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| 1 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 2 | Spontaneous caving and gob-side entry retaining of thin seam with large inclined angle显示文摘Based on the research method of combining simulation analysis with field testing by distinct element process UDEC, we have analyzed the roof deformation and failure laws and roadway support technology of gob-side entry retaining in a thin seam with a large inclined angle. The results show that during exploitation in seams with large inclined angle, rotational subsidence of the main roof under the gob area is small and can maintain balance, so there is no need to provide artificial permanent support resistance for the main roof near the upper side to control rotational subsidence. Obstructed by the dense scrap rail,waste rock from the immediate roof caving slides from the upper gob area to the lower area and fills it,which strikes a balance between the immediate roof under the goaf after it fractures into large pieces and filling waste rocks. | Zhang Yongqin Tang Jianxin Xiao Daqiang Sun Lele Zhang Weizhong | 2014 | International Journal of Mining Science and Technology2014，24，4： | 3 |
| 3 | Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy显示文摘Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment. | Wenjun Zhu Qian Chen Qiutong Jin Yu Chao Lele Sun Xiao Han Jun Xu Longlong Tian Jinglei Zhang Teng Liu Zhuang Liu | 2021 | Nano Research2021，14，1： | 3 |
| 4 | Advancing the incremental fusion of robotic sensory features using online multi-kernel extreme learning machine显示文摘 | Lele CAO Fuchun SUN Hongbo LI Wenbing HUANG | 2017 | Frontiers of Computer Science2017，11，2： | 2 |
| 5 | Functional-template directed self-assembly(FTDSA) of mesostructured organic-inorganic hybrid materials显示文摘Since the discovery of a surfactant directed self-assembly approach for the fabrication of mesoporous silica in 1992,increasing attention has been focused on the design and synthesis of mesostructured functional materials.Organic functionalization is becoming a major topic in this research field,since highly ordered mesostructured organic-inorganic hybrids offer novel functionalities and enhanced performance over their individual components.We begin with a brief overview of the three fundamental methods(post-synthetic grafting technique,co-condensation method,and preparation of periodic mesoporous organosilicas) for the preparation of organically functionalized mesostructured silica,and focus on one of the most promising approaches,which herein was named as functional-template directed self-assembly(FTDSA) approach,and in the eyes of the authors it has a special position in the preparation of this class of hybrid materials.A comprehensive overview of the state of research in the area of FTDSA and its potential applications will be given. | LI LeLe SUN LingDong ZHANG YaWen m YAN ChunHua | 2009 | Science China Chemistry2009，52，11： | 2 |
| 6 | Controlled synthesis and assembly of ceriabased nanomaterials 显示文摘 | Yuan Quan Duan Haohong Li Lele Sun Lingdong Zhang Yawen Yan Chunhua | 2009 | Journal of Colloid and Interface Science2009，335，2： | 1 |
| 7 | Generalized photo- voltaic array module using Matlab/Simulink 显示文摘 | Peng Lele Sun Yize Chen Yujie | 2011 | Journal of Northeastern University2011，37，1： | 1 |
| 8 | Recent advances in quantum dot catalysts for hydrogen evolution:Synthesis,characterization,and photocatalytic application显示文摘Photocatalytic water splitting is beneficial for the effective mitigation of global energy and environmental crises.Owing to multi-exciton generation,impressive light harvesting,and excellent photochemical properties,the quantum dot(QD)-based catalysts reveal a considerable potential in photocatalytic hydrogen(H_(2))production compared with bulk competitors.In this review,we summarize the recent advances in QDs for photocatalytic H_(2) production by enumerating different synthetic and characterization strategies for QDs.Various QDs-based photocatalysts are introduced and summarized in categories,and the role of different QDs in varied systems,as well as the mechanism and key factors that enhance the photocatalytic H_(2) generation performance,is discussed.Finally,conclusions and future perspectives in the exploration of highly efficient QDs-based photocatalysts for innovative applications are highlighted. | Haiwei Su Weikang Wang Run Shi Hua Tang Lijuan Sun Lele Wang Qinqin Liu Tierui Zhang | 2023 | Carbon Energy2023，5，9： | 1 |
| 9 | Switching O-O bond formation mechanism between WNA and I2M pathways by modifying the Ru-bda backbone ligands of water-oxidation catalysts显示文摘Understanding the seven coordination and O-O coupling pathway of the distinguished Ru-bda catalysts is essential for the development of next generation efficient water-oxidation catalysts based on earthabundant metals.This work reports the synthesis,characterization and catalytic properties of a monomeric ruthenium catalyst Ru-bnda(H2 bnda=2,2’-bi(nicotinic acid)-6,6’-dicarboxylic acid)featuring steric hindrance and enhanced hydrophilicity on the backbone.Combining experimental evidence with systematic density functional theory calculations on the Ru-bnda and related catalysts Ru-bda(H_(2)bda=2,2’-bipyridine-6,6’-dicarboxylic acid),Ru-pda(H_(2)pda=1,10-phenanthroline-2,9-dicarboxylic acid),and Ru-biqa(H_(2)biqa=(1,1’-biisoquinoline)-3,3’-dicarboxylic acid),we emphasized that seven coordination clearly determines presence of Ru^(Ⅴ)=O with high spin density on the ORu^(Ⅴ)=O atom,i.e.oxo with radical properties,which is one of the necessary conditions for reacting through the O-O coupling pathway.However,an additional factor to make the condition sufficient is the favorable intermolecular faceto-face interaction for the generation of the pre-reactive[Ru^(Ⅴ)=O…O=Ru^(Ⅴ)],which may be significantly influenced by the secondary coordination environments.This work provides a new understanding of the structure-activity relationship of water-oxidation catalysts and their potential to adopt I2M pathway for O-O bond formation. | Biaobiao Zhang Shaoqi Zhan Tianqi Liu Linqin Wang A.Ken Inge Lele Duan Brian J.J.Timmer Oleksandr Kravchenko Fei Li Marten S.G.Ahlquist Licheng Sun | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 10 | Tough silk fibers prepared in air using a biomimetic microfluidic chip显示文摘 | Jie Luo Lele Zhang Qingfa Peng Mengjie Sun Yaopeng Zhang Huili Shao Xuechao Hu | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 11 | Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin‐interacting protein显示文摘 | Hui Su Lele Ji Wenjuan Xing Wei Zhang Heping Zhou Xinhong Qian Xiaoming Wang Feng Gao Xin Sun Haifeng Zhang | 2013 | J. Cell. Mol. Med2013，，1： | 1 |
| 12 | Biological membrane derived nanomedicines for cancer therapy显示文摘The development of nanomedicine systems for applications in cancer therapies has been widely explored in the last decade.With inherent biocompatibility,nanomedicine devices derived from biological membranes have shown many unique advantages compared with traditional artificial nanomaterials for biomedical applications.Herein,we present a comprehensive review of the recent development of cell membrane derived nanomedicines in cancer treatment.We firstly outline the advantages of biological membranes in nanomedicine design derived from their intrinsic characteristics,and then discuss the applications of biological membrane derived nanomedicines.For the first major category of membrane-derived nanomedicine,synthetic nanoparticles are usually camouflaged with cell membranes to acquire additional functionalities.The other type of membrane-based nanomedicine is directly using the engineered cell membrane-derived vesicles or nanovesicles secreted by cells for tumor treatment.At last,we discuss the challenges of membrane-derived nanomedicines towards future clinical applications,following with perspectives on possible solutions to the current problems. | Lele Sun Zijian Xiong Fengyun Shen Zhanhui Wang Zhuang Liu | 2021 | Science China Chemistry2021，64，5： | 1 |
| 13 | Cylindrical cavity expansion responses in anisotropic unsaturated soils under plane stress condition显示文摘In this paper,an anisotropic critical state model for saturated soils was extended to unsaturated conditions by introducing suction into its yield function.Combining this model with soil-water characteristic curves related to porosity ratio was employed to characterize the coupled hydromechanical behavior of unsaturated anisotropic soil.Based on the plane stress condition,the problem of the cylindrical cavity expansion in unsaturated anisotropic soils was transformed into first-order differential equations using the Lagrangian description.The equations were solved as an initial value problem using the Runge-Kutta algorithm,which can reflect the soil-water retention behavior during cavity expansion.Parametric analyses were conducted to investigate the influences of overconsolidation ratio(OCR),suction,and degree of saturation on the expansion responses of a cylindrical cavity in unsaturated anisotropic soil under plane stress condition.The results show that the above factors have obvious influences on the cavity responses,and the plane strain solution tends to overestimate expansion pressure and degree of saturation but underestimates suction around the cavity compared to the proposed plane stress solution.The theoretical model proposed in this paper provides a reasonable and effective method for simulating pile installation and soil pressure gauge tests near the ground surface of the unsaturated soils. | Haohua Chen Xiaolin Weng Lele Hou Dean Sun | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，6： | 0 |
| 14 | Magnetic properties,crystalline and magnetic microstructures of dual-main-phase(Nd,Ce)-Fe-B sintered magnets显示文摘The(Nd,Ce)-Fe-B sintered magnets were prepared by a dual-main-phase(DMP)process under the same conditions using different combinations of Nd-Fe-B with Ce-Fe-B and(Nd,Ce)-Fe-B strips.The crystalline and magnetic microstructures of DMP(Nd,Ce)-Fe-B magnets with the remanence of 11.92-12.68 kGs,the intrinsic coercivity of 3.97-5.31 kOe,and the maximum energy product of 23.08-32.99 MGOe have been investigated.Magnetic force microscope(MFM)investigations reveal that the DMP(Nd,Ce)-Fe-B magnets show maze-like patterns,which are like that of standard anisotropy Nd-Fe-B sintered magnets by and large.However,much finer domain structures mixing with coarse ones can be observed obviously in DMP(Nd,Ce)-Fe-B sintered magnets.The size distribution of the domain width of the DMP(Nd,Ce)-Fe-B magnet is not uniform obviously.The average domain width is W=0.912μm,and the fine domain width has only 0.216μm.The smaller domain width and more branch domain patterns exist in poorer coercivity DMP magnets.This is caused by the non-uniform Ce composition of poorer property DMP magnets and the grain boundary microstructure that is not conducive to improving the coercivity.Furthermore,it is found that some domains of rare-earth-rich grain boundary phases exhibit the characteristics of plate-like patterns rather than no-contrast by using MFM,indicating their ferromagnetism.Obvious correlations between the crystalline microstructure,chemical composition of phases,and magnetic structure were demonstrated for the DMP magnets. | Yifei Xiao Lele Zhang Tao Liu Xiaolong Song Qisong Sun Yikun Fang Minggang Zhu Wei Li | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 15 | Highly delocalized endohedral metal in Gd@C2v(9)-C82 metallofullerenes co-crystallized with α-Se显示文摘 | Cheng Li Xuejiao J. Gao Huanli Yao Huan Huang Rongli Cui Xihong Guo Lele Zhang Bing Liu Binggang Xu Weiqun Shi Jinquan Dong Lai Feng Xingfa Gao Baoyun Sun | 2018 | Nano Research2018，11，4： | 0 |
| 16 | Defensins as a promising class of tick antimicrobial peptides: a scoping review显示文摘Background: Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts.Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestrated innate immune system.Antimicrobial peptides(AMPs)are important components of tick innate immunity.Among these humoral effector molecules,defensins are well-studied and widely identified in various species of Ixodidae(hard ticks)and Argasidae(soft ticks).This review was aimed at presenting the characterization of tick defensins from structure-based taxonomic status to antimicrobial function.Main text: All published papers written in English from 2001 to May 2022 were searched through PubMed and Web of Science databases with the combination of relevant terms on tick defensins.Reports on identification and characterization of tick defensins were included.Of the 329 entries retrieved,57 articles were finally eligible for our scoping review.Tick defensins mainly belong to the antibacterial ancient invertebrate-type defensins of the cis-defensins superfamily.They are generally small,cationic,and amphipathic,with six cysteine residues forming three intra-molecular disulfide bonds.Tick defensins primarily target membranes of a variety of pathogens,including Gram-positive and Gram-negative bacteria,fungi,viruses,and protozoa.Since tick defensins have a high degree of variability,we summarize their common biological properties and enumerate representative peptides.Along with the various and potent antimicrobial activities,the role of tick defensins in determining vector competence is discussed.Conclusions: Due to their broad-spectrum antimicrobial activities,tick defensins are considered novel candidates or targets for controlling infectious diseases. | Jiahui Wu Xia Zhou Qiaoqiao Chen Zhiqiang Chen Jinyu Zhang Lele Yang Yuxuan Sun Guohui Wang Jianfeng Dai Tingting Feng | 2022 | Infectious Diseases of Poverty2022，11，3： | 0 |
| 17 | Regioselective acylation of pyridoxine catalyzed by immobilized lipase in ionic liquid显示文摘The regioselective acylation of pyridoxine catalyzed by immobilized lipase(Candida Antarctica)in 1-butyl-3-methylimidazolium hexafluorophosphate([BMIM]PF_(6))has been investigated,and compared with that in acetonitrile(ACN).The acetylation of pyridoxine using acetic anhydride in[BMIM]PF6 gave comparable conversion of pyridoxine to 5-monoacetyl pyridoxine with considerably higher regioselectivity(93%-95%)than that in ACN(70%-73%).Among the tested parameters,water activity(aw)and temperature have profound effects on the reaction performances in either[BMIM]PF6 or ACN.For the reaction in[BMIM]PF6,higher temperature(50℃-55℃)and lower aw(<0.01)are preferable conditions to obtain better conversion and regioselectivity.Mass transfer limitation and intrinsic kinetic from the ionic nature of ionic liquids(ILs)may account for a different rate-temperature profile and a lower velocity at lower temperature in[BMIM]PF_(6)-mediated reaction.Moreover,consecutive batch reactions for enzyme reuse also show that lipase exhibited a much higher thermal stability and better reusability in[BMIM]PF_(6)than in ACN,which represents another advantage of ILs as an alternative to traditional solvents beyond green technology. | Shu BAI Mengyuan REN Lele WANG Yan SUN | 2008 | Frontiers of Chemical Science and Engineering2008，2，3： | 0 |
| 18 | Nonlinear dynamic response and stability analysis of the stapes reconstruction in human middle ear显示文摘Stapes fracture causes hearing loss and instability in the middle ear hearing system(MEHS). The material used in the stapes reconstruction restores stapes, but the effects of the nonlinear material parameters on the stability of the MEHS are still unknown. To address this challenge, the nonlinear dynamic response and stability of the stapes reconstruction are investigated using a multi-degree-of-freedom mechanical model. The material parameters of the implant are tentatively determined by analyzing the natural frequencies of the undamped system. The dynamical properties of the MEHS are characterized under different external excitations. The approximate solution of the MEHS near the resonant frequency is derived through the multiple-time-scale method(MTSM). The results show that the nonlinear stiffness of the material has little influence on the MEHS in the healthy state, but it causes resonant phenomena between the ossicle and the implant in the pathological state. | Lele WANG Liang WANG Yueting ZHU Zhanli LIU Yongtao SUN Jie WANG Hongge HAN Shuyi XIANG Huibin SHI Qian DING | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，10： | 0 |
| 19 | New insights into the dispersion history and adaptive evolution of taxon Aegilops tauschii in China显示文摘Aegilops tauschii,the wild progenitor of wheat D-genome and a valuable germplasm for wheat improvement,has a wide natural distribution from eastern Turkey to China.However,the phylogenetic relationship and dispersion history of Ae.tauschii in China has not been scientifically clarified.In this study,we genotyped 208 accessions(with 104 in China)using dd RAD sequencing and 55K SNP array,and classified the population into six sublineages.Three possible spreading routes or events were identified,resulting in specific distribution patterns,with four sublineages found in Xinjiang,one in Qinghai,two in Shaanxi and one in Henan.We also established the correlation of SNP-based,karyotypebased and spike-morphology-based techniques to demonstrate the internal classification of Ae.tauschii,and developed consensus dataset with 1245 putative accessions by merging data previously published.Our analysis suggested that eight inter-lineage accessions could be assigned to the putative Lineage 3and these accessions would help to conserve the genetic diversity of the species.By developing the consensus phylogenetic relationships of Ae.tauschii,our work validated the hypothesis on the dispersal history of Ae.tauschii in China,and contributed to the efficient and comprehensive germplasm-mining of the species. | Hao Li Fang Nie Lele Zhu Menghua Mu Ruixiao Fan Jingyao Li Aaqib Shaheen Yifan Liu Can Li Wenjuan Liu Huihui Liang Xinpeng Zhao Shenglong Bai Guanghui Guo Zheng Li Yiheng Hu Yuannian Jiao Jonathan Adams Assaf Distelfeld Guiling Sun Suoping Li Yun Zhou Chun-Peng Song | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 20 | Investigation on the Current Situation of China’s DTP Pharmacy and Suggestions for Its Development显示文摘Objective To summarize the main characteristics and development approaches of direct-to-patient(DTP)pharmacies,and to explore its future development trend.Methods Firstly,relevant policies of DTP pharmacies were sorted out based on some documents on the government website,and related articles were studied.Secondly,499 DTP pharmacies were investigated.Finally,the current status of the industry was summarized and analyzed.Results and Conclusion Policies on China’s DTP pharmacy have been constantly improved.According to industry standards,the current compliance rate of DTP pharmacies is about 46.09%.In terms of varieties,the market share concentration rate of biological products is higher than that of chemical drugs.The regional distribution of these drugs is mainly concentrated in the central and eastern provinces.However,63.45%of DTP pharmacies have less than 50 product specifications.DTP pharmacies have an average of 7.3 pharmacy technicians and 2.3 licensed pharmacists,which is higher than that of ordinary pharmacies.Due to the policy promotion,DTP pharmacies will be paid more attention by the public and the government,and the market share will become larger than before.Patients shifting from hospitals to drug-to-pharmacies can make them better layout.Besides,pharmaceutical services will become more specialized,and disease division will be more detailed.With the deepening of medical reform and the continuous improvement of national medical security as well as drug procurement and medical insurance payment methods,DTP pharmacies can play an important role in the national basic medical security system. | Wen Dong Dou Lele Sun Yuyuan Wang Shuling | 2023 | Asian Journal of Social Pharmacy2023，18，2： | 0 |
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