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| 1 | An Outbreak of Multidrug-Resistant Tuberculosis in a Secondary School --Hubei Province, 2019显示文摘What is already known about this topic?Multidrug-resistant tuberculosis(MDR-TB)is a type of tuberculosis with resistance to common treatments such as isoniazid and rifampicin.MDR-TB is a major global health challenge and needs to be controlled tightly through prevention measures,early diagnosis,and full treatment and management.What is added by this report?This outbreak was the first MDR-TB related public health emergency in Hubei Province.In total,five MDR-TB cases and nine clinically diagnosed cases were identified within one class in a secondary school.Students and teachers from other classes were monitored,but no other cases were found.What are the implications for public health practice?The implementation of TB prevention and control measures in schools is important to increase knowledge on TB and to raise awareness on protecting personal wellbeing.The Automatic Early Warning Information System alerted the local health department and allowed for a timely response to prevent further disease spread. | Mengxian Zhang Tang Wang Shuangyi Hou Jianjun Ye Liping Zhou Zhong Zhang Zhiqiang Deng Qin Da Guoming Li Shiyue Li | 2019 | China CDC weekly2019，1，5： | 5 |
| 2 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 3 | A Non-Stop Double Buffering Mechanism for Dataflow Architecture显示文摘两倍缓冲是有效机制隐藏在在薄片上和离开薄片记忆之间的数据转移的潜伏。在 dataflow 建筑学,因为 dataflow 加速器的重复充满并且排干,然而,交换二在许多瓦减少的执行期间缓冲性能。在这个工作,我们为 dataflow 建筑学建议连续双的缓冲机制。没有停止通过在 dataflow 建筑学优化控制逻辑处理元素的执行,建议不停的机制把瓦分到处理元素数组。而且,我们建议一个工作流节目与连续双的缓冲机制合作。在控制逻辑上并且在工作流节目上的优化以后,充满并且排干数组需要越过属于一样的 dataflow 图的所有瓦的执行被做仅仅一次。试验性的结果证明没有优化,为 dataflow 建筑学的建议双缓冲机制在那上完成 16.2% 平均效率改进。 | Xu Tan Xiao-Wei Shen Xiao-Chun Ye Da Wang Dong-Rui Fan Lunkai Zhang Wen-Ming Li Zhi-Min Zhang Zhi-Min Tang | 2018 | Journal of Computer Science & Technology2018，33，1： | 3 |
| 4 | Observation of biophoton emission from plants in the process of defense response显示文摘Biophoton emission from germinating soybean under adverse circumstance has been observed by high sensitive imaging system based on ICCD detector. It is found that the intensity of biophoton emission from the injured position of the cotyledon is enhanced obviously compared with the intact position. In addition, a strong biophoton emission has been detected at the tip | Da Xing Shici Tan Yonghong Tang Yonghong He Dehong Li | 1999 | Chinese Science Bulletin1999，44，23： | 3 |
| 5 | High-throughput screening and machine learning for the efficient growth of high-quality single-wall carbon nanotubes显示文摘It has been a great challenge to optimize the growth conditions toward structure-controlled growth of single-wall carbon nanotubes(SWCNTs).Here,a high-throughput method combined with machine learning is reported that efficiently screens the growth conditions for the synthesis of high-quality SWCNTs.Patterned cobalt(Co)nanoparticles were deposited on a numerically marked silicon wafer as catalysts,and parameters of temperature,reduction time and carbon precursor were optimized.The crystallinity of the SWCNTs was characterized by Raman spectroscopy where the featured G/D peak intensity(IG/ID)was extracted automatically and mapped to the growth parameters to build a database.1,280 data were collected to train machine learning models.Random forest regression(RFR)showed high precision in predicting the growth conditions for high-quality SWCNTs,as validated by further chemical vapor deposition(CVD)growth.This method shows great potential in structure-controlled growth of SWCNTs. | Zhong-Hai Ji Lili Zhang Dai-Ming Tang Chien-Ming Chen Torbjörn EMNordling Zheng-De Zhang Cui-Lan Ren Bo Da Xin Li Shu-Yu Guo Chang Liu Hui-Ming Cheng | 2021 | Nano Research2021，14，12： | 3 |
| 6 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Yi Mao Liang Da Hong Tang Jiali Yang Yinrui Lei Pierre Tiollais Tsaiping Li Mujun Zhao | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 2 |
| 7 | Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression显示文摘 | Hong Tang Liang Da Yi Mao Ying Li Dong Li Zhenhua Xu Feng Li Yifei Wang Pierre Tiollais Tsaiping Li Mujun Zhao | 2008 | Hepatology2008，，1： | 2 |
| 8 | A Pipelining Loop Optimization Method for Dataflow Architecture显示文摘与 exascale 来超级计算的时代,电源效率成为了最重要的障碍造一个 exascale 系统。Dataflow 建筑学在为科学应用完成高电源效率有本国的优点。然而,最先进的 dataflow 体系结构没能为循环处理利用高并行。处理这个问题,我们建议一个 pipelining 环优化方法(PLO ) ,它在处理元素(PE ) 在环流动做重复 dataflow 的数组加速器。这个方法由二种技术,帮助建筑学的硬件重复和帮助说明的软件重复组成。在硬件重复执行模型,一个在薄片上循环控制器被设计产生循环索引,减少计算内核并且打为 pipelining 执行的一个好基础的复杂性。在软件重复实行模型,另外的环指令被论述解决重复相关性问题。经由这二种技术,准备好了每周期执行的指令的平均数字被增加使浮点联合起来忙。当这二种技术的硬件费用是可接受的时,模拟结果证明分别地,我们的建议方法平均由 2.45x 和 1.1x 在浮点效率超过静电干扰和动态循环执行模型。 | Xu Tan Xiao-Chun Ye Xiao-Wei Shen Yuan-Chao Xu Da Wang Lunkai Zhang Wen-Ming Li Dong-Rui Fan Zhi-Min Tang | 2018 | Journal of Computer Science & Technology2018，33，1： | 2 |
| 9 | Tracing type 1 diabetic T ibet miniature pig’s bone marrow mesenchymal stem cells in vitro by magnetic resonance imaging (1型糖尿病西藏小型猪骨髓间充质干细胞体外磁共振成像示踪)显示文摘 | Kuan‐Xiao Tang Jin‐Hua Yan Yun‐Feng Shen Bao‐Ying Li Ying‐Ming Chen Da‐Yue Liu De‐Dong Ma Jie Li Hua Liang Jian‐Ping Weng | 2014 | Journal of Diabetes2014，，： | 1 |
| 10 | Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression显示文摘 | Tang H Da L Mao Y Li Y Li D Xu Z | 2009 | Hepatology2009，49，： | 1 |
| 11 | Retrospective analysis of 88 patients with pancreatic duct stone显示文摘 | Jian Shui li Zhao Da zhang Yong Tang | 2007 | Hepatobiliary Pancreat Dis Int2007，6，2： | 1 |
| 12 | Construction and evaluation of a multistage Mycobacterium tuberculosis subunit vaccine candidate Mtb10.4–HspX显示文摘 | Hongxia Niu Lina Hu Qing Li Zejiao Da Bingxiang Wang Kefeng Tang Qi Xin Hongjuan Yu Ying Zhang Yong Wang Xingming Ma Bingdong Zhu | 2011 | Vaccine2011，，51： | 1 |
| 13 | 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuna impatiens显示文摘A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively. | Peng SUN Yang Hua YI Ling LI Min GUI Hai Feng TANG Da Zhi ZHANG Shi Long ZHANG | 2006 | Chinese Chemical Letters2006，17，11： | 1 |
| 14 | Design,synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors显示文摘一系列 gem-dimethyl-bearing C 配糖物被设计并且作为 SGLT2 禁止者综合了,与无水的铝构造是的 gem-dimethyl 功能的调停氯化物的 Friedel 手艺完化关键步。在里面 vivo anti-hyperglycemic 活动带着老鼠被评估口头的葡萄糖忍耐测试(OGTT ) ,和重要的显示出的所有综合混合物但是更少的有势力 anti-hyperglycemic 活动比积极控制 dapagliflozin。 | Wen Jing Zhao Yong Heng Shi Gui Long Zhao Yu Li Wang Hua Shao Li Da Tang Jian Wu Wang | 2011 | Chinese Chemical Letters2011，22，10： | 1 |
| 15 | CpG methylation plays a vital role in determining tissue-and cell-specific expression of the human cell-death-inducing DFF45-like effector a gene through the regulation of Sp1/Sp3 binding显示文摘 | Li D Da L Tang H | | 0，，01： | 1 |
| 16 | Forecasting regional income inequality in China显示文摘 | Fei Zheng Li Da xu BingYong Tang | | 0，，02： | 1 |
| 17 | An agent-based geographical information system显示文摘 | Tang Chao Xu Li Da | 2001 | Knowledge-Based System2001，14，： | 1 |
| 18 | The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population显示文摘Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index(BMI), and estimate their interactions with soybean food intake. Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model. Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly higher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64(95% confidence interval: 1.15-2.34, P<0.01) after adjusting for the common confounders. Conclusion Our study has suggested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake. | WANG Jin Wei TANG Xun LI Na WU Yi Qun LI Shuai LI Jin QIN Xue Ying ZHANG Zong Xin HU Yong Hua CHEN Da Fan | 2014 | Biomedical and Environmental Sciences2014，27，3： | 1 |
| 19 | Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa显示文摘Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference specimens.Awide geographic and taxonomic range of fungal taxa are detailed.In the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are introduced.Newly introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,C.quinquefoliae,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,M.pongdueatensis,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,O.ratnapurensis,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,P.dimocarpi,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,S.pseudorosae,Sigarispora ononidis and Towyspora aestuari.New combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium pini.Descriptions,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,Petrakia echinata,Phragmoporthe conformis and Pseudocamarosporium pini.The new species of Basidiomycota are Agaricus coccyginus,A.luteofibrillosus,Amanita atrobrunnea,A.digitosa,A.gleocystidiosa,A.pyriformis,A.strobilipes,Bondarzewia tibetica,Cortinarius albosericeus,C.badioflavidus,C.dentigratus,C.duboisensis,C.fragrantissimus,C.roseobasilis,C.vinaceobrunneus,C.vinaceogrisescens,C.wahkiacus,Cyanoboletus hymenoglutinosus,Fomitiporia atlantica,F.subtilissima,Ganoderma wuzhishanensis,Inonotus shoreicola,Lactifluus armeniacus,L.ramipilosus,Leccinum indoaurantiacum,Musumecia alpina,M.sardoa,Russula amethystina subp.tengii and R.wangii are introduced.Descriptions,illustrations,notes and/or reference specimens are designated for Clarkeinda trachodes,Dentocorticium ussuricum,Galzinia longibasidia,Lentinus stuppeus and Leptocorticium tenellum.The other new genera,species new combinations are Anaeromyces robustus,Neocallimastix californiae and Piromyces finnis from Neocallimastigomycota,Phytophthora estuarina,P.rhizophorae,Salispina,S.intermedia,S.lobata and S.spinosa from Oomycota,and Absidia stercoraria,Gongronella orasabula,Mortierella calciphila,Mucor caatinguensis,M.koreanus,M.merdicola and Rhizopus koreanus in Zygomycota. | Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke Verbeken Alfredo Vizzini Josef Vlasák Kerstin Voigt Dhanushka N.Wanasinghe Yong Wang Gothamie Weerakoon Hua An Wen Ting Chi Wen Nalin N.Wijayawardene Sarunyou Wongkanoun Marta Wrzosek Yuan Pin Xiao Jian Chu Xu Ji Ye Yan Jing Yang Shu Da Yang Yu Hu Jin Feng Zhang Jie Zhao Li Wei Zhou Derek Peršoh Alan J.L.Phillips Sajeewa S.N.Maharachchikumbura | 2016 | Fungal Diversity2016，，3： | 1 |
| 20 | A distinct lineage of influenza A virus from bats 显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo DA Chen LM Recuenco S Ellison JA Davis CT York IA Turmelle AS Moran D Rogers S Shi M Tao Y Weil MR Tang K Rowe LA Sammons S Xu X France M Lindblade KA Cox NJ Anderson LJ Rupprecht CE Donis RO | 2012 | Proc Natl Acad Sci USA2012，109，11： | 1 |
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