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| 1 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Variation in allelic frequencies at loci associated with kernel weight and their effects on kernel weight-related traits in winter wheat显示文摘Knowledge of allelic frequencies at loci associated with kernel weight and effects on kernel weight-related traits is crucial for yield improvement in wheat. Kernel weight-related traits were evaluated in 200 Chinese winter wheat cultivars(lines) grown at the Xinxiang Experimental Station, Chinese Academy of Agricultural Sciences, Xinxiang in Henan Province, for three consecutive years from 2014 to 2016. Alleles associated with kernel weight at nine loci, TaCKX6-D1, TaCwi-A1, TaCWI-4A, TaGS1a, TaGS5-A1, TaGS3-3A, TaGW2-6A, TaSus2-2B, and TaTGW6-A1, were determined for all cultivars(lines). ANOVA showed that genotypes, years and their interactions had significant effects on thousand-kernel weight(TKW), kernel length(KL) and kernel width(KW). The overall mean frequencies of alleles conferring high and low TKW at the nine loci were 65.9% and 33.4%, with the ranges of 37.0%–85.0% and 13.5%–63.0% for single loci. The frequencies of high-TKW alleles were over 50.0% at eight of the loci. Genotypes at each locus with the high-TKW allele had higher TKW than those with the low-TKW allele. The high-TKW allele Hap-H at the TaSus2-2B locus can be preferably used to increase grain yield due to its high TKW(49.32 g). A total of 18 main allelic combinations(ACs) at nine loci were detected. Three ACs(AC1–AC3) had significantly higher TKW than AC6 with high-TKW alleles at all nine loci even though they contained some low-TKW alleles. This indicated that other loci controlling kernel weight were present in the high-TKW cultivars. This work provides important information for parental selection and marker-assisted selection for breeding. | Teng Li Hongwei Liu Chunyan Mai Guangjun Yu Huili Li Lingzhi Meng Dawei Jian Li Yang Yang Zhou Hongjun Zhang Hongjie Li | 2019 | The Crop Journal2019，7，1： | 2 |
| 4 | Synthesis and anion recognition of neutral receptors based on multiamide calix[4]arene显示文摘Two multiamide calyx[4].arenas(5,6)were synthesized and characterized by IR,1H NMR,MS and elemental analysis.The binding properties of receptors with some anions (p-O2NphOpO2-3,p-O2NphO-,H2PO-4,Ac-,CI-,Br- and I-)Were studied by UV-Vis spectra.The results indicate that the tetraamide calix[4]arenas (5,6) have a good selectivity to the anions containing aromatic ring (p-O2NphOpO2-3,p-O2NphO-).The 1:1 complexes between host and guest were formed through multiple hydrogen bonding and π-π interactions.The hosts 5 and 6 also show a definite binding ability for the anions (H2PO-4,Ac-,CI-) that have no ultraviolet absorption,which provides a simple method of spectrum detection for these anions. | LIU Shunying WANG Fajun WEI Lanhua XIAO Wang MENG Lingzhi HE Yongbing | 2004 | Science China Chemistry2004，47，2： | 2 |
| 5 | Thermo-and pH-sensitive of thiosemicarbazone-incorporated, fluorescent and amphiphilic poly ( N-isopropylacrylamide ) 显示文摘 | Li Cheng Meng Lingzhi Lu Xiaoju | 2005 | Micromolecular Chemistry and Physics2005，206，： | 1 |
| 6 | Deciphering structural and functional roles of disulfide bonds in decorsin显示文摘Decorsin,an antagonist of integrin glycoprotein IIb/IIIa,contains Arg-Gly-Asp(RGD)sequence and three disulfide bridges.The function of RGD sequence has already been well defined,but the roles of conserved disulfide bonds in antihemostatic proteins still remain unclear.Herein we use the fusion expression and characterization of mutant decorsin to study the functions of disulfide bonds in protein structure,stability and biological activity.The purified protein shows an apparent inhibition of activity to platelet aggregation induced by ADP with IC50 of 500 nM.The removal of cys7-cys15(from cysteine to serine)at the N-terminal causes a thirty-fold decrease of the inhibition activity with IC50 of 15 M,whereas the mutation of cys22-cys38 at the C-terminal completely impairs the biological activity of decorsin.The overall secondary and tertiary structures of decorsin are disrupted inevitably without disulfide bonds.Using a domain insertion mutation,the retaining of RGD loop and the adjacent disulfide bond produces a week antihemostatic activity of decorsin.This reveals that the overall structure of decorsin stabilized by the three conserved disulfide bridges is cooperative for antihemostatic function.Our study on the effect of disulfide bonds together with RGD-sequence on the protein function is helpful for structure-based drug design of antithrombotic research. | WU LingZhi LI Ying YANG Yang QIN Meng | 2013 | Science China Chemistry2013，56，10： | 1 |
| 7 | Preparation and properties of nanosize silicone resin显示文摘 | Gong Shuling Mei Gongxiong Meng Lingzhi Hu Ling Zhang Xianliang Zhang Qunchao Chen Shenyun Liao Jun | 2002 | Youiigui Cailiao2002，16，5： | 1 |
| 8 | Preparation and coordination behavior of cellulose beads derivative modified by 1,5-diaminoethyl-3-hydroxy-1,5-diazacycloheptane 显示文摘 | He Yongbing Meng Lingzhi Wu Chengtai | 1999 | J Appl Poly Sc1999，74，5： | 1 |
| 9 | Thermodynamical properties of protein kinase with adenine inhibitors显示文摘The protein-based molecular recognition of the adenine ring is essential to understand protein function and drug design as well.In this paper,a variety of the adenine-based inhibitors with modified groups of amino groups,nitrogen and oxygen atoms in the aromatic ring are designed,and the binding capability of these adenosine analogues with an aminoglycoside antibiotic kinase [APH(3')-IIIa] are investigated with activity assays and isothermal titration calorimetry(ITC) experiments.1-aminoisoquinoline is one of the weakest substrates bound to APH(3')-IIIa with the lowest affinity(high ki and high kd) and the smallest negative value of free energy change(G) among the inhibitors tested.The binding process of adenine and 5-nitroisoquinoline to APH(3')-IIIa is an enthalpy-driven event with unfavorable entropy,which is consistent with the energy change induced by the binding of ATP to the enzyme.However,the reverse is true for 1-aminoisoquinoline,3-amino-5-nitrobenzisothiazole,5-aminoisoquinoline binding to the enzyme because the entropy is more favorable and the enthalpy makes a lower contribution to the binding process.These results suggest that small changes of the adenine ring can lead to significant influence on the ability of these analogues to occupy the adenine-binding region of the enzyme,which can be the potential inhibitors as drug candidates against the bacterial resistance. | WU LingZhi HU Dong TANG LiHua HU XiaoFei QIN Meng | 2013 | Chinese Science Bulletin2013，58，1： | 1 |
| 10 | NETWORK CROWN ETHER POLYMERS WITH CENTRIC FUNCTIONAL GROUPS.Ⅱ.SYNTHESIS OF NETWORK CROWN ETHER POLYMER WITH PENDANT SULFIDE SIDE CHAIN AND ITS PLATINUM COMPLEX显示文摘NETWORKCROWNETHERPOLYMERSWITHCENTRICFUNCTIONALGROUPS.Ⅱ.SYNTHESISOFNETWORKCROWNETHERPOLYMER WITH PENDANT SULFIDE SIDE CHAIN AN... | CHEN Yuanyin MENG Lingzhi YIN Yihua (Department of Chemistry, Wuhan University, Wuhan 430072) | 1995 | Chinese Journal of Reactive Polymers1995，4，1： | 1 |
| 11 | In-Fiber Thermally Diffused Coupler and Fiber Bragg Grating Inscribed in Twin-Core Fiber for Sensitivity-Enhanced Vector Bending Sensing显示文摘A vector bending fiber sensor based on core-by-core inscribed fiber Bragg gratings in a twin-core fiber has been proposed and experimentally demonstrated.An in-fiber integrated vector bending sensor is realized by using the thermal diffusion technique to fabricate the coupler.The characteristics of the coupler fabricated by thermal diffusion are simulated and experimented.By inscribing fiber Bragg gratings with different reflection wavelengths in the two cores of a symmetrical twin-core fiber,the curvature sensitivity can be enhanced by tracking the wavelength difference between the fiber Bragg gratings of the two cores.The measured bending sensitivity of the fiber Bragg grating ranges from–161.6 pm/m^(−1) to+165.5 pm/m^(−1).The differential sensitivity of the two cores is twice that of a conventional single grating,and the temperature-induced crosstalk is also reduced.The bending sensor proposed in this paper has the advantages of high integration,enhancing the sensitivity and two-dimensional orientation recognizability,and reducing temperature crosstalk,which can be a promising candidate for structural health monitoring or wearable artificial electronics applications. | Lingzhi MENG Hongye WANG Qi XIA Tingting YUAN Xiaotong ZHANG Libo YUAN | 2023 | Photonic Sensors2023，13，3： | 0 |
| 12 | SYNTHESIS AND CATALYTIC ACTIVITY OF PLATINUM COMPLEX OF ACRYLATE TERPOLYMER WITH Se, N BIDENTATE LIGAND显示文摘Acrylate terpolymer- bound Se, N bidentate ligand was synthesized fromthe side chain chlorine of copolymer and β- dimethylamino -β - hydroxyl diethyl selenoether. The polymer - supported platinum complex exhibited highcatalytic activity in the hodrosilylation of olefins with triethoxysilane. | Meng Lingzhi Qi Liangwei Hu Ling Chen Yuanyin(Department of Chemistry, Wuhan University, Wuhan 430072) | 1998 | Chinese Journal of Reactive Polymers1998，7，1： | 0 |
| 13 | Induced temperature-dependent DNA degradation by C_(60) without photoactivation显示文摘This study shows that C_(60) can degrade pBR322 plasmid DNA at room temperature without photoactivation. The degradation was enhanced by increasing incubation temperature, reaction time or C_(60) concentration. We also found that superoxide radical anions (O 2 · ) were formed in the C_(60) solution. Superoxide dismutase significantly inhibited DNA cleavage and O 2 · generation induced by C_(60) . These results suggest that DNA cleavage was caused by the formation of reactive oxygen species induced by C_(60) at room temperature. Furthermore, we demonstrate that the DNA degradation was significantly inhibited by acid amide chemicals such as formamide, and by increased ionic strength of the reaction solution. These results indicate that the DNA conformation stability and the surface properties of C_(60) are important factors regulating DNA degradation. We propose that C_(60) can bind DNA, decrease DNA conformation stability, and induce the formation of reactive oxygen species and DNA cleavage at room temperature. Our results provide a possible explanation for the genotoxicity of C_(60) , which should be considered in future use of this particular nano-material. | WANG Chang LIN Yan WANG Ying LIANG Yong MENG LingZhi ZHANG Jie ZHOU QunFang JIANG GuiBin | 2011 | Chinese Science Bulletin2011，56，28： | 0 |
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