|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A system dynamics approach for water resources policy analysis in arid land:a model for Manas River Basin显示文摘The Manas River Basin in Xinjiang Uygur autonomous region,similar to other arid regions,is facing water constraints which challenge decision-makers as to how to rationally allocate the available water resources to meet the demands from industries and natural ecosystems.Policies which integrate the supply and demand are needed to address the water stress issues.An object-oriented system dynamics model was developed to capture the interrelationships between water availability and increasing water demands from the growth of industries,agricultural production and the population through modeling the decision-making process of the water exploration explicitly,in which water stress is used as a major indicator.The model is composed of four sectors:1) natural surface and groundwater resources;2) water demand;3) the water exploitation process,including the decision to build reservoirs,canals and pumps;4) water stress to which political and social systems respond through increasing the supply,limiting the growth or improving the water use efficiency.The model was calibrated using data from 1949 to 2009 for population growth,irrigated land area,industry output,perceived water stress,groundwater resources availability and the drying-out process of Manas River;and simulations were carried out from 2010 to 2050 on an annual time step.The comparison of results from calibration and observation showed that the model corresponds to observed behavior,and the simulated values fit the observed data and trends accurately.Sensitivity analysis showed that the model is robust to changes in model parameters related to population growth,land reclamation,pumping capacity and capital contribution to industry development capacity.Six scenarios were designed to investigate the effectiveness of policy options in the area of reservoir relocation,urban water recycling,water demand control and groundwater pumping control.The simulation runs demonstrated that the technical solutions for improving water availability and water use efficiency are not sustainable.Acknowledging the carrying capacity of water resources and eliminating a growth-orientated value system are crucial for the sustainability of the Manas River Basin. | ShanShan DAI LanHai LI HongGang XU XiangLiang PAN XueMei LI | 2013 | Journal of Arid Land2013，5，1： | 14 |
| 2 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 3 | Macrobenthic Community in the Xiaoqing River Estuary in Laizhou Bay,China显示文摘The macrobenthic community of the Xiaoqing River Estuary and the adjacent sea waters was investigated in May and November 2008,August 2009,and May and September 2010,respectively.A total of 95 species of macrobenthos were identified in the five cruises and most of them were polychaetes(46.39%),mollusks(28.86%) and crustaceans(20.62%).The Shannon-Wiener index of macrobenthos was lower than 2 in 67% sites.Along the stream channel,estuary and the coastal waters,the species of polychaetes reduced gradually,while the abundance increased at first and then decreased.The abundance was the biggest at regions with salinity of 5 20 in the estuary.The species and abundance of mollusks and crustaceans increased gradually.As for seasonal distribution,the species,abundance and biomass were higher in spring and lower in summer and autumn.Contemporaneously compared with Laizhou Bay and Yellow River Estuary,the species of macrobenthos appeared in the Xiaoqing River Estuary were much less,while the percentage of polychaetes was higher.Abundance and biomass were higher in Xiaoqing River estuary,then consequently followed by Laizhou Bay and Yellow River Estuary.The dominant species in Xiaoqing River Estuary was polychaete,and Layzhou Bay mollusk.The community structure characteristics of macrobenthos in the Xiaoqing River Estuary revealed a significant pollution status in this region. | LUO Xianxiang ZHANG Shanshan YANG Jianqiang PAN Jinfen TIAN Lin ZHANG Longjun | 2013 | Journal of Ocean University of China2013，12，3： | 11 |
| 4 | Exposure to polycyclic aromatic hydrocarbons and risk for premature ovarian failure and reproductive hormones imbalance显示文摘Polycyclic aromatic hydrocarbons(PAHs)are a typical class of persistent organic pollutants that is ubiquitous worldwide.Previous animal studies suggested that PAHs had adverse effects on female reproduction.However,the human data regarding relationship of PAHs exposure with women reproductive health,such as ovarian dysfunction,are scarce.In this case-control study,the associations of serum levels of PAHs with the risk of premature ovarian failure(POF)and reproductive hormones in Chinese women were investigated,with recruiting 157 POF patients and 217 healthy women.The serum levels of 12 types of PAHs,as well as reproductive hormones,including follicle-stimulating hormone,luteinizing hormone and anti-mullerian hormone,were determined.In the logistic regression models,most individual PAH congeners showed significantly positive correlations with the risk of POF(p<0.05),except for fluorine and pyrene.Benzo(a)pyrene(BaP),as the most carcinogenic PAH congener,was observed to be significantly positively associated with the risk of POF.After adjustment for age,body mass index,educational levels and household income,per one-unit increase in the log-transformed BaP concentration was significantly correlated with 2.191-fold increased risk of POF(OR=2.191,95%CI:1.634-2.938,p<0.05).To the best of our knowledge,this is the first study to report an association between internal exposure levels of PAHs and the increased risk of POF in women. | Xiaoqing Ye Wuye Pan Chunming Li Xiaochen Ma Shanshan Yin Jianhong Zhou Jing Liu | 2020 | Journal of Environmental Sciences2020，32，5： | 10 |
| 5 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 6 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 7 | Deep-learning-based ciphertext-only attack on optical double random phase encryption显示文摘Optical cryptanalysis is essential to the further investigation of more secure optical cryptosystems.Learning-based at-tack of optical encryption eliminates the need for the retrieval of random phase keys of optical encryption systems but it is limited for practical applications since it requires a large set of plaintext-ciphertext pairs for the cryptosystem to be at-tacked.Here,we propose a two-step deep learning strategy for ciphertext-only attack(COA)on the classical double ran-dom phase encryption(DRPE).Specifically,we construct a virtual DRPE system to gather the training data.Besides,we divide the inverse problem in COA into two more specific inverse problems and employ two deep neural networks(DNNs)to respectively learn the removal of speckle noise in the autocorrelation domain and the de-correlation operation to retrieve the plaintext image.With these two trained DNNs at hand,we show that the plaintext can be predicted in real-time from an unknown ciphertext alone.The proposed learning-based COA method dispenses with not only the retrieval of random phase keys but also the invasive data acquisition of plaintext-ciphertext pairs in the DPRE system.Numerical simulations and optical experiments demonstrate the feasibility and effectiveness of the proposed learning-based COA method. | Meihua Liao Shanshan Zheng Shuixin Pan Dajiang Lu Wenqi He Guohai Situ Xiang Peng | 2021 | Opto-Electronic Advances2021，4，5： | 7 |
| 8 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 9 | Magnetic performance and corrosion resistance of electroless plating CoWP film显示文摘The CoWP film with good magnetic performance and corrosion resistance was electrolessly plated from alkaline solution. The technical parameters of the electroless plating system were optimized. When the pH value of electroless plating solution was 11.0 and the reducing agent (NaH2PO2) content was 0.4 mol L 1, the target chemical reactions proceeded in the electroless plating solution smoothly with negligible interference and side effects. CoWP film prepared under optimal deposition condition contained more hexagonal close-packed (hcp) cobalt (ε-Co) of [110] and crystallographic orientation of Co [002]. VSM analysis reveals that the saturation magnetization of the CoWP film is 100~220 Am2 kg 1 and coercivity is (2.87~4.38)×104 A·cm 1. The corrosion behavior of CoWP film in 3.5% NaCl aqueous solution was studied by electrochemical experiments. The results prove that the corrosion resistance of the CoWP film deposited under the optimal depo-sition condition exhibites relatively lower corrosion current of (3.054~3.162)×10 6 A·cm 2. The surface morphology analysis indicates that the film is smooth and composed of regular-shaped crystallites. | Jiang, Li Pan, Shanshan Lu, Jianbiao Ke, Xin He, Wenhao Yu, Yundan Wei, Guoying Ge, Hongliang | 2012 | Rare Metals2012，31，3： | 6 |
| 10 | Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects显示文摘Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor,but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site.In this work,we report a rational integration of photonic-responsive two-dimensional(2D)ultrathin niobium carbide(Nb2C)MXene nanosheets(NSs)into the 3D-printed bone-mimetic scaffolds(NBGS)for osteosarcoma treatment.The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared(NIR-II)biowindow with high tissue-penetrating depth,making it highly efficient in killing bone cancer cells.Importantly,Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site,which can transport more oxygen,vitamins and energy around the bone defect for the reparative process,and gather more immune cells around the defect site to accelerate the degradation of NBGS.The degradation of NBGS provides sufficient space for the bone remodeling.Besides,calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue.The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXeneintegrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor. | Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen | 2021 | Nano-Micro Letters2021，13，2： | 5 |
| 11 | Analysis of the binding sites with NL-101 to amino acids and peptides by HPLC/MS/MS显示文摘The binding between NL-101, a novel nitrogen mustard anti-cancer drug, with amino acids and peptides has been investigated by high performance liquid chromatography electrospray tandem mass spectrometry(HPLC/ESI-MS/MS). This study offers supporting data of the interaction among drug and amino acids and peptides, which could potentially explain the cytotoxic and mutagenic effects of the drug. Collision-induced dissociation(CID) experiment demonstrated that under the same collision energy, the amino group combined with NL-101 adducts are sensitive and often produce more fragment ions; the carboxyl group combined with NL-101 adducts are hard to break and display fewer fragment ions. In addition, when other group(like sulfhydryl group) of amino acids binds to NL-101, CID spectra show different fragmentation pattern. These differences could display structural information about the drug adducts and be utilized as location of the authentic binding sites. | Lingzi Dai Nian Guo Yaqin Liu Shanshan Shen Qiufu Ge Yuanjiang Pan | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 12 | 3D-printed controllable gradient pore superwetting structures for high temperature efficient oil-water separation显示文摘Superwetting surfaces have the potential to address oil pollution in water,through their ability to separate the two.However,it remains a great challenge to fabricate stable and efficient separation structures using conventional manufacturing techniques.Furthermore,the materials traditionally used for oil-water separation are not stable at high temperature.Therefore,there is a need to develop stable,customizable structures to improve the performance of oil-water separation devices.In recent years,3D printing technology has developed rapidly,and breakthroughs have been made in the fabrication of complicated ceramic structures using this technology.Here,a ceramic material with a gradient pore structure and superhydrophobic/superoleophilic properties was prepared using 3D printing for high-efficiency oil-water separation.The gradient pore structure developed here can support a flux of up to 25434 L/m^(2)h,which is nearly 40%higher than that an analogous structure with straight pores.At 200℃,the oil-water separation performance was maintained at 97.4%.Furthermore,samples of the material exhibited outstanding mechanical properties,and chemical stability in a variety of harsh environments.This study provides an efficient,simple,and reliable method for manufacturing oil-water separation materials using 3D printing,and may have broader implications for both fundamental research and industrial applications. | Zhipeng Jin Hui Mei Yuekai Yan Longkai Pan Hongxia Liu Shanshan Xiao Laifei Cheng | 2021 | Journal of Materiomics2021，7，1： | 4 |
| 13 | Grain size characteristics of surface sediment and its response to the dynamic sedimentary environment in Qiantang Estuary, China显示文摘The composition and grain size characteristics of sediment in estuarine and coastal environments provide important information on the material source, hydrodynamic environment, environmental events,etc. However, few studies have focused on the sediment characteristics of the entire Qiantang Estuary,particularly, on the correlation between hydrodynamics and sediment properties. Through systematic sampling of the surface sediment in a large area of the Qiantang Estuary, the spatial distribution characteristics of the surface sediment of the Qiantang Estuary, such as the grain size composition and particle size parameters, in different sections of the estuary area are analyzed. By comparing the particle size data of different estuaries, the similarities and differences of the particle size parameters of the Qiantang Estuary and other estuaries are compared and analyzed. According to the differences in the sediment composition, the distribution status of the particle size frequency curves and the morphological characteristics of the probability curves in the entire study area, the Qiantang Estuary is divided into 7 dynamic depositional areas: Fuchunjiang Hydropower Station-Fuyang, Fuyang-Qibao, Qibao-Cao’e River, Cao’e River-Zhapu, North Shore of Hangzhou Bay, middle part of Hangzhou Bay, and South Shore of Hangzhou Bay, which are different from the previous estuary segmentation system. The study area is divided into 13 dynamic depositional sub-regions using the Pejrup M triangle diagram. Combining the calculation results of the mathematical model and the Pejrup M triangle diagram, the relation between the dynamic deposition environment and the bottom shear stress is discussed. It is found that the spatial distribution of the bottom shear stress in the study area is in good agreement with the zoning of the dynamic sedimentary environment. | Shanshan Wang Cunhong Pan Dongfeng Xie Mingwei Xu Yuhan Yan Xinwen Li | 2022 | International Journal of Sediment Research2022，37，4： | 3 |
| 14 | Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases显示文摘The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound. | Haowen Xu Jiahao Chen Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 2 |
| 15 | Modeling of nanoparticle-induced Rayleigh-Gans scattering for nanofiber optical sensing 显示文摘 | Shanshan Wang Xinyun Pan Limin Tong | 2007 | Opt Commun2007，276，2： | 1 |
| 16 | Changes in extreme events of temperature and precipitation over Xinjiang, northwest China, during 1960–2009显示文摘 | Baolong Wang Mingjun Zhang Junlin Wei Shengjie Wang Shanshan Li Qian Ma Xiaofei Li Shukun Pan | 2012 | Quaternary International2012，，： | 1 |
| 17 | Transforming growth factor β3 attenuates the development of radiation-induced pulmonary fibrosis in mice by decreasing fibrocyte recruitment and regulating IFN-γ/IL-4 balance显示文摘 | Long Xu Shanshan Xiong Renfeng Guo Zhihua Yang Qianjun Wang Fengjun Xiao Haibao Wang Xiujie Pan Maoxiang Zhu | 2014 | Immunology Letters2014，，1： | 1 |
| 18 | Lnc-RP5 Regulates the mi R-129-5p/Notch1/PFV Internal Promoter Axis to Promote the Expression of the Prototype Foamy Virus Transactivator Tas显示文摘Prototype foamy virus(PFV)is a unique retrovirus that infects animals and humans and does not cause clinical symptoms.Long noncoding RNAs(lncRNAs)are believed to exert multiple regulatory functions during viral infections.Previously,we utilized RNA sequencing(RNA-seq)to characterize and identify the lncRNA lnc-RP5-1086 D14.3.1-1:1(lnc-RP5),which is markedly decreased in PFV-infected cells.However,little is known about the function of lnc-RP5 during PFV infection.In this study,we identified lnc-RP5 as a regulator of the PFV transcriptional transactivator(Tas).Lnc-RP5 enhanced the activity of the PFV internal promoter(IP).The expression of PFV Tas was found to be promoted by lnc-RP5.Moreover,mi R-129-5 p was found to be involved in the lnc-RP5-mediated promotion of PFV IP activity,while the Notch1 protein suppressed the activity of PFV IP and the expression of Tas.Our results demonstrate that lnc-RP5 promotes the expression of PFV Tas through the miR-129-5 p/Notch1/PFV IP axis.This work provides evidence that host lnc RNAs can manipulate PFV replication by employing mi RNAs and proteins during an early viral infection. | Shanshan Xu Liujun Chen Yinglian Tang Peipei Yuan Jun Yan Yingcheng Zheng Li Huang Zhi Li Yan Sun Song Han Jun Yin Qin Pan Biwen Peng Xiaohua He Wanhong Liu | 2020 | Virologica Sinica2020，35，1： | 1 |
| 19 | High electron mobility fluorinated indacenodithiophene small molecule acceptors for organic solar cells显示文摘Indacenodithiophene(IDT)derivatives are kinds of the most representative and widely used cores of small molecule acceptors(SMAs)in organic solar cells(OSCs).Here we systematically investigate the influence of end-group fluo rination density and position on the photovoltaic properties of the IDT-based SMAs IDIC-nF(n=0,2,4).The absorption edge of IDIC-nF red-shifts with theπ-πstacking and crystallinity improvement,and their electronic energy levels downshift with increasing n.Due to the advantages of J_(sc)and FF as well as acceptable V_(oc),the difluorinated IDIC-2 F acceptor based OSCs achieve the highest power conversion efficiency(PCE)of 13%,better than the OSC devices based on IDIC and IDIC-4 F as acceptors.And the photovoltaic performance of the PTQ10:IDIC-2 F OSCs is insensitive to the active layer thickness:PCE still keep high values of 12.00%and 11.46%for the devices with active layer thickness of 80 and 354 nm,respectively.This work verifies that fine and delicate modulation of the SMAs molecular structure could optimize photovoltaic performance of the corresponding OSCs.Meanwhile,the thickness-insensitivity property of the OSCs has potential for large-scale and printable fabrication technology. | Fei Pan Xiaojun Li Song Bai Tianhao Liu Xian Wei Yingfen Li Shanshan Chen Changduk Yang Xiwen Chen Menglan Lv Yongfang Li | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 20 | Changes in extreme events of temperature and precipitation over Xinjiang, northwest China, during 1960–2009显示文摘 | Baolong Wang Mingjun Zhang Junlin Wei Shengjie Wang Shanshan Li Qian Ma Xiaofei Li Shukun Pan | 2012 | Quaternary International2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员