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| 1 | Zircon SHRIMP U-Pb ages of the “Xinghuadukou Group” in Hanjiayuanzi and Xinlin areas and the “Zhalantun Group” in Inner Mongolia,Da Hinggan Mountains显示文摘A report is presented of SHRIMP zircon U-Pb dating data of meta-igneous and meta-sedimentary rocks of the Xinghuadukou Group(Xinlin-Hanjiayuanzi area,Heilongjiang Province)and meta-volcanic rocks of the Zhalantun Group(Zhalantun district,Inner Mongolia).The SHRIMP analyses show that the meta-igneous rocks from the Xinghuadukou Group formed at 506±10―547±46 Ma,belonging to Early-Middle Precambrian,whereas the meta-sedimentary rocks yielded detrital zircons,with ages of 1.0―1.2,1.6―1.8 and 2.5―2.6 Ga,indicative of deposition age at least<1.0 Ga. Meta-basic volcanic rocks from the Zhalantun Group have a formation age of 506±3 Ma.These data suggest that both the Xinghuadukou and Zhalantun Groups formed during Cambrian and/or Neoproterozoic time,rather than Paleoproterozoic time as previously thought.Early Precambrian inherited zircons in the meta-igneous rocks and numerous Precambrian detrital zircons in the meta-sedimentary rocks imply that these rocks were formed proximal to older crust.It is inferred that the Xinghuadukou and Zhalantun Groups represent Cambrian and/or Neoproterozoic vol- cano-sedimentary sequences formed in an active continental margin setting. | MIAO LaiCheng LIU DunYi ZHANG FuQin FAN WeiMing SHI YuRuo XIE HangQiang | 2007 | Chinese Science Bulletin2007，52，8： | 86 |
| 2 | SHRIMP zircon U-Pb geochronology of early Mesozoic felsic igneous rocks from the southern Lancangjiang and its tectonic implications显示文摘The SHRIMP zircon U-Pb geochronology of three typical samples, including two monzo nitic granites from the Lincang batholith and a rhyolite from the Manghuai Formation are presented in the southern Lancangjiang, western Yunnan Province. The analyses of zircons for the biotite monzonitic granites from the northern (02DX-137) and southern (20JH-10) Lincang batholith show the single and tight clusters on the concordia, and yield the weighted mean 206Pb/238U ages of 229.4 ± 3.0 Ma and 230.4 ± 3.6 Ma, respectively, representing the crystallized ages of these granites. The zircons for the rhyolitic sample (02DX-95) from the Manghuai Formation give a weighted mean 206Pb/238U age of 231.0 ± 5.0 Ma. These data suggest that the igneous rocks from the Lincang granitic batholith and Manghuai Formation have a similar crystallized age. In combination with other data, it is inferred that both were generated at a narrow age span (~230 Ma) and were originated from the postcollisional tectonic regime. An early Proterozoic 206Pb/238U apparent age of 1977±44 Ma is additionally obtained from one zircon from the biotite monzonitic granite (southern Lincang batholith), indicative of devel- opment of the early Proterozoic Yangtze basement in the region. These precisely geochronological data provide important constraints on better understanding the Paleozoic tectonic evolution of the Tethys, western Yunnan Province. | PENG Touping1,2, WANG Yuejun1, FAN Weiming1, LIU Dunyi3, SHI Yuruo3 & MIAO Laicheng4 1. Key Laboratory of Isotope Geochronology and Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 3. SHRIMP isotope Laboratory, Chinese Academy of Geological Sciences, Beijing 100037, China 4. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2006 | Science China Earth Sciences2006，49，10： | 55 |
| 3 | Early Paleozoic subduction of the Paleo-Asian Ocean: Geochronological and geochemical evidence from the Dashizhai basalts, Inner Mongolia显示文摘Zircon U-Pb results of basalt from the Dashizhai Town in Inner Mongolia, NE China, shows that the basaltic lava was erupted at 439±3 Ma, much older than the 'Permian basalts' as previously thought. These rocks show arc-type trace element patterns (i.e., Nb-Ta depletion and light REE and large ion lithophile element enrichment) and unradiogenic Sr and highly radiogenic Nd and Hf isotope compositions. They can be subdivided into two petrogenetic groups: Group 1 basalts have relatively high TiO2, MgO and compatible elements and low Sr and Th, characterized by mid-oceanic ridge basalt (MORB)-type Sr-Nd-Hf isotope compositions (87Sr/86Sr(i)=0.7028―0.7032, εNd(t)=+9.8-+11.2, εHf(t)=+16.1- +18.4). Group 2 has lower TiO2, MgO and compatible elements and higher Sr and Th, and relatively evolved Sr-Nd-Hf isotope compositions (87Sr/86Sr(i)=0.7037-0.7038, εNd(t)=+5.7-+7.3, εHf(t)=+12.6- +13.0). Both groups were interpreted as melts derived from a metasomatized mantle wedge formed during the subduction of Paleo-Asian Ocean. The mantle source for Group 1 was probably a highly isotopically depleted oceanic mantle modified by predominant slab fluids; whereas subducted sediments had an important contribution to the melting source for Group 2. The petrogenesis of the Dashizhai basalts provides clear evidence for early Paleozoic subduction of the Paleo-Asian Ocean, and the highly radiogenic Nd and Hf compositions in these rocks suggest that these lavas and their possible intrusive counterparts were one of the important components for Phanerozoic crustal growth. Our and previous studies on the 'Dashizhai Formation' volcanic rocks yield an unrealistic eruption range of 440-270 Ma for different rock types, we thus advise to disassemble the previously defined 'Dashizhai Formation' into multiple lithologic units and to reinterpret the spatial and temporal distributions of different volcano-sedimentary associations. | GUO Feng FAN WeiMing LI ChaoWen MIAO LaiCheng ZHAO Liang | 2009 | Science China Earth Sciences2009，52，7： | 37 |
| 4 | Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drugresistant sublines显示文摘AIM: To investigate the expression and function of classicalprotein kinase C (PKC) isoenzymes in inducing MDRphenotype in gastric cancer cells.METHODS: Two cell lines were used in the study: gastriccancer cell SGC7901 and its drug-resistant cell SGC7901/VCRstepwise-selected by vincristine 0.3, 0. 7 and 1.0 mg@ L-1 ,respectively. The expression of classical PKC (cPKC)isoenzymes in SGC7901 cells and SGC7901/VCR cells weredetected using immunofluorescent cytochemistry, laserconfocal scanning microscope and Wsstern blot. The effectsof anti-PKC isoenzymes antibody of adriamycinaccumulation in SGC7901/VCR cells were determined usingflow cytometric analysis.RESULTS: (1) SGC7901 cells exhibited positive staining ofPKC-α. SGC7901/VCR cells exhibited stronger staining ofPKC-α than SGC7901 cells. The higher dosage vincristineselected, the much stronger staining of PKC-α was observedon SGC7901/VCR cells. (2) Both SGC7901 and SGC7901/VCRcells exhibited positive staining of PKC-βⅠ and PKC-βⅡ withno significant difference. ( 3 ) Compared with SGC7901,SGC7901/VCR cells had decreased adriamycin accumulationand retention. Accumulation of adriamycin in SGC7901 was5.21 + 2.56 mg@ L-1, in SGC7901/VCR 0.3 was 0.85 + 0.29 mg@L-1 , in SGC7901/VCR 0.7 was 0.81 + 0.32 og@ L-1 , and inSGC7901NCR 1.0 was 0.80 + 0.33 mg @ L-1; Retention ofadriamycin in SGC 7901 was 2.51 + 1.23 mg@L-1, in SGC7901/VCR 0.3 was 0.47 + 0.14 mg@ L-1 , in SGC7901/VCR 0.7 was 0.44 + 0.15 mg@ L-1, and in SGC 7901/VCR 1.0 was 0.41 + 0.1 1mg @ L-1 . (4) Fluorescence intensity presented adriamycinaccumulation in SGC7901/VCR cells was increased from 1.14+0.36 to 2.71 +0.94 when cells were co-incubated with anti-PKC-αbut not with anti-PKC-βⅠ, PKC-βⅡ and PKCγ antibodies.CONCLUSION: PKC-α, but not PKC-βⅠ, PKC-βⅡ or PKCγ,may play a role in multidrug resistance of gastric cancercells SGC7901/VCR. | Ying Han Zhe-Yi Han Xin-Min Zhou Ru Shi Yue Zheng Yong-Quan Shi Ji-Yan Miao Bo-Rong Pan Dai-Ming Fan | 2002 | World Journal of Gastroenterology2002，8，3： | 25 |
| 5 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 6 | Simultaneous Determination of Melamine, Ammelide, Ammeline, and Cyanuric Acid in Milk and Milk Products by Gas Chromatography-tandem Mass Spectrometry显示文摘Objective To develop an analytical method for simultaneously qualitative and quantitative determination of melamine and triazine-related by-products including ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography- tandem mass spectrometry (GC-MS/MS). Methods Melamine and triazine-related by-products namely ammelide, ammeline and cyanuric acid in the samples were extracted in a solvent mixture of diethylamine, water, and acetonitrile (10:40:50, V/V/V). After centrifugation, an aliquot of the supernatant was evaporated to dryness under a gentle stream of nitrogen gas, and then melamine and triazine-related by-products were derivatized using BSTFA with 1% TMCS. The derivatives of melamine and its analogues were determined by gas chromatography/ tandem mass spectrometry using multiple reactional monitoring (MRM) with 2, 6-Diamino-4-chloropyrimidine (DACP) being used as an internal standard. Results The linear detectable ranges were from 0.004 mg/kg to 1.6 mg/kg for melamine, ammelide, ammeline, and cyanuric acid with a correlation coefficient no less than 0.999. The recovery rates of the four compounds in spiked blank milk powder at concentrations 0.5, 1, 2 mg/kg were between 61.4%-117.2%, and the relative standard deviation was no more than 11.5% (n=6). The detection limits of melamine, ammelide, ammeline and cyanuric acid in milk powder were 0.002 mg/kg with a ratio of signal to noise of 3. Conclusion This GC-MS/MS method for simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products is sensitive and specific. | HONG MIAO SAI FAN YONG-NING WU LEI ZHANG PING-PING ZHOU JING-GUANG LI HUI-JING CHEN AND YUN-FENG ZHAO | 2009 | Biomedical and Environmental Sciences2009，22，2： | 21 |
| 7 | A putative 6-transmembrane nitrate transporter OsNRT1.1b plays a key role in rice under low nitrogen显示文摘OsNRT1.1a is a low-affinity nitrate(NO_3^-) transporter gene. In this study, another mRNA splicing product, OsNRT1.1b,putatively encoding a protein with six transmembrane domains, was identified based on the rice genomic database and bioinformatics analysis. OsNRT1.1a/OsNRT1.1b expression in Xenopus oocytes showed OsNRT1.1a-expressing oocytes accumulated ^(15)N levels to about half as compared to OsNRT1.1bexpressing oocytes. The electrophysiological recording of OsNRT1.1b-expressing oocytes treated with 0.25 mM NO_3^- confirmed ^(15)N accumulation data. More functional assays were performed to examine the function of OsNRT1.1b in rice. The expression of both OsNRT1.1a and OsNRT1.1b was abundant in roots and downregulated by nitrogen(N) deficiency. The shoot biomass of transgenic rice plants with OsNRT1.1a or OsNRT1.1b overexpression increased under various N supplies under hydroponic conditions compared to wild-type(WT). The OsNRT1.1a overexpression lines showed increased plant N accumulation compared to the WT in 1.25 mM NH_4NO_3 and 2.5 mM NO_3^- or NH_4^+ treatments, but not in 0.125 mM NH_4NO_3.However, OsNRT1.1b overexpression lines increased total N accumulation in all N treatments, including 0.125 m M NH_4NO_3,suggesting that under low N condition, OsNRT1.1b would accumulate more N in plants and improve rice growth, but also that OsNRT1.1a had no such function in rice plants. | Xiaorong Fan Huimin Feng Yawen Tan Yanling Xu Qisong Miao Guohua Xu | 2016 | Journal of Integrative Plant Biology2016，58，6： | 21 |
| 8 | Effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats显示文摘AIM: To invsstigare the effect of L-NAME on nitric oxide andgastriubtestubal motility alterations in cirrhotic ratsMETHODS: Rats with cirrhosis induced by carbontetrachloride were randomly divided into two groups, one( n= 13) receiving 0. 5 mg@ kg-1 per clay of NG-nitro-L-argininemethyl ester (L-NAME), a nitric oxide synthase inhibitor,for 10 days, whereas the other group ( n = 13) and control( n = 10) rats were administrated the same volume of 9 g@ L-1saline.Half gastric emptying time and 2 h residual rate weremeasured by SPECT, using 99m Tc-DTPA-labeled bariumsuifate as test meal. Gastrointestinal transition time wasrecorded simultaneously. Serum concentration of nitrcoxide (NO) was determined by the kinetic cadmiunreduction and colorimetric methods. ImmunohistochemicalSABC method was used to observe the expression anddistribution of three types of nitric oxide synthase (NOS)isoforms in the mt gastrointestinal tract. Western blot wasused to detect expression of gastrointestinal NOS isoforms.RESULTS: Half gastric emptying time and trans-gastrointestinal time were significantly prolonged( 124.0 ± 26.4min; 33.7± 8.9min;72.1 ± 15.3 min; P<0.01), (12.4±0.5h; 9.5±0.3 h; 8.2±0.8 h; P<0.01), 2h residual rate wasraised in cirrhotic rots than in controls and cirrhotic ratstreated with L-NAME(54.9± 7.6 % ,13.7 ± 3.2 %, 34.9± 10.3%, P< 0.01). Serum concentration of NO was significantlyincreased in cirrhotic rots than in the other groups (8.20 ± 2.48)μmol@L-1, (5.94± 1.07) μmol@L-1 ,and control (5.66± 1.60) tμmol@L-1, P< 0.01. NOS staining intensities which weremainly located in the gastrointestinal tissues were markedlylower in cirrhotic rats than in the controls and cirrhotic ratsafter treated with L- NAME.CONCLUSION: Gastrointestinal motility was remarkablyinhibited in cirrhotic rats, which could he alleviated by L-NAME. Nitric oxide may play an important role in theinhibition of gastrointestinal motility in cirrhotic rats. | Xin Wang Zong-You Zhang Mei Lan Ji-Yan Miao Xue-Gang Guo Yong-Quan Shi Yan-Qiu Zhao Jie Ding Kai-Cun Wu Dai-Ming Fan,Institute of Digestive disease,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Yue-Xia Zhong,Emergency Department,Tangdu Hospital,Fourth Military Medical University,Xi’an 710038,Shaanxi Province,China Ju Lu,Class EE 87,Department of Electronic Engineering,Tsinghua University,Beijing 100084,China Bo-Rong Pan,Oncology Center,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 19 |
| 9 | Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells显示文摘Metrnl is a newly identified secreted protein highly expressed in the intestinal epithelium.This study aimed to explore the role and mechanism of intestinal epithelial Metrnl in ulcerative colitis.Metrnl-/-(intestinal epithelial cell-specific Metrnl knockout)mice did not display any phenotypes of colitis under basal conditions.However,under administration of 3%dextran sodium sulfate(DSS)drinking water,colitis was more severe in Metrnl-/-mice than in WT mice,as indicated by comparisons of body weight loss,the presence of occult or gross blood per rectum,stool consistency,shrinkage in the colon,intestinal damage,and serum levels of inflammatory factors.DSS-induced colitis activated autophagy in the colon.This activation was partially inhibited by intestinal epithelial Metrnl deficiency,as indicated by a decrease in Beclin-1 and LC3-Ⅱ/Ⅰand an increase in p62 in DSS-treated Metrnl-/-mice compared with WT mice.These phenomena were further confirmed by observation of autophagosomes and immunofluorescence staining for LC3 in epithelial cells.The autophagy-related AMPK-mTOR-p70S6K pathway was also activated in DSS-induced colitis,and this pathway was partially blocked by intestinal epithelial Metrnl deficiency,as indicated by a decrease in AMPK phosphorylation and an increase in mTOR and p70S6K phosphorylation in DSS-treated Metrnl-/-mice compared with WT mice.Therefore,Metrnl deficiency deteriorated ulcerative colitis at least partially through inhibition of autophagy via the AMPK-mTOR-p70S6K pathway,suggesting that Metrnl is a therapeutic target for ulcerative colitis. | Sai-long Zhang Zhi-yong Li Dong-sheng Wang Tian-ying Xu Mao-bing Fan Ming-he Cheng Chao-yu Miao | 2020 | Acta Pharmacologica Sinica2020，41，6： | 14 |
| 10 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
| 11 | Unequal-thickness billet optimization in transitional region during isothermal local loading forming of Ti-alloy rib-web component using response surface method显示文摘Avoiding the folding defect and improving the die filling capability in the transitional region are desired in isothermal local loading forming of a large-scale Ti-alloy rib-web component(LTRC). To achieve a high-precision LTRC, the folding evolution and die filling process in the transitional region were investigated by 3 D finite element simulation and experiment using an equal-thickness billet(ETB). It is found that the initial volume distribution in the second-loading region can greatly affect the amount of material transferred into the first-loading region during the second-loading step, and thus lead to the folding defect. Besides, an improper initial volume distribution results in non-concurrent die filling in the cavities of ribs after the second-loading step, and then causes die underfilling. To this end, an unequal-thickness billet(UTB) was employed with the initial volume distribution optimized by the response surface method(RSM). For a certain eigenstructure, the critical value of the percentage of transferred material determined by the ETB was taken as a constraint condition for avoiding the folding defect in the UTB optimization process,and the die underfilling rate was considered as the optimization objective. Then, based on the RSM models of the percentage of transferred material and the die underfilling rate, non-folding parameter combinations and optimum die filling were achieved. Lastly, an optimized UTB was obtained and verified by the simulation and experiment. | Ke WEI Mei ZHAN Xiaoguang FAN He YANG Pengfei GAO Miao MENG | 2018 | Chinese Journal of Aeronautics2018，31，4： | 13 |
| 12 | Experimental Study into Permeability of Broken Mudstone显示文摘Much attention should be paid to the permeability of broken rocks in goafs for the sake of water preservation in mining and to prevent disasters. Using a special device together with the MTS815.02 Rock Mechanics Test System,we tested the permeability of broken mudstone during its compacting process,and obtained the relations between axial stress and differential seepage pressure and between the pressure gradient and the seepage velocity. The effect of axial stress,grain size,and seepage velocities on the permeability coefficient is analyzed. The results show that 1) permability varies abruptly when the load reaches the compressive strength of rock samples,2) for a constant seepage velocity,the differential seepage pressure and the axial stress can be expressed by an exponential function,3) for a constant axial stress,the pressure gradient and the seepage velocity can be also expressed by an exponential function and 4) the permeability coefficient of broken mudstone of different sizes is closely related to its compaction state and will decrease with the increase of axial stress,expressed as a logarithmic function. | MA Zhan-guo MIAO Xie-xing ZHANG Fan LIYu-shou | 2007 | Journal of China University of Mining and Technology2007，17，2： | 13 |
| 13 | Relations between sedimentary sequence and paleoclimatic changes during last 200 ka in the southern South China Sea显示文摘Core NS-93-5 was taken from the mild slope terrace of the southern South China Sea (SCS), which has preserved the steadiness depositional record of the normal marine environment since late Quaternary. Sedimentary sequence and oxygen isotopic stratigraphy of high resolution in the near 200 ka of the southern SCS has been established. By the comparative analysis with GISP2’s ice core, the depositional record of D/O’s events 1-21 and Heinrich’s events H1-H6 in the southern SCS that reflected the quick climate change in short time scale since the last interglacial stage is revealed, which indicates that in the last 200 ka in the southern SCS and the Arctic area there was tele-connection of paleoclimate and the unstability of the Western Pacific Warm Pool. This note shows that the sedimentary layers order of this sea area classified by color identification and by oxygen isotope stratum has the very good corresponding relation. The color feature of sediment changes along with the climate and the former | Muhong Chen Xia Tu Fan Zheng Wen Yan Xianzan Tang Jun Lu Baogui Wang Miao’an Lu | 2000 | Chinese Science Bulletin2000，45，14： | 12 |
| 14 | SIMULATION OF TANK SLOSHING BASED ON OPENFOAM AND COUPLING WITH SHIP MOTIONS IN TIME DOMAIN显示文摘Tank sloshing in ship cargo is excited by ship motions, which induces impact load on tank wall and then affects the ship motion. Wave forces acting on ship hull and the retardation function are solved by using three-dimensional frequency domain theory and an impulse response function method based on the potential flow theory, and global ship motion is examined coupling with nonlinear tank sloshing which is simulated by viscous flow theory. Based on the open source Computational Fluid Dynamics (CFD) development platform Open Field Operation and Manipulation (OpenFOAM), numerical calculation of ship motion coupled with tank sloshing is achieved and the corresponding numerical simulation and validation are carried out. With this method, the interactions of wave, ship body and tank sloshing are completely taken into consideration. This method has quite high efficiency for it takes advantage of potential flow theory for outer flow field and viscous flow theory for inside tank sloshing respectively. The numerical and experimental results of the ship motion agree well with each other. | LI Yu-long ZHU Ren-chuan MIAO Guo-ping FAN Ju | 2012 | Journal of Hydrodynamics2012，24，3： | 11 |
| 15 | Prevalence of cardiovascular disease in subjects hospitalized due to chronic obstructive pulmonary disease in Beijing from 2000 to 2010显示文摘ObjectivesTo 在为长期的妨碍的肺的疾病( COPD )就医的题目调查心血管的疾病( CVD )的全面流行,并且在10年的 period.MethodsMedical 上与 COPD 在病人探索主要 CVD 复杂并发症和趋势的流行在 PLA 医院将军,的记录北京联合医学院医院,并且到 2010/03/03 的从 2000/01/01 的北京医院回顾地被考察。有 COPD 的 4960 个病人的一个总数在学习被考察(3570 男性,意味着年龄, 72.2 ±10.5 年;1390 女性,意味着年龄, 72.0 ±10.4 年) 在 COPD 病人的 CVD 的 .ResultsThe 流行是 51.7% 。三很流行的 CVD 是 ischemic 心疾病(28.9%) ,心失败(19.6%) ,和心律不齐(12.6%) 。在 10 年的学习时期期间,在 COPD 病人的各种各样的 CVD 的流行与增加年龄显示出一个渐渐的增加趋势。由于 ischemic 心疾病有更高的病态(P <0.01 ) 在男 COPD 病人比在女对应物。然而,心失败(P <0.01 ) 并且高血压(P <0.01 ) 比在女 COPD 病人不太经常发生在男 COPD 病人。而且, ischemic 心疾病的流行逐年减少了。除了心失败,在 COPD 病人的 CVD 复杂并发症的各种各样的类型趋于发生在更年轻的题目。在女人的 CVD 的所有主要类型的流行趋于在就医的病人由 CVD 的 year.ConclusionsThe 流行增加年因为在北京的 COPD 高。年龄,性别和 CVD 趋势,以及生活方式变化,当预防和控制策略被提出时,应该被考虑。 | Hua Cui Dong-Mei Miao Zhi-Min Wei Jian-Fang Cai Yi Li Ai-Min Liu Fan Li | 2012 | Journal of Geriatric Cardiology2012，9，1： | 11 |
| 16 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 17 | Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides显示文摘Metrnl 是新奇分泌蛋白质,但是它的生理的角色留下逃犯。在这研究,我们在人调查了 Metrnl 的织物表示模式并且与最高度表示的 levels.Methods 在纸巾探索了它的可能的生理的角色:从 69 个施主包含纸巾的 19 种类型的人的织物 microarray 被用来检验 Metrnl,和表示模式的织物表示模式进一步在新鲜的人和老鼠纸巾被验证。肠的上皮的房间特定的 Metrnl 猛烈老鼠被产生,它被用来分析 Metrnl.Results 的生理的角色:Metrnl 是高度在人的胃肠的道表示的大多数,并且明确地在肠的上皮被表示。与这一致, Metrnl mRNA 最高度也在在 14 之中的胃肠的道测试的纸巾打的老鼠被表示。在肠的上皮的房间特定的 Metrnl 猛烈老鼠,而 Metrnl 浆液层次向减小显示出一个趋势,在内脏液体的 Metrnl 层次显著地被减少,但是这个变化不是统计上重要的。Metrnl 的这房间特定的删除没影响身体重量,食物吸入,血葡萄糖,结肠长度和组织学,肠的渗透,粘液内容或粘蛋白在生理的条件下面的 2 表示,但是统计上减少了抗菌剂肽的表示,例如再生导出小岛 3 gamma (Reg3g ) 和 lactotransferrin.Conclusion:Metrnl 高度在人和老鼠的肠的上皮的房间被表示,它主要贡献本地内脏 Metrnl 层次并且影响浆液 Metrnl 水平到更小的程度。Metrnl 在维持内脏抗菌剂肽起一个作用。 | Zhi-yong LI Mao-bing FAN Sai-long ZHANG Yi QU Si-li ZHENG Jie SONG Chao-yu MIAO | 2016 | Acta Pharmacologica Sinica2016，37，11： | 11 |
| 18 | Review of the fabrication and application of porous materials from silicon-rich industrial solid waste显示文摘Porous materials have promise as sound insulation, heat barrier, vibration attenuation, and catalysts. Most industrial solid wastes, such as tailings, coal gangue, and fly ash are rich in silicon. Additionally, a high silicon content waste is a potential raw material for the syn- thesis of silicon-based, multi-porous materials such as zeolites, mesoporous silica, glass-ceramics, and geopolymer foams. Representative sil- icon-rich industrial solid wastes (SRISWs) are the focus of this mini review of the processing and application of porous silicon materials with respect to the physical and chemical properties of the SRISW. The transformation methods of preparing porous materials from SRISWs are summarized, and their research status in micro-, meso-, and macro-scale porous materials are described. Possible problems in the application of SRISWs and in the preparation of functional porous materials are analyzed, and their development prospects are discussed. This review should provide a typical reference for the recycling and use of industrial solid wastes to develop sustainable “green materials.” | Chao Miao Lixing Liang Fan Zhang Shumei Chen Kaixuan Shang Jinlong Jiang Yi Zhang Jing Ouyang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 10 |
| 19 | Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy显示文摘AIM:To evaluate the role of probiotics in the standard triple Helicobacter pylori therapy.METHODS:In this meta-analysis,we investigated the efficacy of probiotics in a standard triple H.pylori therapy in adults.Searches were mainly conducted in MEDLINE/Pub Med,EMBASE,and the Cochrane Central Register of Controlled Trials.Fourteen studies met our criteria,and the quality of these studies was assessedusing the Jadad scale.We used STATA version 12.0to extract data and to calculate the odds ratios(ORs),which are presented with the corresponding 95%confidence intervals(CIs).The data are presented as forest plots.RESULTS:The pooled ORs for the eradication rates calculated by intention-to-treat analysis and perprotocol analysis in the probiotic group vs the control group were 1.67(95%CI:1.38-2.02)and 1.68(95%CI:1.35-2.08),respectively,using the fixed-effects model.The sensitivity of the Asian studies was greater than that of the Caucasian studies(Asian:OR=1.78,95%CI:1.40-2.26;Caucasian:OR=1.48,95%CI:1.06-2.05).The pooled OR for the incidence of total adverse effects was significantly lower in the probiotic group(OR=0.49,95%CI:0.26-0.94),using the random effects model,with significant heterogeneity(I2=85.7%).The incidence of diarrhea was significantly reduced in the probiotic group(OR=0.21,95%CI:0.06-0.74),whereas the incidence of taste disorders,metallic taste,vomiting,nausea,and epigastric pain did not differ significantly between the probiotic group and the control group.CONCLUSION:Supplementary probiotic preparations during standard triple H.pylori therapy may improve the eradication rate,particularly in Asian patients,and the incidence of total adverse effects. | Rong Zhu Kan Chen Yuan-Yuan Zheng Hua-Wei Zhang Jun-Shan Wang Yu-Jing Xia Wei-Qi Dai Fan Wang Miao Shen Ping Cheng Yan Zhang Cheng-Fen Wang Jing Yang Jing-Jing Li Jie Lu Ying-Qun Zhou Chuan-Yong Guo | 2014 | World Journal of Gastroenterology2014，20，47： | 9 |
| 20 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
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