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| 1 | Welding Deviation Detection Algorithm Based on Extremum of Molten Pool Image Contour显示文摘The welding deviation detection is the basis of robotic tracking welding, but the on-line real-time measurement of welding deviation is still not well solved by the existing methods. There is plenty of information in the gas metal arc welding(GMAW) molten pool images that is very important for the control of welding seam tracking. The physical meaning for the curvature extremum of molten pool contour is revealed by researching the molten pool images, that is, the deviation information points of welding wire center and the molten tip center are the maxima and the local maxima of the contour curvature, and the horizontal welding deviation is the position difference of these two extremum points. A new method of weld deviation detection is presented, including the process of preprocessing molten pool images, extracting and segmenting the contours, obtaining the contour extremum points, and calculating the welding deviation, etc. Extracting the contours is the premise, segmenting the contour lines is the foundation, and obtaining the contour extremum points is the key. The contour images can be extracted with the method of discrete dyadic wavelet transform, which is divided into two sub contours including welding wire and molten tip separately. The curvature value of each point of the two sub contour lines is calculated based on the approximate curvature formula of multi-points for plane curve, and the two points of the curvature extremum are the characteristics needed for the welding deviation calculation. The results of the tests and analyses show that the maximum error of the obtained on-line welding deviation is 2 pixels(0.16 mm), and the algorithm is stable enough to meet the requirements of the pipeline in real-time control at a speed of less than 500 mm/min. The method can be applied to the on-line automatic welding deviation detection. | ZOU Yong JIANG Lipei LI Yunhua XUE Long HUANG Junfen HUANG Jiqiang | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 12 |
| 2 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 3 | Analysis of Powdery Mildew Resistance in Wild Melon MLO Mutants显示文摘Wild species have a potential value in crop breeding. Explore MLO gene which related with powdery mildew natural resistance is very important for improving the quality of melon. Resistance to powdery mildew was examined in cultivar and wild species by leaf inoculation. The wild germplasms showed resistance to powdery mildew Race1. Cloning and sequence analysis of the Cm MLO2 gene identified an 85 bp difference between the wild and cultivated species. The Cm MLO2 gene was expressed in the wild germplasm after fluorescence-labeled Agrobacterium-mediated transformation. A positive transgenic plant showed successful invasion by powdery mildew Race1. These results suggested that the wild species might have failed to encode the MLO protein, thereby resulting in the MLO-negative regulation of powdery mildew, which in turn resulted in the broad-spectrum resistance of the wild species to powdery mildew. | CHENG Hong KONG Weiping Lü Junfen LI Jiping | 2015 | Horticultural Plant Journal2015，1，3： | 5 |
| 4 | Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives显示文摘In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activitiesagainst human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compotmds screened,4,5,6,7-tetrahydrobenzo[d]thiazole(26b) exhibited the most potent antittunor activities with IC50 values of 4.89 and4.03 μmol/L against the two tested cell lines, respectively. Preliminary structure-activity relationship(SAR) studies ofthese compound were subsequently investigated. | LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing YOU Guirong HAN Junfen FU Xiaopan | 2016 | Chemical Research in Chinese Universities2016，32，6： | 3 |
| 5 | COVID-19 vaccine development:milestones,lessons and prospects显示文摘With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered. | Maochen Li Han Wang Lili Tian Zehan Pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 6 | An investigation of the thermal degradation of the intumescent coating containing MoO3and Fe203 显示文摘 | LI Guoxin YANG Junfen HE Tingshu | 2008 | Surf Coat Technol2008，202，： | 1 |
| 7 | An investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3显示文摘 | LI GUOXIN YANG JUNFEN HE TINGSHU | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 8 | An efficient synthesis of 3, 4-dihydropyrimidin-2- ones catalyzed by NH2SO3 H under ultrasound irradiation 显示文摘 | LI Jitai HAN Junfen YANG Jinhui | 2003 | Ultrasonics Sonochemistry2003，10，3： | 1 |
| 9 | Controllable functionalization of single-wall carbon nanotubes by in situ polymerization method for organic photovoltaic devices显示文摘 | Daqin Yun Wei Feng Hongcai Wu Baoming Li Xiaozheng Liu Wenhui Yi Junfen Qiang Song Gao Shaolin Yan | 2008 | Synthetic Metals2008，，21： | 1 |
| 10 | Methane sensor based on nanocomposite of palladium/multi-walled carbon nanotubes grafted with 1,6-hexanediamine显示文摘 | Li Zhongping Li Junfen Wu Xu | 2009 | Sensors and Actuators B2009，139，： | 1 |
| 11 | miR-375 Is Down-Regulated in Squamous Cervical Cancer and Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1显示文摘 | Fenfen Wang Yang Li Jiansong Zhou Junfen Xu Chanjuan Peng Feng Ye Yuanming Shen Weiguo Lu Xiaoyun Wan Xing Xie | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 12 | VEGF-A not Ang2 mediates endothelial-like differentiation of immatureDCs by ERK1/2 signaling in the microenvironment of human colon adenocarcinoma显示文摘 | Jing Lu Kangdong Liu Jimin Zhao Jun Zhao Junfen Ma Hongyan Yang Youtian Huang Zhenzhu Qin Ruihua Bai Lili Jiang Fengshou Lv Pei Li Wenhai Yan Mingyao Zhao Ziming Dong | 2011 | International Journal of Oncology2011，，6： | 1 |
| 13 | miR-375 Is Down-Regulated in Squamous Cervical Cancer and Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1显示文摘 | Fenfen Wang Yang Li Jiansong Zhou Junfen Xu Chanjuan Peng Feng Ye Yuanming Shen Weiguo Lu Xiaoyun Wan Xing Xie | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 14 | Study on the inclusion complexes of eryptotanshinone with β-eyelodextrin and β- hydroxypropyl-β-cyelodextrin显示文摘 | Li Junfen Wei Yuxia Ding Lihua | 2003 | Speetrochim Acta A Mol Biomol Speetrosc2003，59，12： | 1 |
| 15 | Graph Convolutional Network Combined with Semantic Feature Guidance for Deep Clustering显示文摘The performances of semisupervised clustering for unlabeled data are often superior to those of unsupervised learning,which indicates that semantic information attached to clusters can significantly improve feature representation capability.In a graph convolutional network(GCN),each node contains information about itself and its neighbors that is beneficial to common and unique features among samples.Combining these findings,we propose a deep clustering method based on GCN and semantic feature guidance(GFDC) in which a deep convolutional network is used as a feature generator,and a GCN with a softmax layer performs clustering assignment.First,the diversity and amount of input information are enhanced to generate highly useful representations for downstream tasks.Subsequently,the topological graph is constructed to express the spatial relationship of features.For a pair of datasets,feature correspondence constraints are used to regularize clustering loss,and clustering outputs are iteratively optimized.Three external evaluation indicators,i.e.,clustering accuracy,normalized mutual information,and the adjusted Rand index,and an internal indicator,i.e., the Davidson-Bouldin index(DBI),are employed to evaluate clustering performances.Experimental results on eight public datasets show that the GFDC algorithm is significantly better than the majority of competitive clustering methods,i.e.,its clustering accuracy is20% higher than the best clustering method on the United States Postal Service dataset.The GFDC algorithm also has the highest accuracy on the smaller Amazon and Caltech datasets.Moreover,DBI indicates the dispersion of cluster distribution and compactness within the cluster. | Junfen Chen Jie Han Xiangjie Meng Yan Li Haifeng Li | 2022 | Tsinghua Science and Technology2022，27，5： | 1 |
| 16 | An investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3 显示文摘 | LI GUOXIN YANG JUNFEN HE TINGSHU | 2008 | Surface & Caotings Technology2008，202，： | 1 |
| 17 | An Investigation of the thermal degradation of the intumescent coating containing MoO3 and Fe2O3显示文摘 | Guoxin Li a Junfen Yang Tingshu He | 2008 | Surface & Coatings TechnoLogy2008，202，： | 1 |
| 18 | Synthesis and Spectrum Characteristic of New Organic Fluorescence Dyes of Four Pyrazoline Compounds显示文摘 | Guan Bai Peihua Lin Junfen Li Du xin Li Chuan Dong | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 19 | Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer显示文摘Platinum-based chemotherapy remains the main systemic treatment of ovarian cancer(OC).However,the inevitable development of platinum and poly(adenosine diphosphate-ribose)polymerase inhibitor(PARPi)resistance is associated with poor outcomes,which becomes a major obstacle in the management of this disease.The present study developed“all-in-one”nanoparticles that contained the PARPi olaparib and gallium(Ga)(III)(olaparib-Ga)to effectively reverse PARPi resistance in platinum-resistant A2780-cis and SKOV3-cis OC cells and in SKOV3-cis tumor models.Notably,the olaparib-Ga suppressed SKOV3-cis tumor growth with negligible toxicity.Moreover,the suppression effect was more evident when combining olaparib-Ga with cisplatin or carboplatin,as evaluated in A2780-cis and SKOV3-cis cells.Mechanistically,the combined treatment induced DNA damage,which elicited the activation of ataxia telangiectasia mutated(ATM)/AMT-and Rad3-related(ATR)checkpoint kinase 1(Chk1)/Chk2 signal transduction pathways.This led to the arrest of cell cycle progression at S and G2/M phases,which eventually resulted in apoptosis and cell death due to unrepairable DNA damage.In addition,effective therapeutic responses to olaparib-Ga and cisplatin combination or olaparib-Ga and carboplatin combination were observed in SKOV3-cis tumor-bearing animal models.Altogether,the present findings demonstrate that olaparib-Ga has therapeutic implications in platinum-resistant OC cells,and the combination of olaparib-Ga with cisplatin or carboplatin may be promising for treating patients with OC who exhibit resistance to both PARPi and platinum. | Yangyang Li Yixuan Cen Mengyan Tu Zhenzhen Xiang Sangsang Tang Weiguo Lu Hongbo Zhang Junfen Xu | 2023 | Research2023，，3： | 0 |
| 20 | Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells显示文摘Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 Chemical inhibition of the enzymatic activity of PLD1 and PLD2,or genetic down-regulation of their expression both induce tumor suppression,1 while the compounds for PLD expression inhibition are barely reported.Here,we astonishingly found that the anti-hyperglycemic agents biguanides decreased PLD1 protein expression in cancer cells and further investigated its underlying regulatory mechanism. | Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou Derek Toomre Junfen Fu Yingke Xu | 2023 | Genes & Diseases2023，10，5： | 0 |
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