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| 1 | Elevation of tumor necrosis factor-α,interleukin-1β and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes显示文摘有调停毒素的胰腺的损坏的背景大动物模型关于糖尿病 mellitus 和心血管的糖尿病的复杂并发症在研究广泛地被使用了。试图证实有 streptozotocin ( STZ )的中国贵州 minipig 模型导致了糖尿病并且描绘动物的现在的学习由在大动脉的墙中分析煽动性的 cytokine 层次当模特儿,例如肿瘤坏死因素( TNF ), interleukin-1 ( IL-1 )和 interleukin-6 ( IL-6 ) .Methods 22 男中国贵州 minipigs (变老, 4~6 个月;重量, 20 kg 到 30 kg ) 被划分成导致 STZ 的糖尿病的组(n=12 ) 和控制组(n=10 ) 。STZ (125 mg/kg ) 被管理导致多糖症,以后,胰岛素被用来在 10 mmol/L 下面控制 fasting 血葡萄糖层次。口头的葡萄糖忍耐测试(OGTT ) 以前被执行并且在 STZ 管理和丙氨酸 transaminase,天门冬素 transaminase,白朊,血脲氮, creatinine,类脂化合物和白色的浆液集中以后的一个月血房间计数以前并且六个月以后被测量。在六个月和胰为小岛房间 immunohistochemically 被检验以后,在两个组的动物是 euthanized。糖尿病的 minipigs 和控制的大动脉的 intima 在由西方的污点中等的调节的组织为 TNF- 水平被分析。在大动脉的 intima 的 TNF- , IL-1 和 IL-6 mRNA 层次是由反向的抄写和聚合酶链反应(RT-PCR ).Results 的 assayed 在浆液葡萄糖层次的重要举起被观察在 STZ 正式就职(P0.001 ) 和显著地增加的 OGTT 价值以后的一个月和六个月被注意,与基线数据相比。正常的胰有许多不规则的大小的小岛和小岛房间的小簇,当在糖尿病的 minipigs 的胰小岛房间几乎消失了时。没有统计差别以前在生物化学的考试的浆液集中被通知并且在 STZ 以后的六个月感应。西方的污点证明在 aotic intima 的戏剧性地增加的TNF-水平调节了TNF-, IL-1 和 IL-6 的中等、重要的举起 mRNA 层次被现在的学习建立了的 RT-PCR.Conclusions 揭示有 导致STZ 的 diabetes.Inflammatory cytokines 的中国贵州 minipig 模型(TNF-, IL-1 和 IL-6 )显著地在糖尿病的 minipigs 的大动脉的 intima 提高了。 | LU Lin ZHANG Qi PU Li-jin XU Xue-wei ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zheng-kun LU An-kang DING Feng-hua SHEN Jie CHEN Qiu-jin LOU Sheng FANG Dan-hong SHEN Wei-feng | 2007 | Chinese Medical Journal2007，，6： | 43 |
| 2 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 3 | Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats显示文摘瞄准:为了决定象到 streptozotocin (STZ ) 的阴茎的 growthfactor-1 (IGF-1 ) 一样的胰岛素的 adenoviral 基因转移是否导致了糖尿病的老鼠,能改进可勃起的能力。方法:STZ 糖尿病的老鼠是有 AdCMV-β g al 或 AdCMV-IGF-1 的 transfected。Theserats 经历了多孔的神经刺激估计可勃起的功能,他们的回答与匹配年龄的控制老鼠的那些相比在 transfection 以后的 1 ~ 2 天。在控制 andtransfected STZ 糖尿病的老鼠, IGF-1 表示被反向的抄写聚合酶链反应(RT-PCR ) 检验,西方的污点和组织学。STZ 糖尿病的老鼠的阴茎β - 牛乳糖活动和本地化也是坚定的。结果:一~二天 aftertransfection,β - 牛乳糖与 AdCMV-β g al 在糖尿病的老鼠 penistransfected 的光滑的肌肉房间被发现。到在 AdCMV-IGF-1 的管理以后的 2 天, cavernosalpressure 由最大的 intracavernous pressure-to-mean 的比率决定了动脉的压力(ICP/MAP ) 和全部的 intracavernous 压力(ICP ) ,响应多孔的神经刺激被增加。Transgene 表示被 RT-PCR,西方的污点和组织学证实。结论: IGF-1 的基因转移显著地在 STZ 糖尿病的老鼠增加了可勃起的功能。Theseresults 建议在 vivo, IGF-1 的基因转移可能在 STZ 糖尿病的老鼠是为可勃起的机能障碍(编辑) 的治疗的新治疗学的干预。 | Xiao-Yong Pu Li-Quan Hu Huai-Peng Wang Yao-Xiong Luo Xing-Huan Wang | 2007 | Asian Journal of Andrology2007，9，1： | 24 |
| 4 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 7 | Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein显示文摘Background:Abnormal aggregation of brainα-synuclein is a central step in the pathogenesis of Parkinson’s disease(PD),thus,it is reliable to promote the clearance ofα-synuclein to prevent and treat PD.Recent studies have revealed an essential role of glymphatic system and meningeal lymphatic vessels in the clearance of brain macromolecules,however,their pathophysiological aspects remain elusive.Method:Meningeal lymphatic drainage of 18-week-old A53T mice was blocked via ligating the deep cervical lymph nodes.Six weeks later,glymphatic functions and PD-like phenotypes were systemically analyzed.Results:Glymphatic influx of cerebrospinal fluid tracer was reduced in A53T mice,accompanied with perivascular aggregation ofα-synuclein and impaired polarization of aquaporin 4 expression in substantia nigra.Cervical lymphatic ligation aggravated glymphatic dysfunction of A53T mice,causing more severe accumulation ofα-synuclein,glial activation,inflammation,dopaminergic neuronal loss and motor deficits.Conclusion:The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology. | Wenyan Zou Tinglin Pu Weixi Feng Ming Lu Ying Zheng Renhong Du Ming Xiao Gang Hu | 2019 | Translational Neurodegeneration2019，8，1： | 17 |
| 8 | Intelligent control of mode-locked femtosecond pulses by time-stretch-assisted real-time spectral analysis显示文摘Mode-locked fiber lasers based on nonlinear polarization evolution can generate femtosecond pulses with different pulse widths and rich spectral distributions for versatile applications through polarization tuning.However,a precise and repeatable location of a specific pulsation regime is extremely challenging.Here,by using fast spectral analysis based on a time-stretched dispersion Fourier transform as the spectral discrimination criterion,along with an intelligent polarization search algorithm,for the first time,we achieved real-time control of the spectral width and shape of mode-locked femtosecond pulses;the spectral width can be tuned from 10 to 40 nm with a resolution of ~1.47 nm,and the spectral shape can be programmed to be hyperbolic secant or triangular.Furthermore,we reveal the complex,repeatable transition dynamics of the spectrum broadening of femtosecond pulses,including five middle phases,which provides deep insight into ultrashort pulse formation that cannot be observed with traditional mode-locked lasers. | Guoqing Pu Lilin Yi Li Zhang Chao Luo Zhaohui Li Weisheng Hu | 2020 | Light(Science & Applications)2020，9，1： | 16 |
| 9 | Diagnostic accuracy of transient elastography (Fibro Scan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis显示文摘AIM To investigate the diagnostic accuracy of Fibro Scan(FS) in detecting esophageal varices(EV) in cirrhotic patients.METHODS Through a systemic literature search of multiple databases, we reviewed 15 studies using endoscopy as a reference standard, with the data necessary to calculate pooled sensitivity(SEN) and specificity(SPE), positive and negative LR, diagnostic odds ratio(DOR) and area under receiver operating characteristics(AUROC). The quality of the studies was rated by the Quality Assessment of Diagnostic Accuracy studies-2 tool. Clinical utility of FS for EV was evaluated by a Fagan plot. Heterogeneity was explored using meta-regression and subgroup analysis. All statistical analyses were conducted via Stata12.0, MetaD isc1.4 and RevM an5.RESULTS In 15 studies(n = 2697), FS detected the presence of EV with the summary sensitivities of 84%(95%CI: 81.0%-86.0%), specificities of 62%(95%CI: 58.0%-66.0%), a positive LR of 2.3(95%CI: 1.81-2.94), a negative LR of 0.26(95%CI: 0.19-0.35), a DOR of 9.33(95%CI: 5.84-14.92) and an AUROC of 0.8262. FS diagnosed the presence of large EV with the pooled SEN of 0.78(95%CI: 75.0%-81.0%), SPE of 0.76(95%CI: 73.0%-78.0%), a positive and negative LR of 3.03(95%CI: 2.38-3.86) and 0.30(95%CI: 0.23-0.39) respectively, a summary diagnostic OR of 10.69(95%CI: 6.81-16.78), and an AUROC of 0.8321. A meta-regression and subgroup analysis indicated different etiology could serve as a potential source of heterogeneity in the diagnosis of the presence of EV group. A Deek's funnel plot suggested a low probability for publication bias.CONCLUSION Using FS to measure liver stiffness cannot provide high accuracy for the size of EV due to the various cutoff and different etiologies. These limitations preclude widespread use in clinical practice at this time; therefore, the results should be interpreted cautiously given its SEN and SPE. | Ke Pu Jing-Hong Shi Xu Wang Qian Tang Xin-Jie Wang Kai-Lin Tang Zhong-Qi Long Xing-Sheng Hu | 2017 | World Journal of Gastroenterology2017，23，2： | 12 |
| 10 | Inheritance and molecular characterization of resistance to AHAS- inhibiting herbicides in rapeseed显示文摘Rapeseed is a very important oil crop in China;however,its production is challenging due to the absence of effective weed management strategies.This is predominantly because of a shortage of herbicide resistance genes.Acetohydroxyacid synthase(AHAS) herbicides inhibit AHAS,a key enzyme involved in branched-chain amino acid synthesis that is required for plant growth.A rapeseed line designated M342 with AHAS herbicide resistance was developed through seed mutagenesis and was studied to assess the level and mode of inheritance of the resistance and to identify the molecular basis of resistance.M342 possessed a high level of cross-resistance to sulfonylureas(SUs) and imidazolinones(IMIs).This resistance was due to AHAS insensitivity to these herbicides and was inherited as a dominant trait conferred by a single nuclear-encoded gene.Molecular analysis revealed the presence of a Trp574 Leu mutation in M342,and an allele-specific cleaved amplified polymorphic sequence(AS-CAPS) marker was developed and cosegregated with herbicide resistance in the F2,BC1,and BC2 populations.This mutation altered the transcript levels of Bn AHAS1 and Bn AHAS3 in M342 compared with those in the wild type,but it did not affect the agronomic or quality traits.The simple genetic inheritance of this mutation and the availability of the cleaved amplified polymorphic sequence(CAPS) marker and herbicide resistance gene should facilitate the development of herbicide-resistant rapeseed cultivars for effective weed control in China. | HU Mao-long PU Hui-ming GAO Jian-qin LONG Wei-hua CHEN Feng ZHOU Xiao-ying ZHANG Wei PENG Qi CHEN Song ZHANG Jie-fu | 2017 | Journal of Integrative Agriculture2017，16，11： | 11 |
| 11 | miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN显示文摘Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through exosomes.Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting.Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. | LIU Meng Xin LIAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 12 | High power all-fiberized and narrow-bandwidth MOPA system by tandem pumping strategy for thermally induced mode instability suppression显示文摘An all-fiberized and narrow-bandwidth master oscillator power amplification(MOPA) system with record output power of 4 kW level and slope efficiency of 78% is demonstrated. Tandem pumping strategy is tentatively introduced into the narrow-bandwidth MOPA system for thermally induced mode instability(TMI) suppression. The stimulated Brillouin scattering(SBS) effect is balanced by simply using one-stage phase modulation technique. With different phase modulation signals, SBS limited output powers of 336 W, 1.2 kW and 3.94 kW are respectively achieved with spectral bandwidths accounting for 90% power of ~0.025, 0.17 and ~0.89 nm. Compared with our previous 976 nm pumping system, TMI threshold is overall boosted to be >5 times in which tandem pumping increases the TMI threshold of >3times. The beam quality(M~2 factor) of the output laser is well within 1.5 below the TMI threshold while it is ultimately saturated to be 1.86 with the influence of TMI at maximal output power. Except for SBS and TMI, stimulated Raman scattering(SRS) effect will be another challenge for further power scaling. In such a high power MOPA system, multidetrimental effects(SBS, SRS and TMI) will coexist and may be mutual-coupled, which could provide a well platform for further comprehensively investigating and optimizing the high power, narrow-bandwidth fiber amplifiers. | Pengfei Ma Hu Xiao Daren Meng Wei Liu Rumao Tao Jinyong Leng Yanxing Ma Rongtao Su Pu Zhou Zejin Liu | 2018 | High Power Laser Science and Engineering2018，6，4： | 9 |
| 13 | Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression显示文摘 | Kejie ZHANG Quan-yi LU Xiao-qing NIU Peng ZHANG Jiang-ning ZHAO Zhao WANG Jia-sheng HU Pu LI Wen-li LIU | 2009 | Acta Pharmacologica Sinica2009，30，2： | 9 |
| 14 | All-fiberized and narrow-linewidth 5 kW power-level fiber amplifier based on a bidirectional pumping configuration显示文摘In this paper,an all-fiberized and narrow-linewidth 5 kW power-level fiber amplifier is presented.The laser is achieved based on the master oscillator power amplification configuration,in which the phase-modulated single-frequency laser is applied as the seed laser and a bidirectional pumping configuration is applied in the power amplifier.The stimulated Brillouin scattering,stimulated Raman scattering,and transverse mode instability effects are all effectively suppressed in the experiment.Consequently,the output power is scaled up to 4.92 kW with a slope efficiency of as high as approximately 80%.The 3-dB spectral width is about 0.59 nm,and the beam quality is measured to be M^(2)~1.22 at maximum output power.Furthermore,we have also conducted a detailed spectral analysis on the spectral width of the signal laser,which reveals that the spectral wing broadening phenomenon could lead to the obvious decrease of the spectral purity at certain output power.Overall,this work could provide a reference for obtaining and optimizing high-power narrow-linewidth fiber lasers. | Pengfei Ma Hu Xiao Wei Liu Hanwei Zhang Xiaolin Wang Jinyong Leng Pu Zhou | 2021 | High Power Laser Science and Engineering2021，9，3： | 9 |
| 15 | Tandem pumping architecture enabled high power random fiberlaser with near-diffraction-limited beam quality显示文摘In this contribution, we present the tandem pumping avenue leveraged performance scaling of random fiber laser to record 3 kW level with inherent temporal stability and near-diffraction-limited beam quality. The high power system employs a four-stage master oscillator power amplifier chain. The master oscillator is a half-opened cavity structured random distributed feedback fiber laser centered at 1080 nm and pumped by incoherent amplified spontaneous emission source. Narrowband random laser seed is selected by employing a spectral filtering module with a maximum output power of 1.08 W, full width at half maximum linewidth of 0.47 nm and spectral optical-signal-to-noise ratio of about 42 dB. As to the main amplification stage, for given 104 W pre-amplified random laser seed and 3.61 kW pump laser, an ultimate output power of 3.03 kW can be obtained,corresponding to an optical-to-optical conversion efficiency of 81.05%. Nearly single-transverse-mode amplified random laser can be achieved even at full power level for inherent high thermal modal instability threshold enabled by tandem pumping and inducing bending loss for high-order transverse-mode. Further performance scaling of this high power random laser system, such as power boosting, operation wavelength tuning and linewidth alteration, is the next goal. | XU JiangMing YE Jun ZHOU Pu LENG JinYong XIAO Hu ZHANG HangWei WU Jian CHEN JinBao | 2019 | Science China(Technological Sciences)2019，62，1： | 8 |
| 16 | Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion显示文摘Objective:Coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods:Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results:Low (Rentrop score of 0 or 1) and high (Rentrop score of 2 or 3) coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high collateralization (for all comparisons, P<0.05). In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein (hsCRP) compared with those with high collateralization. Multivariate analysis revealed that age of ≥65 years, female gender, diabetes, no history of hypertension, dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were independently associated with low coronary collateralization. Conclusions:Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation. | Zhen SUN Ying SHEN Lin LU Rui-yan ZHANG Li-jin PU Qi ZHANG Zheng-kun YANG Jian HU Qiu-jing CHEN Wei-feng SHEN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，8： | 8 |
| 17 | Recently developed strategies to restrain dendrite growth of Li metal anodes for rechargeable batteries显示文摘Lithium metal has been regarded as one of the most promising anode materials for high-energy-density batteries due to its extremely high theoretical gravimetric capacity of 3860 mAh·g^-1 along with its low electrochemical potential of-3.04 V.Unfortunately,uncontrollable Li dendrite growth and repetitive destruction/formation of the solid electrolyte interphase layer lead to poor safety and low Coulombic efficiencies(CEs)for long-term utilization,which largely restricts the practical applications of lithium metal anode.In this review,we comprehensively summarized important progresses achieved to date in suppressing Li dendrite growth.Strategies for protection of Li metal anodes include designing porous structured hosts,fabricating artificial solid electrolyte interface(SEI)layers,introducing electrolyte additives,using solid-state electrolytes and applying external fields.The protection of Li metal anodes can be achieved by regulating the stripping and deposition behaviours of Li ions.Finally,the challenges remaining for lithium metal battery systems and future perspectives for Li metal anodes in practical applications are outlined,which are expected to shed light on future research in this field. | Kai-Chao Pu Xin Zhang Xiao-Lei Qu Jian-Jiang Hu Hai-Wen Li Ming-Xia Gao Hong-Ge Pan Yong-Feng Liu | 2020 | Rare Metals2020，39，6： | 8 |
| 18 | The Induction of Liver Microsomal Cytochrome P450 by Glycyrrhiza uralensis and Glycyrrhetinic acid in Mice显示文摘The effect of Glycyrrhiza uralensis Fisch (GRZ) aqueous extract and one of its active principles Glycyrrhetinic acid (GRT) on hepatic cytochrome P450 in mice were investigated. Oral administration of GRZ at 10g/kg/d or GRT at 50 mg/kg/d for 7 days was foulld to increase the P450 contents up to 4.6 fold compared with the controls. The activities of aryl hydrocarbon hydroxylase (AHH,3. 1 and 3. 3 fold), aminopyrine N-demethylase (ADM, 4. 2 and 3. 2 folds), and 7-ethoxycumarin O-deethylase (ECOD, 2. 8 and 2. 5 fold) were also shown to be increased. Westem blot analysis showed that the subtypes of P450 isoforms induced selectively by GRZ and GRT included CYP1A1 (1. 8 and 1. 5 fold over that of the control, respectively), CYP2B1 (both 1.3 fold), and CYP2C11(3 .2 and 3 .0 fold). Moreover, significant positive correlation between the P450 content or the isoforms and the corresponding enzyme activities mentioned above was observed. | HU WEN-YU LI YA-WEI HOU YAN-NING HE KAN (Department of Pharmacology, Instiute of Materia Medica, Chinese Academy of Medical Scicnces & Beijing Union Medical College, Beijing 100050, China) CHEN JIE-FU (Yang-Ming Medical University, Taipei) BUT PAUL PU | 1999 | Biomedical and Environmental Sciences1999，12，1： | 8 |
| 19 | Clinical observation of gastric bypass in treatment of type 2 diabetes显示文摘 | PU Yong-dong LI Jing-quan CAO Zhi-yu WANG Li HU Xiao DONG Li-guo LI Yue-min ZHAO Hua-zhou QIN Rong YANG Bo HE Jiao-miao WU You-jun WANG Yi LU Gang ZHANG Bo WANG Yue LIU Wei-ping WENG Jian-feng | 2012 | Chinese Medical Journal2012，，11： | 8 |
| 20 | Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention显示文摘Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention. | Li-jin PU Ying SHEN Rui-yan ZHANG Qi ZHANG Lin LU Feng-hua DING Jian HU Zheng-kun YANG Wei-feng SHEN | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，8： | 8 |
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