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| 1 | Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway显示文摘Puerarin,a major isoflavonoid derived from the Chinese medical herb radix puerariae(Gegen),has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role in focal cerebra ischemia model rats.Recent findings regarding stroke pathophysiology have recognized that anti-inflammation is an important target for the treatment of ischemic stroke.The cholinergic anti-inflammatory pathway is a highly robust neural-immune mechanism for inflammation control This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebra ischemia/reperfusion in rats.Results showed that puerarin pretreatment(intravenous injection)reduced the ischemic infarct volume,improved neurological deficit after cerebra ischemia/reperfusion and decreased the levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin brain tissue.Pretreatment with puerarin(intravenous injection)attenuated the inflammatory response in rats,which was accompanied by janus-activated kinase 2(JAK2)and signal transducers and activators of transcription 3(STAT3)activation and nuclear factor kappa B(NF-κB)inhibition.These observations were inhibited by the alpha7 nicotinic acetylcholine recepto(α7nAchR)antagonistα-bungarotoxin(α-BGT).In addition,puerarin pretreatment increased the expression ofα7nAchR mRNA in ischemic cerebral tissue.These data demonstrate that puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory response.Our results also indicated that the anti-inflammatory effect of puerarin may partly be mediated through the activation of the cholinergic anti-inflammatory pathway. | Xiaojie Liu Zhigang Mei Jingping Qian Yongbao Zeng Mingzhi Wang | 2013 | Neural Regeneration Research2013，8，34： | 39 |
| 2 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
| 3 | Monolithic edge-cladding process for the elliptical disk of N31-type Nd-doped high-power laser glass显示文摘This paper investigates the monolithic edge-cladding process for the elliptical disk of N31-type Nd-doped phosphate laser glass,which will be utilized under liquid cooling conditions for high-power laser systems.The thermal stress,interface bubbles and residual refiectivity,which are due to high-temperature casting and bonding during the monolithic edge-cladding process,are simulated and determined.The applied mould is optimized to a rectangular cavity mould,and the casting temperature is optimized to 1000℃.The resulting lower bubble density makes the mean residual refiectivity as low as 6.75×10^(-5),which is enough to suppress the amplified spontaneous emission generated in the Nd-glass disk,and the resulting maximum optical retardation is converged to 10.2–13.3 nm/cm,which is a favourable base for fine annealing to achieve the stress specification of less than or equal to 5 nm/cm.After fine annealing at the optimized 520℃,the maximum optical retardation is as low as 4.8 nm/cm,and the minimum transmitted wavefront peak-to-valley value is 0.222 wavelength(632.8 nm).An N31 elliptical disk with the size of 194 mm×102 mm×40 mm can be successfully cladded by the optimized monolithic edge-cladding process,whose edge-cladded disk with the size of 200 mm×108 mm×40 mm can achieve laser gain one-third higher than that of an N21-type disk of the same size. | Huiyu Chen Min Qian Youkuo Chen Xin Wang Jingping Tang Lei Wen Junjiang Hu Wei Chen Shubin Chen Lili Hu | 2022 | High Power Laser Science and Engineering2022，10，2： | 1 |
| 4 | Task - Oriented optimal Grasp Planning by Three- Fingered Robot Hands 显示文摘 | Qian Ruiming Yan jingping | 1998 | Journal1998，14，1： | 1 |
| 5 | Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts显示文摘 | Fang Li Zhimin He Jingping Shen Qian Huang Wenrong Li Xinjian Liu Yujun He Frank Wolf Chuan-Yuan Li | 2010 | Cell Stem Cell2010，，4： | 1 |
| 6 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 7 | Cross-layer optimization in ultra wideband networks显示文摘Ultra wideband (UWB) network brings both chance and challenge to personal area wireless communications. Compared with other IEEE 802 small range wireless protocols (such as WLAN and Bluetooth), UWB has both extremely high bandwidth (up to 480 Mbps) and low radiation. Moreover, the structured MAC layer of UWB is the fundamental difference to WLAN. The top one is that only when two UWB de-vices belong to the same piconet can they communicate with each other directly, which means that we must jointly consider topology formation and routing when deploying UWB networks because the interaction between routing and topology formation makes separate optimization ineffective. This paper tries to optimize UWB network from a cross-layer point of view. Specifically, given device spatial distribution and traffic requirement, we want to form piconets and determine rout-ing jointly, to maximize the overall throughput. We formulate the problem of joint optimization to mixed-integer programming and give a practical lower bound that is very close to the theoretical upper bound in our simulation. Furthermore, our lower bound is much better than an algorithm that only considers topology formation in UWB networks. | WU Qi BI JingPing GUO ZiHua XIONG YongQiang ZHANG Qian LI ZhongCheng | 2007 | Science in China(Series F)2007，50，5： | 0 |
| 8 | Oral cancer overexpressed 1 (ORAOVI): A regulator for cell growth and tumor angiogenesis in oral squamous cell carcinoma显示文摘 | Qian Ming Chen Lu Jiang Xin Zeng Hanshuo Yang Zhi Wang Jun Shen Jingping Bai Yuanyuan Zhang Feng Gao Min Zhou | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 9 | Evaluation of the submarine debris-flow hazard risks to planned subsea pipeline systems: a case study in the Qiongdongnan Basin, South China Sea显示文摘The ever-increasing deepwater oil and gas development in the Qiongdongnan Basin,South China Sea has initiated the need to evaluate submarine debris-flow hazard risks to seafloor infrastructures.This paper presents a case study on evaluating the debris-flow hazard risks to the planned pipeline systems in this region.We used a numerical model to perform simulations to support this quantitative evaluation.First,one relict failure interpreted across the development site was simulated.The back-analysis modeling was used to validate the applicability of the rheological parameters.Then,this model was applied to forecast the runout behaviors of future debris flows originating from the unstable upslope regions considered to be the most critical to the pipeline systems surrounding the Manifolds A and B.The model results showed that the potential debris-flow hazard risks rely on the location of structures and the selection of rheological parameters.For the Manifold B and connected pipeline systems,because of their remote distances away from unstable canyon flanks,the potential debris flows impose few risks.However,the pipeline systems around the Manifold A are exposed to significant hazard risks from future debris flows with selected rheological parameters.These results are beneficial for the design of a more resilient pipeline route in consideration of future debris-flow hazard risks. | Mingquan Huang Xuesheng Qian Jingping Xu Xuecheng Li | 2023 | Acta Oceanologica Sinica2023，42，5： | 0 |
| 10 | Recent Advances on the Development of Functional Materials in Microbial Fuel Cells:From Fundamentals to Challenges and Outlooks显示文摘Microbial fuel cells(MFCs),as a sustainable and promising technology to solve both environmental pollution and energy shortage,have captured tremendous attention.The conversion efficiency of chemical energy contained in organic waste or wastewater to electricity via microbial metabolism strongly depends on the performance of each functional unit,including the anode,cathode and separator/membrane used in MFCs.Therefore,significant attention has been paid toward developing advanced functional materials to enhance the performance of each unit or provide new featured functions.This review paper provides a comprehensive review on recent achievements and advances in the modification and development of functional materials for MFC systems,including 1)the development of functional anode materials for enhanced microbial compatibilities as well as electron transfer capabilities,2)the development of cost-effective separators/membranes such as ion exchange membrane,porous membrane,polymer electrolyte membrane and composite membrane,and 3)the development of functional cathode catalysts to decrease the over-potential and enhance the electrocatalytic efficiency for oxygen reduction reaction in order to substitute the common costly Pt catalyst.The challenges and outlooks of functional materials for MFC applications are also discussed. | Qian Zhu Jingping Hu Bingchuan Liu Shaogang Hu Sha Liang Keke Xiao Jiakuan Yang Huijie Hou | 2022 | Energy & Environmental Materials2022，5，2： | 0 |
| 11 | Acetyl-L-carnitine protects adipose-derived stem cells exposed to H2O2 through regulating AMBRA1-related autophagy显示文摘The cell activity of adipose-derived stem cells(ADSCs)is affected by the intracellular reactive oxygen species(ROS)and the level of autophagy.Previous studies reveal that acetyl-L-carnitine(ALC)possesses capacities of resisting oxidative stress and regulating autophagy.Activating molecule in Beclin1-regulated autophagy protein 1(AMBRA1)plays a key role in initiating Beclin1-regulated autophagy.In the present study,we discovered ALC pretreatment(1 mM,24 h)significantly increased the activity of ADSCs exposed to H_(2)O_(2)(100μM,2 h)in vitro with improved stemness,and reduced the production of intracellular ROS.In addition,we found for the first time that ALC treatment up-regulated autophagy of ADSCs through strengthening the expressions of Beclin1 and AMBRA1 synchronously,which might be involved in the protective effect of ALC. | YAO QIAN JINGPING WANG ZIWAN JI HAO CHEN YUCANG HE XULING LV ZIKAI ZHANG TIAN LI TIANYUN PAN LIQUN LI MING LIN | 2021 | BIOCELL2021，45，1： | 0 |
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