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| 1 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 2 | Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway显示文摘Puerarin,a major isoflavonoid derived from the Chinese medical herb radix puerariae(Gegen),has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role in focal cerebra ischemia model rats.Recent findings regarding stroke pathophysiology have recognized that anti-inflammation is an important target for the treatment of ischemic stroke.The cholinergic anti-inflammatory pathway is a highly robust neural-immune mechanism for inflammation control This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebra ischemia/reperfusion in rats.Results showed that puerarin pretreatment(intravenous injection)reduced the ischemic infarct volume,improved neurological deficit after cerebra ischemia/reperfusion and decreased the levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin brain tissue.Pretreatment with puerarin(intravenous injection)attenuated the inflammatory response in rats,which was accompanied by janus-activated kinase 2(JAK2)and signal transducers and activators of transcription 3(STAT3)activation and nuclear factor kappa B(NF-κB)inhibition.These observations were inhibited by the alpha7 nicotinic acetylcholine recepto(α7nAchR)antagonistα-bungarotoxin(α-BGT).In addition,puerarin pretreatment increased the expression ofα7nAchR mRNA in ischemic cerebral tissue.These data demonstrate that puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory response.Our results also indicated that the anti-inflammatory effect of puerarin may partly be mediated through the activation of the cholinergic anti-inflammatory pathway. | Xiaojie Liu Zhigang Mei Jingping Qian Yongbao Zeng Mingzhi Wang | 2013 | Neural Regeneration Research2013，8，34： | 39 |
| 3 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 4 | Velocity-Free MS/AE Source Location Method for Three-Dimensional Hole-Containing Structures显示文摘Microseismic/acoustic emission(MS/AE)source localization method is crucial for predicting and controlling of potentially dangerous sources of complex structures.However,the locating errors induced by both the irregular structure and pre-measured velocity are poorly understood in existing methods.To meet the high-accuracy locating requirements in complex three-dimensional hole-containing structures,a velocity-free MS/AE source location method is developed in this paper.It avoids manual repetitive training by using equidistant grid points to search the path,which introduces A*search algorithm and uses grid points to accommodate complex structures with irregular holes.It also takes advantage of the velocity-free source location method.To verify the validity of the proposed method,lead-breaking tests were performed on a cubic concrete test specimen with a size of 10 cm10 cm10 cm.It was cut out into a cylindrical empty space with a size of/6cm10 cm.Based on the arrivals,the classical Geiger method and the proposed method are used to locate lead-breaking sources.Results show that the locating error of the proposed method is 1.20 cm,which is less than 2.02 cm of the Geiger method.Hence,the proposed method can effectively locate sources in the complex three-dimensional structure with holes and achieve higher precision requirements. | Longjun Dong Qingchun Hu Xiaojie Tong Youfang Liu | 2020 | Engineering2020，6，7： | 22 |
| 5 | Trends in cancer mortality in China from 2004 to 2018:A nationwide longitudinal study显示文摘Background:The long-term trend in cancer death in a rapidly developing country provides information for cancer prophylaxis.Here,we aimed to identify the trends in cancer mortality in China during the 2004-2018 period.Methods:Using raw data from the national mortality surveillance system of China,we assessed the mortalities of all cancer and site-specific cancers during the 2004-2018 period.The participants were divided into three age groups:≥65 years,40-64 years,and≤39 years.Changing trends in cancer death by gender,residency,and tumor location were estimated using fitting joinpoint models to log-transformed crude mortality rates(CMRs)and age-standardizedmortality rates(ASMRs).Results:Cancer death accounted for 24% of all-cause of death in China during 2014-2018.The CMR of all cancer was 150.0 per 100,000 persons.Cancer was the leading cause of death in the population<65 years.The six major cancer types(lung/bronchus cancer,liver cancer,stomach cancer,esophagus cancer,colorectal cancer,and pancreas cancer)accounted for 75.85% of all cancer deaths.The CMR of all cancer increased while the ASMR decreased during 2014-2018(P<0.001).Lung/bronchus cancer and liver cancer were the leading causes of cancer death in the population<65 years,accounting for 45.31%(CMR)and 44.35%(ASMR)of all cancer death,respectively.The ASMR of liver cancer was higher in the 40-64 years population than in the≥65 years population,in contrast to the other five major cancers.The ASMRs of liver cancer,stomach cancer,and esophagus cancer decreased although they were higher in rural residents than in urban residents;the ASMRs of lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents although they were higher in urban residents than in rural residents during 2014-2018.Conclusion:Although the ASMR of all cancer decreased in China during 2004-2018,lung/bronchus cancer and liver cancer remained the leading causes of cancer-related premature death.Lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents. | Dongming Jiang Lijuan Zhang Wenbin Liu Yibo Ding Jianhua Yin Rongbing Ren Qi Li Yifan Chen Jiaying Shen Xiaojie Tan Hongwei Zhang Guangwen Cao | 2021 | Cancer Communications2021，41，10： | 23 |
| 6 | Deformation mechanism of roadways in deep soft rock at Hegang Xing’an Coal Mine显示文摘Engineering geomechanics characteristics of roadways in deep soft rock at Hegang Xing'an Coal Mine were studied and the nature of clay minerals of roadway surrounding rock was analyzed. This paper is to solve the technical problems of high stress and the difficulty in supporting the coal mine, and provide a rule for the support design. Results show that mechanical deformation mechanisms of deep soft rock roadway at Xing'an Coal Mine is of ⅠABⅡABCⅢABCD type, consisting of molecular water absorption (the ⅠAB -type), the tectonic stress type + gravity deformation type + hydraulic type (the ⅡABC -type), and the ⅢABCD -type with fault, weak intercalation and bedding formation. According to the compound mechanical deformation mechanisms, the corresponding mechanical control measures and conversion technologies were proposed, and these technologies have been successfully applied in roadway supporting practice in deep soft rock at Xing'an Coal Mine with good effect. Xing'an Coal Mine has the deepest burial depth in China, with its overburden ranging from Mesozoic Jurassic coal-forming to now. The results of the research can be used as guidance in the design of roadway support in soft rock. | Yang Xiaojie Pang Jiewen Liu Dongming Liu Yang Tian Yihong Ma Jiao Li Shaohua | 2013 | International Journal of Mining Science and Technology2013，23，2： | 21 |
| 7 | Zircon U-Pb geochronology of Archean high-grade metamorphic rocks from Xi Ulanbulang area,central Inner Mongolia显示文摘The early Precambrian high-grade metamorphosed basement in the Xi Ulanbulang area, central Inner Mongolia of China, is composed mainly of intermediate granulites and charnockitic gneisses. Both types of the rocks are closely associated spatially and temporally, with a gradual variation between them. In order to understand timing of the high-grade metamorphism, we carried out SHRIMP U-Pb dating of zircons of the rocks. Zircons from the granulites and charnockitic gneisses are similar in structure and age. Zircon cores show magmatic zoning and have ages of 2507-2545 Ma. The ages are interpreted as the forming time of protolith of the granulites and charnockitic gneisses, indicating that a strong magmatism existed at that time in the Yinshan Block. The zircon mantles and rims show homogeneous structures and record a strong granulite facies metamorphism event around 2500 Ma, with a time interval between the metamorphism and magamatism being less than 50 Ma. These suggest that the Western Block was similar to the Eastern Block in tectono-thermal timing at the end of the Neoarchean. | DONG XiaoJie XU ZhongYuan LIU ZhengHong SHA Qian | 2012 | Science China Earth Sciences2012，55，2： | 16 |
| 8 | Progress of heat-hazard treatment in deep mines显示文摘在深煤矿把为深热的危险的控制技术基于,我们学习了国内外的深热的损坏和冷却技术的地位,总结了深热的危险的原因,分析并且比较热危险控制的紧急。结果证明深热的损坏的原因能被归因于三个方面,即,气候,地质并且采矿因素,地质的因素被认为为热危险的主要原因。也,我们比较了国内、海外的起源的很多种冷却技术,例如使使技术凉下来的技术,冰冷却技术和水凉下来的中央空调,与一种另外的冷却技术,即,使技术凉下来的 HEMS ,它与它的唯一的纯空气有大、重要的效果使技术凉下来,认识到从地下利用热资源到地面。这种技术使用秘密地获得的热;因此,技术能在煤矿支持低碳的环境经济开发,以便在中国完成低碳的煤生产。 | Yang Xiaojie Han Qiaoyun Pang Jiewen Shi Xiaowei Hou Dinggui Liu Chao | 2011 | Mining Science and Technology2011，21，2： | 15 |
| 9 | Combinations of Hd2 and Hd4 genes determine rice adaptability to Heilongjiang Province, northern limit of China显示文摘Heading date is a key trait in rice domestication and adaption, and a number of quantitative trait loci(QTLs)have been identified. The rice(Oryza sativa L.) cultivars in the Heilongjiang Province, the northernmost region of China,have to flower extremely early to fulfill their life cycle.However, the critical genes or different gene combinations controlling early flowering in this region have not been determined. QTL and candidate gene analysis revealed that Hd2/Ghd7.1/Os PRR37 plays a major role in controlling rice distribution in Heilongjiang. Further association analysis with a collection of rice cultivars demonstrated that another three major QTL genes(Hd4/Ghd7, Hd5/DTH8/Ghd8, and Hd1)also participate in regulating heading date under natural long day(LD) conditions. Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 are two major QTLs and function additively. With the northward rice cultivation, the Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 haplotypes became non-functional alleles. Hd1 might be non-functional in most Heilongjiang rice varieties,implying that recessive hd1 were selected during local rice breeding. Non-functional Hd5/DTH8/Ghd8 is very rare, but constitutes a potential target for breeding extremely early flowering cultivars. Our results indicated that diverse genetic combinations of Hd1, Hd2, Hd4, and Hd5 determined the different distribution of rice varieties in this northernmost province of China. | Xiufeng Li Huazhao Liu Maoqing Wang Hualong Liu Xiaojie Tian Wenjia Zhou Tianxiao Lü Zhenyu Wang Chengcai Chu Jun Fang Qingyun Bu | 2015 | Journal of Integrative Plant Biology2015，57，8： | 13 |
| 10 | Formation and timing of the extensional ductile shear zones in Yiwulü Mountain area,Western Liaoning Province,North China显示文摘The NNE-trending ductile shear zones in Yiwulü Mountain area were formed in relation to two successive extensional events.The Yiwulü High Temperature Extensional Ductile Shear Zone and the Waziyu Low Temperature Extensional Ductile Shear Zone were related to ductile deformation at higher temperatures and brittle-ductile deformation at lower temperatures,respectively.Both deformations were accompanied by large scale volcanic eruptions and magmatic intrusions.Based on structural analysis of macroscopic and microscopic deformations,and quartz lattice preferred orientations,we show that the early Yiwulü High Temperature Extensional Ductile Shear Zone was resulted from a NE-SW extension at amphibolite facies in the middle crust,whereas the Waziyu Low Temperature Extensional Ductile Shear Zone was due mainly to a NWW-SEE extension at greenschist facies in the upper crust.The SHRIMP zircon age of a syn-tectonic granitic dike emplaced at the late stage of high temperature extension is 155±2 Ma,indicating that the early extensional event took place in the Middle-Late Jurassic.40Ar-39Ar age of muscovite from tectonic schists in the low temperature extensional ductile shear zone is 131.6±1.0 Ma,suggesting that the late extension occurred in the Early Cretaceous.Subsequent overall uplifting succeeded the late extension.The new discovery of the Middle-Late Jurassic NNE-trending extensional ductile shear zone provides evidence constraining the switch of tectonic regimes and Middle Jurassic thinning of lithosphere in the eastern North China Craton. | LI Gang LIU ZhengHong LIU JunLai LI YongFei XU ZhongYuan DONG XiaoJie | 2012 | Science China Earth Sciences2012，55，5： | 11 |
| 11 | A self-adaptive negative selection algorithm used for anomaly detection显示文摘A novel negative selection algorithm (NSA),which is referred to as ANSA,is presented. In many actual anomaly detection systems,the training data are just partially composed of the normal elements,and the self/nonself space often varies over time. Therefore,anom-aly detection system has to build the profile of the system based on a part of self elements and adjust itself to adapt those variables. However,previous NSAs need a large number of self elements to build the profile of the system,and lack adaptability. In order to over-come these limitations,the proposed approach uses a novel technique to adjust the self radius and evolve the nonself-covering detectors to build an appropriate profile of the system. To determine the performance of the approach,the experiments with the well-known data-set were performed. Results exhibited that our proposed approach outperforms the previous techniques. | Jinquan Zeng,Xiaojie Liu,Tao Li,Caiming Liu,Lingxi Peng,Feixian Sun Department of Computer Science,Sichuan University,Chengdu 610065,China | 2009 | Progress in Natural Science:Materials International2009，19，2： | 10 |
| 12 | Responses of CH_4 Emissions to Nitrogen Addition and Spartina alterniflora Invasion in Minjiang River Estuary, Southeast of China显示文摘The nitrogen(N) input and Spartina alterniflora invasion in the tidal marsh of the southeast of China are increasingly serious. To evaluate CH4 emissions in the tidal marsh as affected by the N inputs and S. alterniflora invasion, we measured CH4 emissions from plots with vegetated S. alterniflora and native Cyperus malaccensis, and fertilized with exogenous N at the rate of 0(N0), 21(N1) and 42(N2) g N/(m2·yr), respectively, in the Shanyutan marsh in the Minjiang River estuary, the southeast of China. The average CH4 fluxes during the experiment in the C. malaccensis and S. alterniflora plots without N addition were 3.67 mg CH4/(m2·h) and 7.79 mg CH4/(m2·h), respectively, suggesting that the invasion of S. alterniflora into the Minjiang River estuary stimulated CH4 emission. Exogenous N had positive effects on CH4 fluxes both in native and in invaded tidal marsh. The mean CH4 fluxes of N1 and N2 treatments increased by 31.05% and 123.50% in the C. malaccensis marsh, and 63.88% and 7.55% in the S. alterniflora marsh, respectively, compared to that of N0 treatment. The CH4 fluxes in the two marshes were positively correlated with temperature and pH, and negatively correlated with electrical conductivity and redox potential(Eh) at different N addition treatments. While the relationships between CH4 fluxes and environmental variables(especially soil temperature, pH and Eh at different depths) tended to decrease with N additions. Significant temporal variability in CH4 fluxes were observed as the N was gradually added to the native and invaded marshes. In order to better assess the global climatic role of tidal marshes as affected by N addition, much more attention should be paid to the short-term temporal variability in CH4 emission. | MOU Xiaojie LIU Xingtu TONG Chuan SUN Zhigao | 2014 | Chinese Geographical Science2014，24，5： | 10 |
| 13 | Lotus Leaf‑Derived Gradient Hierarchical Porous C/MoS2 Morphology Genetic Composites with Wideband and Tunable Electromagnetic Absorption Performance显示文摘Inspired by the nature,lotus leaf-derived gradient hierarchical porous C/MoS2 morphology genetic composites(GHPCM)were successfully fabricated through an in situ strategy.The biological microstructure of lotus leaf was well preserved after treatment.Different pores with gradient pore sizes ranging from 300 to 5μm were hierarchically distributed in the composites.In addition,the surface states of lotus leaf resulted in the Janus-like morphologies of MoS2.The GHPCM exhibit excellent electromagnetic wave absorption performance,with the minimum reflection loss of−50.1 dB at a thickness of 2.4 mm and the maximum effective bandwidth of 6.0 GHz at a thickness of 2.2 mm.The outstanding performance could be attributed to the synergy of conductive loss,polarization loss,and impedance matching.In particularly,we provided a brand-new dielectric sum-quotient model to analyze the electromagnetic performance of the non-magnetic material system.It suggests that the specific sum and quotient of permittivity are the key to keep reflection loss below−10 dB within a certain frequency range.Furthermore,based on the concept of material genetic engineering,the dielectric constant could be taken into account to seek for suitable materials with designable electromagnetic absorption performance. | Fei Pan Zhicheng Liu Baiwen Deng Yanyan Dong Xiaojie Zhu Chuang Huang Wei Lu | 2021 | Nano-Micro Letters2021，13，3： | 9 |
| 14 | Paleomagnetic results of Late Paleozoic rocks from northern Qiangtang Block in Qinghai-Tibet Plateau, China显示文摘Tectonic evolution of the Tethys and the boundary between the Gondwanaland and the Eurasia during the Carboniferous and Permian remain hotly debated. Qiangtang region in the Qinghai-Tibet Plateau may be a key place to study these problems. A paleomagnetic study was conducted on the Late Paleozoic rocks in the northern Qiangtang region (33.7°N, 86.7°W), Tibet. Two sites (21 samples) in the Upper Carboniferous, eleven sites (101 samples) in the Permian, and two sites (16 samples) in the Lower Triassic were investigated. The rock magnetic data revealed hematite and magnetite as the main magnetic carriers. In stepwise thermal demagnetization and/or combined alternating field (AC) demagnetization, two characteristic components in the majority of the samples were identified as (1) the Low-temperature Component (LTC), characterized by northerly decli- nation and moderate to steep inclination, corresponding to a pole position overlay with the present North Pole. A minority of the samples present single component, and their directions are the same as (2) the High-temperature Component (HTC) of double components. The combined single-component and HTC data of the Permian can pass the R-test at 95% level and the F-test at 99% level, as well as the BC-test. The pole position from the Late Carboniferous is at 31.8°S, 45.7°E with dp=2.1, dm=3.9, that from the Early and Middle (Late) Permian is at 31.7°S, 46.8°E with dp=9.2, dm=16.9 (34.4°N, 54.1°E with dp=6.9, dm=12.5) respectively, and that from the Early Triassic is at 16.9°S, 22.5°E with dp=4.9, dm=9.2. These pole positions are different from the other poles for the Qiangtang Block, which suggests the single-component and HTC directions are probably a primary magnetization and the northern Qiangtang Block was paleogeographically situated at low latitudes in the Northern Hemisphere in the Late Paleozoic. | CHENG Xin WU HanNing GUO Qiang HOU BaoNing XIA LingYan WANG HaiJun DIAO ZongBao HUO FeiFei JI WenHua LI RongShe CHEN ShouJian ZHAO ZhenMing LIU XiaoJi | 2012 | Science China Earth Sciences2012，55，1： | 9 |
| 15 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 16 | Orbit determination and prediction for Beidou GEO satellites at the time of the spring/autumn equinox显示文摘Geostationary(GEO) satellites form an indispensable component of the constellation of Beidou navigation system(BDS). The ephemerides, or predicted orbits of these GEO satellites(GEOs), are broadcast to positioning, navigation, and timing users. User equivalent ranging error(UERE) based on broadcast message is better than 1.5 m(root formal errors: RMS) for GEO satellites. However, monitoring of UERE indicates that the orbital prediction precision is significantly degraded when the Sun is close to the Earth's equatorial plane(or near spring or autumn Equinox). Error source analysis shows that the complicated solar radiation pressure on satellite buses and the simple box-wing model maybe the major contributor to the deterioration of orbital precision. With the aid of BDS' two-way frequency and time transfer between the GEOs and Beidou time(BDT, that is maintained at the master control station), we propose a new orbit determination strategy, namely three-step approach of the multi-satellite precise orbit determination(MPOD). Pseudo-range(carrier phase) data are transformed to geometric range(biased geometric range) data without clock offsets; and reasonable empirical acceleration parameters are estimated along with orbital elements to account for the error in solar radiation pressure modeling. Experiments with Beidou data show that using the proposed approach, the GEOs' UERE when near the autumn Equinox of 2012 can be improved to 1.3 m from 2.5 m(RMS), and the probability of user equivalent range error(UERE)<2.0 m can be improved from 50% to above 85%. | LI XiaoJie ZHOU JianHua HU XiaoGong LIU Li GUO Rui ZHOU ShanShi | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 8 |
| 17 | Graphene-based membranes for molecular and ionic separations in aqueous environments显示文摘Graphene-based laminar materials open up to new applications for molecular and ionic separations in aqueous environments due to the atomic thickness, mechanical strength, chemical stability and other fantastic properties.Recent advances on controlling the structure and chemical functionality of graphene-based membranes can potentially lead to new classes of tools for desalination, dehydration, toxicant rejection, specific ionic separation and so on. The recent developments of graphene-based membranes prepared by using a concept to form interlayer space between graphene sheets and creating nanoscale or sub-nanoscale pores in a graphene lattice, together with their mass-transfer mechanisms and potential applications in aqueous environments are reviewed. A summary and outlook is further provided on the opportunities and challenges in this arising field.This article is expected to address the intricate details of mass transport through two distinct graphene-based membranes in aqueous environment and to optimize the fabrication of graphene-based membranes as a fascinating separation system for a wide range of applications. | Zhuang Liu Wei Wang Xiaojie Ju Rui Xie Liangyin Chu | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 8 |
| 18 | Factors affecting genomic selection revealed by empirical evidence in maize显示文摘Genomic selection(GS) as a promising molecular breeding strategy has been widely implemented and evaluated for plant breeding, because it has remarkable superiority in enhancing genetic gain, reducing breeding time and expenditure, and accelerating the breeding process. In this study the factors affecting prediction accuracy(rMG) in GS were evaluated systematically, using six agronomic traits(plant height, ear height, ear length, ear diameter,grain yield per plant and hundred-kernel weight) evaluated in one natural and two biparental populations. The factors examined included marker density, population size, heritability,statistical model, population relationships and the ratio of population size between the training and testing sets, the last being revealed by resampling individuals in different proportions from a population. Prediction accuracy continuously increased as marker density and population size increased and was positively correlated with heritability; rMGshowed a slight gain when the training set increased to three times as large as the testing set. Low predictive performance between unrelated populations could be attributed to different allele frequencies, and predictive ability and prediction accuracy could be improved by including more related lines in the training population. Among the seven statistical models examined, including ridge regression best linear unbiased prediction(RR-BLUP), genomic BLUP(GBLUP), Bayes A, Bayes B, Bayes C, Bayesian least absolute shrinkage and selection operator(Bayesian LASSO), and reproducing kernel Hilbert space(RKHS), the RKHS and additive-dominance model(Add + Dom model) showed credible ability for capturing non-additive effects, particularly for complex traits with low heritability. Empirical evidence generated in this study for GS-relevant factors will help plant breeders to develop GS-assisted breeding strategies for more efficient development of varieties. | Xiaogang Liu Hongwu Wang Hui Wang Zifeng Guo Xiaojie Xu Jiacheng Liu Shanhong Wang Wen-Xue Li Cheng Zou Boddupalli M.Prasanna Michael S.Olsen Changling Huang Yunbi Xu | 2018 | The Crop Journal2018，6，4： | 8 |
| 19 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 20 | High-Efficiency Reduction of Rice Amylose Content via CRISPR/Cas9-Mediated Base Editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,rice production must increase by 40%to meet the growing demand(Khush,2005).In addition,with the improvement of people's living standards,the demand for elite rice with better eating and cooking quality(ECQ)is increasing.ECQ is determined by several factors,including amylose content(AC),gel consistency(GC),gelatinization temperature(GT)and viscosity,where AC is the predominant factor(Juliano,1998). | Li He Li Xiufeng Xu Yang Liu Hualong He Mingliang Tian Xiaojie Wang Zhenyu Wu Xiuju Bu Qingyun Yang Jie | 2020 | Rice science2020，27，6： | 7 |
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