeder J | 2008 | Mol Cell Endocrinol2008，295，12： | 1 |
| 12 | Transcription factor ETS1 is critical for human uterine decidualization显示文摘 | Kessler CA Schroeder JK Brar AK | 2006 | Mol Hum Reprod2006，12，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员