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| 1 | Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease显示文摘Alzheimer's disease(AD) is characterized by the accumulation and deposition of amyloid-beta(Aβ) peptides in the brain. Neuroinflammation occurs in the AD brain and plays a critical role in the neurodegenerative pathology. Particularly, Aβ evokes an inflammatory response that leads to synaptic dysfunction, neuronal death, and neurodegeneration. Apolipoprotein E(ApoE) proteins are involved in cholesterol transport, Aβ binding and clearance, and synaptic functions in the brain. The ApoE4 isoform is a key risk factor for AD, while the ApoE2 isoform has a neuroprotective effect. However, studies have reached different conclusions about the roles of the isoforms; some show that both ApoE3 and ApoE4 have anti-infl ammatory effects, while others show that ApoE4 causes a predisposition to inflammation or promotes an inflammatory response following lipopolysaccharide treatment. These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. Further, little was known about the role of ApoE isoforms in the Aβ-induced inflammatory response and in the neuroinflammation of AD. Our recent work showed that ApoE isoforms differentially regulate and modify the Aβ-induced infl ammatory response in neural cells, with ApoE2 suppressing and ApoE4 promoting the response. In this article, we review the roles, mechanisms, and interrelations among Aβ, ApoE, and neuroinfl ammation in AD. | Evan Dorey Nina Chang Qing Yan Liu Ze Yang Wandong Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 9 |
| 2 | Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection显示文摘Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity,promoting the development of LRRK2 kinase inhibitors as therapeutics.Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise.However,nearly all inhibitors are ATP competitive—some with unwanted side effects and unclear clinical outcome—alternative types of LRRK2 inhibitors are lacking.Herein we identify 5′-deoxyadenosylcobalamin(AdoCbl),a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity.Multiple assays show that AdoCbl directly binds LRRK2,leading to the alterations of protein conformation and ATP binding in LRRK2.STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain.Furthermore,we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization.Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue,and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C.elegans and D.melanogaster expressing LRRK2 disease variants.Finally,AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models.Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism,which can be harnessed to develop new LRRK2-based PD therapeutics in the future. | Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue | 2019 | Cell Research2019，29，4： | 7 |
| 3 | Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction显示文摘The individual difference and non-repeatability in acupuncture have not only restricted the development of acupuncture,but have also affected the specificity of acupoints.The present study used instruments to control needle depth,lifting and thrusting frequency,and the duration of acupuncture.Effects of the quantified acupuncture were observed at Neiguan(PC6)with different stimulation parameters.A frequency of 1,2,or 3 Hz and duration of 5,60,or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery.Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume.Interactions between frequency and duration play a critical role in quantified acupuncture therapy. | Yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding Luo Xuemin Shi | 2013 | Neural Regeneration Research2013，8，28： | 7 |
| 4 | Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis显示文摘The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions.Here,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells.Because of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell volume.The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering. | Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu | 2022 | Advanced Photonics2022，4，1： | 5 |
| 5 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 6 | Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity显示文摘Memory CD8 T cells can provide long-term protection against tumors,which depends on their enhanced proliferative capacity,self-renewal and unique metabolic rewiring to sustain cellular fitness.Specifically,memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill their metabolic demands.In contrast,tumor-infiltrating lymphocytes(TILs)display severe metabolic defects,which may underlie their functional decline.Here,we show that overexpression of proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),the master regulator of mitochondrial biogenesis(MB),favors CD8 T cell central memory formation rather than resident memory generation.PGC-1α-overexpressing CD8 T cells persist and mediate more robust recall responses to bacterial infection or peptide vaccination.Importantly,CD8 T cells with enhanced PGC-1αexpression provide stronger antitumor immunity in a mouse melanoma model.Moreover,TILs overexpressing PGC-1αmaintain higher mitochondrial activity and improved expansion when rechallenged in a tumor-free host.Altogether,our findings indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation,metabolic fitness,and antitumor immunity in vivo. | Nina Dumauthioz Benjamin Tschumi Mathias Wenes Bastien Marti Haiping Wang Fabien Franco Wenhui Li Isabel CLopez-Mejia Lluis Fajas Ping-Chih Ho Alena Donda Pedro Romero Lianjun Zhang | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 7 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 8 | Weekly nab-Paclitaxel in Combination With Carboplatin Versus Solvent-Based Paclitaxel Plus Carboplatin as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer: Final Results of a Phase III Trial显示文摘 | Mark A. Socinski Igor Bondarenko Nina A. Karaseva Anatoly M. Makhson Igor Vynnychenko Isamu Okamoto Jeremy K. Hon Vera Hirsh Paul Bhar Hui Zhang Jose L. Iglesias Markus F. Renschler | 2012 | Journal of Clinical Oncology2012，，17： | 3 |
| 9 | Effects of short photoperiod on energy intake,thermogenesis,and reproduction in desert hamsters(Phodopus roborovskii)显示文摘Desert hamsters(Phodopus roborovskii)are the least known species in the genus Phodopus with respect to ecology and physiology,and deserve scientific attention,particularly because of their small body size.Here,the responses of energy metabolism and reproductive function to short photoperiods in desert hamsters were investigated.Male and female desert hamsters were acclimated to either long day(LD)(L:D 16:8 h)or short day(SD)photoperiods(L:D 8:16 h)for three months,and then the females were transferred back to an LD photoperiod for a further five months,while at the end of the SD acclimation the males were killed and measurements were taken for serum leptin as well as molecular markers for thermogenesis.We found that like the other two species from the genus Phodopus,the desert hamsters under SD decreased body mass,increased adaptive thermogenesis as indicated by elevated mitochondrial protein content and uncoupling protein-1 content in brown adipose tissue,and suppressed reproduction compared to those under LD.However,different from the other two species,desert hamsters did not show any differences in energy intake or serum leptin concentration between LD and SD.These data suggest that different species from the same genus respond in different ways to the environmental signals,and the desert adapted species are not as sensitive to change in photoperiod as the other two species. | Xueying ZHANG Zhijun ZHAO Nina VASILIEVA Anastasia KHRUSHCHOVA Dehua WANG | 2015 | Integrative Zoology2015，10，2： | 2 |
| 10 | Bistable Stochastic Resonance Enhanced 4-ary PAM Signal Detection under Low SNR显示文摘To boost the performance of 4-ary pulse amplitude modulated(PAM) at low signal-to-noise ratio(SNR), bistable stochastic resonance(BSR) system is introduced into digital communications system and get a reliable signal detection scheme. In this paper, we first analyse BSR system for different amplitudes of 4-ary PAM signals. The steadystate of the bistable system will be statistically distinct, and the feasibility of the proposed detection scheme is confirmed. On this basis, we present a detailed study on steady-state transitions of the BSR system, and an explicit expression of the bistable system parameters is derived. By setting the bistable system parameters, bistable system, 4-ary PAM signal, and noise reach the resonance state, and the BSR-based detection scheme is implemented. Moreover, we derive an analytical expression to calculate the symbol error rate(SER) of 4-ary PAM signals with the BSR-based detection under additive white Gaussian noise(AWGN). Finally, the simulation results validate that BSR-based detection scheme can improve the detection performance while efficiently reducing the symbol error rate. | Linlin Liang Nina Zhang Haiyan Huang Zan Li | 2019 | China Communications2019，16，4： | 2 |
| 11 | Prognostic value of ^(18)F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation显示文摘Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography(PET)/computed tomography(CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18 FFDG PET/CT pre-and post-HSCT in predicting outcomes of patients with DLBCL.Methods: DLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18 F-FDG PET/CT in auto-HSCT was evaluated.Results: Eighty-four patients were enrolled. In univariate analysis, pre-and post-HSCT PET findings were correlated with 3-year progression-free survival(PFS) [hazard ratio(HR)=4.391, P=0.001; HR=7.607, P<0.001] and overall survival(OS)(HR=4.792, P=0.008; HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after firstline treatment had better outcomes than relapsed/refractory DLBCL patients(3-year PFS, P<0.001; 3-year OS,P<0.001). In the relapsed/refractory patients, pre-and post-HSCT PET findings were also associated with 3-year PFS(P=0.003 vs. P<0.001) and OS(P=0.027 vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort(3-year PFS, P<0.001;3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET(3-year PFS, P=0.084; 3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis(HR=5.168, P<0.001).Conclusions: PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT. | Zhitao Ying Lan Mi Nina Zhou Xuejuan Wang Zhi Yang Yuqin Song Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu Lijuan Deng Jun Zhu | 2019 | Chinese Journal of Cancer Research2019，31，1： | 2 |
| 12 | Conspicuous cruciform silk decorations deflect avian predator attacks显示文摘Although camouflage as an effective antipredator defense strategy is widespread across animals,highly conspicuous color patterning is not uncommon either.Many orb-web spiders adorn their webs with extra bright white silk.These conspicuous decorations are hypothesized to deter predators by warning the presence of sticky webs,camouflaging spiders,acting as a decoy,or intimidating predators by their apparent size.The decorations may also deflect predator attacks from spiders.However,empirical evidence for this deflection function remains limited.Here,we tested this hypothesis using the X-shaped silk cruciform decorations built by females of Argiope minuta.We employed visual modeling to quantify the conspicuousness of spiders and decorations from a perspective of avian predators.Then,we determined actual predation risk on spiders using naïve chicks as predators.Spider bodies and decorations were conspicuous against natural backgrounds to the avian visual systems.Chicks attacked the spider main bodies significantly less frequently on the decorated webs than on the undecorated webs,thus reducing predation risk.When both spiders and decorations were present,chicks also attacked the spider main bodies and their legs or decorations,and not randomly:they attacked the legs or decorations sooner and more frequently than they attacked the main bodies,independent of the ratio of the surface area between the decoration and spider size.Despite the increase in detectability,incorporating a conspicuous cruciform decoration to the web effectively defends the spider by diverting the attack toward the decoration or leg,but not by camouflaging or intimidating,thus,supporting the deflection hypothesis. | Bingjun WANG Long YU Nina MA Zengtao ZHANG Deyong GONG Rui LIU Daiqin LI Shichang ZHANG | 2022 | Integrative Zoology2022，17，5： | 1 |
| 13 | Aldosterone Receptor Antagonism Induces Reverse Remodeling When Added to Angiotensin Receptor Blockade in Chronic Heart Failure显示文摘 | Anna K.Y. Chan John E. Sanderson Tian Wang Wynnie Lam Gabriel Yip Mei Wang Yat-Yin Lam Yan Zhang Leata Yeung Eugene B. Wu Wilson W.M. Chan John T.H. Wong Nina So Cheuk-Man Yu | 2007 | Journal of the American College of Cardiology2007，，7： | 1 |
| 14 | Su- pramoleeular sensor for eaneer associated nitrosamines 显示文摘 | Tsuyoshi Minami Nina A Esipenko Ben Zhang | 2012 | J Am Chem Soc2012，134，20： | 1 |
| 15 | Adenocarcinomas of the esophagus and gastric cardia: The role of diet显示文摘 | Zuo-Feng Zhang Robert C. Kurtz Guo-Pei Yu Ming Sun Nina Gargon Martin Karpeh Jeffrey S. Fein Susan Harlap | 1997 | Nutrition and Cancer1997，，3： | 1 |
| 16 | First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province,Northeastern China显示文摘Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS),caused by SFTS virus(SFTSV)in the genus Banyangvirus of the family Phenuiviridae,is an emerging tick-borne viral zoonosis(Liu et al.2014).Typical clinical symptoms of SFTS include fever,headache,thrombocytopenia,and leukocytopenia(Yu et al.2011).Since SFTSV was identified in 2009,it has been found in more than 20 provinces in China and is closely related to strains from Japan and South Korea(Kim et al.2013;Takahashi et al.2014). | Xu Zhang Nina Wang Zedong Wang Lihe Che Chen Chen Wen-Zhong Zhao Quan Liu | 2021 | Virologica Sinica2021，36，2： | 1 |
| 17 | Design of the Airbag Inflation System Applicable to Conventional and Autonomous Vehicles显示文摘The emergency transformation of various aspects of life and business these days requires prompt evaluation of autonomous vehicles.One of the primary reassessments deals with the applicability of the vehicle passive safety system to the protec-tion of arbitrarily positioned passengers.To mitigate possible risks caused by the simultaneous deployment of several big airbags,a new principle of their operation is required.Herein,the aspirated inflator for a driver airbag is developed that can provide 50L-airbag inflation within 30-40 ms.As a result,about 3/4 of the air is to be entrained into an airbag from the vehicle compartment.The process is initiated by a supersonic pulse jet(1/3 air volume)generated pyrotechnically.Then the Prandtl-Meyer problem formulation enables guiding linear and angular dimensions of the essential parts of the device.Accordingly,a family of experimental models of varied geometry is fabricated and tested to determine their operational effectiveness in a range of motive pressure within~3-7 MPa.Experiments are performed on a specially designed facility equipped with compressed-air tanks and a high-speed valve to mimic the inflator operation with the pyrotechnic gas generator.The aspirated inflator operability is characterized using multivariate measurements of pressure fields,high-speed video-recording of the airbag inflation process,and evaluation of aspiration(entrainment)ratio.The average volume aspiration ratio measured at 300 K is found to reach 2.8 and it’s expected to almost double at 1200 K. | Nina F.Yurchenko David S.Breed Shaowei Zhang | 2021 | Automotive Innovation2021，4，4： | 1 |
| 18 | Argument interpretations in the ditran-sitive construction显示文摘 | ZHANG NINA N | 1998 | Nordic Journal of Linguistics1998，，21： | 1 |
| 19 | Predicting Control of Primary Tumor and Survival by DCE MRI During Early Therapy in Cervical Cancer显示文摘 | William T. C. Yuh Nina A. Mayr David Jarjoura Dee Wu John C. Grecula Simon S. Lo Susan M. Edwards Vincent A. Magnotta Steffen Sammet Hualin Zhang Joseph F. Montebello Jeffrey Fowler Michael V. Knopp Jian Z. Wang | 2009 | Investigative Radiology2009，，6： | 1 |
| 20 | Longitudinal Changes in Tumor Perfusion Pattern during the Radiation Therapy Course and its Clinical Impact in Cervical Cancer显示文摘 | Nina A. Mayr Jian Z. Wang Dongqing Zhang John C. Grecula Simon S. Lo David Jaroura Joseph Montebello Hualin Zhang Kaile Li Lanchun Lu Zhibin Huang Jeffery M. Fowler Dee H. Wu Michael V. Knopp William T.C. Yuh | 2010 | International Journal of Radiation Oncology, Biology, Physics2010，，： | 1 |
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