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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 3 | Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice显示文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice. | Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang Wendong Huang Li Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 4 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 5 | Characterization and Apparent Kinetics of Polymerization of 1-Decene Catalyzed by Boron Trifluoride/Alcohol System显示文摘Poly-α-olefin(PAO) synthetic oil is the base oil of high-quality lubricants, and has a huge market potential.We illustrate PAO synthesis by catalytic polymerization of 1-decene with a boron trifluoride(BF_3)/alcohol system. Gas chromatography–mass spectrometry, proton nuclear magnetic resonance and ^(13) C nuclear magnetic resonance analysis confirmed dimer, trimer and tetramer structures of PAO. Each component contained branched chains with a 1,2 insertion of a head-to-tail link; a 2,1 insertion of a tail-to-tail link and a methyl-containing linked structure. At a low conversion rate, the reaction rate was related directly with the reaction temperature and the catalyst/1-decene concentration. An apparent kinetic equation for PAO formation was determined during 1-decene polymerization. | Wang Sihan Wang Libo Liu Tong Ma Lili Huo Hongliang Wang Jian | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 7 |
| 6 | Methodology for reliability allocation based on fault tree analysis and dualistic contrast显示文摘Reliability allocation is a difficult multi-objective optimization problem. This paper presents a methodology for reliability allocation that can be applied to determine the reliability characteristics of reactor systems or subsystems. The dualistic contrast,known as one of the most powerful tools for optimization problems,is applied to the reliability allocation model of a typical system in this article. And the fault tree analysis,deemed to be one of the effective methods of reliability analysis,is also adopted. Thus a failure rate allocation model based on the fault tree analysis and dualistic contrast is achieved. An application on the emergency diesel generator in the nuclear power plant is given to illustrate the proposed method. | TONG Lili CAO Xuewu | 2008 | Nuclear Science and Techniques2008，19，4： | 4 |
| 7 | Efficient degradation of Rhodamine B by magnetically recoverable Fe_(3)O_(4)-modified ternary CoFeCu-layered double hydroxides via activating peroxymonosulfate显示文摘Environment-friendly nano-catalysts capable of activating peroxymonosulfate(PMS)have received increasing attention recently.Nevertheless,traditional nano-catalysts are generally well dispersed and difficult to be separated from reaction system,so it is particularly important to develop nano-catalysts with both good catalytic activity and excellent recycling efficiency.In this work,magnetically recoverable Fe_(3)O_(4)-modified ternary CoFeCu-layered double hydroxides(Fe_(3)O_(4)/CoFeCu-LDHs)was prepared by a simple co-precipitation method and initially applied to activate PMS for the degradation of Rhodamine B(Rh B).X-ray diffraction(XRD),fourier transform infrared spectrometer(FT-IR),scanning electron microscope(SEM),transmission electron microscopy(TEM),Brunauer-Emmett-Teller method(BET),and vibrating sample magnetometer(VSM)were applied to characterize morphology,structure,specific surface area and magnetism.In addition,the effects of several key parameters were evaluated.The Fe_(3)O_(4)/CoFeCu-LDHs exhibited high catalytic activity,and Rh B degradation efficiency could reach 100%within 20 min by adding 0.2 g/L of catalyst and 1 mmol/L of PMS into 50 mg/L of Rh B solution under a wide pH condition(3.0-7.0).Notably,the Fe_(3)O_(4)/CoFeCu-LDHs showed good super-paramagnetism and excellent stability,which could be effectively and quickly recovered under magnetic condition,and the degradation efficiency after ten cycles could still maintain 98.95%.Both radicals quenching tests and electron spin resonance(ESR)identified both HO·and SO_(4)^(·-) were involved and SO_(4)^(·-) played a dominant role on the RhB degradation.Finally,the chemical states of the sample’s surface elements were measured by X-ray photoelectron spectroscopy(XPS),and the possible activation mechanism in Fe_(3)O_(4)/CoFeCu-LDHs/PMS system was proposed according to comprehensive analysis. | Tong Li Xiange Du Jieqiong Deng Kai Qi Jiandong Zhang Lili Gao Xiuping Yue | 2021 | Journal of Environmental Sciences2021，33，10： | 4 |
| 8 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 9 | Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits显示文摘Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group. | Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin | 2021 | Bioactive Materials2021，6，11： | 3 |
| 10 | Accration and Subduction of Seamounts in West Junggar显示文摘Recently,through implementation of the National Nature Science Foundation of China(No.41303027)and Special Fund for Basic Scientific Research of Central Colleges(310827153506,310827153407,2014G1271058),we focused on basalts in Darbut and Karamay ophiolitic mélanges in West Junggar which is a part of the Central Asian Orogenic Belt,and made some advances as follows. | YANG Gaoxue LI Yongjun TONG Lili LI Ganyu SHEN Rui WU Le | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 3 |
| 11 | Research on Intelligent Logic Design and Application of Campus MMTC Scene Based on 5G Slicing Technology显示文摘A consensus has been reached that 5G network slicing technology is becoming increasingly important in EMBB,MMTC and URLLC.However,this technology still has a long way to go in education industry.By selecting four types of demands in campus MMTC scenarios as specific application references,this research explores the architectural relationship between network slicing layer,intelligent terminal layer and application capability layer.Besides,emphasis has been put on the influences that virtual logic network design technology,isolation technology and standard technology has on application experiences.Under such goal,a two-dimensional route has been proposed to deploy network slicing technology based on the concept of full life cycle and the synergistic effect that AI algorithms has on slicing technology.This research is expected to nurture slicing technology,not only its technology chain,but more importantly,facilitate its value chain and large-scale vertical industry applications. | Lili Tong Chen Zhang Ronghuai Huang | 2021 | China Communications2021，18，8： | 3 |
| 12 | Simulation of quenching in horizontal geometry channel显示文摘Two tests of refilling and reflooding in the horizontal geometry channel under different pressure conditions,respectively,are conducted to understand the thermal hydraulics behavior during a LOCA in the CANDU reactor.One case of refilling a hot horizontal tube test and four cases of reflooding a horizontal fuel channel test series (35%and 60%break size of reactor inlet header with single-end injection or both-end injection,respectively) have been simulated.The horizontal channel is simulated with the model splitting as parallel pipes with cross flow junction component.The simulation results have been compared with the tests in terms of wall temperature or heated-pin surface temperature.The results are reasonably acceptable and it shows that the code is applicable on horizontal channel quenching. | Yuan Jingtian Tong Lili Cao Xuewu | 2010 | Nuclear Science and Techniques2010，21，6： | 3 |
| 13 | Geochronological and Geochemical Constrains on Petrogenesis of the Jietebutiao A-type Granite in West Junggar,Xinjiang显示文摘晚古生代的 post-collisional granitoids 在西方 Junggar,以及北 Xinjiang 是普遍的。作为那些侵入的一个代表, Jietebutiao 花岗石在西方 Junggar (西北中国) 的西南的边缘发生,并且由中间纹理粗糙的 monzogranite 和 syenogranite 主要构成。在现在的学习,我们报导第一次在 Jietebutiao 花岗石上标明日期的高精确的锆石 laser-ablationinductively-coupled 血浆 massspectrometry UPb 的结果,吗并且产出 287 的加权的吝啬的 206Pb/238U 年龄?????????????????????????????? | YANG Gaoxue LI Yongjun TONG Lili ZHANG Bing TIAN Zhixian YANG Baokai | 2013 | Acta Geologica Sinica(English Edition)2013，87，1： | 3 |
| 14 | Effect of hydrogen combustion in the primary pump compartment显示文摘Hydrogen combustion in a nuclear power plant may threaten the integrity of some important systems and components.In this paper,the effect of hydrogen combustion in the primary pump compartment is analyzed by different initial hydrogen concentration and igniter locations using Computational Fluid Dynamics method.The results show that the combustion is confined to a limited area without pump damage at about 6.6%hydrogen volume fraction.Once igniting the hydrogen,the combustion affects the whole compartment at the 12%hydrogen volume fraction.The stress caused by the great temperature gradient or high temperature may damage the primary pump. Igniters at the lower location accelerate the combustion process and cause a threat to the pump integrity. | LI Jingxi TONG Lili CAO Xuewu | 2012 | Nuclear Science and Techniques2012，23，6： | 3 |
| 15 | Oceanic Island Basalts within the West Junggar Ophiolitic Mélanges: Petrogenetic and Tectonic Implications显示文摘Recently,we focused on the Darbut and Karamay ophiolitic mélanges in West Junggar of the Central Asian Orogenic Belt(CAOB,?engr et al.,1993;Windley et al.,2007;Xiao and Santosh,2014),and made much progress.This study was supported by the National Nature Science Foundation of China(No.41303027)and Special Fund for Basic Scientific Research of Central Colleges Project(No.2014G1271058).The achievements are illustrated as follows. | YANG Gaoxue LI Yongjun TONG Lili LI Ganyu SHEN Rui CHAO Wendi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 3 |
| 16 | Alkaline Basalts in the Bayingou Ophiolitic Melange of Northern Tianshan Mountains:Origination from Seamounts?显示文摘Objective The Bayingou ophiolitic melange is located in Northern Tianshan Mountains of the southern Central Asian Orogenic Belt which is the largest accretionary orogen among the European,Siberian,Tarim and North China cratons.The Bayingou ophiolitic melange provide a critical geological record for unraveling regional tectonic | YANG Gaoxue LI Yongjun TONG Lili LI Ganyu SHEN Rui LI Zhao | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 2 |
| 17 | Design optimization of composite egg-shaped submersible pressure hull for minimum buoyancy factor显示文摘This paper describes a design optimization study of the composite egg-shaped submersible pressure hull employing optimization and finite element analysis(FEA)tools as a first attempt to provide an optimized design of the composite egg-shaped pressure hull for manufacturing or further investigations.A total of 15 optimal designs for the composite egg-shaped pressure hull under hydrostatic pressure are obtained in terms of fibers’angles and the number of layers for 5 lay-up arrangements and 3 unidirectional(UD)composite materials.The optimization process is performed utilizing a genetic algorithm and FEA in ANSYS.The minimization of the buoyancy factor eB:FT is selected as the objective for the optimization under constraints on both material failure and buckling strength.Nonlinear buckling analysis is conducted for one optimal design considering both geometric nonlinearity and imperfections.A sensitivity study is also conducted to further investigate the influence of the design variables on the optimal design of the egg-shaped pressure hull. | Muhammad Imran Dongyan Shi Lili Tong Hafiz Muhammad Waqas Muqeem Uddin | 2021 | Defence Technology(防务技术)2021，17，6： | 2 |
| 18 | Vapor film collapse triggered by external pressure pulse and the fragmentation of melt droplet in FCIs显示文摘The fragmentation process of high-temperature molten drop is a key factor to determine the ratio heat transferred to power in FCIs,which estimates the possible damage degree during the hypothetical severe accident in the nuclear reactors. In this paper,the fragmentation process of melt droplet in FCIs is investigated by theoretic analysis. The fragmentation mechanism is studied when an external pressure pulse applied to a melt droplet,which is surrounded by vapor film. The vapor film collapse which induces fragmentation of melt droplet is analyzed and modeled. And then the generated pressure is calculated. The vapor film collapse model is introduced to fragmentation correlation,and the predicted fragment size is calculated and compared with experimental data. The result shows that the developed model can predict the diameter of fragments and can be used to calculate the fragmentation process appreciatively. | LIN Qian TONG Lili CAO Xuewu KRIVENTSEV Vladimir | 2008 | Nuclear Science and Techniques2008，19，4： | 2 |
| 19 | Reduction-induced interface reconstruction to fabricate MoNi_(4) - based hollow nanorods for hydrazine oxidation assisted energysaving hydrogen production in seawater显示文摘Seawater electrolysis could address the water scarcity issue and realize the grid-scale production of carbon-neutral hydrogen,while facing the challenge of high energy consumption and chloride corrosion.Thermodynamically more favorable hydrazine oxidation reaction(HzOR)assisted water electrolysis is efficiency for energy-saving and chlorine-free hydrogen production.Herein,the MoNi alloys supported on MoO_(2) nanorods with enlarged hollow diameter on Ni foam(MoNi@NF)are synthesized,which is constructed by limiting the outward diffusion of Ni via annealing and thermal reduction of NiMoO_(4) nanorods.When coupling HzOR and hydrogen evolution reaction(HER)by employing MoNi@NF as both anode and cathode in two-electrode seawater system,a low cell voltage of 0.54 V is required to achieve 1,000 mA·cm^(−2) and with long-term durability for 100 h to keep above 100 mA·cm^(−2) and nearly 100%Faradaic efficiency.It can save 2.94 W·h to generate per liter H_(2) relative to alkaline seawater electrolysis with 37%lower energy equivalent input. | Lili Guo Qingping Yu Xuejun Zhai Jingqi Chi Tong Cui Yu Zhang Jianping Lai Lei Wang | 2022 | Nano Research2022，15，10： | 2 |
| 20 | Model comparisons on molten core-concrete interactions显示文摘Based on the plant model of 600-MW PWR,the molten core-concrete interactions(MCCI) under different models are studied.Station blackout (SBO) with steam-driven auxiliary feed water pump failure is selected as the case for the model comparisons analysis.The result shows that thermal resistance model between debris and concrete has much influence on the consequence of MCCI.The concrete erosion rate calculated with gas film model is much higher than that of slag film model.Some other model comparisons such as the chemical reaction heat and the configuration molten pool are also discussed. | TONG Lili CAO Xuewu LI Jingxi YANG Yajun | 2009 | Nuclear Science and Techniques2009，20，4： | 2 |
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