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| 1 | Selective depression action of taurine in flotation separation of specularite and chlorite显示文摘Chlorite,as the most representative gangue mineral associated with specularite,of which the separation of these two minerals is difficult.This paper investigated the depression effect of taurine on specularite/chlorite separation via flotation experiments,adsorption tests,contact angle measurements,Zeta potential detection,FT-IR measurements,and XPS analyses.The results of single mineral flotation indicated that chlorite could be depressed selectively by taurine with the recovery of less than 30%,but the floatability of specularite remains high with recovery rate of 81.77%at pH 10.The artificial mixed mineral flotation results confirmed the effectiveness of taurine as a depressant.Surface adsorption,contact angle,and Zeta potential detection revealed taurine primarily adsorbs on the chlorite surface,which hampered the DDA’s subsequent adsorption and results in the chlorite’s poor floatability.The FT-IR spectra and XPS analyses provided further proof that taurine adsorbed on chlorite surface as an electron donor,and part of the electrons transferred from the sulfonic acid group of taurine to metal ions during the adsorption process.In addition,the hydrogen bond between amino-group of taurine and O ions in chlorite surface was also formed in the adsorption process.Finally,optimized adsorption configurations of taurine on chlorite surfaces were proposed. | Mingyang Li Cheng Yang Zhaoyang Wu Xiangpeng Gao Xiong Tong Xiankun Yu Hongming Long | 2022 | International Journal of Mining Science and Technology2022，32，3： | 4 |
| 2 | A model to assess fundamental and realized carrying capacities of island ecosystem:A case study in the southern Miaodao Archipelago of China显示文摘Research on carrying capacity, aiming at maintaining the limited ability of the Earth's life supporting system to sustain human development, requires a comprehensive and ecosystem-based approach to monitor and assess the localized sustainability of coupled social and ecological systems. A definition termed the ecosystem-based carrying capacity of island(EBCCI) was developed in this paper of which the indices of fundamental and realized carrying capacities of island(FCCI and RCCI) were highlighted to emphasize the inter-dependencies between social systems and ecological systems. In order to avoid the difficulties and uncertainties of direct assessment, the related assessment model was established on the basis of synthetic evaluation of inherent and external factors affecting the EBCCI. The southern Miaodao Archipelago(SMA) located in the intersection of the Bohai Sea and the Yellow Sea, China, was taken as a typical example to acquire integrated recognition of the island ecosystem and its carrying capacity so as to discuss its sustainable development. The index scores of FCCI and RCCI in the SMA were 0.818 5 and 0.712 9 out of 1.0, respectively, with acceptable uncertainties. The results showed a relatively well capacity to sustain progress and relatively well realization of the carrying capacity of island ecosystem, owing to a well capacity of ecologically regulating, general performance of both ecologically supporting and resource provisioning, and a relatively high level of social supporting system. The study implied that it was critical to optimize the inter-dependencies and to sustain the relative balance between social systems and ecological systems so as to improve the RCCI and further facilitate the sustainability of SMA. The approach proposed in this paper provides a powerful tool which is well applicative to the regional level of an oceanic island or archipelago to study the sustainable development and can be further popularized to the coastal zone. | SHI Honghua SHEN Chengcheng ZHENG Wei LI Fen WANG Xiaoli CHI Yuan GUO Zhen QIAO Mingyang GAO Liyuan DING Dewen | 2016 | Acta Oceanologica Sinica2016，35，2： | 4 |
| 3 | A seasonal grade division of the global offshore wind energy resource显示文摘Under the background of energy crisis, the development of renewable energy will significantly alleviate the energy and environmental crisis. On the basis of the European Centre for Medium-Range Weather Forecasts(ECMWF)interim reanalysis(ERA-interim) wind data, the annual and seasonal grade divisions of the global offshore wind energy are investigated. The results show that the annual mean offshore wind energy has great potential. The wind energy over the westerly oceans of the Northern and Southern Hemispheres is graded as Class 7(the highest), whereas that over most of the mid-low latitude oceans are higher than Class 4. The wind energy over the Arctic Ocean(Class 4) is more optimistic than the traditional evaluations. Seasonally, the westerly oceans of the Northern Hemisphere with a Class 7 wind energy are found to be largest in January, followed by April and October, and smallest in July. The area of the Class 7 wind energy over the westerly oceans of the Southern Hemisphere are found to be largest in July and slightly smaller in the other months. In July, the wind energy over the Arabian Sea and the Bay of Bengal is graded as Class 7, which is obviously richer than that in other months. It is shown that in this data set in April and October, the majority of the northern Indian Ocean are regions of indigent wind energy resource. | ZHENG Chongwei LI Chongyin GAO Chengzhi LIU Mingyang | 2017 | Acta Oceanologica Sinica2017，36，3： | 4 |
| 4 | Unconventional dual-vacancies in nickel diselenide-graphene nanocomposite for high-efficiency oxygen evolution catalysis显示文摘Although nickel-based catalysts display good catalytic capability and excellent corrosion resistance under alkaline electrolytes for water splitting,it is still imperative to enhance their activity for real device applications.Herein,we decorated Ni0.85Se hollow nanospheres onto reduced graphene oxide(RGO)through a hydrothermal route,then annealed this composite at different temperatures(400℃,NiSe2-400 and 450℃,NiSe2-450)under argon atmosphere,yielding a kind of NiSe2/RGO composite catalysts.Positron annihilation spectra revealed two types of vacancies formed in this composite catalyst.We found that the NiSe2-400 catalyst with dual Ni-Se vacancies is able to catalyze the oxygen evolution reaction(OER)efficiently,needing a mere 241 mV overpotential at 10 mA·cm−2.In addition,this catalyst exhibits outstanding stability.Computational studies show favorable energy barrier on NiSe2-400,enabling moderate OH−adsorption and O2 desorption,which leads to the enhanced energetics for OER. | Pengkun Wei Zewei Hao Yang Yang Mingyang Liu Haijun Zhang Min-Rui Gao Shu-Hong Yu | 2020 | Nano Research2020，13，12： | 2 |
| 5 | Energetic particles’fluxes and dose in the Radiation Gene Box measured by space radiation detector onboard SJ-10 satellite显示文摘Background To evaluate the hazard of space radiation posing to the tissues,it is important to obtain exact fluxes of different radiation particles.The Radiation Gene Box(RGB)onboard SJ-10 spacecraft was an instrument designed to investigate the effects of space environment on the mESCs and drosophila.To derive the dose received by the tissues inside the RGB,the Space Radiation Detector(SRD)was installed inside it.Purpose The SRD was designed to derive the fluxes of electron,proton,hellion and gamma rays around it.If the type of the particles,the energies,the fluxes and the conversion coefficients are known,the dose received by the tissues could be evaluated.Methods The SRDwas designed as a △E-E solid-state telescope.By measuring the energy deposited in the three subdetectors,the particles’type and their energies could be discriminated.The data of SRDwere divided into 15 bins by the types of particles and their energy ranges.Results The gamma ray flux was higher than any other particle flux inside the RGB,and the electron was the most intense charge particle,while the helium ion was the most harmful radiation to the cells inside the RGB.Conclusion The dose rate inside the Radiation Gene Box was much higher than in the ground,but the integral dose of 12 days inside the RGB was about 2.13 mSv.It seemed unlikely to have obvious biological effects on the tissues of mice and drosophila. | Xingzhu Cui Yaqing Liu Wenxi Peng Jinzhou Wang Min Gao Dongya Guo Xiaohua Liang Ruirui Fan Huanyu Wang Yunlong Zhang Zhongjian Ma Mingyang Yan Hong Xiao Yuanda Jiang Haiying Hang | 2018 | Radiation Detection Technology and Methods2018，2，2： | 2 |
| 6 | Hybrid Channel Access Mechanism Based on Coexistence Scenario of NR-Unlicensed显示文摘With the rapid development of 5G NR(New Radio),the explosive increment of traffic amount is calling the utilization of unlicensed band.3GPP has proposed LAA(Licensed Assisted Access)to use LTE in unlicensed band and pointed out that NR-U(NR-Unlicensed)can reuse most designs of it.However,the existing channel access mechanism of LAA is conservative under the coexistence scenario of NR-U,which leads to the waste of time resource.To address the problem this paper proposes a hybrid channel access mechanism to take advantage of the LBT(Listen-Before-Talk)mechanism of LAA when channel is quite busy and transmit directly with reduced power when it is relatively idle.The channel busy degree is judged by a series of periodically updated adaptive thresholds.System-level simulation verifies that under the coexistence scenario of NR-U the proposed mechanism can achieve higher UPT(User Perceived Throughput)and lower delay than other channel access mechanisms. | Zhening Zhang Jingyi Chen Mingyang Dong Yuehong Gao Jingjing Wang | 2020 | China Communications2020，17，1： | 2 |
| 7 | Engineering the morphology and electronic structure of atomic cobalt-nitrogen-carbon catalyst with highly accessible active sites for enhanced oxygen reduction显示文摘The stabilization of non-precious metals as isolated active sites with high loading density over nitrogendoped carbon materials is essential for realizing the industrial application of single atom catalysts.However,achieving high loading of single cobalt active sites with greatly enhanced oxygen reduction reaction(ORR)activity and stability remains challenging.Here,an efficient approach was described to create a single atom cobalt electrocatalyst(Co SAs/NC)which possesses enhanced mesoporosity and specific surface area that greatly favor the mass transportation and exposure of accessible active sites.The electronic structure of the catalyst by the strong metal-support interaction has been elucidated through experimental characterizations and theoretical calculations.Due to dramatically enhanced mass transport and electron transfer endowed by morphology and electronic structure engineering,Co SAs/NC exhibits remarkable ORR performance with excellent activity(onset and half-wave potentials of 1.04 V(RHE)and 0.90 V(RHE),Tafel slope of 69.8 mV dec^(-1)and J_(k) of 18.8 mA cm^(-2)at 0.85 V)and stability(7 mV activity decay after 10,000 cycles).In additio n,the catalyst demonstrates great promise as an alternative to traditional Pt/C catalyst in zinc-air batteries while maintaining high performance in terms of high specific capacity of(796.1 mAh/g_(Zn)),power density(175.4 mW/cm^(2)),and long-term cycling stability(140 h).This study presents a facile approach to design SACs with highly accessible active sites for electrochemical transformations. | Zhijun Li Leipeng Leng Siqi Ji Mingyang Zhang Hongxue Liu Jincheng Gao Jiangwei Zhang J.Hugh Horton Qian Xu Junfa Zhu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 8 | Colonization and development of the gut microbiome in calves显示文摘Colonization and development of the gut microbiome are crucial for the growth and health of calves.In this review,we summarized the colonization,beneficial nutrition,immune function of gut microbiota,function of the gut barrier,and the evolution of core microbiota in the gut of calves of different ages.Homeostasis of gut microbiome is beneficial for nutritional and immune system development of calves.Disruption of the gut microbiome leads to digestive diseases in calves,such as diarrhea and intestinal inflammation.Microbiota already exists in the gut of calf fetuses,and the colonization of microbiota continues to change dynamically under the influence of various factors,which include probiotics,diet,age,and genotype.Colonization depends on the interaction between the gut microbiota and the immune system of calves.The abundance and diversity of these commensal microbiota stabilize and play a critical role in the health of calves. | Yufeng Du Ya Gao Mingyang Hu Jinxiu Hou Linhai Yang Xianghuang Wang Wenjuan Du Jianxin Liu Qingbiao Xu | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 9 | Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients in industrial crystallization显示文摘Solubility has been widely regarded as a fundamental property of small molecule drugs and drug candidates,as it has a profound impact on the crystallization process.Solubility prediction,as an alternative to experiments which can reduce waste and improve crystallization process efficiency,has attracted increasing attention.However,there are still many urgent challenges thus far.Herein we used seven descriptors based on understanding dissolution behavior to establish two solubility prediction models by machine learning algorithms.The solubility data of 120 active pharmaceutical ingredients(APIs)in ethanol were considered in the prediction models,which were constructed by random decision forests and artificial neural network with optimized data structure and model accuracy.Furthermore,a comparison with traditional prediction methods including the modified solubility equation and the quantitative structure-property relationships model was carried out.The highest accuracy shown by the testing set proves that the ML models have the best solubility prediction ability.Multiple linear regression and stepwise regression were used to further investigate the critical factor in determining solubility value.The results revealed that the API properties and the solute-solvent interaction both provide a nonnegligible contribution to the solubility value. | Yiming Ma Zhenguo Gao Peng Shi Mingyang Chen Songgu Wu Chao Yang Jing-Kang Wang Jingcai Cheng Junbo Gong | 2022 | Frontiers of Chemical Science and Engineering2022，16，4： | 1 |
| 10 | Efficient Catalytic Conversion of Polysulfides by Biomimetic Design of “Branch‑Leaf” Electrode for High‑Energy Sodium–Sulfur Batteries显示文摘Rechargeable room temperature sodium–sulfur(RT Na–S)batteries are seriously limited by low sulfur utilization and sluggish electrochemical reaction activity of polysulfide intermediates.Herein,a 3D“branch-leaf”biomimetic design proposed for high performance Na–S batteries,where the leaves constructed from Co nanoparticles on carbon nanofibers(CNF)are fully to expose the active sites of Co.The CNF network acts as conductive“branches”to ensure adequate electron and electrolyte supply for the Co leaves.As an effective electrocatalytic battery system,the 3D“branch-leaf”conductive network with abundant active sites and voids can effectively trap polysulfides and provide plentiful electron/ions pathways for electrochemical reaction.DFT calculation reveals that the Co nanoparticles can induce the formation of a unique Co–S–Na molecular layer on the Co surface,which can enable a fast reduction reaction of the polysulfides.Therefore,the prepared“branch-leaf”CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g^−1 at 0.1 C and superior rate performance. | Wenyan Du Kangqi Shen Yuruo Qi Wei Gao Mengli Tao Guangyuan Du Shu‑juan Bao Mingyang Chen Yuming Chen Maowen Xu | 2021 | Nano-Micro Letters2021，13，3： | 1 |
| 11 | Seroprevalence of Toxoplasma gondii Infection in Pet Dogs in Shenyang, Northeastern China显示文摘 | Yang Na Mu Mingyang Li Hongkui Hu Jianmin Gao Weifan Yang Shuhua He Jianbin | 2013 | The Journal of Parasitology2013，，1： | 1 |
| 12 | Weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copyright Protection显示文摘The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every day.For art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright protection.However,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level annotations.To alleviate this,we propose a novel weakly supervised object localization(WSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level labels.First,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by leveraging high-level semantic information.Second,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance mechanism.Finally,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization results.Extensive experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE. | Chaojie Wu Mingyang Li Ying Gao Xinyan Xie Wing W.Y.Ng Ahmad Musyafa | 2024 | Machine Intelligence Research2024，21，1： | 0 |
| 13 | Decision-making Method of Sharing Mode for Multi-microgrid System Considering Risk and Coordination Cost显示文摘Power sharing can improve the benefit of the multi-microgrid(MMG)system.However,the information disclosure may appear during the sharing process,which would bring privacy risk to a local microgrid.Actually,the risk and coordination cost are different in different sharing modes.Therefore,this paper develops a decision-making method to decide the most suitable one of three mostly used sharing modes(i.e.,cooperative game with complete information,cooperative game with incomplete information,and noncooperative game).Firstly,power sharing paradigms and coordination mechanisms in the three modes are formulated in detail.Particularly,different economic operation models of MMG system are included to analyze the economic benefit from different sharing modes.Based on the different disclosed information,the risk cost is evaluated by using the simplified fuzzy analytic hierarchy process(FAHP).And the coordination cost for different sharing modes is expressed in different functions.In addition,a hierarchical evaluation system including three decision-making factors(e.g.,economics,risk,and coordination)is set up.Meanwhile,a combination weighting method(e.g.,the simplified FAHP combined with the anti-entropy weight method)is applied to obtain the weight of each factor for comprehensive evaluation.Finally,the optimal sharing solution of MMG system is decided by comparing and analyzing the difference among the three sharing modes.Numerical results validate that the proposed method can provide a reference to deciding a suitable sharing mode. | Hongjun Gao Jingxi Yang Shuaijia He Jianglin Zhang Junyong Liu Mingyang Hu | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，6： | 0 |
| 14 | Efficient Heterogeneous Hydroformylation over Zeolite-Encaged Isolated Rhodium Ions显示文摘Alkene hydroformylation is an extremely important industry process currently accomplished via homogeneous catalysis.Heterogeneous hydroformylation is being avidly pursued as a more economical and sustainable process.Herein,we report the construction of zeolite-encaged rhodium catalyst for efficient hydroformylation.Through a facile in situ hydrothermal strategy,isolated Rh^(δ+)(δ=2.5)can be encaged in faujasite and efficiently stabilized via interaction with framework oxygen atoms,producing a Rh@Y model catalyst with well-defined rhodium sites and coordination environment.Rh@Y exhibits high catalytic activity,perfect chemoselectivity,and recyclability in 1-hexene hydroformylation under mild reaction conditions,making it a robust heterogeneous catalyst for potential applications.A state-of-the-art turnover frequency value of 6567 molC=C/molRh/h for Rh@Y can be achieved in 1-hexene hydroformylation at 393 K,outperforming all heterogeneous catalysts and most homogeneous catalysts under comparable conditions.With the well-defined structure of Rh@Y,the detailed mechanism of alkene hydroformylation can be interpreted via theoretical calculations,and the advantages of heterogeneous hydroformylation are well explained.This work provides a promising solution toward efficient heterogeneous noble metal catalysis by encaging stable isolated ions in a zeolite matrix. | Weixiang Shang Bin Qin Mingyang Gao Xuetao Qin Yuchao Chai Guangjun Wu Naijia Guan Ding Ma Landong Li | 2023 | CCS Chemistry2023，5，7： | 0 |
| 15 | Rational design of imine-linked three-dimensional mesoporous covalent organic frameworks with bor topology显示文摘Three-dimensional(3D)covalent organic frameworks(COFs)possess great potential applications in various fields.Constructing 3D COFs with large pore sizes is extremely challenging due to the interpenetration and collapse.Herein,we report a series of crystalline imine-linked 3D COFs(3D-bor-COF-1,3D-borCOF-2,3D-bor-COF-3)with mesoporous channels through rationally designing the topology configuration.These 3D-bor-COFs display permanent porosity and Brunauer–Emmett–Teller(BET)surfaces of 3205.5,1752.7,and 2077.3 m2 g−1(SLangmuir=4277.7,2480.3,and 2698.0 m2 g−1),respectively.The pore sizes of 3Dbor-COFs were confirmed by the lattice fringes from high-resolution transmission electron microscopy,as well as structural simulation and nitrogen adsorption isotherm analysis.3D-bor-COFs display large pore sizes(3.8 nm for 3D-borCOF-3),which is among the highest record of 3D COFs.Owing to the unstackedaromatic pore environment and high specific surface area,3D-bor-COFs display excellent adsorption capacity for benzene vapor(1203.9 mg g−1 for 3D-bor-COF-3)under 298 K,which is three times higher than that of the best-reported 2D COF.This work not only provides inspiration for designing 3D mesoporous imineCOFs,but also demonstrates a strategy for constructing aromatics adsorption materials. | Zonglong Li Chouhung Hsueh Zhuozhuo Tang Jia Chen Xiaolin Wang Hao Cui Yang Yang Xiaodan Wang Dongsheng Ren Hongqiang Gao Mingyang Li Hong Xu Xiangming He | 2022 | SusMat2022，2，2： | 0 |
| 16 | A laboratory method to simulate seismic waves induced by underground explosions显示文摘The seismic waves induced by underground explosions generate geological hazards affecting deep buried tunnels such as rockbursts and engineering-induced earthquakes. This issue is difficult to study through full-scale testing due to the expense and unpredictable danger. To solve this problem, the authors developed experimental apparatus and presented a laboratory method to simulate seismic waves induced by underground explosions. In this apparatus, a combined structure of a diffusive-shaped water capsule and a special-shaped oil capsule was designed. This structure can provide an applied confining stress and freely transmit the stress wave generated by external impact. Therefore, the coupled loading of in situ stress and seismic waves induced by underground explosions in the deep rock mass was simulated. The positive pressure time and peak value of the stress wave could be adjusted by changing the pulse-shaper and the initial impact energy. The obtained stress waves in the experiments correspond to that generated by 0.15-120 kt of TNT equivalent explosion at a scaled distance of 89.9-207.44 m/kt. | Yuguo Ji Mingyang Wang Jie Li Shuxin Deng Zhihao Li Tianhan Xu Fei Gao | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 0 |
| 17 | Evaluation of China Healthy Lifestyle for All Interventions Based on RE-AIM Framework — China, 2007–2020显示文摘Summary What is already known about this topic?Since the launch of China Healthy Lifestyle for All(CHLA),each action area has been evaluated at the local level and effective results have been achieved in most areas.What is added by this report?Based on the Reach,Effectiveness,Adoption,Implementation,and Maintenance(RE-AIM)model,the study found that there is an imbalance in the development of CHLA,and some of the action goals and indicators are not satisfactory.What are the implications for public health practices?A national action evaluation index system should be built to ensure the sustainability and scientific nature of this strategy.In addition,the government needs to attach great importance to CHLA to effectively help residents take health actions. | Fugui Wu Lu Zhang Wenbo Guo Mingyang Wang Yang Gao Dan Liu Yamin Bai Yanfang Zhao Shengquan Mi Wenhua Zhao Zhuoqun Wang Man Li | 2022 | China CDC weekly2022，4，19： | 0 |
| 18 | Human thermal comfort under lateral radiant asymmetries显示文摘Occupants’thermal comfort in buildings may be affected by the cool wall and warm wall,which is attributed to the effect of asymmetric radiation.However,the previous majority of the researches on asymmetric radiation were mainly about the comfort limits under thermally neutral condition within 1∼1.5 h but had not considered the effect of exposure duration and the condition beyond neutral.To investigate the human thermal comfort under an asymmetric environment caused by the cool wall and warm wall,forty-four subjects were exposed to neutral air temperature with lateral radiant asymmetries in winter and summer for 3 h.The results indicated that the cool wall caused thermal discomfort easier than the warm wall because the thermal sensation decreased and deviated from neutral with time.Subjects’sensitivity of local parts to asymmetric radiation was affected in the conditions beyond neutral,thus their acceptability to asymmetric radiation decreased.The currently used limits of radiant temperature asymmetry tended to underestimate the local discomfort due to the walls.For the conditions tested,The limits of 5%dissatisfaction in radiant temperature asymmetry were 4.4°C(180 min)and 1.8°C(60 min and 120 min)for the warm wall,and 1.8°C at 60 min for the cool wall. | Siru Gao Liu Yang Mingyang Shi Shengkai Zhao Xiang Zhou Yongchao Zhai | 2023 | Energy and Built Environment2023，4，4： | 0 |
| 19 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 20 | Investigating the impact of air pollution on AMI and COPD hospital admissions in the coastal city of Qingdao,China显示文摘Air pollution has been widely associated with adverse effects on the respiratory and cardiovascular systems.We investigated the relationship between acute myocardial infarction(AMI),chronic obstructive pulmonary disease(COPD)and air pollution exposure in the coastal city of Qingdao,China.Air pollution in this region is characterized by inland and oceanic transportation sources in addition to local emission.We examined the influence of PM_(2.5),PM_(10),NO_(2),SO_(2),CO and O_(3) concentrations on hospital admissions for AMI and COPD from October 1,2014,to September 30,2018,in Qingdao using a Poisson generalized additive model(GAM).We found that PM_(2.5),PM_(10),NO_(2),SO_(2) and CO exhibited a significant short-term(lag 1 day)association with AMI in the singlepollutant model among older adults(>65 years old)and females,especially during the cold season(October to March).In contrast,only NO2 and SO2 had clear cumulative lag associations with COPD admission for females and those over 65 years old at lag 01 and lag 03,respectively.In the twopollutant model,the exposure-response relationship fitted by the two-pollutant model did not change significantly.Our findings indicated that there is an inflection point between the concentration of certain air pollutants and the hospital admissions of AMI and COPD even under the linear assumption,indicative of the benefits of reducing air pollution vary with pollution levels.This study has important implications for the development of policy for air pollution control in Qingdao and the public health benefits of reducing air pollution levels. | Jiuli Yang Mingyang Liu Qu Cheng Lingyue Yang Xiaohui Sun Haidong Kan Yang Liu Michelle LBell Rohini Dasan Huiwang Gao Xiaohong Yao Yang Gao | 2022 | Frontiers of Environmental Science & Engineering2022，16，5： | 0 |
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