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| 1 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 2 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 3 | Experimental study on the flow behaviour of water-sand mixtures in fractured rock specimens显示文摘The study of flow behaviour of water-sand mixtures in fractured rocks is of great necessity to understand the producing mechanism and prevention of water inrush and sand gushing accidents.A self-developed seepage test system is used in this paper to conduct laboratory experiments in order to study the influence of the particle size distribution,the void ratio,and the initial mass of Aeolian sand on the flow behavior.It is concluded that the water flow velocity is insensitive to the initial mass of the Aeolian sand but increases with the power exponent in the Talbot formula and the specimen height.The outflow of the Aeolian sand increases with the power exponent in the Talbot formula,the specimen height,and the initial mass of the Aeolian sand.Besides,the outflow of the Aeolian sand changes exponentially with the water flow velocity.Finally,it is found that the fractured specimen has a maximum sand filtration capacity beyond which the outflow of the Aeolian sand significantly increases with the initial mass of the Aeolian sand. | Boyang Zhang Qingyuan He Zhibin Lin Zhenhua Li | 2021 | International Journal of Mining Science and Technology2021，31，3： | 9 |
| 4 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 5 | Genetic Polymorphisms in the Precursor MicroRNA Flanking Region and Non-Small Cell Lung Cancer Survival显示文摘 | Hu, Zhibin Shu, Yongqian Chen, Yijiang Chen, Jiaping Dong, Jing Liu, Yao Pan, Shiyang Xu, Lin Xu, Jing Wang, Yi Dai , Juncheng Ma, Hongxia Jin, Guangfu Shen,Hongbing | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 8 |
| 6 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 7 | 校近期发表IF≥4.0的SCI论文摘要--Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population显示文摘 | Jin Guangfu Shu Yongqian Tian Tian Liang Jie Xu Yan Wang Furu Chen Jianjian Dai Juncheng Hu Zhibin Shen Hongbing Xu Lin | 2009 | 南京医科大学学报(自然科学版)2009，29，10： | 7 |
| 8 | Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese显示文摘Apoptosis plays a key role in inhibiting tumor growth, progression and resistance to anti-tumor therapy. We hypothesized that genetic variants in apoptotic genes may affect the prognosis of lung cancer. To test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (SNPs) from 12 genes (BAX, BCL2, BID, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, FAS, FASLG and MCL1) involved in apoptosis to assess their prognostic significance in lung cancer in a Chinese case cohort with 568 non-small cell lung cancer (NSCLC) patients. Thirty-five SNPs passing quality control underwent association analyses, 11 of which were shown to be significantly associated with NSCLC survival (P<0.05). After Cox stepwise regression analyses, 3 SNPs were independently associated with the outcome of NSCLC (BID rs8190315: P=0.003; CASP9 rs4645981: P=0.007 and FAS rs1800682: P=0.016). A favorable survival of NSCLC was significantly associated with the genotypes of BID rs8190315 AG/GG (adjusted HR=0.65, 95% CI: 0.49-0.88), CASP9 rs4645981 AA (HR=0.22, 95% CI: 0.07-0.69) and FAS rs1800682 GG (adjusted HR=0.67, 95% CI: 0.46-0.97). Time-dependent receptor operation curve (ROC) analysis revealed that the area under curve (AUC) at year 5 was significantly increased from 0.762 to 0.819 after adding the risk score of these 3 SNPs to the clinical risk score. The remaining 32 SNPs were not significantly associated with NSCLC prognosis after adjustment for these 3 SNPs. These findings indicate that BID rs8190315, CASP9 rs4645981 and FAS rs1800682 polymorphisms in the apoptotic pathway may be involved in the prognosis of NSCLC in the Chinese population. | Songyu Cao Cheng Wang Xinen Huang Juncheng Dai Lingmin Hu Yao Liu Jiaping Chen Hongxia Ma Guangfu Jin Zhibin Hu Lin Xu Hongbing Shen | 2013 | The Journal of Biomedical Research2013，27，3： | 6 |
| 9 | Effects of Different Biochars on Pinus elliottii Growth,N Use Efficiency,Soil N_2O and CH_4 Emissions and C Storage in a Subtropical Area of China显示文摘Intensive management of planted forests may result in soil degradation and decline in timber yield with successive rotations.Biochars may be beneficial for plant production, nutrient uptake and greenhouse gas mitigation. Biochar properties vary widely and are known to be highly dependent on feedstocks, but their effects on planted forest ecosystem are elusive. This study investigated the effects of chicken manure biochar, sawdust biochar and their feedstocks on 2-year-old Pinus elliottii growth, fertilizer N use efficiency(NUE), soil N_2O and CH_4 emissions, and C storage in an acidic forest soil in a subtropical area of China for one year. The soil was mixed with materials in a total of 8 treatments: non-amended control(CK); sawdust at 2.16 kg m-^(2)(SD); chicken manure at 1.26 kg m-^(2)(CM); sawdust biochar at 2.4 kg m-^(2)(SDB); chicken manure biochar at 2.4 kg m-^(2)(CMB);^(15)N-fertilizer alone(10.23 atom%^(15)N)(NF); sawdust biochar at 2.4 kg m-^(2)plus15N-fertilizer(SDBN) and chicken manure biochar at 2.4 kg m-^(2)plus15N-fertilizer(CMBN). Results showed that the CMB treatment increased P. elliottii net primary production(aboveground biomass plus litterfall)and annual net C fixation(ANCF) by about 180% and 157%, respectively, while the the SDB treatment had little effect on P. elliottii growth. The15 N stable isotope labelling technique revealed that fertilizer NUE was 22.7% in CK, 25.5% in the NF treatment, and37.0% in the CMB treatment. Chicken manure biochar significantly increased soil p H, total N, total P, total K, available P and available K. Only 2% of the N in chicken manure biochar was available to the tree. The soil N_2O emission and CH_4 uptake showed no significant differences among the treatments. The apparent C losses from the SD and CM treatments were 35% and 61%, respectively;while those from the CMB and SDB treatments were negligible. These demonstrated that it is crucial to consider biochar properties while evaluating their effects on plant growth and C sequestration. | LIN Zhibin LIU Qi LIU Gang Annette L.COWIE BEI Qicheng LIU Benjuan WANG Xiaojie MA Jing ZHU Jianguo XIE Zubin | 2017 | Pedosphere2017，27，2： | 6 |
| 10 | Analysis of a Water-Inrush Disaster Caused by Coal Seam Subsidence Karst Collapse Column under the Action of Multi-Field Coupling in Taoyuan Coal Mine显示文摘Minin-induced water inrush from a confined aquifer due to subsided floor karst collapse column(SKCC)is a type of serious disaster in the underground coal extraction.Karst collapse column(KCC)developed in a confined aquifer occurs widely throughout northern China.A water inrush disaster from SKCC occurred in Taoyuan coal mine on February 3,2013.In order to analyze the effect of the KCC influence zone’s(KCCIZ)width and the entry driving distance of the water inrush through the fractured channels of the SKCC,the stress,seepage,and impact dynamics coupling equations were used tomodel the seepage rule,and a numerical FLAC3D model was created to determine the plastic zones,the vertical displacement development of the rockmass surrounding the entry driving working face(EDWF),and the seepage vector and water inflow development of the seepage field.The hysteretic mechanism of water inrush due to SKCC in Taoyuan coal mine was investigated.The results indicate that a water inrush disaster will occur when the width of the KCCIZ exceeds 16 m under a driving,which leads to the aquifer connecting with the fractured zones of the entry floor.Hysteretic water inrush disasters are related to the stress release rate of the surrounding rocks under the entry driving.When the entry driving exceeds about 10 m from the water inrush point,the stress release rate reaches about 100%,and a water inrush disaster occurs. | Zhibin Lin Boyang Zhang Jiaqi Guo | 2021 | Computer Modeling in Engineering & Sciences2021，，1： | 6 |
| 11 | Epitaxial growth of large-area and highly crystalline anisotropic ReSe2 atomic layer显示文摘各向异性二维(2D ) 分层的材料金来二硫化物(因为它的不平常的性质和有希望的应用, ReSe 2) 吸引了可观的注意在电子并且 optoelectronic 设备。因为它的低格子对称和夹层去耦,各向异性的生长和 out-of-plane 生长不管多么容易发生,产出厚薄片,树枝状的结构,或象花的结构。在这研究,我们表明了一个自底向上的方法为控制并且由货车 der Waals 取向附生的 ReSe 2 的可伸缩的合成。完成可控制的生长,一与一个限制反应空格微反应堆被在化学蒸汽免职系统叠二云母底层构造。在限制反应空间以内, ReSe 2 的成核密度和生长率显著地被减少,赞成有一致单层厚度的 ReSe 2 的大区域的合成。有生长温度的 ReSe 2 的词法进化显示各向异性的生长在低生长温度被压制(< 600 吗? | Fangfang Cui Xiaobo Li Qingliang Feng Jianbo Yin Lin Zhou Dongyan Liu Kaiqiang Liu Xuexia He Xing Liang Shengzhong Liu Zhibin Lei Zonghuai Liu Hailin Peng Jin Zhang Jing Kong Hua Xu | 2017 | Nano Research2017，10，8： | 6 |
| 12 | Spatiotemporal evolution rule of rocks fracture surrounding gob-side roadway with model experiments显示文摘A series of plane-strain physical model experiments are carried out to study the spatiotemporal evolution rule of rocks fracture surrounding gob-side roadway, which is subjected to the pressure induced by the mining process. The digital photogrammetry technology and large deformation analysis method are applied to measure the deformation and fracture of surrounding rocks. The experimental results indicate that the deformation and fracture of coal pillars are the cause to the instability and failure of the surrounding rocks. The spatiotemporal evolution rule of the rock deformation and fracture surrounding gob-side roadway is obtained. The coal pillar and the roof near coal pillar should be strengthened in support design. The engineering application results also can provide a useful guide that the combined support with wire meshes, beam, anchor bolt and cable is an effective method. | Li Yuanhai Zhang Qi Lin Zhibin Wang Xiaodong | 2016 | International Journal of Mining Science and Technology2016，26，5： | 6 |
| 13 | On secondary new particle formation in China显示文摘新大气的喷雾器粒子的形成是被观察了发生在甚至重重地弄脏的环境的全球现象。然而,在所有环境,看起来是冷凝作用水池的阀值价值(由于先存在喷雾器粒子) 在哪个以后 3 个 nm 粒子的形成率不再被检测。在中国,新粒子生产在很高的污染层次被观察了(冷凝作用水池在几个大城市,包括的北京,上海和南京以及在珀尔河三角洲(PRD ) 的大约 0.1 s -1) 。这里,我们总结从这些研究获得的最近的调查结果并且讨论这些调查结果将在未来研究和政策上有的各种各样的含意。 | Markku Kulmala Tuukka Petaja Veli-Matti Kerminen Joni Kujansuu Taina Ruuskanen Aijun Ding Wei Nie Min HU Zhibin Wang Zhijun Wu Lin Wang Douglas R. Worsnop | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 14 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 15 | Electron back-scattering diffraction preliminary analysis of heterogeneous nuclei in magnesium alloy during solidification process under GPa high pressure显示文摘The effective heterogeneous nuclei in Mg-7.92 Zn-1.70 Y alloy during solidification process under high pressure was investigated by EBSD. It is found that the orientation relationship between Mg matrix and MgY phase, [111]_(MgY)//[1210]_(α-Mg) and(101)_(MgY)//(0001)_(α-Mg), exists between Mg matrix and MgY phase.The MgY phase is the potential heterogeneous nuclei substrate for a-Mg solidified under high pressure. It is calculated by Bramfitt mode that the mismatch between Mg matrix and MgY phase is greater than 12% under atmospheric pressure. When solidified under high pressure of 4 GPa, the solidification pressure can increase the number of the α-Mg nucleus by reducing the size of the nucleus, decreasing interfacial energy of MgY/a-Mg, and changing the wettability between MgY phase and α-Mg from non-wetting under atmospheric pressure to wetting under high pressure. The MgY phase becomes a powerful heterogeneous nuclei for α-Mg crystal. Increasing the number of valid heterogeneous nuclei substrate increases nucleus number and refines the grain of the alloy. | Zhibin Fan Xiaoping Lin Rui Xu Yun Dong Bin Wen Lin Wang Shengshi Zhao | 2018 | Journal of Rare Earths2018，36，2： | 3 |
| 16 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 17 | Room temperature compressive properties and strengthening mechanism of Mg96.17Zn3.15Y0.50Zr0.18 alloy solidified under high pressure显示文摘The microstructures of Mg96.17Zn3.15Y0.50Zr0.18 alloys solidified under 2-6 GPa high pressure were investigated by employing SEM(EDS) and TEM.The strengthening mechanism of experimental alloy solidified under high pressure is also discussed by analyzing the compressive properties and compression fracture morphology.The results show that the microstructure of experimental alloy becomes significantly fine-grained with increasing GPa level high pressure during solidification process,and the secondary dendrite arm spacing reduces from 40 μm at atmospheric pressure to 10 μm at 6 GPa pressure.The morphology of the second phases changes from the net structure by the lamellar-type eutectic structure at atmospheric pressure to discontinuous thin rods or particles at 6 GPa pressure.Besides,the solid solubility of Zn in the Mg matrix is improved with the increase of the solidification pressure.Compared with atmospheric-pressure solidification,high-pressure solidification can improve the strength of the experimental alloy.The compressive stre ngth is improved from 263 to 437 MPa at 6 GPa.The fracture mechanism of the experimental alloy changes from cleavage fracture at atmospheric pressure to quasi-cleavage fracture at high pressure.The main mechanism of the strength improvement of the experimental alloy includes the grain refinement strengthening caused by the refinement of the solidification microstructure,the second phase strengthening caused by the improvement of the morphology and distribution of the second phases,and solid solution strengthening caused by the increase of the solid solubility of Zn in the Mg matrix. | Xiaoping Lin Zhibin Fan Chang Xu Kunyu Guo Chang Xu Shiqi Guo | 2020 | Journal of Rare Earths2020，38，6： | 2 |
| 18 | Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares显示文摘With recent advances in biotechnology, genome-wide association study(GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression(LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression(PC-LR), partial least squares-based logistic regression(PLS-LR), have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor?mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism(SNP) set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis.On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data. | Honggang Yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
| 19 | 原发性肺滑膜肉瘤术后胸膜转移1例报告并文献复习(英文)显示文摘We describe a case of primary pulmonary synovial sarcoma arising in the lung of a 35-year-old woman.The tumor was a single mass and had a well-defined pleural-based with homogeneous density in the edge of the middle lobe,with no calcification and a fat component on plain CT scan.On the contrast-enhanced CT scan,the tumor showed moderately enhancement and circular enhancement with no enlargement of mediastinal,hilar lymph nodes.Skeleton single photon emission CT(ECT) was unremarkable.Gross and histological findings by postoperative pathology showed the tumor had pseudo-capsule and was well-circumscribed with foci of necrosis,hemorrhage and cystic change,under microscope tumor was typically mitotically active,spindle cells growing in intersecting fascicles or in solid sheets with epithelial differentiation.The immunohistochemical examination of CD99,Vim,PCK and EMA were positive.The tumor recurred with multiple pleural nodules and mass at 5 months after surgery,chest CT revealed the tumor was in the ipsilateral costophrenic angle for chest pain of the patient.After dynamic contrast-enhanced,the solid parts and the capsule of the lesion showed progressive enhancement and the liquefied area of the lesion without enhancement.This case indicates that a primary pulmonary synovial sarcoma is extremely rare and malignant,its prognosis is poor.There are some relatively specific imaging findings. | Haiquan Yao Zhibin Hu Hongping Lin Heshui Shi | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，9： | 2 |
| 20 | Nlrc3-like is required for microglia maintenance in zebrafish显示文摘Microglia are tissue-resident macrophages residing in the central nervous system (CNS) and play critical roles in removing cellular debris and infectious agents as well as regulating neurogenesis and neuronal activities. Yet, the molecular basis underlying the establishment of microglia pool and the maintenance of their homeostasis in the CNS remain largely undefined. Here we report the identification and characterization of a mutant zebrafish, which harbors a point mutation in the nucleotide-binding oligomerization domain (NOD) like receptor gene nlrc3-like, resulting in the loss of microglia in a temperature sensitive manner. Temperature shift assay reveals that the late onset of nlrc3-like deficiency leads to excessive microglia cell death. Further analysis shows that the excessive microglia death in nlrc3-like deficient mutants is attributed, at least in part, to aberrant activation of canonical inflammasome pathway. Our study indicates that proper regulation of inflammasome cascade is critical for the maintenance of microglia homeostasis. | Tienan Wang Bo Yan Liang Lou Xi Lin Tao Yu Shuting Wu Qing Lu Wei Liu Zhibin Huang Mingjie Zhang Wenqing Zhang Zilong Wen | 2019 | Journal of Genetics and Genomics2019，46，6： | 2 |
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