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| 1 | Fractional differential approach to detecting textural features of digital image and its fractional differential filter implementation显示文摘This paper mainly discusses fractional differential approach to detecting textural features of digital image and its fractional differential filter. Firstly,both the geometric meaning and the kinetic physical meaning of fractional differential are clearly explained in view of information theory and kinetics,respectively. Secondly,it puts forward and discusses the definitions and theories of fractional stationary point,fractional equilibrium coefficient,fractional stable coefficient,and fractional grayscale co-occurrence matrix. At the same time,it particularly discusses fractional grayscale co-occurrence matrix approach to detecting textural features of digital image. Thirdly,it discusses in detail the structures and parameters of n×n any order fractional differential mask on negative x-coordinate,positive x-coordinate,negative y-coordinate,positive y-coordinate,left downward diagonal,left upward diagonal,right downward diagonal,and right upward diagonal,respectively. Furthermore,it discusses the numerical implementation algorithms of fractional differential mask for digital image. Lastly,based on the above-mentioned discussion,it puts forward and discusses the theory and implementation of fractional differential filter for digital image. Experiments show that the fractional differential-based image operator has excellent feedback for enhancing the textural details of rich-grained digital images. | PU YiFei WANG WeiXing ZHOU JiLiu WANG YiYang JIA HuaDing | 2008 | Science in China(Series F)2008，51，9： | 50 |
| 2 | Experimental Investigation into Characteristics of Plasma Aerodynamic Actuation Generated by Dielectric Barrier Discharge显示文摘This article carries out synthetic measurements and analysis of the characteristics of the asymmetric surface dielectric barrier discharge plasma aerodynamic actuation.The rotational and vibrational temperatures of an N2 (C3Пu) molecule are measured in terms of the optical emission spectra from the N2 second positive system.A simplified collision-radiation model for N2(C) and N2+(B) is established on the basis of the ratio of emission intensity at 391.4 nm to that at 380.5 nm and the ratio of emission intensity at 371.1 nm to that at 380.5 nm for calculating temporal and spatial averaged electron temperatures and densities.Under one atmosphere pressure,the electron temperature and density are on the order of 1.6 eV and 1011cm-3 respectively.The body force induced by the plasma aerodynamic actuation is on the order of tens of mN while the induced flow velocity is around 1.3m/s.Starting vortex is firstly induced by the actuation;then it develops into a near-wall jet,about 70 mm downstream of the actuator.Unsteady plasma aerodynamic actuation might stimulate more vortexes in the flow field.The induced flow direction by nanosecond discharge plasma aerodynamic actuation is not parallel,but vertical to the dielectric layer surface. | Wu Yun Li Yinghong Jia Min Song Huimin Su Changbing Pu Yikang | 2010 | Chinese Journal of Aeronautics2010，23，1： | 20 |
| 3 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 4 | Spatial distribution and temporal trends in potential evapotranspiration over Hengduan Mountains region from 1960 to 2009显示文摘在 19612009 期间在 Hengduan 山区域基于 20 个车站的气象学的数据,潜在的土壤水分蒸发蒸腾损失总量的年度、季节的变化与 Penman-Monteith 模型一起在联合被分析。与在 ArcGIS 下面的花键插值的方法,潜在的土壤水分蒸发蒸腾损失总量的空间分发被介绍研究地区性的差别,并且关联分析被用来讨论影响潜在的土壤水分蒸发蒸腾损失总量的主导的因素。结果显示自从 1960 年代,年度潜在的土壤水分蒸发蒸腾损失总量显示出一个减少的趋势,特别从 1980 年代到 1990 年代,当自从 2000,它显示出一个增加的趋势时。地区性的潜在的土壤水分蒸发蒸腾损失总量显示出 0.17 公里 a1 的率。在 Hengduan 山的北方,中间和南方的潜在的土壤水分蒸发蒸腾损失总量在学习时期上展出了减少的趋势,并且它的地区性的趋势在从西南的衰落上到东北。 | ZHU Guofeng HE Yuanqing PU Tao WANG Xufeng JIA Wenxiong LI Zongxing XIN Huijuan | 2012 | Journal of Geographical Sciences2012，22，1： | 16 |
| 5 | Progress and Prospects of Salt Lake Research in China显示文摘China has unique salt lake resources, and they are distributed in the east of Eurasian salt lake subzone of the Northern Hemisphere Salt Lake Zone, mainly concentrated in the regions with modern mean annual precipitation lower than 500 mm. This paper preliminarily reviews the progress made in salt lake research in China for the past 60 years. In the research of Paleoclimate and paleoenvironment from salt lake sediments, a series of salts have been proposed to be indicators of paleoclimate, and have been well accepted by scholars. The chloride-sulfate depositional regions of the west Qaidam and the east Tarim have been revealed to be the drought center of China since the Quaternary, and more than 6 spreading stages of arid climate(salt forming) have been identified. Five pan-lake periods with highstands have been proved to exist during the late Quaternary on the Tibetan Plateau. In mineral resource prospecting and theories of the forming of salt deposits: the atlas(1:2500000) of hydrochemical zoning of salt lakes on the Tibetan Plateau has been compiled for the first time, revealing the zonal distribution and transition from carbonate type to chloride type from south to north and presenting corresponding mineral assemblages for different type of salt lakes; several large continental salt deposits have been discovered and the theory of continental potash deposition has been developed, including the salt deposition in deep basins surrounded by high mountains, the mineral deposition from multistage evolution through chains of moderate or shallow lakes with multilevels, the origin of potassium rich brines in gravel layers, and the forming of potassium deposits through the inheriting from ancient salt deposits, thus establishing the framework of 'Continental Potash Deposition Theory'; several new types of Mg-borate deposits have been discovered, including the ulexite and pinnoite bed in Da Qaidam Lake, Qinghai, the pinnoite and kurnakovite bed in Chagcam Caka, Tibet, the kurnakovite bed in Lake Nyer, and the corresponding model of borate deposition from the cooling and dissolution of boron rich brines was proposed based on principles of geology, physics and chemistry. The anti-floatation-cold crystallization method developed independently has improved the capacity of KCl production to 3 million tons per year for the Qarham, serving the famous brand of potash fertilizer products. One 1.2 million ton K-sulfate production line, the biggest in the world, has been built in Lop Nor, and K-sulfate of about 1.6 million tons was produced in 2015. Supported by the new technology, i.e. brine preparation in winter-cooling-solarization-isolation-lithium deposition from salt gradient solar pond' the highest lithium production base at Zabuye Lake(4421 m), Tibet, has been established, which is the first lithium production base in China that reaches the year production of 5000 tons of lithium carbonate. The concept of Salt lake agriculture(Salt land agriculture) has been established based on the mass growth of Dunaliella and other bacillus-algae and the occurrence of various halophytes in saltmarsh and salt saline-alkali lands, finding a new way to increase arable lands and develop related green industry in salt rich environments. Finally this paper presents some new thoughts for the further research and development on salt science, and the further progress in salt science and technology will facilitate the maturing of the interdisciplinary science 'Salinology'. | ZHENG Mianping ZHANG Yongsheng LIU Xifang NIE Zhen KONG Fanjing QI Wen Jia Qingxian PU Linzhong HOU Xianhua WANG Hailei ZHANG Zhen KONG Weigang LIN Yongjie | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 15 |
| 6 | Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization显示文摘许多研究建议了的背景 angiogenic 因素和 anti-angiogenic 因素表示的不平衡显著地作出贡献到 choroidal 的开发 neovascularization (CNV ) ,和超声 microbubble 联合系统能成功地增加基因 transfection 效率。这研究被设计调查调停超声的 microbubble 破坏是否,并且是否能有效地交付治疗学的 plasmid 进老鼠的视网膜导出上皮的因素( PEDF )能禁止的颜料的基因转移 CNV.Methods 人的网膜的颜料上皮的房间独自与超声或 plasmid 被孤立并且对待任何一个,或与接近 提高microbubble 的超声的可行性的 plasmid ,超声和 microbubbles 的联合提高 PEDFgene expressio 因为在 vivo 动物学习, CNV 被氩 lasgon 激光在老鼠导致。这些老鼠随机被分到五个组并且被灌输与 PEDF 的裸体 plasmid DNA 依附进的 microbubbles 对待立即的超声暴露(intravitreal 注射) 跟随的老鼠玻璃;与 PEDF 的裸体 plasmid DNA 灌输 liposomes 进玻璃(lipofectamine + PEDF ) ;灌输立即与超声照耀与 PEDF 依附进老鼠的轨道的 microbubbles (retrobular 注射) ;灌输 microbubbles 与 PEDF 属于进老鼠的大腿骨的静脉与立即暴露了到超声(静脉注射) 。没有任何处理的 CNV 老鼠用作控制。老鼠被牺牲,眼睛是在在处理以后的 7, 14,和 28 天的 enucleated。PEDF 的基因和蛋白质表示被量的即时 RT-PCR,西方的弄污和分别地染色的 immunofluorescence 检测。CNV 上的 PEDF 基因转移的效果被荧光黄宫底 angiography.Results 在房间实验显示出的 vitro 检验有超声照耀的那 microbubbles 能显著地独自作为与 microbubbles 或超声相比提高 PEDF 交货。在老鼠 CNV 模型, transfection 效率由 ultrasound/microbubbles 调停了由在在处理以后的 28 天的调停 lipofectamine 的基因转移比那显著地高。学习也证明与调停超声的 microbubbles 破坏的管理,老鼠的 CNV 被禁止 effectively.Conclusions Ultrasound-microbubble 技术能增加 PEDF 基因转移进老鼠的视网膜和 chorioid ,与 CNV 的发展的重要抑制联合,建议这个 noninvasive 基因转移方法可以为临床的基因治疗提供一个有用工具。 | ZHOU Xi-yuan LIAO Qing PU Yi-min TANG Yong-qiang GONG Xiao LI Jia XU Yan WANG Zhi-gang | 2009 | Chinese Medical Journal2009，，22： | 12 |
| 7 | Idiopathic ventricular fibrillation with fragmented QRS complex and J wave in resting electrocardiogram显示文摘ObjectiveTo 在放松从 21 大小写的考察数据在我们的医院里使遭到的 electrocardiogram.MethodsWe 与碎裂的 QRS 建筑群( f-QRS )和 J 波浪描述自发的室的纤维性颤动( IVF )的临床的特征由于 IVF 在心脏的拘捕以后被复活并且在放松心电图估计了 f-QRS 和 J 波浪的流行( ECG )。所有盒子题目基于 electrocardiographic 形态学在三个组之中被分类:组我, f-QRS 和 J 波浪被观察(n = 6 ) ,组 II,仅仅 J 波浪被观察(n = 9 ) ,组 III,两 f-QRS 也不 J 波浪被观察(n = 6 ) 。人口特征,中略的历史或突然的心脏的拘捕,室的纤维性颤动( VF )的发生,和 VF 的情形在索引事件的三 groups.ResultsThe 发生之中被评估(中略,在可植入的 cardioverter 使用高压脉冲来消减心脏( ICD )或心律调整器记录的熬过的心脏的拘捕和 VF 事件)是 13.4 ± ;在组的 5.6 每年我, 10.8 ±在组 II 的 3.9 每年,和 9.8 ±在组 III 的 4.2 每年。在在三个组,之中的发生有重要差别最经常的索引事件在组被观察我。为发生的危险比率是 3.2 (95%CI, 1.1-7.9;P = 0.01 ) 。索引事件的历史和情形在这些组之中是不同的。在组我,所有索引事件在清早发生在睡觉期间。在组 II,四个题目在奋发的物理活动或焦虑状态期间承受了 VF,二在在清早的睡觉期间,三在里面平常的活动。在组 III ,一个题目在清早在睡觉期间承受了 VF ,处于焦虑状态的,四在平常的 activity.ConclusionsThis ,学习建议有在休息 ECG 的 f-QRS 和 J 波浪的联合外观的 IVF 病人承受 VF 的增加的风险, IVF 病人的这亚群有一个唯一的临床的特征。 | Jing Wang Min Tang Ke-Xiu Mao Jian-Min Chu Wei Hua Yu-He Jia Ying-Jie Zhao Wei Wei Xu-Hua Chen Jie-Lin Pu Shu Zhang | 2012 | Journal of Geriatric Cardiology2012，9，2： | 10 |
| 8 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 9 | Prophylactic vertebroplasty procedure applied with a resorbable bone cement can decrease the fracture risk of sandwich vertebrae:long-term evaluation of clinical outcomes显示文摘A sandwich vertebra is formed after multiple osteoporotic vertebral fractures treated by percutaneous vertebroplasty,which has a risk of developing new fractures.The purpose of our study was to(i)investigate the occurrence of new fractures in sandwich vertebra after cement augmentation procedures and to(ii)evaluate the clinical outcomes after prophylactic vertebral reinforcement applied with resorbable bone cement.From June 2011 to 2014,we analysed 55 patients with at least one sandwich vertebrae and treated with percutaneous vertebroplasty.Eighteen patients were treated by prophylactic vertebroplasty with a resorbable bone cement to strengthen the sandwich vertebrae as the prevention group.The others were the non-prevention group.All patients were examined by spinal radiographs within 1 day,6 months,12 months,24 months and thereafter.The incidence of sandwich vertebra is 8.25%(55/667)in our study.Most sandwich vertebrae(69.01%,49/71)are distributed in the thoracic-lumbar junction.There are 24 sandwich vertebrae(18 patients)and 47 sandwich vertebrae(37 patients)in either prevention group or non-prevention group,respectively.No significant difference is found between age,sex,body mass index,bone mineral density,cement disk leakage,sandwich vertebrae distribution or Cobb angle in the two groups.In the follow-up,8 out of 37(21.6%)patients(with eight sandwich vertebrae)developed new fractures in non-prevention’group,whereas no new fractures were detected in the prevention group.Neither Cobb angle nor vertebral compression rate showed significant change in the prevention group during the follow-up.However,in the non-prevention group,we found that Cobb angle increased and vertebral height lost significantly(P<0.05).Prophylactic vertebroplasty procedure applied with resorbable bone cement could decrease the rate of new fractures of sandwich vertebrae. | Pu Jia Hai Tang Hao Chen Li Bao Fei Feng He Yang Jinjun Li | 2017 | Regenerative Biomaterials2017，4，1： | 8 |
| 10 | Identification of Porphyra lines using computerized DNA fingerprinting显示文摘RAPD (Randomly Amplified Polymorphic DNA) analysis was performed with filaments of 15 Porphyra lines representing four important groups (P. yezoensis, P. haitanensis, P. katadai var. Hemiphylla and P. digospermatangia). Eight stable and repeatable RAPD bands amplified with two primers, OPN-02 and OPJ-18, were selected for the construction of DNA fingerprinting. The RAPD results were scored based on the presence or absence of each of the 8 bands and then converted to computer language expressed with two digitals, 1 and 0, which represented the presence (numbered as 1) or absence (numbered as 0) of each band, respectively. Based on these results, a model DNA fingerprint and a computerized DNA fingerprint were constructed. In the constructed DNA fingerprint, each Porphyra line has its unique fingerprinting pattern and can be easily distinguished from each other. Later, a software, named as PhGI, was designed based on this DNA fingerprinting. It can be used in practical Porphyra line identification. | WangBin, Jia Jianhang, Shi Jinfeng, Chen Yihua, JinDemin, Xu Pu, Mei Junxue, Weng Manli 1. Institute of Genetics, Chinese Academy of Sciences, Beijing 100101 (E-mail: mlweng@genetics. ac. cn), China 2. Jiangsu Marine Fishery Institute, Nan | 2001 | Acta Oceanologica Sinica2001，20，3： | 7 |
| 11 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
| 12 | Depression of the Thoracolumbar Posterior Vertebral Body on the Estimation of Cement Leakage in Vertebroplasty and Kyphoplasty Operations显示文摘 | Hao Chen Pu Jia Li Bao Fei Feng He Yang Jin-Jun Li Hai Tang | 2015 | Chinese Medical Journal2015，，23： | 7 |
| 13 | Nutrition deficiency promotes apoptosis of cartilage endplate stem cells in a caspase-independent manner partially through upregulating BNIP3显示文摘营养缺乏被报导在兔子导致 chondrocytes 的 apoptosis 和软骨终板(CEP ) 的退化。软骨终板干细胞(CESC ) 为结构的完整和 CEP 的功能是重要的。(BNIP3 ) Bcl-2/adenovirus E1B 19-kDa-interacting 蛋白质 3 被报导了调整 apoptosis, autophagy,和 cytoprotection。在这研究,我们试图决定营养缺乏是否导致 CESC 的 apoptosis,并且 BNIP3 相关的小径是否在营养缺乏期间在 CESC 被激活。从堕落人的 CEP 孤立的 CESC 在正常或营养缺乏的状况下面是有教养的。然后, apoptosis 被流动 cytometry 分析。表示和 BNIP3 的细胞内部的本地化被量的即时聚合酶链反应,西方的污点分析,和 immunofluorescence 试金分别地检测。Mitochondrial 膜潜力(MMP ) 和 caspase-3 活动被 JC-1 染色和 caspase-3 活动试金测量。我们的结果证明那营养缺乏在 CESC 支持 apoptosis 和 BNIP3 表示。尤其是, BNIP3 击倒能部分减少营养 CESC 的导致缺乏的 apoptosis。另外,营养缺乏能也导致 BNIP3 的 upregulation,导致 BNIP3 的 mitochondrial translocation 和在以一种时间依赖者方式的 CESC 的 MMP 的损失。然而,营养缺乏没在 CESC 在 caspase-3 活动显示出效果。在摘要,营养缺乏可以通过 upregulating BNIP3 部分支持 CESC apoptosis,它可能以一种 caspase 独立的方式导致 BNIP3 相关的小径的激活和 CESC 的 apoptosis。 | Zhiliang He Luqiao Pu Chao Yuan Min Jia Jian Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 7 |
| 14 | Orally administered moxifloxacin prolongs QTc in healthy Chinese volunteers: a randomized, single-blind, crossover study显示文摘目的: 自愿用健康汉语调查口头上地管理的 moxifloxacin 的 QT/QTc 效果。 | Qian CHEN Yan-mei LIU Yun LIU Boaz MENDZELEVSKI Dennis CHANTER Hua-hua PU Gang-yi LIU Onglee WENG Chao-ying HU Wei WANG Chen YU Jing-ying JIA | 2015 | Acta Pharmacologica Sinica2015，36，4： | 6 |
| 15 | In situ catalytic upgrading of heavy crude oil through low-temperature oxidation显示文摘The low-temperature catalytic oxidation of heavy crude oil(Xinjiang Oilfield,China) was studied using three types of catalysts including oil-soluble,watersoluble,and dispersed catalysts.According to primary screening,oil-soluble catalysts,copper naphthenate and manganese naphthenate,are more attractive,and were selected to further investigate their catalytic performance in in situ upgrading of heavy oil.The heavy oil compositions and molecular structures were characterized by column chromatography,elemental analysis,and Fourier transform infrared spectrometry before and after reaction.An Arrhenius kinetics model was introduced to calculate the rheological activation energy of heavy oil from the viscosity-temperature characteristics.Results show that the two oil-soluble catalysts can crack part of heavy components into light components,decrease the heteroatom content,and achieve the transition of reaction mode from oxygen addition to bond scission.The calculated rheological activation energy of heavy oil from the fitted Arrhenius model is consistent with physical properties of heavy oil(oil viscosity and contents of heavy fractions).It is found that the temperature,oil composition,and internal molecular structures are the main factors affecting its flow ability.Oil-soluble catalyst-assisted air injection or air huff-n-puff injection is a promising in situ catalytic upgrading method for improving heavy oil recovery. | Hu Jia Peng-Gang Liu Wan-Fen Pu Xian-Ping Ma Jie Zhang Lu Gan | 2016 | Petroleum Science2016，13，3： | 6 |
| 16 | Establishment and validation of a computer-assisted colonic polyp localization system based on deep learning显示文摘BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequate bowel preparation and withdrawal time(P=0.32;P=0.16,respectively).CONCLUSION CADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas,and further confirmation is warranted. | Sheng-Bing Zhao Wei Yang Shu-Ling Wang Peng Pan Run-Dong Wang Xin Chang Zhong-Qian Sun Xing-Hui Fu Hong Shang Jian-Rong Wu Li-Zhu Chen Jia Chang Pu Song Ying-Lei Miao Shui-Xiang He Lin Miao Hui-Qing Jiang Wen Wang Xia Yang Yuan-Hang Dong Han Lin Yan Chen Jie Gao Qian-Qian Meng Zhen-Dong Jin Zhao-Shen Li Yu Bai | 2021 | World Journal of Gastroenterology2021，27，31： | 5 |
| 17 | High performance and stability of double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δas an oxygen electrode for reversible solid oxide electrochemical cell显示文摘In this study,we successfully synthesized double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δ(NBCCF)using a conventional wet chemical method as the oxygen electrode for reversible solid oxide electrochemical cells(RSOCs).The polarization resistance(Rp)of the composite electrode NBCCFGd0.1Ce0.9O2(GDC)is only 0.079Ωcm^2 at 800℃under air.The single cell based on NBCCF-GDC electrode displays a peak power density of 0.941 W/cm^2 in fuel cell mode and a low Rp value of 0.134Ωcm^2.In electrolysis cell mode,the cell displays an outstanding oxygen evolution reaction(OER)activity and shows current density as high as 0.92 A/cm^2 with 50 vol%AH(Absolute Humidity)at 800℃and applied voltage of 1.3 V.Most importantly,the cell exhibits admirable durability of 60 h both in electrolysis mode and fuel cell mode with distinguished reversibility.All these results suggest that NBCCF is a promising candidate electrode for RSOC. | Yunfeng Tian Yun Liu Wenjie Wang Lichao Jia Jian Pu Bo Chi Jian Li | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 18 | Loading necrostatin-1 composite bone cement inhibits necroptosis of bone tissue in rabbit显示文摘Bone necrosis after injecting of polymethylmethacrylate(PMMA)bone cement will lead to re-fracture of bone tissue.As a new type of necrosis,there is little research related to the necroptosis of surrounding bone tissue near the bone cement.The purpose of our study was to(i)investigate the presence of necroptosis in vivo and,(ii)established as a new type of bone cement containing PMMA,calcium phosphate cement(CPC)and Necrostatin-1(Nec-1)to inhibit necroptosis of bone tissue.A total of 12 Japanese rabbits were used to establish the animal model and randomly divided into 4 groups signed as a control group,PMMA group,PMMA–CPC group and PMMA–CPC–Nec-1 group,respectively.We used scanning electron microscope to observe the structure of the samples,used HE staining to detect the necrosis,and used western blotting as well as ELISA test to examine the iconic molecule receptor interacting protein kinase-3(RIP 3)protein and tumor necrosis factor a(TNF-a).After analyzing the results of our study,we found that the structure in both PMMA bone cement group and composite bone cement group was damaged and there was an evidence of necrosis,but it was absent in control group.Through molecule detection,the RIP 3 protein expression was decreased in PMMA–CPC–Nec-1(P<0.05).TNF-a expression was increased in bone cement groups with and without CPC(P<0.05),but was inhibited in PMMA–CPC–Nec-1 group.We have concluded that the necroptosis could be confirmed in bone tissue necrosis induced by TNF-a after bone cement injection and also could be inhibited by composite bone cement with Nec-1. | Xiang Ji Feng Xu Guoling Dong Chongzhe Jia Pu Jia Hao Chen Hai Tang | 2019 | Regenerative Biomaterials2019，6，2： | 4 |
| 19 | Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis显示文摘Long noncoding RNAs(lncRNAs)have been considered as crucial regulators of acute myocardial infarction(AMI).In this study,to analyze the effect of differentiation antagonizing nonprotein coding RNA(DANCR)of lncRNA on cardiomyocyte damage in AMI,cardiomyocyte injury was induced by oxygen-glucose deprivation(OGD).Cell counting kit-8(CCK-8)assay and flow cytometry were used to assess cell viability and apoptosis,respectively.Quantitative real-time PCR was used to measure the expression levels of DANCR and miR-19a-3p.Bioinformatics analysis and luciferase gene reporter assay were utilized to explore the relationship among DANCR,miR-19a-3p,and mitogen-activated protein kinase 1(MAPK1).CCK-8 and TUNEL assays were used to explore the effects of DANCR alone or plus miR-19a-3p on the viability and apoptosis of OGD/R-exposed HL-1 cells.Western blot analysis was used to detect changes in the MAPK1/ERK1/2 pathway in HL-1 cells.We found that DANCR expression and miR-19a-3p level are negatively correlated as DANCR expression is increased,while miR-19a-3p level is decreased in AMI patients’serum and OGD/R-exposed HL-1 cells.DANCR knockdown increased miR-19a-3p level,and miR-19a-3p inhibition increased DANCR expression.Moreover,DANCR directly binds to miR-19a-3p.DANCR knockdown reduced viability but induced apoptosis in OGD/R-exposed HL-1 cells,while miR-19a-3p inhibition weakens these effects.Furthermore,MAPK1 is a target of miR-19a-3p.miR-19a-3p overexpression decreases MAPK1 and ERK1/2 in HL-1 cells,while miR-19a-3p inhibition increases MAPK1 and ERK1/2 in HL-1 cells.Moreover,DANCR knockdown reduces myocardium apoptosis in mice with the left anterior descending artery ligated.DANCR knockdown effectively restores myocardial cell apoptosis by regulating the miR-19a-3p/MAPK1/ERK1/2 axis. | Yang Ruan Hong Li Xiaojing Cao Shuai Meng Ruofei Jia Lianmei Pu Hao Fu Zening Jin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 4 |
| 20 | Giant and light modifiable third-order optical nonlinearity in a free-standing h-BN film显示文摘Recently,hexagonal boron nitride(h-BN)has become a promising nanophotonic platform for on-chip information devices due to the practicability in generating optically stable,ultra-bright quantum emitters.For an integrated information-processing chip,high optical nonlinearity is indispensable for various fundamental functionalities,such as all-optical modulation,high order harmonic generation,optical switching and so on.Here we study the third-order optical nonlinearity of free-standing h-BN thin films,which is an ideal platform for on-chip integration and device formation without the need of transfer.The films were synthesized by a solution-based method with abundant functional groups enabling high third-order optical nonlinearity.Unlike the highly inert pristine h-BN films synthesized by conventional methods,the free-standing h-BN films could be locally oxidized upon tailored femtosecond laser irradiation,which further enhances the third-order nonlinearity,especially the nonlinear refraction index,by more than 20 times.The combination of the free-standing h-BN films with laser activation and patterning capability establishes a new promising platform for high performance on-chip photonic devices with modifiable optical performance. | Jun Ren Han Lin Xiaorui Zheng Weiwei Lei Dan Liu Tianling Ren Pu Wang Baohua Jia | 2022 | Opto-Electronic Science2022，1，6： | 3 |
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