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| 1 | Structure and deformation around the Gyirong basin, north Himalaya, and onset of the south Tibetan detachment system显示文摘Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma. | YANG XiongYing ZHANG JinJiang QI GuoWei WANG DeChao GUO Lei LI PengYuan LIU Jiang | 2009 | Science China Earth Sciences2009，52，8： | 33 |
| 2 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 3 | An Analysis and Modeling Study of a Sea Fog Event over the Yellow and Bohai Seas显示文摘In this study, a sea fog event which occurred on 27 March 2005 over the Yellow and Bohai Seas was investigated obser- vationally and numerically. Almost all available observational data were used, including satellite imagery of Geostationary Opera- tional Environmental Satellite (GOES)-9, three data sets from station observations at Dandong, Dalian and Qingdao, objectively reanalyzed data of final run analysis (FNL) issued by the National Center for Environmental Prediction (NCEP) and Regional At- mospheric Modeling System (RAMS) results. Synoptic conditions and fog characteristics were analyzed. The fog formed when warm, moist air was advected northwards over the cool water of the Yellow and Bohai Seas, and dissipated when a cold front brought northerly winds and cool, dry air. In order to better understand the fog formation mechanism, a high-resolution RAMS modeling with a 6 km×6 km grid, initialized and validated by FNL data, was designed. A 48 h modeling that started from 12 UTC 26 March 2005 reproduced the main characteristics of this sea fog event. The simulated lower visibility area agreed reasonably well with the sea fog region identified from the satellite imagery. Advection cooling effect seemed to play a significant role in the fog formation. | FU Gang GUO Jingtian Angeline Pendergrass LI Pengyuan | 2008 | Journal of Ocean University of China2008，7，1： | 26 |
| 4 | Simple and cost-effective methods for precise analysis of trace element abundances in geological materials with ICP-MS显示文摘Inductively coupled plasma mass spectrometry(ICP-MS) is the most commonly used technique to determine the abundances of trace elements in a wide range of geological materials. However, incomplete sample digestion, isobaric interferences and instrumental drift remain obvious problems that must be overcome in order to obtain precise and accurate results. For this reason, we have done many experiments and developed a set of simple, cost-effective and practical methods widely applicable for precise and rapid determination of trace element abundances in geological materials using ICP-MS. Commonly used high-pressure digestion technique is indeed effective in decomposing refractory phases, but this inevitably produces fluoride complexes that create new problems. We demonstrate that the fluoride complexes formed during high-pressure digestion can be readily re-dissolved using high-pressure vessel at 190 °C for only 2 h for 50 mg sample. In the case of isobaric interferences, although oxide(e.g., MO+/M+) and hydroxide(e.g., MOH+/M+) productivity is variable between runs, the(MO+/M+)/(Ce O+/Ce+)and(MOH+/M+)/(Ce O+/Ce+) ratios remain constant, making isobaric interference correction for all other elements of interest straightforward, for which we provide an easy-to-use off-line procedure. We also show that mass-time-intensity drift curve is smooth as recognized previously, for which the correction can be readily done by analyzing a quality-control(QC) solution and using off-line Excel VBA procedure without internal standards. With these methods, we can produce data in reasonable agreement with recommended values of international rock reference standards with a relative error of <8% and precision generally better than 5%. Importantly, compared to the widely used analytical practice, we can effectively save >60% of time(e.g., <24 h vs. >60 h). | Shuo Chen Xiaohong Wang Yaoling Niu Pu Sun Meng Duan Yuanyuan Xiao Pengyuan Guo Hongmei Gong Guodong Wang Qiqi Xue | 2017 | Science Bulletin2017，62，4： | 17 |
| 5 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 6 | The Structure and Formation Mechanism of a Sea Fog Event over the Yellow Sea显示文摘In this paper, a heavy sea fog event occurring over the Yellow Sea on 11 April 2004 was investigated based upon observational and modeling analyses. From the observational analyses, this sea fog event is a typical advection cooling case. Sea surface temperature(SST) and specific humidity(SH) show strong gradients from south to north, in which warm water is located in the south and consequently, moisture is larger in the south than in the north due to evaporation processes. After fog formation, evaporation process provides more moisture into the air and further contributes to fog evolution. The sea fog event was reproduced by the Regional Atmospheric Modeling System(RAMS) reasonably. The roles of important physical processes such as radiation, turbulence as well as atmospheric stratification in sea fog's structure and its formation mechanisms were analyzed using the model results. The roles of long wave radiation cooling, turbulence as well as atmospheric stratification were analyzed based on the modeling results. It is found that the long wave radiative cooling at the fog top plays an important role in cooling down the fog layer through turbulence mixing. The fog top cooling can overpower warming from the surface. Sea fog develops upward with the aid of turbulence. The buoyancy term, i.e., the unstable layer, contributes to the generation of TKE in the fog region. However, the temperature inversion layer prevents fog from growing upward. | GUO Jingtian LI Pengyuan FU Gang ZHANG Wei GAO Shanhong ZHANG Suping | 2015 | Journal of Ocean University of China2015，14，1： | 4 |
| 7 | Structural features and deformational ages of the northern Dabashan thrust belt显示文摘大规模弹出式结构发生在北 Dabashan 戳带(NDTB ) 的前面,由到南方的蘸 NNE Chengkou 差错的界限,和蘸 SSW Gaoqiao 指责到北方。弹出式结构作为构造活动的紧张的直接思考沿着它的罢工显示出不同特征。到西北,结构被形成积极象花的结构的一个二方向性的戳系统描绘。相反,东南的部分由垂直 Chengkou 差错和一系列指导 N 的 backthrusts 组成,显示出 semi-flower-like 结构。我们从 syntectonic microthermal 标明日期证明 Chengkou 指责的变形绢云母的 Ar-Ar 的现在的结果经历了强烈变丑在期间中间 -- 中生代 Yanshanian 历元(大约 143.3 妈) ,引起快速高举并且北 Dabashan 戳带推进。在这戳的繁殖期间,因为阻塞,一系列 backthrusts 从 Dabashan 戳带的边疆形成了,导致弹出式结构的发展。 | Pengyuan Li Jinjiang Zhang Lei Guo Xiongying Yang | 2012 | Geoscience Frontiers2012，3，1： | 4 |
| 8 | TiO_2-functionalized mesoporous materials for sensitive analysis of multi-phosphopeptides显示文摘Protein phosphorylation as one of the most important post-translational modifications in mammalian cells regulates numerous biological processes. Here we propose a novel strategy for the selective isolation and sensitive analysis of multi-phosphopeptides based on TiO2-gratfed mesoporous materials, in which MCM-41 and SBA-15 were chosen as the hard templates. The commercialized IMAC and TiO2 nanopartices were further investigated in the phosphopeptide analysis for comparison. The enrichment efficiency was evaluated and measured by MALDI-TOF mass spectrometry. The results indicated that both TiO2-SBA-15 and TiO2-MCM-41 exhibited the preferential affinity to multi-phosphopeptides compared with the other two widely used strategies. The mesoporous TiO2 based protocol showed highly selective and sensitive properties, where phosphopeptides could be identified at femtomole. | GUO WeiChao WAN JingJing QIAN Kun YU ChengZhong KONGJiLie YANG PengYuan LIU BaoHong | 2011 | Science China Chemistry2011，54，8： | 1 |
| 9 | Phenolic Profile, Antioxidant Activity and Anti-proliferative Activity of Crabapple Fruits显示文摘To explore the potential of crabapples as functional food, polyphenols in crabapples and ‘Fuji’ apples were extracted, and the phenolic profile,total polyphenols, antioxidant activity and anti-proliferative activity against several human cancer cells were determined. The results indicated that crabapple extracts have more abundant phenols and higher total polyphenols(from 4.46 to 46.63 mg GAE·g-1 DW) compared to ‘Fuji’ apples.Crabapple extracts possessed higher antioxidant activity than apple by DPPH and ABTS analysis. All fruit extracts exhibited inhibitory effects on proliferation in different cancer cells;however, crabapple extracts performed significantly better, with half inhibitory concentration(IC50)values varied from 48.34 μg·m L-1 to 974.81 μg·m L-1 for colon cancer cells SW480, 64.67–1 466.35 μg·m L-1 for stomach cancer cells BGC-803,78.88–910.64 μg·m L-1 for esophageal cancer cells CaEs-17. Besides, the red crabapples had higher antioxidant activity and anti-proliferative activity than yellow fruits. These results showed that crabapples, especially red crabapples, have great potential as a healthy food, as they are rich in phenolic compounds with high antioxidant and anti-proliferative activities to cancer cells. | Meiling Han Guo Li Xiaowei Liu Ai Li Peiqi Mao Pengyuan Liu Houhua Li | 2019 | Horticultural Plant Journal2019，5，4： | 1 |
| 10 | Strigolactone and gibberellin signaling coordinately regulate metabolic adaptations to changes in nitrogen availability in rice显示文摘Modern semi-dwarf rice varieties of the“Green Revolution”require a high supply of nitrogen(N)fertilizer to produce high yields.A better understanding of the interplay between N metabolism and plant developmental processes is required for improved N-use efficiency and agricultural sustainability.Here,we show that strigolactones(SLs)modulate root metabolic and developmental adaptations to low N availability for ensuring efficient uptake and translocation of available N.The key repressor DWARF 53(D53)of the SL signaling pathway interacts with the transcription factor GROWTH-REGULATING FACTOR 4(GRF4)and prevents GRF4 from binding to its target gene promoters.N limitation induces the accumulation of SLs,which in turn promotes SL-mediated degradation of D53,leading to the release of GRF4 and thus promoting the expression of genes associated with N metabolism.N limitation also induces degradation of the DELLA protein SLENDER RICE 1(SLR1)in an D14-and D53-dependent manner,effectively releasing GRF4 from competitive inhibition caused by SLR1.Collectively,our findings reveal a previously unrecognized mechanism underlying SL and gibberellin crosstalk in response to N availability,advancing our understanding of plant growth–metabolic coordination and facilitating the design of the strategies for improving N-use efficiency in high-yield crops. | Huwei Sun Xiaoli Guo Xiuli Zhu Pengyuan Gu Wei Zhang Wenqing Tao Daojian Wang Yunzhe Wu Quanzhi Zhao Guohua Xu Xiangdong Fu Yali Zhang | 2023 | Molecular Plant2023，16，3： | 1 |
| 11 | Diagnosis and Numerical Modeling of an Explosive Cyclone over the Northwestern Pacific显示文摘An explosive cyclone that took place over the Northwestern Pacific from 12 UTC 18 to 18 UTC 21 November 2007 was investigated.The synoptic situations and structure of this cyclone were documented by using the 1°×1°final analysis data of the National Center for Environmental Prediction.This cyclone developed explosively around 18 UTC 19 and reached its maximum deepening rate(MDR,1.3 Bergeron)around 06 UTC 20 November 2007.At its MDR moment,the surface cyclone center was located in the downstream of the upper-level trough and northern entrance zone of the upper-level jet.The diagnosis using Zwack-Okossi equation suggested that cyclonic-vorticity advection and warm air advection acted to deepen this cyclone,while adiabatic cooling suppressed its development.In an investigation of this cyclone development,numerical sensitivity results obtained by using the Weather and Research Forecasting model showed that the latent heat release in the lower level had less contribution,whereas the surface sensible and latent fluxes played important roles.With a warmer ocean surface,the cyclone tended to intensify.Two topography tests were designed to examine the mountain influences on the development of this cyclone:removing a mountain and doubling the height of a mountain.Results show that the Changbai Mountains suppressed the development of the cyclone by preventing the southern moisture air from invading the inland.Without the moisture air,no latent heat release occurs when this cyclone passes over the Changbai Mountains. | SUN Baitang LI Pengyuan ZHANG Shuqin GUO Jingtian FU Gang | 2021 | Journal of Ocean University of China2021，20，4： | 1 |
| 12 | Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis显示文摘 | Cun Wang Kai Jiang Xiaonan Kang Dongmei Gao Chun Sun Yan Li Lu Sun Shu Zhang Xiaohui Liu Weizhong Wu Pengyuan Yang Kun Guo Yinkun Liu | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 13 | A re-assessment of nickel-doping method in iron isotope analysis on rock samples using multi-collector inductively coupled plasma mass spectrometry显示文摘Element doping has been proved to be a useful method to correct for the mass bias fractionation when analyzing iron isotope compositions.We present a systematic re-assessment on how the doped nickel may affect the iron isotope analysis in this study by carrying out several experiments.We find three important factors that can affect the analytical results,including the Ni:Fe ratio in the analyte solutions,the match of the Ni:Fe ratio between the unknown sample and standard solutions,and the match of the Fe concentration between the sample and standard solutions.Thus,caution is required when adding Ni to the analyte Fe solutions before analysis.Using our method,theδ56Fe and δ57Fe values of the USGS standards W-2 a,BHVO-2,BCR-2,AGV-2 and GSP-2 are consistent with the recommended literature values,and the long-term(one year) external reproducibility is better than 0.03 and 0.05‰(2 SD) for δ56Fe and δ57Fe,respectively.Therefore,the analytical method established in our laboratory is a method of choice for high quantity Fe isotope data in geological materials. | Hongmei Gong Pengyuan Guo Shuo Chen Meng Duan Pu Sun Xiaohong Wang Yaoling Niu | 2020 | Acta Geochimica2020，39，3： | 1 |
| 14 | China's progress in radionuclide migration study over the past decade(2010–2021):Sorption,transport and radioactive colloid显示文摘The radionuclide(RN)migration study is not only helpful to understand environmental behavior of RNs,but also can establish the basis for the safety assessment of geological disposal of high-level radioactive waste(HLW).In the context of China’s HLW disposal,this review briefly summaries the progress of China’s RN migration studies over the past decade regarding three aspects,RN sorption,RN transport and radioactive colloid.Domestic studies from other disciplines(such as geology and environmental science)are also included in this review because they can provide references for the RN migration study.Overall,China has achieved clear progress in RN migration study over the past decade,although large-scaled field experiments are lacked and a gap still exists comparing with the international advanced level.Finally,several suggestions are proposed for future RN migration research in China. | Zongyuan Chen Siyuan Wang Huijuan Hou Kang Chen Pengyuan Gao Zhen Zhang Qiang Jin Duoqiang Pan Zhijun Guo Wangsuo Wu | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 15 | Crystallographic Characterization of Lu_(2)O@C_(s)(6)-C_(82)and Er_(2)O@C_(s)(6)-C_(82):The Role of Metal Species on Cluster Configuration显示文摘Comprehensive Summary Intramolecular interactions are fundamental for the unique structures and outstanding properties of metallofullerenes.However,how the internal metal species interplay with the cluster configuration inside oxide clusterfullerenes remains poorly understood.Herein,we successfully captured two oxide clusterfullerenes with different metals,namely,Lu_(2)O@C_(82)and Er_(2)O@C_(82),to elucidate the role of metal species in tuning cluster configuration.The two molecules have been fully characterized by mass spectrometry,Vis-NIR absorption spectroscopy,cyclic voltammetry,and single-crystal X-ray diffraction. | Pengwei Yu Haocheng Mei Shuaifeng Hu Changwang Pan Wangqiang Shen Pengyuan Yu Kun Guo Yunpeng Xie Takeshi Akasaka Lipiao Bao Xing Lu | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
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