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| 1 | The DTH8-Hd1 Module Mediates Day-Length-Dependent Regulation of Rice Flowering显示文摘Photoperiodic flowering 是最重要的小径之一在米饭(Oryza sativa ) 管理 flowering,在哪个标题日期 1 (Hd1 ) , Arabidopsis CONSTANS 基因的 ortholog,编码一个枢轴的管理者。Hd1 在短天的条件(SD ) 下面支持 flowering,但是镇压在由调整领导日期 3a (Hd3a ) 的表示的长天的条件(LD ) 下面的 flowering,在米饭的 FLOWERING 地点 T (英尺) ortholog。然而, Hd1 怎么响应天长度改变它的规章的活动的分子的机制仍然保持大部分未知。在这研究,我们证明在由 Hd1 的 LD 的 flowering 的压抑依赖于到领导 8 的抄写因素天(DTH8 ) 。DTH8 功能的损失由 Hd1 导致 Hd3a 的激活,导致早 flowering。我们发现 Hd1 直接与 DTH8 交往并且 DTH8-Hd1 建筑群的形成为由在 LD 的 Hd1 的 Hd3a 的 transcriptional 压抑是必要的,含有 Hd1 功能的开关被 DTH8 在 LD 而非在 SD 调停。而且,我们表明 DTH8 与 Hd3a 倡导者联系在 Hd3a 地点调制 H3K27 trimethylation (H3K27me3 ) 的水平。面对 DTH8-Hd1 建筑群, H3K27me3 水平在 Hd3a 被增加,而 DTH8 功能的损失在 Hd3a 导致了减少的 H3K27me3 水平。一起拿,我们的调查结果显示响应天长度, DTH8 在调停起一个关键作用 ? 由通过到在 photoperiodic flowering 的形状 epigenetic 修正的 DTH8-Hd1 模块的 Hd1 的 Hd3a 的 transcriptional 规定。 | Anping Dul Wei Tian Menghao Wei Wei Yan Hang He Da Zhou Xi Huang Shigui Li Xinhao Ouyang | 2017 | Molecular Plant2017，10，7： | 21 |
| 2 | β-Glucosidase treatment and infestation by the rice brown planthopper Nilaparvata lugens elicit similar signaling pathways in rice plants显示文摘β-Glucosidase has been reported to induce the production of herbivore-induced plant volatiles. How-ever, how it works remains unclear. Here, we investigated the levels of salicylic acid (SA), jasmonic acid (JA), ethylene, and H2O2, all of which are known signaling molecules that play important roles in in-duced plant defense in rice plants treated with β-glucosidase, and compared these to levels in plants infested by the rice brown planthopper Nilaparvata lugens (Stl). Results showed that wounding and treatment by β-glucosidase increased the levels of SA, ethylene, and H2O2, but not JA, in all plants compared to control plants. The signaling pathways activated by β-glucosidase treatment are similar to those activated by an infestation by N. lugens, although the magnitude and timing of the signals elicited by the two treatments are different. This may explain why both treatments have similar volatile profiles and are equally attractive to the parasitoid Anagrus nilaparvatae Pang et Wang. | WANG Xia ZHOU GuoXin XIANG CaiYu DU MengHao CHENG JiaAn LIU ShuSheng LOU YongGen | 2008 | Chinese Science Bulletin2008，53，1： | 5 |
| 3 | Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway显示文摘 | Kejing Tao Lin Du Xueqian Sun Menghao Cai Tianjiao Zhu Xiangshan Zhou Qianqun Gu Yuanxing Zhang | 2008 | Tetrahedron Letters2008，，9： | 1 |
| 4 | Statisticaloptimization of medium composition for aspergiolide A productionby marine-derived fungus Aspergillus glaucus显示文摘 | CAI Menghao ZHOU Xiangshan SUN Xueqian | 2009 | Journal of IndustrialMicrobiology and Biotechnology2009，36，3： | 1 |
| 5 | Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications显示文摘The devastating coronavirus disease 2019(COVID-19)pandemic has prompted worldwide efforts to study structural biological traits of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its viral components.Compared to the Spike protein,which is the primary target for currently available vaccines or antibodies,knowledge about other virion structural components is incomplete.Using high-resolution mass spectrometry,we report a comprehensive post-translational modification(PTM)analysis of nucleocapsid phosphoprotein(NCP),the most abundant structural component of the SARS-CoV-2 virion.In addition to phosphoryl groups,we show that the SARS-CoV-2 NCP is decorated with a variety of PTMs,including N-glycans and ubiquitin.Based on newly identified PTMs,refined protein structural models of SARS-CoV-2 NCP were proposed and potential immune recognition epitopes of NCP were aligned with PTMs.These data can facilitate the design of novel vaccines or therapeutics targeting NCP,as valuable alternatives to the current vaccination and treatment paradigm that is under threat of the ever-mutating SARS-CoV-2 Spike protein. | Zeyu Sun Xiaoqin Zheng Feiyang Ji Menghao Zhou Xiaoling Su Keyi Ren Lanjuan Li | 2021 | Infectious Microbes & Diseases2021，3，3： | 1 |
| 6 | Identi-fied biosynthetic pathway of aspergiolide A and a novel strate-gy to increase its production in a marine-derived fungusAspergillus glaucus by feeding of biosynthetic precursors andinhibitors simultaneously显示文摘 | Sun Xueqian Zhou Xiangshan Cai Menghao | 2009 | Bioresource Technology2009，100，18： | 1 |
| 7 | Statisti-cal optimization of medium composition for aspergiolide Aproduction by marine-derived fungus Aspergillus glaucus显示文摘 | Cai Menghao Zhou Xiangshan? Sun Xueqian? | 2009 | Journal of Industrial Microbiology and Biotechnology?2009，36，3： | 1 |
| 8 | Statisti- cal optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus显示文摘 | Cai Menghao Zhou Xiangshan Sun Xueqian | 2009 | Journal of Inhustrial Microbiology and Biotechnulogy2009，36，3： | 1 |
| 9 | Identi- fied biosynthetic pathway of aspergiolide A and a novel strate- gy to increase its production in a marine-derived fungus As- pergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously显示文摘 | Sun Xueqian Zhou Xiangshan Cai Menghao | 2009 | Bioresource Technology2009，100，18： | 1 |
| 10 | Rational design of Fe-N-C electrocatalysts for oxygen reduction reaction:From nanoparticles to single atoms显示文摘As an alternative energy,hydrogen can be converted into electrical energy via direct electrochemical conversion in fuel cells.One important drawback of full cells is the sluggish oxygen reduction reaction(ORR)promoted by the high-loading of platinum-group-metal(PGM)electrocatalysts.Fe-N-C family has been received extensive attention because of its low cost,long service life and high oxygen reduction reaction activity in recent years.In order to further enhance the ORR activity,the synthesis method,morphology regulation and catalytic mechanism of the active sites in Fe-N-C catalysts are investigated.This paper reviews the research progress of Fe-N-C from nanoparticles to single atoms.The structure-activity relationship and catalytic mechanism of the catalyst are studied and discussed,which provide a guidance for rational design of the catalyst,so as to promote the more reasonable design of Fe-N-C materials. | Mengru Sun Changli Chen Menghao Wu Danni Zhou Zhiyi Sun Jianling Fan Wenxing Chen Yujing Li | 2022 | Nano Research2022，15，3： | 0 |
| 11 | Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro显示文摘Autoimmune hepatitis(AIH)is a severe globally distributed liver disease that could occur at any age.Human menstrual blood-derived stem cells(MenSCs)have shown therapeutic effect in acute lung injury and liver failure.However,their role in the curative effect of AIH remains unclear.Here,a classic AIH mouse model was constructed through intravenous injection with concanavalin A(Con A).MenSCs were intravenously injected while Con A injection in the treatment groups.The results showed that the mortality by Con A injection was significantly decreased by MenSCs treatment and liver function tests and histological analysis were also ameliorated.The results of phosphoproteomic analysis and RNA-seq revealed that MenSCs improved AIH,mainly by apoptosis and c-Jun N-terminal kinase/mitogen-activated protein signaling pathways.Apoptosis analysis demonstrated that the protein expression of cleaved caspase 3 was increased by Con A injection and reduced by MenSCs transplantation,consistent with the TUNEL staining results.An AML12 co-culture system and JNK inhibitor(SP600125)were used to verify the JNK/MAPK and apoptosis signaling pathways.These findings suggested that MenSCs could be a promising strategy for AIH. | Fen Zhang Lanlan Xiao Ya Yang Menghao Zhou Yalei Zhao Zhongyang Xie Xiaoxi Ouyang Feiyang Ji Shima Tang Lanjuan Li | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 12 | Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions显示文摘Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions. | Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 13 | Oxygen-modulated metal nitride clusters with moderate binding ability to insoluble Li_(2)S_(x) for reversible polysulfide electrocatalysis显示文摘Multiphase sulfur redox reactions with advanced homogeneous and heterogeneous electrochemical processes in lithium–sulfur(Li–S)batteries possess sluggish kinetics.The slow kinetics leads to significant capacity decay during charge/discharge processes.Therefore,electrocatalysts with adequate sulfurredox properties are required to accelerate reversible polysulfide conversion in cathodes.In this study,we have fabricated an oxygen-modulated metal nitride cluster(C-MoN_(x)-O)that has a moderate binding ability to the insoluble Li_(2)S_(x)for reversible polysulfide electrocatalysis.A Li–S battery equipped with CMoN_(x)-O electrocatalyst displayed a high discharge capacity of 875 mAh g^(-1)at 0.5 C.The capacity decay rate of each cycle was only 0.10%after 280 cycles,which is much lower than the control groups(C-MoO_(x):0.16%;C-MoN_(x):0.21%).Kinetic studies and theoretical calculations suggest that C-MoN_(x)-O electrocatalyst presents a moderate binding ability to the insoluble Li_(2)S_(2)and Li_(2)S when compared to the C-MoO_(x)and C-MoN_(x)surfaces.Thus,the C-MoN_(x)-O can effectively immobilize and reversibly catalyze the solid–solid conversion of Li_(2)S_(2)–Li_(2)S during charge–discharge cycling,thus promoting reaction kinetics and eliminating the shuttle effect.This study to design oxygen-doped metal nitrides provides innovative structures and reversible solid–solid conversions to overcome the sluggish redox chemistry of polysulfides. | Menghao Cheng Zhenyu Xing Rui Yan Zhenyang Zhao Tian Ma Mi Zhou Xikui Liu Shuang Li Chong Cheng | 2023 | InfoMat2023，5，4： | 0 |
| 14 | Integrative Proteomic Analysis of Multiple Posttranslational Modifications in Inflammatory Response显示文摘Posttranslational modifications(PTMs)of proteins,particularly acetylation,phosphorylation,and ubiquitination,play critical roles in the host innate immune response.PTMs’dynamic changes and the crosstalk among them are complicated.To build a comprehensive dynamic network of inflammation-related proteins,we integrated data from the whole-cell proteome(WCP),acetylome,phosphoproteome,and ubiquitinome of human and mouse macrophages.Our datasets of acetylation,phosphorylation,and ubiquitination sites helped identify PTM crosstalk within and across proteins involved in the inflammatory response.Stimulation of macrophages by lipopolysaccharide(LPS)resulted in both degradative and non-degradative ubiquitination.Moreover,this study contributes to the interpretation of the roles of known inflammatory molecules and the discovery of novel inflammatory proteins. | Feiyang Ji Menghao Zhou Huihui Zhu Zhengyi Jiang Qirui Li Xiaoxi Ouyang Yiming Lv Sainan Zhang Tian Wu Lanjuan Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
| 15 | High‑Valence Transition Metal Modified FeNiV Oxides Anchored on Carbon Fiber Cloth for Efficient Oxygen Evolution Catalysis显示文摘Developing efficient and durable non-noble metal-based oxygen evolution catalysts is of great importance for electrochemical water splitting.Here,we report a new and facile strategy for controllable synthesis of high-valence Mo modified FeNiV oxides as efficient OER catalysts.The Mo-dopant displays a significant influence on the valence state of Fe species in the catalysts,which lead to tunable OER performance.When the feed ratio of Mo-dopant is 5%,the Mo-modified FeNiV oxide shows the best OER performance in terms of low overpotential(237 mV at the current density of 10 mA cm^(−2)),Tafel slope(38 mV per decade),and high mass activity,which exceeds its counterparts and most reported OER catalysts.Furthermore,by assembling the catalyst with a carbon fiber cloth,the fabricated water-splitting device exhibits excellent activity and longterm durability in alkaline electrolyte compared with commercial catalysts equipped device.This work not only provides a series of Mo-modified FeNiV-based oxides as high-performance OER catalysts but also offers a new pathway to tune the charge states of OER active centers. | Zihe Wu Jiehui Yang Wenjie Shao Menghao Cheng Xianglin Luo Mi Zhou Shuang Li Tian Ma Chong Cheng Changsheng Zhao | 2022 | Advanced Fiber Materials2022，4，4： | 0 |
| 16 | Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis显示文摘Background:Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma(HCC),but the relationship between ubiquitination and metastasis need to be studiedmore systematically.We analyzed the ubiquitinome of HCC in this study to have a more comprehensive insight into human HCC metastasis.Methods:The protein ubiquitination levels in 15 HCC specimens with vascular invasion and 15 without vascular invasion were detected by ubiquitinome.Proteins with significantly different ubiquitination levels between HCCs with and without vascular invasion were used to predict E3 ubiquitin ligases associated with tumor metastasis.The topological network of protein substrates and corresponding E3 ubiquitin ligaseswas constructed to identify the key E3 ubiquitin ligase.Besides,the growth,migration and invasion ability of LM3 and HUH7 hepatoma cell lines with andwithout SYVN1 expression interferencewere measured by cell proliferation assay,subcutaneous tumor assay,umphal vein endothelium tube formation assay,transwell migration and invasion assays.Finally,the interacting proteins of SYVN1 were screened and verified by protein interaction omics,immunofluorescence,and immunoprecipitation.Ubiquitin levels of related protein substrates in LM3 and HUH7 cells were compared in negative control,SYVN1 knockdown,and SYVN1 overexpression groups.Results:In this study,our whole-cell proteomic dataset and ubiquitinomic dataset contained approximately 5600 proteins and 12,000 ubiquitinated sites.We discovered increased ubiquitinated sites with shorter ubiquitin chains during the progression ofHCC metastasis.In addition,proteomic and ubiquitinomic analyses revealed that high expression of E3 ubiquitin-protein ligase SYVN1 is related with tumor metastasis.Furthermore,we found that SYVN1 interacted with heat shock protein 90(HSP90)and impacted the ubiquitination of eukaryotic elongation factor 2 kinase(EEF2K).Conclusions:The ubiquitination profiles of HCC with and without vascular invasion were significantly different.SYVN1 was the most important E3 ubiquitin-protein ligase responsible for this phenomenon,and itwas related with tumormetastasis and growth.Therefore,SYVN1might be a potential therapeutic target for HCC. | Feiyang Ji Menghao Zhou Zeyu Sun Zhengyi Jiang Huihui Zhu Zhongyang Xie Xiaoxi Ouyang Lingjian Zhang Lanjuan Li | 2021 | Cancer Communications2021，41，10： | 0 |
| 17 | Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation显示文摘Primary hepatocytes(PHCs)are widely used in various fields,but the progressive deterioration of liverspecific features in vitro significantly limits their application.While the transcriptional regulation and whole cell proteome(WCP)of PHCs have been extensively studied,only a small number of studies have addressed the role of posttranslational modifications in this process.To elucidate the underlying mechanisms that induce dedifferentiation,we carried out parallel quantifications of the transcriptome,WCP,ubiquitinome,and phosphoproteome of rat PHCs after 0,6,12,24,and 48 h of in vitro culture.Our data constitute a detailed proteomic analysis of dedifferentiated PHCs including 2196 proteins,2056 ubiquitinated sites,and 4932 phosphorylated peptides.We revealed a low correlation between the transcriptome and WCP during dedifferentiation.A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiation of PHCs led to an increase in nondegradative K27 ubiquitination.Functional analysis of the altered phosphoproteins suggested a significant enrichment in ferroptosis.In all,404 proteins with both ubiquitination and phosphorylation were identified to be involved in critical metabolic events.Furthermore,Ptbph Hnqjd,Hnrnpu,and Srrm2 were identified as hub genes.Taken together,our data provide new insights into proteome dynamics during PHC dedifferentiation and potential targets to inhibit the dedifferentiation process. | Zhengyi Jiang Zeyu Sun Xiaoxi Ouyang Yalei Zhao Menghao Zhou Baohong Wang Qirui Li Linxiao Fan Sainan Zhang Lanjuan Li | 2020 | Engineering2020，6，11： | 0 |
| 18 | Field-free switching through bulk spin−orbit torque in L10-FePt films deposited on vicinal substrates显示文摘L1_(0)-FePt distinguishes itself for its ultrahigh perpendicular magnetic anisotropy(PMA),enabling thermally stabile memory cells to scale down to 3 nm.The recently discovered“bulk”spin−orbit torques in L1_(0)-FePt provide an efficient and scalable way to manipulate the L1_(0)-FePt magnetization.However,the existence of an external field during the switching limits its practical application,and therefore field-free switching of L1_(0)-FePt is highly demanded.In this manuscript,by growing the L1_(0)-FePt film on vicinal MgO(001)substrates,we realize the field-free switching of L1_(0)-FePt.This method is different from previously established strategies as it does not need to add other functional layers or create asymmetry in the film structure.The dependence on the vicinal angle,film thickness,and growth temperature demonstrates a wide operation window for the fieldfree switching of L1_(0)-FePt.We confirm the physical origin of the field-free switching is due to the tilted anisotropy of L1_(0)-FePt induced by the vicinal surface.We also quantitatively characterize the spin-orbit torques in the L1_(0)-FePt films.Our results extend beyond the established strategies to realize field-free switching,and potentially could be applied to mass production. | Yongming Luo Yanshan Zhuang Zhongshu Feng Haodong Fan Birui Wu Menghao Jin Ziji Shao Hai Li Ru Bai Yizheng Wu Ningning Wang Tiejun Zhou | 2022 | Frontiers of physics2022，17，5： | 0 |
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