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| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 3 | Modulation of Guard Cell Turgor and Drought Folerance by a Peroxisomal Acetate-Malate Shunt显示文摘 | Huan Dong Ling Bai Yu Zhang Guozeng Zhang Yanqing Mao Lulu Min Fuyou Xiang Dongdong Qian Xiaohong Zhu Chun-Peng Song | 2018 | Molecular Plant2018，11，10： | 6 |
| 4 | Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro显示文摘This study investigated the effects of small interfering RNA(siRNA)-mediated silencing of chemokine receptor 4(CXCR4)on the invasion capacity of human neuroblastoma cell line SHSY5 Y in vitro.Three siRNAs targeting CXCR4 were chemically synthesized and individually transfected into SH-SY5Y cells.Expression of CXCR4 mRNA and protein was significantly suppressed in transfected cells by all three sequence-specific siRNAs compared with control groups.Furthermore,the invasion capacity of SH-SY5Y cells was significantly decreased following transfection with CXCR4-specific siRNA compared with the control groups.These data demonstrate that down-regulation of CXCR4 can inhibit in vitro invasion of neuroblastoma. | Xin Chen Yongjie Zhu Lulu Han Hongting Lu Xiwei Hao Qian Dong | 2014 | Neural Regeneration Research2014，9，10： | 4 |
| 5 | ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation显示文摘Ischemic stroke is an acute and serious cerebral vascular disease,which greatly affects people’s health and brings huge economic burden to society.Microglia,as important innate immune components in central nervous system(CNS),are double-edged swords in the battle of nerve injury,considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 phenotypes.High mobility group box 1(HMGB1)is one of the potent pro-inflammatory mediators that promotes the M1 polarization of microglia.18β-glycyrrhetinic acid(GA)is an effective intracellular inhibitor of HMGB1,but of poor water solubility and dose-dependent toxicity.To overcome the shortcomings of GA delivery and to improve the efficacy of cerebral ischemia therapy,herein,we designed reactive oxygen species(ROS)responsive polymer-drug conjugate nanoparticles(DGA)to manipulate microglia polarization by suppressing the translocation of nuclear HMGB1.DGA presented excellent therapeutic efficacy in stroke mice,as evidenced by the reduction of infarct volume,recovery of motor function,suppressed of M1 microglia activation and enhanced M2 activation,and induction of neurogenesis.Altogether,our work demonstrates a close association between HMGB1 and microglia polarization,suggesting potential strategies for coping with inflammatory microglia-related diseases. | Lulu Jin Zhixin Zhu Liangjie Hong Zhefeng Qian Fang Wang Zhengwei Mao | 2023 | Bioactive Materials2023，，1： | 3 |
| 6 | Clay mineralogy and its palaeoclimatic significance in the Luochuan Ioess-palaeosols over -1.3 Ma, Shaanxi, northwestern China显示文摘 | Changdok WON Hanlie HONG Feng CHENG Qian FANG Chaowen WANG Lulu ZHAO Gordon Jock CHURCHMAN | 2018 | Frontiers of Earth Science2018，12，1： | 2 |
| 7 | DNA addition using linear self-assembly显示文摘This paper presents a DNA algorithm which adds two nonnegative binary integers using self-assembly in constant steps. The approach has the benefit of greater experimental simplicity when compared with previous DNA addition algorithms. For the addition of two binary n-bit integers,O(n) is different from DNA strands and only O(1) biochemical experimental procedures are required. | ZHAO Jian QIAN LuLu LIU Qiang ZHANG ZhiZhou HE Lin | 2007 | Chinese Science Bulletin2007，52，11： | 2 |
| 8 | Scaling up digital circuit computation with DNA strand displacement cascades显示文摘 | Lulu Qian Winfree E | 2011 | Science2011，332，： | 1 |
| 9 | Bmi‐1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance显示文摘 | Jianliang Jin Xianhui Lv Lulu Chen Wei Zhang Jinbo Li Qian Wang Rong Wang Xiang Lu Dengshun Miao | 2014 | Aging Cell2014，，5： | 1 |
| 10 | C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment显示文摘The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory cascade.The decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating neuroinflammation.To combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with C-176.Nanoparticles are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic structures.Our work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor synergistically.In conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis. | Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik Kwan Lo Zhengwei Mao Haifei Shi | 2023 | Bioactive Materials2023，，11： | 1 |
| 11 | Development and Impacts of the Sierra Leone-China Laboratory for Parasitic Diseases Testing and Surveillance显示文摘BACKGROUND The Republic of Sierra Leone is located on the west coast of Africa,bordering Guinea and Liberia,with a population of 7.8 million in 2019(1).It has a tropical monsoon climate,with high temperatures and plentiful precipitation.As one of the least developed countries in the world(2),Sierra Leone has long struggled with poor health outcomes with a life expectancy at birth of 59 for male and 61 for female,and high maternal and neonatal mortality,threatened by infectious diseases such as malaria,tuberculosis,typhoid fever,cholera,and Lassa fever(3). | Lei Duan Lili Wang Shenning Lu Bei Wang Yanbing Li Qiuli Xu Lulu Huang Wei Ding Yingjun Qian Hongmei Li Xuejiao Ma Duoquan Wang Yayi Guan Xiaochun Wang Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，15： | 1 |
| 12 | In-situ constructed polymer/alloy composite with high ionic conductivity as an artificial solid electrolyte interphase to stabilize lithium metal anode显示文摘Lithium(Li)metal is regarded as the best anode material for lithium metal batteries(LMBs)due to its high theoretical specific capacity and low redox potential.However,the notorious dendrites growth and extreme instability of the solid electrolyte interphase(SEI)layers have severely retarded the commercialization process of LMBs.Herein,a double-layered polymer/alloy composite artificial SEI composed of a robust poly(1,3-dioxolane)(PDOL)protective layer,Sn and LiCl nanoparticles,denoted as PDOL@Sn-LiCl,is fabricated by the combination of in-situ substitution and polymerization processes on the surface of Li metal anode.The lithiophilic Sn-LiCl multiphase can supply plenty of Li-ion transport channels,contributing to the homogeneous nucleation and dense accumulation of Li metal.The mechanically tough PDOL layer can maintain the stability and compact structure of the inorganic layer in the long-term cycling,and suppress the volume fluctuation and dendrites formation of the Li metal anode.As a result,the symmetrical cell under the double-layered artificial SEI protection shows excellent cycling stability of 300 h at 5.0 mA·cm^(−2)for 1 mAh·cm^(−2).Notably,the Li||LiFePO_(4)full cell also exhibits enhanced capacity retention of 150.1 mAh·g^(−1)after 600 cycles at 1.0 C.Additionally,the protected Li foil can effectively resist the air and water corrosion,signifying the safe operation of Li metal in practical applications.This present finding proposed a different tactic to achieve safe and dendrite-free Li metal anodes with excellent cycling stability. | Ai-Long Chen Yushan Qian Shujun Zheng Yuyang Chen Yue Ouyang Lulu Mo Zheng-Long Xu Yue-E Miao Tianxi Liu | 2023 | Nano Research2023，16，3： | 0 |
| 13 | Current Implementation and Experience of Natural Farming in Japan显示文摘The natural farming in Japan mainly includes Mokich Okadas natural farming theory and Masanobu Fukuokas natural farming theory in terms of genre.Natural farming was proposed and implemented to deal with the anabatic soil degradation and food safety problems.Among themꎬMokich Okadas natural farming theory advocates the restoration of the agricultural tradition of the past and combination with modern agricultural science and technologyꎻMasanobu Fukuokas natural farming theory advocates a complete return to natural and traditional farming and puts forward a set of green agricultural cultivation methods focusing on injurious insect control with beneficial insectꎬweed control with green herbaceous plantsꎬsoil reclamation with grassꎬnontoxic and cost￣reducing method based on the Japanese ancient agricultural books.Their natural farming theories have been widely popularized and applied in Japanꎬand its successful experience is worthy of study and reference for China. | Lulu QIAN Hong LI Lei YE | 2023 | Asian Agricultural Research2023，15，11： | 0 |
| 14 | Research on the Development of Rural Commodity Economy in the Edo Period显示文摘The rural commodity economy in the Edo period developed by leaps and bounds under the influence of institution,policy,technology and other factors. From the mid 17 th century,the specific area of cash crops gradually took shape in Japan and the largescale cultivation of cash crops greatly promoted the development of rural handicrafts,thereby creating the conditions for the initiation of the capitalist relations of production. The development of rural commodity economy not only changed the traditional mode of operation and production of Japanese farmers,but also accelerated the class differentiation,shook and disintegrated the economic foundation and class basis of Bakuhan society,and created the preconditions for the later Meiji Restoration. | Lei YE Lulu QIAN | 2014 | Asian Agricultural Research2014，6，12： | 0 |
| 15 | A nomogram based on lymphocyte percentage for predicting hospital mortality in exertional heatstroke patients: a 13-year retrospective study显示文摘BACKGROUND: Exertional heatstroke(EHS) is a life-threatening disease without ideal prognostic markers for predicting hospital mortality.METHODS: This is a single-center retrospective study. Clinical data from EHS patients admitted to the Intensive Care Unit(ICU) of the General Hospital of Southern Theatre Command between January 1, 2008, and December 31, 2020, were recorded and analyzed. Univariate and multivariate logistic regression were used to identify the factors for mortality. The prediction model was developed with the prognostic markers, and a nomogram was established.RESULTS: The study ultimately enrolled 156 patients, and 15(9.6%) of patients died before discharge. The lymphocyte count(Lym) and percentage(Lym%) were significantly lower in nonsurvivors(P<0.05). The univariate and multivariate logistic regression analyses indicated that Lym% at the third day of admission(Lym% D3)(OR=0.609, 95%CI: 0.454–0.816) and hematocrit(HCT)(OR=0.908, 95%CI: 0.834–0.988) were independent protective factors for hospital mortality. A nomogram incorporating Lym% D3 with HCT was developed and demonstrated good discrimination and calibration ability. The comparison between the prediction model and scoring systems revealed that the prediction model had the largest area under the curve(AUC)(0.948, 95%CI: 0.900–0.977), with 100.00% sensitivity and 83.69% specificity, and a greater clinical net benefit.CONCLUSION: Severe EHS patients had a higher risk of experiencing prolonged lymphopenia. A nomogram based on Lym% D3 and HCT was developed to facilitate early identification and timely treatment of patients with potentially unfavorable prognoses. | Jiale Yang Fanghe Gong Xuezhi Shi Fanfan Wang Jing Qian Lulu Wan Yi Chen Huaisheng Chen Huasheng Tong | 2023 | World Journal of Emergency Medicine2023，14，6： | 0 |
| 16 | Photoelectrochemical Biosensor for 5-Formylcytosine Based on WS_(2)/Bi/Bi_(2)O_(2)CO_(3) Nanocomposite and Rolling Circle Amplification显示文摘As a key epigenetic modification,5-formylcytosine(5fC)controls many important cell functions,such as gene expression and cell differentiation.However,5fC exists in mammalian tissues and cells with low content,and its structure is highly similar to 5-methylcytosine(5mC),5-hydroxymethylcytosine(5hmC)and 5-carboxycytosine(5caC), which requires the detection method for detecti ng 5fC with high sensitivity and specificity.In this experiment,WS_(2)/Bi/Bi_(2)O_(2)CO_(3) was used as the photoactive material,5fC antibody was used as the target molecule recog nition reage nt,and rolling amplification(RCA)was employed as the signal amplification strategy to con struct a no vel photoelectrochemical biose nsor for detecti ng 5-formylcytosi ne deox ynu cleotide(SfdCTP). | Qian Wang Huanshun Yin Yunlei Zhou Lulu Cao Zhengkun Yu Yamin Xu Shiyun Ai | 2022 | Chinese Journal of Chemistry2022，40，2： | 0 |
| 17 | A gap-free reference genome reveals structural variations associated with flowering time in rapeseed(Brassica napus)显示文摘Allopolyploid oilseed rape(Brassica napus)is an important oil crop and vegetable.However,the latest version of its reference genome,with collapsed duplications,gaps,and other issues,prevents comprehensive genomic analysis.Herein,we report a gap-free assembly of the rapeseed cv.Xiang5A genome using a combination of ONT(Oxford Nanopore Technologies)ultra-long reads,PacBio high-fidelity reads,and Hi-C datasets.It includes gap-free assemblies of all 19 chromosomes and telomere-to-telomere assemblies of eight chromosomes.Compared with previously published genomes of B.napus,our gap-free genome,with a contig N50 length of 50.70 Mb,has complete assemblies of 9 of 19 chromosomes without manual intervention,and greatly improves contiguity and completeness,thereby representing the highest quality genome assembly to date.Our results revealed that B.napus Xiang5A underwent nearly complete triplication and allotetraploidy relative to Arabidopsis thaliana.Using the gap-free assembly,we found that 917 flowering-related genes were affected by structural variation,including BnaA03.VERNALIZATION INSENSITIVE 3 and BnaC04.HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1.These genes may play crucial roles in regulating flowering time and facilitating the adaptation of Xiang5A in the Yangtze River Basin of China.This reference genome provides a valuable genetic resource for rapeseed functional genomic studies and breeding. | Bao Li Qian Yang Lulu Yang Xing Zhou Lichao Deng Liang Qu Dengli Guo Rongkui Hui Yiming Guo Xinhong Liu Tonghua Wang Lianyi Fan Mei Li Mingli Yan | 2023 | Horticulture Research2023，10，10： | 0 |
| 18 | The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto-binding of OsBSK2显示文摘Japonica/geng and indica/xian are two major rice(Oryza sativa)subspecies with multiple divergent traits,but how these traits are related and interact within each subspecies remains elusive.Brassinosteroids(BRs)are a class of steroid phytohormones that modulate many important agronomic traits in rice.Here,using different physiological assays,we revealed that japonica rice exhibits an overall lower BR sensitivity than indica.Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms.Among these,we demonstrate that the C38/T variant in BR Signaling Kinase2(OsBSK2),causing the amino acid change P13L,plays a central role in mediating differential BR signaling in japonica and indica rice.OsBSK2in indica plays a greater role in BR signaling than OsB SK2in japonica by affecting the auto-binding and protein accumulation of OsBSK2.Finally,we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice,including grain shape,tiller number,cold adaptation,and nitrogen-use efficiency.Our study suggests that the natural variation in OsB SK2 plays a key role in the divergence of BR signaling,which underlies multiple divergent traits between japonica and indica. | Wenchao Yin Lulu Li Zhikun Yu Fan Zhang Dapu Liu Hongkai Wu Mei Niu Wenjing Meng Xiaoxing Zhang Nana Dong Yanzhao Yang Jihong Liu Yongqiang Liu Guoxia Zhang Jianlong Xu Shimei Wang Chengcai Chu Qian Qian Hongning Tong | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 19 | A Study on Japanese Traditional Rice Production Technique in Warm Areas and Its Modern Ecological Value显示文摘Japanese traditional rice production technique features ' sparse seeding,long cultivation,scattered planting and limited transplanting',and scientific rice production methods of deep plowing,fertilization,weeding,irrigation and drainage are employed.This technique has reversed the common practice of ' dense seeding and planting' in rice paddies and changed the history of growing rice spikes purely out of stems,thus enabling stable and high yields of several tillering grain crops including rice.The technique can provide a useful reference for developing modern rice production in warm areas. | Lei YE Lulu QIAN | 2019 | Asian Agricultural Research2019，11，1： | 0 |
| 20 | Evolution of Palaeoenvironment of the South Yellow Sea Since the Last Deglaciation显示文摘The sediments in core YS01 recovered from the South Yellow Sea mud deposit zone contain abundant benthic foraminifera,particularly shallow continental shelf species,but rare of planktonic foraminifera.The benthic foraminifera are dominated by stenohaline cold shallow-water species and euryhaline brackish-water species.In this paper,the palaeoenvironmental changes were discussed based on the grain-size compositions and benthic foraminiferal assemblages.Six different benthic foraminiferal assemblages were discriminated by species analysis from the foraminiferal fauna.According to AMS14C dating data in core YS01,we identified four main stages of marine environmental changes since the last deglaciation:a near-shore depositional stage(13.1–9.5 kyr B.P.),a transitional stage from near-shore deposition to shallow-sea deposition(9.5–5.6 kyr B.P.),a high sea level stage with shallow-sea deposition(5.6–2.9 kyr B.P.),and a stable shallow-sea depositional stage(2.9 kyr B.P.to the present). | WANG Haoyin LI Guangxue ZHANG Yang LIU Yong LIU Dongsheng DING Dong XU Jishang MA Yanyan QIAO Lulu WANG Liyan LI Qian | 2020 | Journal of Ocean University of China2020，19，4： | 0 |
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