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| 1 | Onset velocity of circulating fluidization and particle residence time distribution:A CFD-DEM study显示文摘Until now,the onset velocity of circulating fluidization in liquid-solid fluidized beds has been defined by the turning point of the time required to empty a bed of particles as a function of the superficial liquid velocity,and is reported to be only dependent on the liquid and particle properties.This study presents a new approach to calculate the onset velocity using CFD-DEM simulation of the particle residence time distribution(RTD).The onset velocity is identified from the intersection of the fitted lines of the particle mean residence time as a function of superficial liquid velocity.Our results are in reasonable agreement with experimental data.The simulation indicates that the onset velocity is influenced by the density and size of particles and weakly affected by riser height and diameter.A power-law function is proposed to correlate the mean particle residence time with the superficial liquid velocity.The collisional parameters have a minor effect on the mean residence time of particles and the onset velocity,but influence the particle RTD,showing some humps and trailing.The particle RTD is found to be related to the particle trajectories,which may indicate the complex flow structure and underlying mechanisms of the particle RTD. | Qiqi Han Ning Yang Jiahua Zhu Mingyan Liu | 2015 | Particuology2015，13，4： | 8 |
| 2 | Evolution Characteristics of Government-Industry-University Cooperative Innovation Network of Electronic Information Industry in Liaoning Province, China显示文摘It is important to optimize the cooperative innovation network for the improvement of economic competence and innovative power. Based on the patent information services platform, we obtain invention patent data for the electronic information industry in Liaoning from 1985 to 2015. This paper analyzes the cooperative innovation network structure, its spatiotemporal evolution and the triple helix relationship of government-industry-university(GIU) by using the social network analysis method and the triple helix theory as well as UCINet, ArcGIS and NetDraw. The empirical results show that: 1) the number of the subjects of the electronic information industry GIU cooperative innovation network in Liaoning demonstrates a gradual increase from 1985 to 2015, with the same trend in concentration. In terms of its subject and its centrality, the universities have a higher position, and the industries have a lower position,while the status of the government is still unclear. 2) The cooperative innovation network presents a core-periphery structure, and the polarization effect of innovation subjects tends to be obvious. There is certain distance-decay regularity in the cooperative innovation network, and a strong geographical proximity to cooperative innovation. 3) The compactness shows a downward trend as a whole. In terms of the extent of participation, the industries are better than the government but worse than the universities. This means that the cooperative innovation network of GIU in the electronic information industry in Liaoning is in the initial stage of formation. | PENG Fei ZHANG Qiqi HAN Zenglin DING Yan FU Ningning | 2019 | Chinese Geographical Science2019，29，3： | 7 |
| 3 | Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome显示文摘Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS) and has been widely used for thousands of years.However,the quality control (QC) standards of SJZD are insufficient.Chinmedomics has been designed to discover and verify bioactive compounds of a variety of formularapidly.In this study,we used Chinmedomics to evaluate the SJZD's efficacy against SQDS to discover the potential quality-markers (q-markers) for QC.A total of 56 compounds in SJZD were characterized in vitro,and 23 compounds were discovered in vivo.A total of 58 biomarkers were related to SQDS,and SJZD can adjust a large proportion of marker metabolites to normal level and then regulate the metabolic profile to the health status.A total of 10 constituents were absorbed as effective ingredients that were associated with overall efficacy.We preliminarily determined malonyl-ginsenoside Rb2 and ginsenoside Ro as the q-markers of ginseng;dehydrotumulosic acid and dihydroxy lanostene-triene-21-acid as the q-markers of poria;glycyrrhizic acid,isoglabrolide,and glycyrrhetnic acid as the q-markers of licorice;and 2-atractylenolide as the q-marker of macrocephala.According to the discovery of the SJZD q-markers,we can establish the quality standard that is related to efficacy. | Qiqi Zhao Xin Gao Guangli Yan Aihua Zhang Hui Sun Ying Han Wenxiu Li Liang Liu Xijun Wang | 2020 | Frontiers of Medicine2020，14，3： | 7 |
| 4 | ERF4 affects fruit ripening by acting as a JAZ interactor between ethylene and jasmonic acid hormone signaling pathways显示文摘The regulation of apple(Malus domestica)fruit texture during ripening is complex and a fundamental determinant of its commercial quality.In climacteric fruit,ripening-related processes are regulated by ethylene(ET),and jasmonate(JA)is also involved in the ethylene biosynthesis pathway,mainly through the transcription factor MYC2.However,the molecular genetic mechanism for fruit ripening processes between the JA and ET signaling pathways still needs to be elucidated.In order to explore how JA regulates apple fruit ripening through ERF4,we used’Gala’and’Ralls Janet’fruit at different developmental stages as experimental materials to determine the fruit firmness and related gene expression analysis.Meanwhile,we carried out different hormone treatments on’Gala’fruit at ripening stage.Here,we show that ERF4 is a core JA signaling hub protein JASMONATE ZIM-DOMAIN(JAZ)interactor that affects ethylene signaling pathways.During fruit development,ERF4 represses the expression of ACS1 and ACO1 by interacting with JAZ,as well as with the JA-activated transcription factor MYC2.Ripening is promoted in JAZ-suppressed apples.Thus,ERF4 acts as a molecular link between ethylene and JA hormone signals,and the natural variation of the ERF4Ethylene-responsive binding factor-associated amphiphilic repression(EAR)motif decreases repression of ethylene biosynthesis genes. | Yanan Hu Hualin Sun Zhenyun Han Shuai Wang Ting Wang Qiqi Li Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
| 5 | Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis显示文摘Fractures are frequently occurring diseases that endanger human health. Crucial to fracture healing is cartilage formation, which provides a bone-regeneration environment. Cartilage consists of both chondrocytes and extracellular matrix (ECM). The ECM of cartilage includes collagens and various types of proteoglycans (PGs), which play important roles in maintaining primary stability in fracture healing. The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilage and bone. Our previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fracture sites. However, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown. To further detect the potential role of DMP1-PG in fracture repair, we established a mouse fracture model by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse). Upon inspection, fewer cartilaginous calluses and down-regulated expression levels of chondrogenesis genes were observed in the fracture sites of S89G-DMP1 mice. Given the deficiency of DMP1-PG, the impaired IL-6/JAK/STAT signaling pathway was observed to affect the chondrogenesis of fracture healing. Overall, these results suggest that DMP1-PG is an indispensable proteoglycan in chondrogenesis during fracture healing. | Hui Xue Dike Tao Yuteng Weng Qiqi Fan Shuang Zhou Ruilin Zhang Han Zhang Rui Yue Xiaogang Wang Zuolin Wang Yao Sun | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 6 | Canolol induces apoptosis in human gastric carcinoma cell through PI3K/Akt signaling pathway显示文摘Canolol is a natural polyphenolic compound in rapeseed oil with multiple biological activities.Anti-cancer potential of canolol has been proposed in some studies.However,the effect and underlying mechanism of canolol on human gastric carcinoma(AGS)cells have not been well understood.This study showed that canolol had significant inhibition in proliferation and strongly apoptotic effects in AGS cells,which were verified by the decrease of cell viability,high level of reactive oxygen species(ROS),and damage in mitochondria membrane potential(MMP).Treatment with canolol arrested cells in S phase,and increased expressions of Bax,cleaved caspase-9,and cleaved caspase-3 proteins.Meanwhile,low expression of Bcl-2 and cytochrome C(Cyt C)release were found.The expressions of PI3K(phosphoinositide 3-kinase)and p-AKT(phosphorylated serine/threonine kinase)were also downregulated.Overall,these results suggested that canolol inhibited proliferation and induced apoptosis in AGS cells by regulating PI3K/Akt pathway,demonstrating a potential in gastric cancer treatment. | Ling Han Xiaoyang Xia Qianchun Deng Chang Zheng Zhen Zhang Qiqi Ji Xia Xiang | 2019 | Oil Crop Science2019，4，4： | 1 |
| 7 | Research on bit error rate in the presence of local wavefront aberration in intersatellite laser communications显示文摘 | Yuqiang Yang Qiqi Han Liying Tan | 2011 | J Lightwave Technology2011，29，19： | 1 |
| 8 | Reductive damage induced autophagy inhibition for tumor therapy显示文摘Numerous therapeutic anti-tumor strategies have been developed in recent decades.However,their therapeutic efficacy is reduced by the intrinsic protective autophagy of tumors.Autophagy plays a key role in tumorigenesis and tumor treatment,in which the overproduction of reactive oxygen species(ROS)is recognized as the direct cause of protective autophagy.Only a few molecules have been employed as autophagy inhibitors in tumor therapy to reduce protective autophagy.Among them,hydroxychloroquine is the most commonly used autophagy inhibitor in clinics,but it is severely limited by its high therapeutic dose,significant toxicity,poor reversal efficacy,and nonspecific action.Herein,we demonstrate a reductive-damage strategy to enable tumor therapy by the inhibition of protective autophagy via the catalytic scavenging of ROS using porous nanorods of ceria(PN-CeO_(2))nanozymes as autophagy inhibitor.The antineoplastic effects of PN-CeO_(2)were mediated by its high reductive activity for intratumoral ROS degradation,thereby inhibiting protective autophagy and activating apoptosis by suppressing the activities of phosphatidylinositide 3-kinase/protein kinase B and p38 mitogen-activated protein kinase pathways in human cutaneous squamous cell carcinoma.Further investigation highlighted PN-CeO_(2)as a safe and efficient anti-tumor autophagy inhibitor.Overall,this study presents a reductive-damage strategy as a promising anti-tumor approach that catalytically inhibits autophagy and activates the intrinsic antioxidant pathways of tumor cells and also shows its potential for the therapy of other autophagy-related diseases. | Yuqian Wang Yingjian Huang Yu Fu Zhixiong Guo Da Chen Fangxian Cao Qi Ye Qiqi Duan Meng Liu Ning Wang Dan Han Chaoyi Qu Zhimin Tian Yongquan Qu Yan Zheng | 2023 | Nano Research2023，16，4： | 1 |
| 9 | 16S rRNA Cloning and Identification of a Strain Isolated from Intestinal Tract of Rex Rabbit显示文摘This study was conducted to identify bacterial strain He Nan-001 isolated from intestinal tract of healthy rex rabbit.The strain was identified by gram staining,and OD_(600) values at different culture time were measured to develop a bacterial growth curve.The metabolic pathways of the bacterium using sugar in fermentation was identified with biochemical tubes.Total RNA of the strain was extracted,and total cDNA was obtained by Oligo(dT) method.Primers were designed using Primer 5.0 bio-software according to the 16S rRNA sequence published in Gen Bank,through cloning,ligation to vector PMD18T,construction of PMD18T/16S rRNA vector and transformation into DH5α,plasmid was extracted and sequenced,and the sequencing result was compared with sequences in NCBI followed by drawing of phylogenetic tree.The strain was verified to be double-stranded gram-positive cocci,which could ferment glucose,mannose,maltose and sorbitol,producing acids production,but failed to ferment sucrose,serum inulin and β-galactosidase.The phylogenetic tree analysis showed that the isolated bacterium shared the highest homology with an India isolate,and belongs to diplostreptococcus.This study provides significance experimental data and theoretical guidance for further development and utilization of the bacterial strain. | Guangjun GUO Yumao WANG Sufang LYU Jing HAN Xinming WU Hanjie ZHANG Qiqi ZOU Qiang FU Zhiqiang SHEN | 2016 | Agricultural Biotechnology2016，5，5： | 1 |
| 10 | High-precision potassium isotope analysis using the Nu Sapphire collision cell(CC)-MC-ICP-MS显示文摘This study presents high-precision analyses of stable potassium(K)isotope ratio using the recently-developed,collision-cell multi-collector inductively coupled plasma mass spectrometry(CC-MC-ICP-MS,Nu Sapphire).The accuracy of our analyses is confirmed by measuring well-characterized geostandards(including rocks and seawater).Our results are consistent with literature values and a precision of 0.04‰(2SD)has been achieved based on multiple measurements of BCR-2 geostandard over a six-month period.We also evaluate factors that may lead to artificial isotope fractionations,including the mismatches in K concentration and acid molarity between samples and bracketing standards,as well as potential matrices.As the K adsorption capacity of AGW50-X8(200-400 mesh)is reduced with an increasing amount of matrix elements,less than 150µg K was loaded during the column chemistry.To evaluate the potential use of K isotopes as an archive of paleo seawater composition,δ^(41)K values of an international seawater standard(IAPSO),a Mn-nodule(NOD-P-1),and two iron formation standards(FeR-2 and FeR-4)are reported.The δ^(41)K value of IAPSO is consistent with other seawater samples reported previously,further substantiating a homogeneous K isotopic distribution in modern global oceans.The K isotopes in Mn-nodule(NOD-P-1:−0.121±0.013‰)and iron formation samples(FeR-2:−0.538±0.009‰;FeR-4:−0.401±0.008‰)seem to be an effective tracer of their formation genesis and compositional changes of ancient seawater.Our results suggest that high-precision measurements of stable K isotopes can be routinely obtained and open up a large variety of geological applications,such as continental weathering,hydrothermal circulation and alteration of oceanic crust. | Wenjun LI Mengmeng CUI Qiqi PAN Jing WANG Bingyu GAO Shanke LIU Meng YUAN Benxun SU Ye ZHAO Fang-Zhen TENG Guilin HAN | 2022 | Science China Earth Sciences2022，65，8： | 1 |
| 11 | Spatial Distribution Characteristics and Coverage Rate of Commercial Facilities in 15-minute Radius Livelihood Service Circles of Chunshu Street显示文摘Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,Xicheng District of Beijing served as a national pilot of the 15-minute radius livelihood service circle.Based on the data of POI,urban walking network and building outline,this paper studies the coverage of commercial service facilities in the 15-minute radius livelihood service circle of Chunshu Street by using kernel density analysis and urban network analysis tools.The research shows that the commercial facilities are concentrated in Zhuangsheng Square and Dazhalan commercial district.There are large gaps in housekeeping and couriers logistics facilities,which need to be further improved. | HAN Qiqi YANG Kaitai | 2024 | Journal of Landscape Research2024，16，1： | 0 |
| 12 | Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion显示文摘Hepatitis B virus(HBV) belongs to Hepadnaviridae family and mainly infects hepatocytes, which can cause acute or chronic hepatitis. Currently, two types of antiviral drugs are approved for chronic infection clinically: interferons and nucleos(t)ide analogues. However, the clinical cure for chronic infection is still rare, and it is a huge challenge for all researchers to develop high-efficiency, safe, non-tolerant, and low-toxicity anti-HBV drugs. Antazoline hydrochloride is a first-generation antihistamine with anticholinergic properties, and it is commonly used to relieve nasal congestion and in eye drops. Recently, an in vitro high-throughput evaluation system was constructed to screen nearly 800 compounds from the Food and Drug Administration(FDA)-approved Drug Library. We found that arbidol hydrochloride and antazoline hydrochloride can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC_(50) of4.321 lmol/L and 2.910 lmol/L in HepAD38 cells, respectively. Moreover, the antiviral effects and potential mechanism of action of antazoline hydrochloride were studied in different HBV replication systems. The results indicate that antazoline hydrochloride also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells,with an EC_(50) of 2.349 lmol/L. These findings provide new ideas for screening and research related to HBV agents. | Jing Li Yangyang Hu Yifei Yuan Yinan Zhao Qiqi Han Canyu Liu Xue Hu Yuan Zhou Yun Wang Yu Guo Chunchen Wu Xinwen Chen Rongjuan Pei | 2021 | Virologica Sinica2021，36，3： | 0 |
| 13 | Typhoon Case Comparison Analysis Between Heterogeneous Many-Core and Homogenous Multicore Supercomputing Platforms显示文摘In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homogenous multicore(Intel)supercomputing platforms.We construct a hindcast of Typhoon Lekima on both the SW and Intel platforms,compare the simulation results between these two platforms and compare the key elements of the atmospheric and ocean modules to reanalysis data.The comparative experiment in this typhoon case indicates that the domestic many-core computing platform and general cluster yield almost no differences in the simulated typhoon path and intensity,and the differences in surface pressure(PSFC)in the WRF model and sea surface temperature(SST)in the short-range forecast are very small,whereas a major difference can be identified at high latitudes after the first 10 days.Further heat budget analysis verifies that the differences in SST after 10 days are mainly caused by shortwave radiation variations,as influenced by subsequently generated typhoons in the system.These typhoons generated in the hindcast after the first 10 days attain obviously different trajectories between the two platforms. | LIU Xin YU Xiaolin ZHAO Haoran HAN Qiqi ZHANG Jie WANG Chengzhi MA Weiwei XU Da | 2023 | Journal of Ocean University of China2023，22，2： | 0 |
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