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| 1 | Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population显示文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies. | Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 16 |
| 2 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 3 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 4 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 5 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 6 | Spectral and Energy Efficiency of Line-of-Sight OAM-MIMO Communication Systems显示文摘Not only high spectral efficiency(SE)but also high energy efficiency(EE)are required for future wireless communication systems.Radio orbital angular momentum(OAM)provides a new perspective of mode multiplexing to improve SE.However,there are few studies on the EE performance of OAM mode multiplexing.In this paper,we investigate the SE and EE of a misaligned uniform concentric circle array(UCCA)-based multi-carrier multimode OAM and multiple-input multiple-output(MCMM-OAM-MIMO)system in the line-ofsight(LoS)channel,in which two transceiver architectures implemented by radio frequency(RF)analog synthesis and baseband digital synthesis are considered.The distance and angle of arrival(AoA)estimation are utilized for channel estimation and signal detection,whose training overhead is much less than that of traditional MIMO systems.Simulation results validate that the UCCA-based MCMM-OAM-MIMO system is superior to conventional MIMOOFDM system in the EE and SE performances. | Rui Chen Hong Zhou Wen-Xuan Long Marco Moretti | 2020 | China Communications2020，17，9： | 6 |
| 7 | Antioxidant effect of Lactobacillus fermentum HFY02-fermented soy milk on D-galactose-induced aging mouse model显示文摘This study aimed to investigate the antioxidant effect of soybean milk fermented by a new type of Lactobacillus fermentum(LF-HFY02)by using D-galactose induced aging mice model.Firstly,the optimal fermentation conditions was screened out by detecting the effects of different fermentation temperature and time on the active components and antioxidant activity of soybean milk in viro.And then unfermented soybean milk and the soybean milk fermented by different Lactobacillus was given by gavage to D-galactose-induced aging mouse.The activities of GSH,GSH-Px,SOD,CAT and T-AOC in serum,brain and liver of soybean milk fermented by LF-HFY02 were significantly increased,while the content of MDA and the level of AGEs in hippocampal were significantly decreased compared with D-galactose induced group.Further more,the mRNA expression of GSH and SOD in mouse liver were obviously up-regulated by soybean milk fermented by LF-HFY02.The skin tissue structure of mice in the LF-HFY02 fermented soybean milk group was more complete,the collagen fibers were increased and arranged orderly and liver inflammation has improved compared with the model group.And Western blot analysis showed that LF-HFY02 effectively upregulated EGFR,SOD and GSH protein expression in mouse liver.These findings suggest that LF-HFY02 can effectively prevent D-galactose-induced oxidation and aging in mice,and the effect was even better than that of the Lactobacillus delbruechii subsp.bulgaricus and vitamin C.Thus,LF-HFY02 may be potentially employed as a probiotic strain.In conclusion,soybean milk fermented by LF-HFY02 can increase the content of antioxidant factors and the activity of antioxidant enzymes by regulating gene and protein expression,and finally inhibit the process of tissue cell peroxidation,and improve the oxidative damage of mouse skin and liver.The results could provide a basis for the research and development and industrial production of probiotic-related fermented soybean milk products. | Tiantian Hu Rui Chen Yu Qian Ke Ye Xingyao Long Kun-Young Park Xin Zhao | 2022 | Food Science and Human Wellness2022，11，5： | 6 |
| 8 | Preparation and evaluation of a phospholipid-based injectable gel for the long term delivery of leuprolide acetaterrh显示文摘A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate(LA). The gel system was prepared using biocompatible materials(SPME), including soya phosphatidyl choline(SPC), medium chain triglyceride(MCT) and ethanol. The system displayed a sol state with low viscosity in vitro and underwent in situ gelation in vivo after subcutaneous injection. An in vitro release study was performed using a dialysis setup with different release media containing different percentages of ethanol. The stability of LA in the SPME system was investigated under different temperatures and in the presence of various antioxidants. In vivo studies in male rats were performed to elucidate the pharmacokinetic profiles and pharmacodynamic efficacy. A sustained release of LA for 28 days was observed without obvious initial burst in vivo. The pharmacodynamic study showed that once-amonth injection of LA-loaded SPME(SPME-LA) led to comparable suppression effects on the serum testosterone level as observed in LA solution except for the onset time. These findings demonstrate excellent potential for this novel SPME system as a sustained release delivery system for LA. | Danhong Long Tao Gong Zhirong Zhang Rui Ding Yao Fu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 6 |
| 9 | MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might be unknown factors capable of regulating the vitamin D receptor(VDR).Genome-wide analysis showed that miRNAs were associated with VDRs.We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS,mice with experimental autoimmune encephalomyelitis(EAE),which was induced by myelin oligodendrocyte glycoprotein 35–55 peptides.EAE mice showed decreased mean body weight but increased mean clinical scores compared with vehicle or control mice.And inflammatory infiltration was found in the lumbosacral spinal cord of EAE mice.In addition,VDR expression was significantly lower while the expression of miR-125a-5p was markedly higher in the spinal ventral horn of EAE mice than in vehicle or control mice.Importantly,activation of VDRs by paricalcitol or inhibition of miR-125a-5p by its antagomir markedly decreased the mean clinical scores in EAE mice.Interestingly,VDR and miR-125a-5p were co-localized in the same neurons of the ventral horn.More importantly,inhibition of miR-125a-5p remarkably blocked the decrease of VDRs in EAE mice.These results support a critical role for miR-125a-5p in modulating VDR activity in EAE and suggest potential novel therapeutic interventions. | Han-Chun Long Rui Wu Chun-Feng Liu Fei-Long Xiong Zu Xu Dian He Yi-Fan Zhang Bing Shao Ping-An Zhang Guang-Yin Xu Lan Chu | 2020 | Neuroscience Bulletin2020，36，2： | 6 |
| 10 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 11 | Petrogenesis and tectonic setting of the Queershan composite granitic pluton, eastern Tibetan Plateau: Constraints from geochronology, geochemistry and Hf isotope data显示文摘The Queershan composite granitic pluton is located in the north of the late Paleozoic Yidun arc collision-orogenic belt, eastern Tibetan Plateau. The main rock types are coarse-grained porphyritic alkalic-monzonite granite with minor fine-grained porphyritic monzogranite and granodiorite distributed in the eastern and southwestern regions. Here we report their zircon U-Pb ages and geo- chemical data. The intrusive contact relations indicate that granodiorite was formed earlier than the alkalic-monzonite granite(105.9±1.3 Ma) and monzogranite(102.6±1.1 Ma). These suggest that the Queershan composite granitic pluton was formed through three-stage magmatic events. The alkalic-monzonite granite(105.9±1.3 Ma) and monzogranite(102.6±1.1 Ma) are characterized by high SiO2(73.5%–77.7%), K2O+Na2O(6.9%–8.5%), Ga/Al ratios(2.6–3.4) and low Al2O3(11.8%–14.5%), CaO(0.25%–1.5%), MgO(0.18%–0.69%), negative Ba, Sr and Eu anomalies, showing A-type granite affinities. The granodiorite exhibits lower SiO2, P2O5 and K2O+Na2O contents, but higher Al2O3, CaO and MgO contents than alkalic-monzonite granite and monzogranite, showing I-type granite affinity. 176Hf/177 Hf ratios of the alkalic-monzonite granite and the monzogranite are 0.282692–0.282749 and 0.282685–0.282765, respectively, and with similar ?Hf(t) values(?0.56 to 1.43 and ?0.87 to 1.90 respectively). They also present similar TDM2 model ages(1.04–1.22 and 1.07–1.2 Ga respectively), indicating they may be sourced from a similar rock source, mostly like Kangding Complex. The homogeneity of the Hf isotopic compositions and the absence of the MMEs demonstrate that little depleted mantle materials have contributed to the source. We propose that the Mesoproterozoic crust materials of the Yangtze Craton exist beneath the Yidun arc terrane and support it was a dismembered part of the Yangtze Craton. The A-type granites of Queershan composite granitic pluton are most probably related to the closure of the Bangong-Nujiang Tethys ocean. | WU Tao XIAO Long GAO Rui YANG HaiJun YANG Gang | 2014 | Science China Earth Sciences2014，57，11： | 5 |
| 12 | A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared显示文摘Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic designs.Herein,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction PD.Firstly,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,etc.The narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of PD.Secondly,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+PQDs.Thirdly,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+PQDs.In contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 cycles.This work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices. | Nan Ding Yanjie Wu Wen Xu Jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai Ji Zhou Hongwei Song | 2022 | Light(Science & Applications)2022，11，5： | 5 |
| 13 | The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization显示文摘Objective:Macrophages are a major component of the tumor microenvironment.M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development,whereas tumor-associated macrophages(TAMs)mainly exhibit an M2 phenotype.Our previous studies have shown that the interleukin-33/ST2(IL-33/ST2)axis is essential for activation of the M1 phenotype.This study investigates the role of the IL-33/ST2 axis in TAMs,its effects on tumor growth,and whether it participates in the mutual conversion between the M1 and M2 phenotypes.Methods:Bone marrow-derived macrophages were extracted from wildtype,ST2 knockout(ST2-/-),and Il33-overexpressing mice and differentiated with IL-4.The mitochondrial and lysosomal number and location,and the expression of related proteins were used to analyze mitophagy.Oxygen consumption rates and glucose and lactate levels were measured to reveal metabolic changes.Results:The IL-33/ST2 axis was demonstrated to play an important role in the metabolic conversion of macrophages from OXPHOS to glycolysis by altering mitophagy levels.The IL-33/ST2 axis promoted enhanced cell oxidative phosphorylation,thereby further increasing M2 polarization gene expression and ultimately promoting tumor growth(P<0.05)(Figure 4).This metabolic shift was not due to mitochondrial damage,because the mitochondrial membrane potential was not significantly altered by IL-4 stimulation or ST2 knockout;however,it might be associated with the m TOR activity.Conclusions:These results clarify the interaction between the IL-33/ST2 pathway and macrophage polarization,and may pave the way to the development of new cancer immunotherapies targeting the IL-33/ST2 axis. | Huadan Xu Dong Li Jiaoyan Ma Yuanxin Zhao Long Xu Rui Tian Yanan Liu Liankun Sun Jing Su | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 14 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 15 | Quality metrics and outcomes among critically ill patients in China:results of the national clinical quality control indicators for critical care medicine survey 2015-2019显示文摘Background:It is crucial to improve the quality of care provided to ICU patient,therefore a national survey of the medical quality of intensive care units(ICUs)was conducted to analyze adherence to quality metrics and outcomes among critically ill patients in China from 2015 to 2019.Methods:This was an ICU-level study based on a 15-indicator online survey conducted in China.Considering that ICU care quality may vary between secondary and tertiary hospitals,direct standardization was adopted to compare the rates of ICU quality indicators among provinces/regions.Multivariate analysis was performed to identify potential factors for in-hospital mortality and factors related to ventilator-associated pneumonia(VAP),catheter-related bloodstream infections(CRBSIs),and catheter-associated urinary tract infections(CAUTIs).Results:From the survey,the proportions of structural indicators were 1.83%for the number of ICU inpatients relative to the total number of inpatients,1.44%for ICU bed occupancy relative to the total inpatient bed occupancy,and 51.08%for inpatients with Acute Physiology and Chronic Health Evaluation II scores≥15.The proportions of procedural indicators were 74.37%and 76.60%for 3-hour and 6-hour surviving sepsis campaign bundle compliance,respectively,62.93%for microbiology detection,58.24%for deep vein thrombosis prophylaxis,1.49%for unplanned endotracheal extubations,1.99%for extubated inpatients reintubated within 48 hours,6.38%for unplanned transfer to the ICU,and 1.20%for 48-hour ICU readmission.The proportions of outcome indicators were 1.28‰for VAP,3.06‰for CRBSI,3.65‰for CAUTI,and 10.19%for in-hospital mortality.Although the indicators varied greatly across provinces and regions,the treatment level of ICUs in China has been stable and improved based on various quality control indicators in the past 5 years.The overall mortality rate has dropped from 10.19%to approximately 8%.Conclusions:The quality indicators of medical care in China’s ICUs are heterogeneous,which is reflected in geographic disparities and grades of hospitals.This study is of great significance for improving the homogeneity of ICUs in China. | Xi Rui Fen Dong Xudong Ma Longxiang Su Guangliang Shan Yanhong Guo Yun Long Dawei Liu Xiang Zhou | 2022 | Chinese Medical Journal2022，，9： | 4 |
| 16 | The Non-Singularity and Regularity of GP-Vˊ-Rings显示文摘In this paper,we introduce a non-trivial generalization of ZI-rings-quasi ZI-rings.A ring R is called a quasi ZI-ring,if for any non-zero elements a,b ∈ R,ab = 0 implies that there exists a positive integer n such that an = 0 and anRbn = 0.The non-singularity and regularity of quasi ZI,GP-Vˊ-rings are studied.Some new characterizations of strong regular rings are obtained.These effectively extend some known results. | Xiao Bin YIN Rui WANG Xiao Long LI | 2011 | Journal of Mathematical Research and Exposition2011，31，6： | 4 |
| 17 | Relationship between neuromyelitis optica-IgG status and spinal cord magnetic resonance imaging in patients with neuromyelitis optica显示文摘尽管有大规模的背景被做了的技术革新,有 neuromyelitis optica ( NMO )的很多个病人在浆液和脑髓的 fluid.Longitudinally 广泛的针的绳索( LESC )损害正在缺乏 NMO-IgG ,线性损害与 NMO.However 被联系,包括 LESC 损害和线性损害,磁性的回声成像( MRI )展示的针的绳索的差别在 NMO-IgG 积极、否定的病人之间仍然是现在的学习的 unknown.The 目的到过 | Zhong Xiao-nan Wang Hong-hao Bao Tian Li Rui Long You-ming Lu Zheng-qi Dai Yong-qiang Qiu Wei Hu Xue-qiang | 2012 | Chinese Medical Journal2012，，2： | 4 |
| 18 | Evaluation of the Biodiversity Conservation Function in Liaohe Delta Wetland,Northeastern China显示文摘The scientific evaluation of the wetland biodiversity conservation function is the basis of balanced wetland protection and development. Our research sought to provide references for the protection of wetland ecological environments as well as the related planning and management policies. The study established a fitting model for evaluating the biodiversity conservation function in the Liaohe Delta, northeastern China. The new model, the Wetland Biodiversity Conservation Indicator(WBCI), was with four input factors, including the vegetation coverage(VC), habitat suitability index(HI), land use and land cover(LULC) index(LI), and threat factor index(TI) of the LULC type. The values assigned to HI and TI were based on Integrated Valuation of Ecosystem Services and Tradeoffs(In VEST)habitat quality models. The weights of all the factors in WBCI were valued with the Principal Component Analysis(PCA). We evaluated the wetland biodiversity conservation function of Panjin, Liaohe Delta, China, by using the WBCI model based on Gaofen-1(GF-1) satellite data in 2018, and the result was verified with In VEST and other models. It showed that the output map was similar to that of In VEST, with the higher-quality habitat including the wetland, tidal flat, water body, and forest, as well as the lower-quality land use types including the paddy field, crop field, construction land, and land used by traffic. The wetland biodiversity conservation function was better in areas less affected by human disturbance, with very abundant species and good-quality habitat. It was poor in areas impacted by more frequent human activities such as the land cultivation, housing, and traffic, which led to the landscape fragmentation. The WBCI model provided a more accurate reflection of the bird distribution than the In VEST model. The WBCI model was able to reflect the difference in quality of each habitat grade, in contrast to the net primary productivity(NPP) method and species distribution models(SDMs). The new model was, therefore, simpler and suitable in reflecting the quality of wetland biodiversity function in the Liaohe Delta. | Wenying YU Ruipeng JI Xiuzhen HAN Long CHEN Rui FENG Jinwen WU Yushu ZHANG | 2020 | Journal of Meteorological Research2020，34，4： | 4 |
| 19 | Ionic thermal up-diffusion in nanofluidic salinity-gradient energy harvesting显示文摘Advances in nanofabrication and materials science give a boost to the research in nanofluidic energy harvesting.Contrary to previous efforts on isothermal conditions,here a study on asymmetric temperature dependence in nanofluidic power generation is conducted.Results are somewhat counterintuitive.A negative temperature difference can significantly improve the membrane potential due to the impact of ionic thermal up-diffusion that promotes the selectivity and suppresses the ion-concentration polarization;especially at the low-concentration side,which results in dramatically enhanced electric power.A positive temperature difference lowers the membrane potential due to the impact of ionic thermal down-diffusion,although it promotes the diffusion current induced by decreased electrical resistance.Originating from the compromise of the temperature-impacted membrane potential and diffusion current,a positive temperature difference enhances the power at low transmembrane-concentration intensities and hinders the power for high transmembrane-concentration intensities.Based on the system’s temperature response,we have proposed a simple and efficient way to fabricate tunable ionic voltage sources and enhance salinity-gradient energy conversion based on small nanoscale biochannels and mimetic nanochannels.These findings reveal the importance of a long-overlooked element-temperature-in nanofluidic energy harvesting and provide insights for the optimization and fabrication of high-performance nanofluidic power devices. | Rui Long Zhengfei Kuang Zhichun Liu Wei Liu | 2019 | National Science Review2019，6，6： | 4 |
| 20 | Recent advances in single metal atom-doped MoS_(2) as catalysts for hydrogen evolution reaction显示文摘The development of low-cost and highly efficient electrocatalysts for hydrogen evolution reaction(HER)is critical to the wide-spread applications of water splitting technology.In recent years,many efforts are devoted to exploring HER catalysts with high activity and stability based on non-precious metals.Benefited from the advantages of two-dimensional(2D)materials with unique physicochemical properties along with the single-atom catalysts with high activity,excellent stability and maximized atom utility efficiency,a new category of catalysts with 2D materials confining single atoms have shown great promises as high-performance HER catalysts.In this review,MoS_(2),as one of the typical 2D materials,doped with various single metal atoms as HER catalysts are fully discussed,including different synthetic strategies,catalytic performances and mechanisms toward HER as well as the major challenges ahead. | Rui Liu Hui‑Long Fei Gong‑Lan Ye | 2020 | Tungsten2020，2，2： | 4 |
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