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| 1 | Structure and deformation around the Gyirong basin, north Himalaya, and onset of the south Tibetan detachment system显示文摘Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma. | YANG XiongYing ZHANG JinJiang QI GuoWei WANG DeChao GUO Lei LI PengYuan LIU Jiang | 2009 | Science China Earth Sciences2009，52，8： | 33 |
| 2 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 3 | An Analysis and Modeling Study of a Sea Fog Event over the Yellow and Bohai Seas显示文摘In this study, a sea fog event which occurred on 27 March 2005 over the Yellow and Bohai Seas was investigated obser- vationally and numerically. Almost all available observational data were used, including satellite imagery of Geostationary Opera- tional Environmental Satellite (GOES)-9, three data sets from station observations at Dandong, Dalian and Qingdao, objectively reanalyzed data of final run analysis (FNL) issued by the National Center for Environmental Prediction (NCEP) and Regional At- mospheric Modeling System (RAMS) results. Synoptic conditions and fog characteristics were analyzed. The fog formed when warm, moist air was advected northwards over the cool water of the Yellow and Bohai Seas, and dissipated when a cold front brought northerly winds and cool, dry air. In order to better understand the fog formation mechanism, a high-resolution RAMS modeling with a 6 km×6 km grid, initialized and validated by FNL data, was designed. A 48 h modeling that started from 12 UTC 26 March 2005 reproduced the main characteristics of this sea fog event. The simulated lower visibility area agreed reasonably well with the sea fog region identified from the satellite imagery. Advection cooling effect seemed to play a significant role in the fog formation. | FU Gang GUO Jingtian Angeline Pendergrass LI Pengyuan | 2008 | Journal of Ocean University of China2008，7，1： | 26 |
| 4 | In vitro Anthocyanin Induction and Metabolite Analysis in Malus spectabilis Leaves Under Low Nitrogen Conditions显示文摘Anthocyanins are the most widely produced secondary metabolites in plants,and they play an important role in plant growth and reproduction.The nitrogen source is an important factor affecting anthocyanin production,but the nitrogen concentrations on metabolism and the underlying genetic basis remain unclear.In this study,in vitro anthocyanin induction was conducted on Malus spectabilis.The leaf explants were cultivated in media containing different nitrogen concentrations.The results suggested that when the nitrogen contents decreased in limit,the color of leaf explants turned from green to red,and increased anthocyanin accumulation led to a change in phenotype.Furthermore,the content of other flavonoids,such as dihydroquercetin,epicatechin,and catechin,increased under low nitrogen conditions.The transcription levels of the general flavonoid pathway genes,from phenylalanine ammonia lyase(PAL)to anthocyanidin synthase(ANS),were associated with the concentration of corresponding flavonoid compounds and phenotype changes.In particular,the expression level of ANS increased substantially under a low nitrogen treatment,which was significantly and positively correlated with the anthocyanin levels(R2=0.72,P<0.05).The increased expression patterns of anthocyanin pathway genes were similar to that of the transcription factor MYB10.We further verified MYB10 played an important role in the anthocyanin pathway in leaves of Malus spectabilis.These results suggested that we can improve the desirable ornamental plant phenotypes by controlling nitrogen content.This process may offer clues to further development of new agricultural practices. | Jiaxin Meng Yan Gao Meiling Han Pengyuan Liu Chen Yang Ting Shen Houhua Li | 2020 | Horticultural Plant Journal2020，6，5： | 13 |
| 5 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 6 | Novel Surface Design of Deployable Reflector Antenna Based on Polar Scissor Structures显示文摘Space-deployable mechanisms can be used as supporting structures for large-diameter antennas in space engineering.This study proposes a novel method for constructing the surface design of space reflector antennas based on polar scissor units.The concurrency and deployability equations of the space scissor unit with definite surface constraints are derived using the rod and vector methods.Constraint equations of the spatial transformation for space n-edge polar scissor units are summarized.A new closed-loop deployable structure,called the polar scissor deployable antenna(PSDA),is designed by combining planar polar scissor units with spatial polar scissor units.The overconstrained problem is solved by releasing the curve constraint that locates at the end-point of the planar scissor mechanism.Kinematics simulation and error analysis are performed.The results show that the PSDA can effectively fit the paraboloid of revolution.Finally,deployment experiments verify the validity and feasibility of the proposed design method,which provides a new idea for the construction of large space-reflector antennas. | Pengyuan Zhao Jinguo Liu Chenchen Wu Yangmin Li Keli Chen | 2020 | Chinese Journal of Mechanical Engineering2020，33，5： | 7 |
| 7 | A 38-Year Climatology of Explosive Cyclones over the Northern Hemisphere显示文摘Explosive cyclones(ECs)over two basins in the Northern Hemisphere(20°-90°N)from January 1979 to December2016 are investigated using ERA-Interim and Optimum Interpolation Sea Surface Temperature(OISST)data.The classical definition of an EC is modified considering not only the rapid drop of the central sea level pressure of the cyclone,but also the strong wind speed at the height of 10 m in which maximum wind speeds greater than 17.2 m s^-1are included.According to the locations of the northern Atlantic and northern Pacific,the whole Northern Hemisphere is divided into the'A region'(20°-90°N,90°W-90°E)and'P region'(20°-90°N,90°E-90°W).Over both the A and P regions,the climatological features of ECs,such as their spatial distribution,intensity,seasonal variation,interannual variation,and moving tracks,are documented. | Gang FU Yawen SUN Jilin SUN Pengyuan LI | 2020 | Advances in Atmospheric Sciences2020，37，2： | 6 |
| 8 | The Structure and Formation Mechanism of a Sea Fog Event over the Yellow Sea显示文摘In this paper, a heavy sea fog event occurring over the Yellow Sea on 11 April 2004 was investigated based upon observational and modeling analyses. From the observational analyses, this sea fog event is a typical advection cooling case. Sea surface temperature(SST) and specific humidity(SH) show strong gradients from south to north, in which warm water is located in the south and consequently, moisture is larger in the south than in the north due to evaporation processes. After fog formation, evaporation process provides more moisture into the air and further contributes to fog evolution. The sea fog event was reproduced by the Regional Atmospheric Modeling System(RAMS) reasonably. The roles of important physical processes such as radiation, turbulence as well as atmospheric stratification in sea fog's structure and its formation mechanisms were analyzed using the model results. The roles of long wave radiation cooling, turbulence as well as atmospheric stratification were analyzed based on the modeling results. It is found that the long wave radiative cooling at the fog top plays an important role in cooling down the fog layer through turbulence mixing. The fog top cooling can overpower warming from the surface. Sea fog develops upward with the aid of turbulence. The buoyancy term, i.e., the unstable layer, contributes to the generation of TKE in the fog region. However, the temperature inversion layer prevents fog from growing upward. | GUO Jingtian LI Pengyuan FU Gang ZHANG Wei GAO Shanhong ZHANG Suping | 2015 | Journal of Ocean University of China2015，14，1： | 4 |
| 9 | Structural features and deformational ages of the northern Dabashan thrust belt显示文摘大规模弹出式结构发生在北 Dabashan 戳带(NDTB ) 的前面,由到南方的蘸 NNE Chengkou 差错的界限,和蘸 SSW Gaoqiao 指责到北方。弹出式结构作为构造活动的紧张的直接思考沿着它的罢工显示出不同特征。到西北,结构被形成积极象花的结构的一个二方向性的戳系统描绘。相反,东南的部分由垂直 Chengkou 差错和一系列指导 N 的 backthrusts 组成,显示出 semi-flower-like 结构。我们从 syntectonic microthermal 标明日期证明 Chengkou 指责的变形绢云母的 Ar-Ar 的现在的结果经历了强烈变丑在期间中间 -- 中生代 Yanshanian 历元(大约 143.3 妈) ,引起快速高举并且北 Dabashan 戳带推进。在这戳的繁殖期间,因为阻塞,一系列 backthrusts 从 Dabashan 戳带的边疆形成了,导致弹出式结构的发展。 | Pengyuan Li Jinjiang Zhang Lei Guo Xiongying Yang | 2012 | Geoscience Frontiers2012，3，1： | 4 |
| 10 | TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma显示文摘 | Pengyuan Yang Qi-Jing Li Yuxiong Feng Yun Zhang Geoffrey J. Markowitz Shanglei Ning Yuezhen Deng Jiangsha Zhao Shan Jiang Yunfei Yuan Hong-Yang Wang Shu-Qun Cheng Dong Xie Xiao-Fan Wang | 2012 | Cancer Cell2012，，3： | 4 |
| 11 | Design and application of solar sailing: A review on key technologies显示文摘Solar sail technology has been proposed and developed for space explorations with advantages of low launch cost,no-propellant consumption,and continuous thrust,which has great potentials in earth polar detection,interstellar explorations and etc.The development of solar sail has made significant progress in structural design,manufacturing,materials,orbit transfer,and stability control in the past few decades,which makes meaningful contributions to astronomy,physics,and aerospace science.Technological breakthroughs of Solar Radiation Pressure(SRP)propulsion and interstellar transfer have been achieved in current solar sail missions.However,there are still many challenges and problems need to be solved.This paper attempts to summarize the research schemes and potential applications of solar sailing in space missions from the viewpoint of key technologies,so as to provide an overall perspective for researchers in this field.Analyses of the key technologies of solar sailing system design are provided.Finally,challenges and prospective development of solar sailing are discussed. | Pengyuan ZHAO Chenchen WU Yangmin LI | 2023 | Chinese Journal of Aeronautics2023，36，5： | 3 |
| 12 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 13 | Recent progress in Chinese fusion research based on superconducting tokamak configuration显示文摘Fusion energy is a promising source of clean energy,which could solve energy shortages and environmental pollution.Research into controlled fusion energy has been ongoing for over half a century.China has created a clear roadmap for magnetic confinement fusion development,where superconducting tokamaks will be used in commercial fusion reactors.The Experimental Advanced Superconducting Tokamak(EAST)is the world’s first fully superconducting tokamak with upper and lower divertors,which aims at longpulse,steady-state,H-mode operation,and 101-s H-mode discharge had been achieved.In 2007,China joined the International Thermonuclear Experimental Reactor(ITER)and became one of its seven members.Thirteen procurement packages are undertaken by China,covering superconducting magnets,power supplies,plasma-facing components(PFCs),diagnostics,etc.To bridge the gap between the ITER and fusion demonstration power plants(DEMOs),China is planning to build the Chinese Fusion Engineering Testing Reactor(CFETR)to demonstrate related technologies and physics models.The engineering design of the CFETR was completed in 2020,and Comprehensive Research Facilities for Fusion Technology(CRAFT)are being constructed to explore the key technologies used in the CFETR. | Jinxing Zheng Jinggang Qin Kun Lu Min Xu Xuru Duan Guosheng Xu Jiansheng Hu Xianzu Gong Qing Zang Zhihong Liu Liang Wang Rui Ding Jiming Chen Pengyuan Li Lei Xue Lijun Cai Yuntao Song | 2022 | The Innovation2022，3，4： | 3 |
| 14 | Monitoring gas-and particulate-phase short-chain polychlorinated paraffins in the urban air of Dalian by a self-developed passive sampler显示文摘The concentration of short-chain polychlorinated paraffins(SCCPs) in the urban air of Dalian,China was monitored from September 2016 to August 2017 with a self-developed passive sampler(PAS1) and an active high-volume sampler, simultaneously. PAS1 successfully collected the entire target SCCPs in the ambient air. Air SCCPs sampled by PAS1 were found be in the linear uptake stage during 181 days of sampling. Passive and active samples showed comparable congener profiles, and the dominant contributors of SCCPs in the two kinds of samples were similar. A significant linear correlation was observed between the total concentration of SCCPs sampled by PAS1 and active sampler in the four seasons. The passive sampling rates of the PAS1 for the gas and particulate phases of SCCPs were measured. The quantitative structure–property relationship of the sampling rate of PAS1(Rair) for gas-phase SCCPs was studied. From the molecular point of view, Rairwas mainly affected by the molecular weight and sub-cooled liquid vapor pressure of SCCPs. In general, SCCPs in the urban air of Dalian mainly existed in gas phase,lower molecular weight SCCPs primarily occurred in the gas phase, whereas higher molecular weight SCCPs were predominately adsorbed or absorbed on airborne particles. The air concentration of SCCPs in the four seasons were different, the correlation of the concentration of SCCPs in the air with the meteorology parameters was conducted. The exposure risk by intake air SCCPs of the residents around the sampling sites was evaluated according to the European risk assessment standards. | Yifan Wang Xiuhua Zhu Yuan Gao Hao Bai Pengyuan Wang Jiping Chen Heping Yuan Longxing Wang Xiaoxiao Li Wei Wang | 2019 | Journal of Environmental Sciences2019，31，6： | 2 |
| 15 | Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer显示文摘Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.In this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of CRPC.By combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic effects.From nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and chemotherapy.Doxorubicin(DOX)was selected as the chemotherapeutic agent for cytotoxicity.In terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug delivery.The nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)irradiation.Through the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in vitro.This work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision. | Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu | 2023 | Nano Research2023，16，7： | 2 |
| 16 | The conceptual alternative design for ITER magnet gravity support using clamp bolt 显示文摘 | Hou Binglin Li Pengyuan Remy Gallix | 2010 | Fusion Engineering and Design2010，85，： | 1 |
| 17 | Constrained robust feed-back model predictive control for uncertain systems with polytopic description显示文摘 | LI Dewei XI Yugeng ZHENG Pengyuan | 2009 | International Journal of Control2009，82，7： | 1 |
| 18 | Redesign of gravity support system for ITER construction 显示文摘 | Li Pengyuan Hou Binglin Jian Guangde | 2010 | Fusion Engineering and Design2010，85，： | 1 |
| 19 | Improved model prediction and RMPC design for LPV systems with bounded changes显示文摘 | ZHENG Pengyuan LI Dewei XI Yugeng | 2013 | Automatica2013，49，12： | 1 |
| 20 | Phenolic Profile, Antioxidant Activity and Anti-proliferative Activity of Crabapple Fruits显示文摘To explore the potential of crabapples as functional food, polyphenols in crabapples and ‘Fuji’ apples were extracted, and the phenolic profile,total polyphenols, antioxidant activity and anti-proliferative activity against several human cancer cells were determined. The results indicated that crabapple extracts have more abundant phenols and higher total polyphenols(from 4.46 to 46.63 mg GAE·g-1 DW) compared to ‘Fuji’ apples.Crabapple extracts possessed higher antioxidant activity than apple by DPPH and ABTS analysis. All fruit extracts exhibited inhibitory effects on proliferation in different cancer cells;however, crabapple extracts performed significantly better, with half inhibitory concentration(IC50)values varied from 48.34 μg·m L-1 to 974.81 μg·m L-1 for colon cancer cells SW480, 64.67–1 466.35 μg·m L-1 for stomach cancer cells BGC-803,78.88–910.64 μg·m L-1 for esophageal cancer cells CaEs-17. Besides, the red crabapples had higher antioxidant activity and anti-proliferative activity than yellow fruits. These results showed that crabapples, especially red crabapples, have great potential as a healthy food, as they are rich in phenolic compounds with high antioxidant and anti-proliferative activities to cancer cells. | Meiling Han Guo Li Xiaowei Liu Ai Li Peiqi Mao Pengyuan Liu Houhua Li | 2019 | Horticultural Plant Journal2019，5，4： | 1 |
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