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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | The Auxin-Regulated Protein ZmAuxRPI Coordinates the Balance between Root Growth and Stalk Rot Disease Resistance in Maize显示文摘To optimize fitness, plants must efficiently allocate their resources between growth and defense. Although phytohormone crosstalk has emerged as a major player in balancing growth and defense, the genetic basis by which plants man age this balance remai ns elusive. We previously ide ntified a quantitative disease . resistance locus, qRfg2, in maize (Zea mays) that protects against the fungal disease Gibberella stalk rot. Here, through map-based cloning, we demonstrate that the causal gene at qRfg2 is ZmAuxRPI, which encodes a plastid stroma-localized auxin-regulated protein. ZmAuxRPI responded quickly to pathogen challenge with a rapid yet transient reduction in expression that led to arrested root growth but enhanced resista nee to Gibberella stalk rot and Fusarium ear rot. ZmAuxRPI was show n to promote the biosynthesis of indole-3-acetic acid (IAA), while suppressing the formation of benzoxazinoid defense compounds. ZmAuxRPI presumably acts as a resource regulator modulating indole-3-glycerol phosphate and/or indole flux at the branch point between the IAA and benzoxazinoid biosynthetic pathways. The concerted interplay between IAA and benzoxazinoids can regulate the growth-defense balance in a timely and efficient manner to optimize plant fitness. | Jianrong Ye Tao Zhong Dongfeng Zhang Chuanyu Ma Lina Wang Lishan Yao Qianqian Zhang Mang Zhu Mingliang Xu | 2019 | Molecular Plant2019，12，3： | 19 |
| 3 | Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction显示文摘This study was designed to determine the levels of early endothelial progenitor cells(EPCs),apelin,vascu-lar endothelial growth factor(VEGF) and stromal cell-derived growth factor-1(SDF-1) after acute myocardial infarction(AMI),and to investigate the relationships between these cytokines and early EPCs.Early EPCs,de-fined as CD133+,KDR+,and CD34+ cells,were quantified by flow cytometry.The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls(P < 0.05).Plasma apelin levels were inversely correlated with Gensini score and early EPCs(both P < 0.01).Early EPCs,VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h.The trend in the change of early EPCs was proportionally correlated with that of VEGF(P < 0.05).AMI patients exhibited in-creased early EPCs with remarkably decreased apelin levels and enhanced VEGF levels. | Jiaxin Ye Ping Ni Lina Kang Biao Xu | 2012 | The Journal of Biomedical Research2012，26，6： | 16 |
| 4 | A radiomic nomogram based on an apparent diffusion coefficient map for differential diagnosis of suspicious breast findings显示文摘Objective: To develop and validate a radiomic nomogram based on an apparent diffusion coefficient(ADC) map for differentiating benign and malignant lesions in suspicious breast findings classified as Breast Imaging Reporting and Data System(BI-RADS) category 4 on breast magnetic resonance imaging(MRI).Methods: Eighty-eight patients diagnosed with BI-RADS 4 findings on breast MRI in the First Affiliated Hospital of China Medical University from December 2014 to December 2015 were retrospectively analyzed in this study. Sixty-three were randomized electronically to establish forecasting models, and the other 25 were used for validation. Radiomic features based on the ADC map were generated automatically by Artificial Intelligence Kit software(A.K. software; GE Healthcare, China). Feature reduction was conducted using the Mann-Whitney test and Spearman correlation after pre-treatment. A prediction model of ADC radiomics was established by logistic linear regression and cross-validation. A nomogram was established based on ADC radiomic features,pharmacokinetics and clinical features, including the morphology and ADC value for breast BI-RADS 4 lesions on MRI.Results: A total of 396 radiomic features were extracted automatically by the A.K. software. Five features were selected after pre-processing, Mann-Whitney tests and Spearman correlation analysis. The area under the ROC curve of the prediction model comprising ADC radiomic features was 0.79 when the cutoff value was 0.45, and the accuracy, sensitivity and specificity were 80.0%, 0.813 and 0.778, respectively. A visualized differential nomogram based on the radiomic score, pharmacokinetics and clinical features was established. The decision curve showed good consistency.Conclusions: ADC radiomic features could provide an important reference for differential diagnosis between benign and malignant lesions in suspicious BI-RADS 4 lesions. The visualized nomogram based on ADC radiomic features, pharmacokinetics and clinical features may have good prospects for clinical application. | Bin Hu Ke Xu Zheng Zhang Ruimei Chai Shu Li Lina Zhang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 15 |
| 5 | A review of the end-effector of large space manipulator with capabilities of misalignment tolerance and soft capture显示文摘The space manipulator which has advantages of high dexterity and universality, is used to the space capturing usually. According to the different types of mechanical interfaces of targets, the on orbit capturing operation includes capturing of cooperative target and capturing of uncooperative target. The performances of the famous large space manipulators named space shuttle remote manipulator system(SRMS), the space station remote manipulator system(SSRMS) and the Europe robotic arm(ERA) are reviewed and studied respectively. Moreover, the space manipulators being developed by China for space station is also surveyed. Based on the performance analysis of the large space manipulators and end-effectors, which are adapted to the construction and daily maintenance for the large space structure such as the space station, the basic requirements of large misalignment tolerance capability, soft capturing capability and hard docking capability for the end-effector of large space manipulator are proposed in this paper. According to these requirements, the capture mechanism and methods that can enable the end-effector to have the capability of misalignment tolerance and soft capturing are presented. The development trend and key technologies of the large space manipulators and the end-effectors are also reviewed. | FENG Fei TANG LiNa XU JianFeng LIU Hong LIU YiWe | 2016 | Science China(Technological Sciences)2016，59，11： | 15 |
| 6 | Interaction between Rice stripe virus Disease- Specific Protein and Host PsbP Enhances Virus Symptoms显示文摘瑞斯条纹病毒(RSV ) 在许多东方亚洲国家在 Oryza sativa (米饭) 引起严重疾病。RSV 的疾病特定的蛋白质(SP ) 是非结构的蛋白质,它在米饭植物的 accumulationlevel 被显示决定 RSV 症状的严厉。这里,我们在米饭或 Nicotiana benthamiana 独自一个的 RSVSP 的那表情没生产可见症状的现在的证据。然而,在这二植物的 SP 的表示提高了 RSV- 或土豆病毒 X (PVX ) 导致了症状。通过酵母二混血儿的屏蔽, GST 下拉,和双分子的荧光互补试金,我们证明 RSV SP 与 PsbP 交往了, 23-kDa 演变氧的复杂蛋白质,在米饭和 N。benthamiana。而且,我们的调查证明在两植物的 PsbP 表示的 silencing 增加了疾病症状 severityand 病毒累积。共焦的显微镜学使用 N。benthamiana 原物证明 PsbP 在野类型的 N 在叶绿体主要积累了。benthamiana 房间。面对 RSV SP,大多数 PsbP 被招募进 assayed 房间的细胞质。另外, accumulationof SP 在 RSV 感染期间导致了叶绿体结构和功能的改变。我们的调查结果使位于 RSV 疾病症状 development.Key 词下面的 molecularmechanism 清楚些: | Lingfang Kong Jianxiang Wu Lina Lu Yi Xu Xueping Zhou | 2014 | Molecular Plant2014，7，4： | 13 |
| 7 | Synthesis of High Purity SiC Powder for High-resistivity SiC Single Crystals Growth显示文摘高纯净硅碳化物(原文如此)粉末被在硅之间的 chemicalreaction 在原处综合,保证 theresulting 的杂质集中原文如此搽粉的碳 powder.In 顺序对高抵抗力的原文如此单个的水晶生长合适, preparationtechnology 原文如此搽粉与的不同原文如此形态学和阶段作文上的形状和 sizeof 碳粒子的 ceramic.The 影响原文如此获得了粉末 werediscussed.The | Li WANG Xiaobu HU Xiangang XU Shouzheng JIANG Lina NING Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，1： | 13 |
| 8 | The calcium-dependent kinase OsCPK24 functions in cold stress responses in rice显示文摘Calcium-dependent protein kinases(CPKs)are serine/threonine protein kinases that function in plant stress responses. Although CPKs are recognized as key messengers in signal transduction, the specific roles of CPKs and the molecular mechanisms underlying their activity remain largely unknown. Here, we characterized the function of Os CPK_(24), a cytosol-localized calciumdependent protein kinase in rice. Os CPK_(24) was universally and highly expressed in rice plants and was induced by cold treatment. Whereas Os CPK_(24) knockdown plants exhibited increased sensitivity to cold compared to wild type(WT), Os CPK_(24)-overexpressing plants exhibited increased cold tolerance. Plants overexpressing Os CPK_(24) exhibited increased accumulation of proline(an osmoprotectant) and glutathione(an antioxidant) and maintained a higher GSH/GSSG(reduced glutathione to oxidized glutathione) ratio during cold stress compared to WT. In addition to these effects in response to cold stress, we observed the kinase activity of Os CPK_(24) varied under different calcium concentrations. Further,Os CPK_(24) phosphorylated Os Grx_(10), a glutathionedependent thioltransferase, at rates modulated by changes in calcium concentration. Together, our results support the hypothesis that Os CPK_(24) functions as a positive regulator of cold stress tolerance in rice, a process mediated by calcium signaling and involving phosphorylation and the inhibition of Os Grx_(10) to sustain higher glutathione levels. | Yu Liu Chunjue Xu Yanfen Zhu Lina Zhang Taiyu Chen Fei Zhou Hao Chen Yongjun Lin | 2018 | Journal of Integrative Plant Biology2018，60，2： | 12 |
| 9 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 10 | Influence of plant architecture on maize physiology and yield in the Heilonggang River valley显示文摘The size and distribution of leaf area determine light interception in a crop canopy and influence overall photosynthesis and yield. Optimized plant architecture renders modern maize hybrids(Zea mays L.) more productive, owing to their tolerance of high plant densities. To determine physiological and yield response to maize plant architecture, a field experiment was conducted in 2010 and 2011. With the modern maize hybrid ZD958, three plant architectures, namely triangle, diamond and original plants, were included at two plant densities, 60,000 and 90,000 plants ha-1. Triangle and diamond plants were derived from the original plant by spraying the chemical regulator Jindele(active ingredients,ethephon, and cycocel) at different vegetative stages. To assess the effects of plant architecture, a light interception model was developed. Plant height, ear height, leaf size,and leaf orientation of the two regulated plant architectures were significantly reduced or altered compared with those of the original plants. On average across both plant densities and years, the original plants showed higher yield than the triangle and diamond plants,probably because of larger leaf area. The two-year mean grain yield of the original and diamond plants were almost the same at 90,000 plants ha-1(8714 vs. 8798 kg ha-1). The yield increase(up to 5%) of the diamonds plant at high plant densities was a result of increased kernel number per ear, which was likely a consequence of improved plant architecture in the top and middle canopy layers. The optimized light distribution within the canopy can delay leaf senescence, especially for triangle plants. The fraction of incident radiation simulated by the interception model successfully reflected plant architecture traits. Integration of canopy openness is expected to increase the simulation accuracy of the present model. Maize plant architecture with increased tolerance of high densities is probably dependent on the smaller but flatter leaves around the ear. | Shoubing Huang Yingbo Gao Yebei Li Lina Xu Hongbin Tao Pu Wang | 2017 | The Crop Journal2017，5，1： | 11 |
| 11 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 12 | 一种面向WSN的双向身份认证协议及串空间模型显示文摘随着工业互联网、智慧农业、智能家居等领域的发展,无线传感网络(WSN)得到了更广泛的应用,但安全问题也随之凸显。针对无线传感网络中传感器节点易失效、能量和计算存储能力受限等问题,构建了一种基站与传感器节点间的基于状态信息的双向身份认证协议,其能在满足无线传感网络轻量级和低成本要求的同时确保安全性。协议首先在节点接入阶段基于可信网络连接进行平台可信情况的认证,以验证节点的可信情况并实现节点的加密注册。然后在运行阶段通过重要数据双向认证过程对重要数据的传输过程进行保护,利用定时更新认证确认传感器节点的状态和可靠性。协议允许基站定时检测节点的运行状态信息,及时监测到节点的物理损坏,并利用节点的运行状态信息进行认证,以进一步增强协议的安全性。同时,该协议还引入了报警机制,该机制可以区分通信错误、节点的物理损坏以及攻击者攻击。本协议降低了认证过程的通信量,引入的报警消息可以增强排障能力。利用串空间模型对协议进行形式化分析,证明了协议的安全性。最后通过实验验证了设计的双向身份认证协议能提供较好的安全性,而且发送数据增加的延迟时间在可接受的范围内,网络可扩展性好。所提方案能够加强网络接入安全并且有效防御来自节点系统内部的攻击,具有较好的应用价值。 | 刘静 赖英旭 杨胜志 Lina Xu | 2019 | 计算机科学2019，46，9： | 10 |
| 13 | Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study显示文摘BACKGROUND: Plasma inflammatory factor, such as C-reactive protein, whose content is regarded as a sensitively pathological marked protein and quantitative indexes of central nervous system injury, has been paid more and more attention in clinic. OBJECTIVE: To observe the effects and clinical significance of C-reactive protein in patients with craniocerebral injury after hyperbaric oxygenation. DESIGN: Randomized controlled study. SETTING: Departments of Neurosurgery, Laboratory and Hyperbaric Oxygen, the Second Affiliated Hospital, Medical College of Shantou University. PARTICIPANTS: A total of 60 patients with craniocerebral injury were selected from Department of Neurosurgery, the Second Affiliated Hospital, Medical College of Shantou University from October 2006 to April 2007. There were 37 males and 23 females and the mean age was 26 years. All subjects were certainly diagnosed as history of craniocerebral injury. Patients hospitalized at 24 hours after injury, Glasgow Coma Score ranged from 3 to 12 points, and all patients were certainly diagnosed with CT or MR scanning. Patients and their relatives provided confirmed consent. All the subjects were randomly divided into hyperbaric oxygenation group and control group with 30 in each group. METHODS: Patients in the control group were treated with routinely neurosurgical therapy after hospitalization; however, based the same basic treatment in the control group, patients in the hyperbaric oxygenation group received hyperbaric oxygenation by using iced-wheel four-door 2-cabin air-compression chamber (made in Yantai) from 24 hours to 10 days after operation or injury. After entering the cabin, patients who had a clear consciousness breathed the oxygen by using face mask; contrarily, patients directly breathed the oxygen. Therapeutic project: Expression was increased for about 15–20 minutes, maintained for about 70–80 minutes, and decreased for 20 minutes. Otherwise, pressure was maintained from 0.2 to 0.25 MPa. Hyperbaric oxygenation took an hour for once a day and 10 times were regarded as a course. Venous blood was collected before treatment and on the next day of the first course end. Content of C-reactive protein in plasma was measured with immune turbidimetry in hyperbaric oxygenation group; in addition, content of C-reactive protein in plasma was directly measured with the same method at the corresponding time in the control group. If the content was less or equal to 8 mg/L, it was regarded as normal value. Effects of the two groups were evaluated based on Glasgow Coma Score before and after treatment. MAIN OUTCOME MEASURES: Content of plasma C-reactive protein and Glasgow Coma Score in the two groups before and after treatment. RESULTS: All 60 patients were involved in the final analysis. ① Content of plasma C-reactive protein: The two contents were obviously higher than normal value after craniocerebral injury. There was no significant difference in the two groups before treatment (P > 0.05), but both contents were decreased after treatment, and there was significant difference between HBOT group and control group after treatment (t =4.756, P < 0.01). In addition, there was significant difference in hyperbaric oxygen therapy group before and after treatment (t =5.236, P < 0.01). ② Glasgow Coma Score: There was no significant difference in the two groups before treatment (P > 0.05), but scores were increased in both groups after treatment (t =9.92, 2.51, P < 0.01, 0.05); on the other hand, therefore, there was significant difference between the two groupsafter treatment (t =9.21, P < 0.01). CONCLUSION: Hyperbaric oxygenation can remarkably decrease content of plasma C-reactive protein in patients with craniocerebral injury at the phase of stress. | Zeyu Xie Minghua Zhuang Lan Lin Hongwu Xu Linxing Chen Lina Hu | 2007 | Neural Regeneration Research2007，2，5： | 9 |
| 14 | Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization显示文摘Background:Autologous platelet-rich plasma(PRP)has been suggested to be effective for wound healing.However,evidence for its use in patients with acute and chronic wounds remains insufficient.The aims of this study were to comprehensively examine the effectiveness,synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair.Methods:Full-thickness wounds were made on the back of C57/BL6 mice.PRP or saline solution as a control was administered to the wound area.Wound healing rate,local inflammation,angiogenesis,re-epithelialization and collagen deposition were measured at days 3,5,7 and 14 after skin injury.The biological character of epidermal stem cells(ESCs),which reflect the potential for re-epithelialization,was further evaluated in vitro and in vivo.Results:PRP strongly improved skin wound healing,which was associated with regulation of local inflammation,enhancement of angiogenesis and re-epithelialization.PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β.An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1.Moreover,PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs,and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14.Conclusion:PRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization.However,the underlying regulatory mechanism needs to be investigated in the future.Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration. | Pengcheng Xu Yaguang Wu Lina Zhou Zengjun Yang Xiaorong Zhang Xiaohong Hu Jiacai Yang Mingying Wang Binjie Wang Gaoxing Luo Weifeng He Biao Cheng | 2020 | Burns & Trauma2020，8，1： | 8 |
| 15 | The wheat MYB-related transcription factor TaMYB72 promotes flowering in rice显示文摘Through large-scale transformation analyses, Ta MYB72 was identified as a flowering time regulator in wheat. Ta MYB72 is a MYB family transcription factor localized to the nucleus. Three Ta MYB72 homologs,Ta MYB72-A, Ta MYB72-B and Ta MYB72-D, cloned from hexaploid wheat were mapped to the short arm of the group 6 chromosomes. Under the long-day conditions,over-expression of the Ta MYB72 in rice shortened the flowering time by approximately 12 d. Expression analyses suggest that Ta MYB72 may function through upregulation of florigen genes Hd3 a and RFT1. | Lichao Zhang Guoxiang Liu Jizeng Jia Guangyao Zhao Chuan Xia Lina Zhang Fu Li Qiang Zhang Chunhao Dong Shuangcheng Gao Longzhi Han Xiuping Guo Xin Zhang Jinxia Wu Xu Liu Xiuying Kong | 2016 | Journal of Integrative Plant Biology2016，58，8： | 8 |
| 16 | Radiomic features from computed tomography to differentiate invasive pulmonary adenocarcinomas from non-invasive pulmonary adenocarcinomas appearing as part-solid groundglass nodules显示文摘Objective:We aim to investigate radiomic imaging features extracted in computed tomography(CT)images to differentiate invasive pulmonary adenocarcinomas(IPAs)from non-IPAs appearing as part-solid ground-glass nodules(GGNs),and to incorporate significant radiomic features with other clinically-assessed features to develop a diagnostic nomogram model for IPAs.Methods:This retrospective study was performed,with Institutional Review Board approval,on 88 patients with a total of 100 part-solid nodules(56 IPAs and 44 non-IPAs)that were surgically confirmed between February 2014and November 2016 in the First Affiliated Hospital of China Medical University.Quantitative radiomic features were computed automatically on 3D nodule volume segmented from arterial-phase contrast-enhanced CT images.A set of regular risk factors and visually-assessed qualitative CT imaging features were compared with the radiomic features using logistic regression analysis.Three diagnostic models,i.e.,a basis model using the clinical factors and qualitative CT features,a radiomics model using significant radiomic features,and a nomogram model combining all significant features,were built and compared in terms of receiver operating characteristic(ROC)curves.Decision curve analysis was performed for the nomogram model to explore its potential clinical benefit.Results:In addition to three visually-assessed qualitative imaging features,another three quantitative features selected from hundreds of radiomic features were found to be significantly(all P<0.05)associated with IPAs.The diagnostic nomogram model showed a significantly higher performance[area under the ROC curve(AUC)=0.903]in differentiating IPAs from non-IPAs than either the basis model(AUC=0.853,P=0.0009)or the radiomics model(AUC=0.769,P<0.0001).Decision curve analysis indicates a potential benefit of using such a nomogram model in clinical diagnosis.Conclusions:Quantitative radiomic features provide additional information over clinically-assessed qualitative features for differentiating IPAs from non-IPAs appearing as GGNs,and a diagnostic nomogram model including all these significant features may be clinically useful in preoperative strategy planning. | Ting Luo Ke Xu Zheng Zhang Lina Zhang Shandong Wu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 8 |
| 17 | Synthesis of Bimodal Mesoporous TiO_(2)-PTA/BMMS and Its Enhanced Performance in the Photocatalytic Oxidative Desulfurization显示文摘With the bimodal mesoporous silica(BMMS)acting as the support and the composite of TiO2 with phosphotungstic acid(PTA)functioning as the active constituent,TiO_(2)-PTA/BMMS was synthesized by the two-step impregnation route.This catalyst was applied in the photocatalytic oxidative desulfurization(PODS)process,with dibenzothiophene serving as the model sulfur compound.PODS proceeds in one pot,in which H_(2)O_(2) acts as the oxidant and methanol plays the role of the solvent.TiO_(2)-PTA/BMMS was characterized by XRD,N_(2) adsorption and desorption,XRF,FTIR,UV-vis,SEM,EDS and TEM techniques.It showed that the introduction of PTA contributes higher order,higher surface area and pore volume to the bimodal mesoporous support.With TiO_(2)-PTA/BMMS used as the catalyst under the UV irradiation,the desulfurization rate can reach 99.6%.This result is obviously higher than that achieved by TiO_(2)/BMMS.The catalyst also has no significant drop in catalytic activity after eight runs of reusing.In such catalytic system,the synergistic effects of this photocatalytic oxidation and the extraction with the methanol serving as the solvent played an indispensable role. | Yang Lina Zhang Xi Cui Licheng Xu Meizhen Li Jian | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 8 |
| 18 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 19 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 20 | Photocatalytic Oxidative Desulfurization of Dibenzothiophene on TiO2 Modified Bimodal Mesoporous Silica显示文摘By using the bimodal mesoporous silica(BMMS) as the carrier and butyl titanate as the titanium source, the TiO_2/BMMS catalyst was prepared. The samples were characterized by XRD, XRF, N_2 adsorption and desorption, FTIR, UVvis,SEM, EDS, and TEM techniques. The test results showed that TiO_2 was amorphous, the TiO_2/BMMS catalyst had an ordered bimodal mesoporous structure, and the chemical interaction existed between BMMS and TiO_2. Since the TiO_2/BMMS had a lower band gap, its photocatalytic activity was better than TiO_2. Under UV irradiation a one-pot PODS system was set up, using TiO_2/BMMS as the catalyst, H_2O_2 as the oxidant, and methanol as the solvent. The TiO_2/BMMS catalyst showed better photocatalytic activity than the mono-modal mesoporous TiO_2/SBA-15 catalyst, and the desulfurization rate of dibenzothiophene(DBT) over TiO_2/BMMS catalyst could reach 99._2%. The TiO_2/BMMS catalyst also had so good stability that the desulfurization rate of DBT did not drop apparently after 8 cycles of reusing, and could still be close to 90%. | Xu Meizhen Yang Lina Li Jian | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 6 |
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