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| 1 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017，14，11： | 6 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | MicroRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis 显示文摘 | Li CL Nie H Wang M | 2012 | Oncol Rep2012，27，6： | 1 |
| 4 | Locally administered adipose- derived stem cells accelerate wound healing through different- tiation and vasculogenesis 显示文摘 | Nie CL Yang DP Xu J | 2011 | Cell Transplant2011，20，： | 1 |
| 5 | K30, H150, and H168 are essential residues for coordinating pyridoxal 5'-Phosphate of O-acetylserine sulfhydrylase from Acidithiobacillus ferrooxidans显示文摘 | Zheng CL Nie L Qian L | 2010 | Curr Microbiol2010，60，： | 1 |
| 6 | Musca domestica larva lectin induces apoptosis in BEL-7402 cells through a Ca2+/JNK- mediated mitochondrial pathway显示文摘 | Wang CL Xia Y Nie Z | 2012 | Cell Biochem Biophys2012，22，4： | 1 |
| 7 | Changes in conformation of human neuronal tau during denaturation in formaldehyde solution 显示文摘 | Nie CL Zhang W Zhang D | 2005 | Protein Pept Lett2005，12，1： | 1 |
| 8 | MicroRNA-155 is downregulated in gastric cancer ceils and involved in cell metastasis显示文摘 | Li CL Nie H Wang M | 2012 | Oncol Rep2012，27，： | 1 |
| 9 | Formaldehyde at low concentration induces protein tau into globular amyloid- like aggregates in vitro and in vivo显示文摘 | Nie CL Wei Y Chen X | 2007 | PLoS One2007，2，7： | 1 |
| 10 | Metabonomic studies of human hepatocellular carcinoma using high-resolution magicangle spinning ^1H NMR spectroscopy in conjunction with multivariate data analysis显示文摘 | Yang YX Li CL Nie X | 2007 | J Proteome Res2007，6，7： | 1 |
| 11 | Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells显示文摘 | Nie CL Wang XS Liu Y | 2007 | BMC Neurosci2007，9，： | 1 |
| 12 | Formaldehyde at low concentra- tion induces protein tau into globular amyloid like aggregates in vitro and in vivo显示文摘 | Nie CL Wei Y Chen X | 2007 | Plos One2007，2，7： | 1 |
| 13 | Inhibitory effect of antisense oligonu-cleotide targeting TIMP-2 on immune-induced liver fibrosis显示文摘 | Nie QH Zhu CL Zhang YF | 2010 | DigDis Sci2010，55，5： | 1 |
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