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| 1 | Design of Vibrio 16S rRNA Gene Specific Primers and Their Application in the Analysis of Seawater Vibrio Community显示文摘类 Vibrio 原因 vibriosis 的病原的种, maricultured 动物和海味消费者的最流行的疾病之一。在海味生产的链监视他们的动力学,处理并且消费为食物和海洋生物养殖安全是很重要的。为了充实代表 Vibrio 16S ribosomal RNA 基因(rDNA ) ,碎裂并且识别进一步真实及时的这些细菌并且同时地在在链的细菌的植物群之中,有选择地放大 Vibrio 16S rDNA 碎片的一双教材与他们在海水 Vibrio 的分析证明的特性和报道被设计社区。二份教材, VF169 和 VR744 的 Thespecificities 和范围,被使用强风节目在在 GenBank 可得到的细菌的 16S rDNAs 之中理论上决定,实际上,由放大 Vibrio16S, rDNA 从海水 DNA 碎裂。超过 88.3% 序列在 GenBank,与 VR744 显示出相同火柴,属于 Vibrio 类。33 克隆的一个总数随机被选择并且定序。所有序列显示出他们的最高的类似到并且多样的已知的 Vibrio 种类在那些附近聚类。设计的教材能够检索宽范围 ofVibrio 16S rDNA 在海水在细菌的植物群之中明确地碎裂,海味耕作的最重要的自然环境。 | LIU Yong YANG Guanpin WANG Hualei CHEN Jixiang SHI Xianming ZOU Guiwei WEI Qiwei SUN Xiuqin | 2006 | Journal of Ocean University of China2006，5，2： | 5 |
| 2 | Impact of Land Use Change on Vegetation Carbon Storage During Rapid Urbanization:A Case Study of Hangzhou,China显示文摘Land use changes have significant impacts on the carbon balance in an urban ecosystem.When there is rapid development in urbanizing regions,land use changes have a dramatic effect on vegetation carbon storage(VCS).This study investigates the impact of land use change on VCS in a period of rapid urbanization in Hangzhou,China.The results show that:1)from 2000 to 2015,land use in Hangzhou underwent huge changes,mainly reflected in decrease in cropland and wetland and the increased settlement.More than 34.58%of the land was transformed,and the land use changes are primarily characterized by a significant decrease in cropland due to the occupation by settlement.2)over the 15 years,changes in land use led to a decrease of 3.93×10^(5) t of VCS in the urban ecosystem.The large-scale transformation of cropland and wetland,which have a comparatively high carbon density,into land for settlement exerted a negative impact on VCS.3)The central city,which with the Circle-E/I/O mode,had the lowest comprehensive land use dynamic degree,leading to moderate land use change and an increase in VCS;Yuhang and Xiaoshan,which with Multicore-E/O/I mode and Fan-E/O/I modes,had a higher comprehensive land use dynamic degree,drastic changes in land use,and a decrease in VCS.This study proposes a reliable method of estimating changes in VCS,clarifies the relationship between land use change and VCS during rapid urbanization,and provides recommendations for sustainable urban development. | WANG Zhi XU Lihua SHI Yijun MA Qiwei WU Yaqi LU Zhangwei MAO Liwei PANG Enqi ZHANG Qi | 2021 | Chinese Geographical Science2021，31，2： | 3 |
| 3 | SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi Qiwei Zhai | 2007 | Cell Metabolism2007，，4： | 3 |
| 4 | SIRT1 Improves Insulin Sensitivity under Insulin - Resistant Conditions by Re- pressing PTP1 B 显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi and Qiwei Zha | 2007 | Cell Metabolism2007，6，： | 1 |
| 5 | A novel co-precipitation synthesis of a new phosphor Lu2O3:Eu^3+ 显示文摘 | CHEN Qiwei SHI Ying AN Liqiong | 2007 | J Eur Ceram Soc2007，27，1： | 1 |
| 6 | SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi Qiwei Zhai | 2007 | Cell Metabolism2007，，4： | 1 |
| 7 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 8 | A new concept of endoscopic lung cancer resection: Single-direction thoracoscopic lobectomy显示文摘 | Lunxu Liu Guowei Che Qiang Pu Lin Ma Yigen Wu Qiwei Kan Xuepeng Zhuge Lu Shi | 2009 | Surgical Oncology2009，，2： | 1 |
| 9 | Stable perovskite solar cells with 23.12% efficiency and area over 1 cm^(2) by an all-in-one strategy显示文摘To realize the commercialization of perovskite solar cells(PSCs), it is required to overcome the remaining challenges in device enlargement and operational stability. Here, we report an all-in-one strategy by integrating the oxidation of hole-transport material(HTM) with the formation of the passivation layer, which simultaneously solved the stability issues caused by HTM oxidation and realized the uniform defects in passivation over a large area. The resulting devices achieved a certified PCE of23.12% on average with an aperture area of 1.04 cm^(2) and are reproducible with high operational stability because of the exclusion of air exposure, hygroscopic Li-TFSI, and the lithium-based wastes, maintaining ca. 90% of their initial PCEs after operation at the maximum power point under continuous 1 sun illumination for 1,600 h. Our strategy simplifies the fabrication process of PSCs, which is compatible with commercial-scale methods, offering facile access to efficient and stable large-area PSCs. | Hongzhen Su Xuesong Lin Yanbo Wang Xiao Liu Zhenzhen Qin Qiwei Shi Qifeng Han Yiqiang Zhang Liyuan Han | 2022 | Science China Chemistry2022，65，7： | 0 |
| 10 | Discovery and development of ferrocene-based tetradentate ligands for Ir-catalysed asymmetric hydrogenation of ketone显示文摘The development of highly active and enantioselective ligands and catalysts for the asymmetric hydrogenation of ketone has been the goal of synthetic chemists for more than fifty years.Herein,a series of ferrocene-based tetradentate ligands were developed and applied in Ir-catalysed asymmetric hydrogenation of ketone.The hydrolytic ring-opening of the oxazoline moiety of ligand f-amphox leads to the accidental discovery of a highly efficient and enantioselective tetradentate ligand f-phamidol which showed extraordinarily high reactivity and enantioselectivity(up to 99%yield,up to>99%ee and up to 1,000,000 TON).In addition,two types of other tetradentate ligands f-phamida and f-phamide were also synthesized and evaluated. | Jianfei Yu Fanping Huang Wei Fang Congcong Yin Chuan Shi Qiwei Lang Gen-Qiang Chen Xumu Zhang | 2022 | Green Synthesis and Catalysis2022，3，2： | 0 |
| 11 | GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer显示文摘Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer. | Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 12 | Trigger System for γ-ray Total Absorption BaF2 Facility显示文摘The γ-ray total absorption facility(GTAF)is designed to measure the cross-sections of theneutron radioactive capture reactions by online method,in which the data acquisition system is developed based on the flash analog-to-digital converter(FADC).The digital total waveform acquisition method is used.The trigger | HE Guozhu PENG Meng SHI Bin ZHANG Qiwei LUO Hong BAO Jie LI Xia RUAN Xichao NIE Yangbo HUANG Hanxiong REN Jie ZHOU Zuying TANG Hongqing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 13 | Study on Neutron Capture Reaction Cross-section Measurement显示文摘Theγ-ray total absorption BaF2facility was constructed to measure the neutron capture crosssection with high precision.An neutron source experimental condition of keV energy range was set up through the ~7Li(p,n)7Be reaction,based on the HI-13tandem accelerator providing the pulsed proton beam.The lithium target for | HE Guozhu SHI Bin ZHANG Qiwei RUAN Xichao NIE Yangbo HUANG Hanxiong REN Jie ZHOU Zuying TANG Hongqing | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | Design of Neutron Source Based on HI-13 Tandem Accelerator显示文摘Neutron source of keV energy range will be built via ~7Li(p,n)~7Be reaction based on pulsed proton beam of HI-13tandem accelerator at China Institute of Atomic Energy.HI-13tandem accelerator can provide frequency of 6 MHz,pulse width of 2ns,average beam intensity of about 1μA,and the lowest end voltage of 3 | ZHANG Qiwei HE Guozhu SHI Bin RUAN Xichao ZHOU Zuying WANG Yali | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 15 | Nutrition in Alzheimer's disease:a review of an underappreciated pathophysiological mechanism显示文摘Alzheimer's disease(AD)is the leading cause of dementia in older individuals and is an escalating challenge to global public health.Pharmacy therapy of AD is one of the well-funded areas;however,little progress has been made due to the complex pathogenesis.Recent evidence has demonstrated that modifying risk factors and lifestyle may prevent or delay the incidence of AD by 40%,which suggests that the management should pivot from single pharmacotherapy toward a multipronged approach because AD is a complex and multifaceted disease.Recently,the gut-microbiota-brain axis has gained tremendous traction in the pathogenesis of AD through bidirectional communication with multiple neural,immune,and metabolic pathways,providing new insights into novel therapeutic strategies.Dietary nutrition is an important and profound environmental factor that influences the composition and function of the microbiota.The Nutrition for Dementia Prevention Working Group recently found that dietary nutrition can affect cognition in AD-related dementia directly or indirectly through complex interactions of behavioral,genetic,systemic,and brain factors.Thus,considering the multiple etiologies of AD,nutrition represents a multidimensional factor that has a profound effect on AD onset and development.However,mechanistically,the effect of nutrition on AD is uncertain;therefore,optimal strategies or the timing of nutritional intervention to prevent or treat AD has not been established.Thus,this review summarizes the current state of knowledge concerning nutritional disorders,AD patient and caregiver burden,and the roles of nutrition in the pathophysiology of AD.We aim to emphasize knowledge gaps to provide direction for future research and to establish optimal nutrition-based intervention strategies for AD. | Jiwei Jiang Hanping Shi Shirui Jiang Anxin Wang Xinying Zou Yanli Wang Wenyi Li Yuan Zhang Mengfan Sun Qiwei Ren Jun Xu | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 16 | Spatial sight analysis of Hangzhou Xiaoyingzhou based on tourists’landscape preference显示文摘Tourist preferences are important for the high-quality planning and design of recreation spaces.The famous scenic locale of West Lake in Hangzhou,China,is used as an example in this study.Based on multi-source data(e.g.,online comments,and tourist photographs),we used content analysis,kernel density estimation,and image semantic segmentation technology to determine the spatial distribution of tourists’landscape preferences.We analyzed these spatial sight characteristics from the viewpoint,sight distance,and perspectives.The results show that tourists’landscape preferences are mainly concentrated on landscape architecture for recreation.The viewpoints of these preferences are concentrated in the north-south embankmentdfar beyond that of the east-west embankment.The preferences also show a spatial sequence in terms of sight distance,and the best visual effect is the open platform at the north and south islands of Xiaoyingzhou.From the perspective of vision,the degree of spatial openness in the tourists’landscape preferences is proportional to the distance of vision;the two factors have a convergent relationship.The discussion of the characteristics of tourists’landscape preference and space sight creation in Xiaoyingzhou provides a reference for the quality improvement of island recreation space. | Yiying Chen Qiwei Ma Lihua Xu Yijun Shi Zhangwei Lu Yaqi Wu Mao Feng | 2023 | Frontiers of Architectural Research2023，12，6： | 0 |
| 17 | Methods and Case Studies of Ultra-deep Fault Seal Evaluation显示文摘Fault seals are significant for petroleum exploration and production.This study summarizes the fault sealing impacting factors,including lithological juxtaposition,mud smearing,fault rocks and the fault plane stress states,as well as evaluation methods like Allan maps and Shale Gouge Ratio(SGR).The seal evaluation for a wrench fault focuses on its particular structural features.The evaluation methods were applied to the Jinma-Yazihe structure and the Shunbei oilfield.The source rock is the Xujiahe Formation of the Upper Triassic,the reservoirs and caprocks being of the Shaximiao Formation of the Lower Jurassic.The fault sealing evaluations in major faults proved the reservoir formation processes in the wells Jinfo 1(JF1)and Chuanya 609(CY-609),based on the editions of the Allan map showing lithological juxtaposition,the calculation of SGR showing mud smear and analyses of fault stress states.The analyses of stress states were also applied to Shunbei 5 strike-slip fault in the Shunbei area in Tarim Basin.The various sections along the fault were of different mechanical properties,such as compression and extension.Petroleum exploration has demonstrated that the extensional sections are more favorable for oil accumulation than the compressional sections.These evolutionary methods and other understandings will help in analyses of deep fault sealing. | CHEN Shuping YU Yixin CHEN Shi WANG Xinpeng FENG Guimin YUAN Haowei GOU Qiwei XU Shidong ZHAO Huaibo KONG Linghua | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 0 |
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