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| 1 | Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients显示文摘 | YU Shan ZHANG Ying LI Mei-zhen XU Hua WANG Qian SONG Jun LIN Peng ZHANG Li LIU Qian HUANG Qing-xian WANG Kun HOU Wei-kai | 2012 | Chinese Medical Journal2012，，19： | 27 |
| 2 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 3 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 4 | Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment显示文摘AIM:To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation(RFA) of the feeding artery of hepatocellular carcinoma(HCC) in reducing the blood-flow-induced heat-sink effect of RFA.METHODS:A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two groups.Seventy-one patients with 75 HCCs(average tumor size,4.3 ± 1.1 cm) were included in group A,in which the feeding artery of HCC was identified by color Doppler flow imaging,and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery(PAA)] before routine RFA treatment of the tumor.Eighty-three patients with 102 HCC(average tumor size,4.1 ± 1.0 cm) were included in group B,in which the tumors were treated routinely with RFA.Contrast-enhanced computed tomography was used as post-RFA imaging,when patients were followed-up for 1,3 and 6 mo.RESULTS:In group A,feeding arteries were blocked in 66(88%) HCC lesions,and the size of arteries decreased in nine(12%).The average number of punctures per HCC was 2.76 ± 1.12 in group A,and 3.36 ± 1.60 in group B(P = 0.01).The tumor necrosis rate at 1 mo post-RFA was 90.67%(68/75 lesions) in group A and 90.20%(92/102 lesions) in group B.HCC recur-rence rate at 6 mo post-RFA was 17.33%(13/75) in group A and 31.37%(32/102) in group B(P = 0.04).CONCLUSION:PAA blocked effectively the feeding artery of HCC.Combination of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC. | Yi-Bin Hou Min-Hua Chen Kun Yan Jin-Yu Wu Wei Yang | 2009 | World Journal of Gastroenterology2009，15，21： | 17 |
| 5 | Magnolol additive as a replacer of antibiotic enhances the growth performance of Linwu ducks显示文摘Magnolol rich in Magnolia officinalis is a bioactive polyphenolic compound. The aim of this study was to examine the effects of magnolol additive(MA) on growth performance, expression levels of antioxidantrelated genes, and intestinal mucosal morphology of Linwu ducks aged from 49 to 70 days, comparing with that of an antibiotic additive(colistin sulfate [CS]). A total of 275,49-day-old ducks were assigned to5 groups with 5 cages of 11 ducks each and fed diets supplemented with 0,100, 200 and 300 mg of MA/kg and 300 mg of CS/kg for 3 weeks, respectively. The results showed that the average daily body weight gain(ADG) was increased significantly in MA-fed groups(200 and 300 mg/kg), compared with the basal diet(BD) group(P < 0.05). The mRNA levels of superoxide dismutase-1(SOD1), manganese superoxide dismutase-2(MnSOD2) and catalase(CAT) were also increased significantly in MA groups(P < 0.05). In addition, hematoxylin and eosin staining revealed that Linwu ducks fed the diets with MA had more intact intestinal mucosa than those fed the BD and CS diets. In addition, ileal villus height, ileal villus height/crypt depth ratio(V/C) and duodenal V/C were also improved significantly(P < 0.05). Taken together, these data demonstrated that MA is an effective feed additive to enhance the growth performance of the Linwu ducks by improving the antioxidant and intestinal mucosal status, suggesting that MA will be a potential additive to replace antibiotic(CS). | Qian Lin Jianfei Zhao Kun Xie Yushi Wang Guili Hu Guitao Jiang Qiuzhong Dai Zhiyong Fan Jianhua He Xi He De-Xing Hou | 2017 | Animal Nutrition2017，，2： | 14 |
| 6 | Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease显示文摘背景 Alzheimer 疾病(广告)是与在场的 aging.At 有关的 neurodegenerative 疾病,它的病理学的机制 unclear.Family 留下高血压蛋白原酶血管收缩素系统(地岬)的成员祈祷在 neuronal 粘性的一个角色,以及学习和记忆的形成在这研究,我们探索改变的变换血管收缩素的酶(王牌)的效果,并且调查 perindopril 的可能的机制,一个王牌禁止者在在广告的一个老鼠模型的大脑结构和功能上。 | HOU De-ren WANG Yan ZHOU Lin CHEN Kun TIAN Yi SONG Zhi BAO Juan YANG Qi-dong | 2008 | Chinese Medical Journal2008，，22： | 11 |
| 7 | Cultivation, identification and quantification of one species of yeast-like symbiotes, Candida, in the rice brown planthopper, Nilaparvata lugens显示文摘提炼棕色的 planthopper (BPH ) , Nilaparvata lugens 圣 ? l,是米饭的最破坏的害虫之一,被证实了在胖身体怀有似酵母的 symbiotes (YLS ) 。几词法上不同的 YLS 以前被孤立并且在从 BPH 的 vitro 有教养,却直接证据正在缺乏进一步澄清有教养的 YLS 是否从 BPH。在这研究, YLS 的一种在 vitro 是成功地有教养的并且同时验证了由顺序分析在 BPH 的胖身体存在并且嵌套聚合酶链反应(PCR ) 。有教养的 YLS 在 vitro 孤立根据 18S rDNA (ribosomal DNA ) 和 5.8S-ITS (内部抄录分隔符) 作为类 Candida 的一个成员被识别 rDNA 顺序和它从酵母的序列的种系发生的分析。因此,这酵母孤立作为象 Candida 一样 symbiotes 被说出。象 Candida 一样 symbiotes 被发现在胖身体,卵巢和 BPH 的最新生的卵,然而并非在头,存在胸并且中间勇气。另外,在 1 а的象 Candida 一样 symbiotes | Kun Pang Sheng-Zhang Dong Yun Hou Ya-Lin Bian Ke Yang Xiao-Ping Yu | 2012 | Insect Science2012，19，4： | 8 |
| 8 | Functional analysis of a miRNA‐like small RNA derived from Bombyx mori cytoplasmic polyhedrosis virus显示文摘Bombyx mori cytoplasmic polyhedrosis virus(BmCPV)is a major pathogen of the economic insect silkworm,Bombyx mori.Virus‐encoded microRNAs(miRNAs)have been proven to play important roles in host–pathogen interactions.In this study we identified a BmCPV‐derived miRNA‐like 21 nt small RNA,BmCPV‐miR‐1,from the small RNA deep sequencing of BmCPV‐infected silkworm larvae by stem‐loop quantitative real‐time PCR(qPCR)and investigated its functions with qPCR and lentiviral expression systems.Bombyx mori inhibitor of apoptosis protein(BmIAP)gene was predicted by both target prediction software miRanda and Targetscan to be one of its target genes with a binding site for BmCPV‐miR‐1 at the 5′untranslated region.It was found that the expression of BmCPV‐miR‐1 and its target gene BmIAP were both up‐regulated in BmCPV‐infected larvae.At the same time,it was confirmed that BmCPV‐miR‐1 could up‐regulate the expression of BmIAP gene in HEK293T cells with lentiviral expression systems and in BmN cells by transfecting mimics.Furthermore,BmCPV‐miR‐1 mimics could up‐regulate the expression level of BmIAP gene in midgut and fat body in the silkworm.In the midgut of BmCPV‐infected larvae,BmCPV‐miR‐1 mimics could be further up‐regulated and inhibitors could lower the virus‐mediated expression of BmIAP gene.With the viral genomic RNA segments S1 and S10 as indicators,BmCPV‐miR‐1 mimics could up‐regulate and inhibitors down‐regulate their replication in the infected silkworm.These results implied that BmCPV‐miR‐1 could inhibit cell apoptosis in the infected silkworm through up‐regulating BmIAP expression,providing the virus with a better cell circumstance for its replication. | Jian-Yong Guo Yong-Sheng Wang Tian Chen Xiao-Xu Jiang Ping Wu Tao Geng Zhong-Hua Pan Meng-Ke Shang Cheng-Xiang Hou Kun Gao Xi-Jie Guo | 2020 | Insect Science2020，27，3： | 6 |
| 9 | Separate Neural Networks for Gains and Losses in Intertemporal Choice显示文摘An important and unresolved question is how human brain regions process information and interact with each other in intertemporal choice related to gains and losses. Using psychophysiological interaction and dynamic causal modeling analyses, we investigated the functional interactions between regions involved in the decisionmaking process while participants performed temporal discounting tasks in both the gains and losses domains. We found two distinct intrinsic valuation systems underlying temporal discounting in the gains and losses domains:gains were specifically evaluated in the medial regions,including the medial prefrontal and orbitofrontal cortices,and losses were evaluated in the lateral dorsolateral prefrontal cortex. In addition, immediate reward or punishment was found to modulate the functional interactions between the dorsolateral prefrontal cortex and distinct regions in both the gains and losses domains: in the gains domain, the mesolimbic regions; in the losses domain, the medial prefrontal cortex, anterior cingulate cortex, and insula. These findings suggest that intertemporal choice of gains and losses might involve distinct valuation systems,and more importantly, separate neural interactions may implement the intertemporal choices of gains and losses.These findings may provide a new biological perspective for understanding the neural mechanisms underlying intertemporal choice of gains and losses. | Yang-Yang Zhang Lijuan Xu Zhu-Yuan Liang Kun Wang Bing Hou Yuan Zhou Shu Li Tianzi Jiang | 2018 | Neuroscience Bulletin2018，34，5： | 6 |
| 10 | Robust RGB-D Camera and IMU Fusion-based Cooperative and Relative Close-range Localization for Multiple Turtle-inspired Amphibious Spherical Robots显示文摘In the narrow, submarine, unstructured environment, the present localization approaches, such as GPS measurement, dead?rcckoning, acoustic positioning, artificial landmarks-based method, are hard to be used for multiple small-scale underwater robots. Therefore, this paper proposes a novel RGB-D camera and Inertial Measurement Unit (IMU) fusion-based cooperative and relative close-range localization approach for special environments, such as underwater caves. Owing to the rotation movement with zero-radius, the cooperative localization of Multiple Turtle-inspired Amphibious Spherical Robot (MTASRs) is realized. Firstly, we present an efficient Histogram of Oriented Gradient (HOG) and Color Names (CNs) fusion feature extracted from color images ofTASRs. Then, by training Support Vector Machine (SVM) classifier with this fusion feature, an automatic recognition method of TASRs is developed. Secondly, RGB-D camerabased measurement model is obtained by the depth map In order to realize the cooperative and relative close-range localization of MTASRs, the MTASRs model is established with RGB-D camera and IMU. Finally, the depth measurement in water is corrected and the efficiency of RGB-D camera for underwater application is validated. Then experiments of our proposed localization method with three robots were conducted and the results verified the feasibility of the proposed method for MTASRs. | Huiming Xing Liwei Shi Kun Tang Shuxiang Guo Xihuan Hou Yu Liu Huikang Liu Yao Hu | 2019 | Journal of Bionic Engineering2019，16，3： | 6 |
| 11 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 12 | Anoxic degradation of nitrogenous heterocyclic compounds by activated sludge and their active sites显示文摘The potential for degradation of five nitrogenous heterocyclic compounds(NHCs), i.e.,imidazole, pyridine, indole, quinoline, and carbazole, was investigated under anoxic conditions with acclimated activated sludge. Results showed that NHCs with initial concentration of 50 mg/L could be completely degraded within 60 hr. The degradation of five NHCs was dependent upon the chemical structures with the following sequence:imidazole > pyridine > indole > quinoline > carbazole in terms of their degradation rates.Quantitative structure–biodegradability relationship studies of the five NHCs showed that the anoxic degradation rates were correlated well with highest occupied molecular orbital.Additionally, the active sites of NHCs identified by calculation were confirmed by analysis of intermediates using gas chromatography and mass spectrometry. | Peng Xu Hongjun Han Haifeng Zhuang Baolin Hou Shengyong Jia Dexin Wang Kun Li Qian Zhao | 2015 | Journal of Environmental Sciences2015，27，5： | 5 |
| 13 | Basal insulin therapy strategy is superior to premixed insulin therapy in the perioperative period blood glucose management显示文摘 | Huang Qing-xian Lou Fu-chen Wang Ping Liu Qian Wang Kun Zhang Li Zhu Lei Yu Shan Xu Hua Wang Qian Zhang Ying Hou Wei-kai | 2013 | Chinese Medical Journal2013，，21： | 4 |
| 14 | Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats显示文摘 | Yu-Chen Shi Wei-Wei Lu Yue-Long Hou Kun Fu Feng Gan Shu-Juan Cheng Shao-Ping Wang Yong-Fen Qi Jing-Hua Liu | 2018 | Chinese Medical Journal2018，，5： | 4 |
| 15 | A NUMERICAL MODEL OF FAR-FIELD COD CONCENTRATION DISTRIBUTION FOR NATURAL RIVER显示文摘A far field numerical model is developed to simulate jet pollution into natural rivers. Its character is to compute the velocity and pollution concentration separately. The velocity is computed by SIMPLEC algorithm in boundary fitted coordinate systems. The pollution concentration distribution is computed by developed QUAL IIm and QAIIL 2D program. The present model was applied to the Xiantao section of the Hanjiang River a tributary of Yangtze River, and Xiangjiang River. The flow field and COD distribution are in good agreement with field data. | Hou Guo xiang, Li Qi, Shi Zhong kun, Chen Cai kan Faculty of Traffic Sci. & Eng., Huazhong University of Science and Technology, Wuhan 430074, P.R.China Ye Ming, Deng Lian mu Yangtze Water Resources Protection Institute, Wuhan 430051, P.R.China | 2000 | Journal of Hydrodynamics2000，12，1： | 3 |
| 16 | Effects of glucose and insulin on the H9c2 (2-1) cell proliferation may be mediated through regulating glucose transporter 4 expression显示文摘 | Liu Qian Huang Qing-xian Lou Fu-chen Zhang Li Wang Kun Yu Shan Xu Hua Wang Qian Zhang Ying Hou Wei-kai | 2013 | Chinese Medical Journal2013，，21： | 3 |
| 17 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 18 | Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf显示文摘Cystic echinococcosis,which is caused by larval infection of Echinococcus granulosus(E.granulosus)sensu lato,is a widespread chronic cyst-forming helminthic disease that affects up to 3 million people.1 E.granulosus can actively divert the host immune response towards anergy and anti-inflammatory pathways.2 Previous studies have shown that E.granulosus can escape host immunosurveillance by modulating the maturation of dendritic cells(DCs).3,4 Nevertheless,how E.granulosus,an extracellular pathogen,modulates the inflammatory response in DCs remains poorly understood.In this study,we investigated the effects of E.granulosus cyst fluid(EgCF)on bone marrow-derived DCs(BMDCs)exposed to LPS,an inflammatory stimulus,and the mechanisms involved in the EgCF–DCs immune modulation. | Jun Hou Linlin Li Dan Dong Lianghai Wang Xian Wang Kun Yang Xiaodan Xu Congzhe Chen Xiangwei Wu Xueling Chen | 2020 | Cellular & Molecular Immunology2020，17，4： | 3 |
| 19 | National guidelines for diagnosis and treatment of thyroid cancer 2022 in China(English version)显示文摘Contents 1. Overview 2. Diagnosis and management 2.1 Screening for high-risk group 2.2 Clinical manifestations 2.2.1 Symptoms 2.2.2 Signs 2.2.3 Invasion and metastasis 2.3 Laboratory examination 2.3.1 Routine examination 2.3.2 Special examination 2.4 Imaging 2.4.1 Ultrasonography 2.4.2 Computed tomography (CT)2.4.3 Magnetic resonance imaging (MRI)2.4.4 Positron emission tomography (PET)-CT。 | 无 Shaoyan Liu Yansong Lin Yiming Zhu Lin Gui Xiaorong Hou Ziren Kong Yuanlin Piao Yuqing Sun Hao Wang Jian Wang Bo Zhang Ye Zhang Kun Zheng | 2022 | Chinese Journal of Cancer Research2022，34，3： | 2 |
| 20 | Designing heterostructured FeP–CoP for oxygen evolution reaction:Interface engineering to enhance electrocatalytic performance显示文摘It is significant to develop highly efficient electrocatalysts for energy conversion systems.Interface engineering is one of the most feasible approaches to effectively enhance the electrocatalytic activity.Herein,the density functional theory(DFT)calculations predict that the potential barriers of Fe sites at the interface of FeP–CoP heterostructures are lower than that of Fe sites in FeP nanoparticles(NPs),Co sites in CoP NPs,or Co sites in heterostructures.Motivated by the DFT calculation results,FeP–CoP heterostructures have been designed and synthesized by a metal–organic frameworks(MOFs)confined-phosphorization method.The FeP–CoP exhibits the lowest overpotential of 230 mV at the current density of 10 mA·cm^(−2)for oxygen evolution reaction(OER),compared with FeP(470 mV)and CoP(340 mV),which outperforms most of transition metal-based catalysts.The Tafel analysis of FeP–CoP heterostructures shows an improved reaction kinetic pathway with the smallest slope of 90.3 mV·dec^(−1),as compared to the Tafel slopes of FeP NPs(137 mV·dec^(−1))and CoP NPs(114 mV·dec^(−1)).And the FeP–CoP shows extraordinary long-term stability over 24 h.The excellent activity and long-term stability of FeP–CoP derive from the synergistic effect between FeP and CoP. | Shuang Hou Ansai Zhang Qi Zhou Yingjie Wen Sixie Zhang Linfeng Su Xinjie Huang Tian Wang Kun Rui Cheng Wang Huiling Liu Zhiyi Lu Peilei He | 2023 | Nano Research2023，16，5： | 2 |
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