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| 1 | Trends in particulate matter and its chemical compositions in China from 2013–2017显示文摘Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control strategies.Based on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from 2013-2017.The results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased significantly.The mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,respectively.The mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,respectively.The mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,respectively.The mean concentration of mineral and unresolved chemical components(MI)dropped by 70%,24%and 13%in BTH,the PRD and the Fenhe and Weihe River Plain,respectively.The change in the PM2.5 chemical composition is consistent with the decrease of the PM2.5mass concentration.(3)In 2015,the mean OM concentration contributions to fine particles and coarse particles were 13-46%and 46-57%,respectively,and the mean MI concentration contributions to fine particles and coarse and particles were 31-60%and 39-73%,respectively;these values are lower than the 2013 values from the key regions,which is the most important factor behind the decrease of the particulate matter mass concentration.From 2013 to 2015,among the chemical components of different particle size fractions,the peak value of the coarse particle size fraction decreased significantly,and the fine particle size fractions of SO42-,NO3-,and NH4+decreased with the decrease of the particulate matter mass concentration in different particle size fractions.The fine-particle size peaks of SO42-,NO3-and NH4+shifted from 0.65-1.1μm to the finer size range of0.43-0.65μm during the same time frame. | Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG | 2019 | Science China Earth Sciences2019，62，12： | 23 |
| 2 | The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells显示文摘几研究证明了有自然产品和化疗代理人的联合治疗能改进化疗代理人的 sensitivityand cytotoxicity。Resveratrol,一个自然产品,包括 antitumor andantiviral 活动,以及脉管的保护的效果有许多生物效果。这研究的目的是与 cisplatin 和涉及 A549 房间的潜在的 anticancer 机制在联合调查 resveratrol 的 synergistic anticancereffect。从数 Kit-8 和 isobolographic 分析的房间的 resultsobtained 表明了 resveratrol 和 cisplatin resultedin synergistic 的那联合在 A549 房间的细胞毒素的效果。从染色的 Hoechst 的结果,流动 cytometry 和西方的污点分析 suggestedthat resveratrol 提高了调停 cisplatin 的 apoptosis。同时, LC3-II 和 P62 层次和在有 cisplatin 的联合的 resveratrol 触发了的 autophagosomesuggested 的形成的变化 autophagy。更重要地,由 3-methyladeninemarkedly 禁止 autophagy 稀释了 resveratrol 和 cisplatin 的联合在 A549 房间引起的 apoptosis。一起拿,我们的 studyprovides resveratrol synergistically 与 cisplatin 相结合的第一条证据在 A549 房间经由 modulating autophagiccell 死亡导致 apoptosis。这些调查结果也帮助我们在肺癌症与 chemotherapyagents 在联合理解自然产品的角色。 | Song Hu Xiaolin Li Rongrong Xu Lingyun Ye Hui Kong Xiaoning Zeng Hong Wang Weiping Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 9 |
| 3 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 4 | Current signal amplification strategies in aptamer-based electrochemical biosensor:A review显示文摘Due to their high specificity and affinity towards various targets,along with other unique advantages such as stability and low cost,aptamers are widely applied in analytical techniques.A typical aptamerbased electrochemical biosensor is composed of a aptamer as the biological recognition element and transducer converting the biologic interaction into electrical signals for the quantitative measurement of targets.Improvement of the sensitivity of a biosensor is significantly important in order to achieve the detection of biomolecules with low abundance,and different amplification strategies have been explored.The strategies either employ nanomaterials such as gold nanoparticles to con struct electrodes which can transfer the biological reactions more efficiently,or attempt to obtain enhanced signal through multi-labeled carriers or utilize enzyme mimics to catalyze redox cycling.This review discusses recent advances in signal amplification methods and their applications.Critical assessment of each method is also considered. | Lei He Rongrong Huang Pengfeng Xiao Yuan Liu Lian Jin Hongna Liu Song Li Yan Deng Zhu Chen Zhiyang Li Nongyue He | 2021 | Chinese Chemical Letters2021，32，5： | 3 |
| 5 | Current status,trends,and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019显示文摘Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC. | Shimin Chen Ke Han Yang Song Shaohua Liu Xuehang Li Shengshu Wang Haowei Li Rongrong Li Jianhua Wang Yao He Miao Liu | 2022 | Chinese Medical Journal2022，，14： | 2 |
| 6 | Magnetofection:Magic magnetic nanoparticles for efficient gene delivery显示文摘Magnetic nanoparticles(MNPs)have become a research hotspot and widely used in the biomedical field in recent decades due to their unique magnetic properties.This minireview summarizes the specific gene transfection of magnetic particles(magnetofection)during eversy dynamic process of gene delivery(gene binding,cellular uptake,endosomal escape,intracellular trafficking and in vivo targeting).Meanwhile,the synergistic biomedical application of magnetofection and the effects of MNPs have also been discussed,including magnetic resonance imaging(MRI),magnetic mediated hyperthermia(MMH),Fenton reaction and autophagy.Finally,the clinical prospect of magnetofection was briefly expected. | Qunjie Bi Xu Song Ao Hu Tianying Luo Rongrong Jin Hua Ai Yu Nie | 2020 | Chinese Chemical Letters2020，31，12： | 2 |
| 7 | Surface activated carbon nanospheres for fast adsorption of silver ions from aqueous solutions显示文摘 | Xianghua Song Poernomo Gunawan Rongrong Jiang Susanna Su Jan Leong Kean Wang Rong Xu | 2011 | Journal of Hazardous Materials2011，，： | 2 |
| 8 | Iron oxide nanoparticles promote vascular endothelial cells survival from oxidative stress by enhancement of autophagy显示文摘Dextran-coated superparamagnetic iron oxide nanoparticles(Dex-SPIONs)are excellent magnetic resonance imaging contrast agents for disease diagnosis and therapy.They can be delivered to target tissues mainly though vascular endothelium cells,which are major targets of oxidative stress.In cardiovascular cells,autophagy serves primarily on a pro-survival approach that protects the cells from oxidative stress even some autophagy inducers have been developed for adjuvant therapy of cardiovascular disorders.Our study demonstrated that the nanoparticles could be taken up by human umbilical vein endothelial cells(HUVECs)without causing obvious cytotoxicity but triggering autophagy.Furthermore,our results revealed that Dex-SPIONs could enhance HUVECs survival and reverse the reduction of nitric oxide secretion under the condition of H2O2 damage.However,these effects could be diminished by the autophagy inhibitor.In particular,we discovered that Dex-SPIONs evoked autophagy in HUVECs by reducing the phosphorylation of PRAS40,an upstream regulator of autophagy initiation.These results suggested that Dex-SPIONs functions as an autophagic-related antioxidant in HUVECs which may be utilized as an adjuvant therapy to cardiovascular disease associated with oxidative stress. | Jimei Duan Jiuju Du Rongrong Jin Wencheng Zhu Li Liu Li Yang Mengye Li Qiyong Gong Bin Song James MAnderson and Hua Ai | 2019 | Regenerative Biomaterials2019，6，4： | 2 |
| 9 | The aptamers generated from HepG2 cells显示文摘Liver cancer, as the second cause of cancer death all around the world, resulted in a series of chronic liver diseases. More than 80%of the patients cannot receive effective treatment because of their advanced disease or poor liver function. It is time to improve early clinical diagnosis and find optimal therapeutic treatments. As the tumor cells behave differently from the cell-surface molecules, it is necessary to find a highly specific probe. The aptamers, known as 'chemical antibodies', can bind to their target molecules with high affinity and high specificity. The apatmers were obtained by Cell-SELEX, which was aimed at finding the aptamers against whole living cells. In the article, after 19 selections, the ssDNA pool was cloned and sequenced. After that, six aptamers were obtained, named apt_A to apt_F. By incubating the aptamers with different cells, except apt_E, the other aptamers showed high specificity. As for apt_E, which showed high affinity to several cancer cells, was a potential probe for the common protein presented by several different cancer cells. The equilibrium dissociation constants(Kd) were evaluated by measuring the flow cytometry signal that characterized the binding ability of aptamers to the target cells at a series of concentrations ranging from 46.3(4.5) nM to 199.4(44.2) nM, which exposed the high binding affinities of these aptamers. The research in the confocal fluorescence images further confirmed the specificity of these aptamers and the fact that the aptamers were combined with the targets on the cell-surface. | Rongrong Huang Zhongsi Chen Mei Liu Yan Deng Song Li Nongyue He | 2017 | Science China Chemistry2017，60，6： | 2 |
| 10 | Xylo-Oligosaccharide Preparation through Enzyme Hydrolysis of Hemicelluloses Isolated from Press Lye显示文摘The emerging food additive, xylo-oligosaccharide(XOSs), was prepared through enzymatic hydrolysis of hemicelluloses isolated from press lye. Two of the three experimental enzyme preparations presented favourable effects, while the other one consisting of the nominal enzyme preparations with high enzyme activity was found to have poor catalytic effects. The conversion of xylan exceeded 40% and the selectivity for XOSs reached 90% when the temperature, hemicellulose concentration, dosage of enzymes, and hydrolysis time were 40?C, 100 g/L, 1 ku/g, and 4 h, respectively. Xylo-oligosaccharide preparation through enzymatic hydrolysis of hemicelluloses isolated from press lye was proved to be a feasible process to utilize the by-product of the lye regeneration, which will substantially improve the economy of the lye regeneration and recycling. | WANG Tiangui LI Chuang FAN Rongrong SONG Mengmeng | 2018 | Grain & Oil Science and Technology2018，1，4： | 1 |
| 11 | Sur- face activated carbon nanospheres for fast adsorption of silver ions from aqueous solutions显示文摘 | Song Xianghua Gunawan Poernomo Jiang Rongrong | 2011 | Journal of Hazardous Materi- als2011，194，： | 1 |
| 12 | Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery显示文摘The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers. | Xiaobing Chen Huan Yang Xu Song Hong Liang Yu Wei Jiao Lu Matthias Barz Rongrong Jin Yu Nie | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 13 | Coupler dynamic performance analysis of heavy haul locomotives显示文摘 | MA Weihua LUO Shihui SONG Rongrong | | 0，，3： | 1 |
| 14 | Enhancing radi- osensitivity of human pulmonary adenocarcinoma cell line A549 by CpG ODN1826 显示文摘 | Li RongRong Song YiPing Chen WanTao | 2011 | Cancer Biother Radiopharm2011，26，1： | 1 |
| 15 | Mineral element concentrations in grains of Chinese wheat cultivars显示文摘 | Yong Zhang Qichao Song Jun Yan Jianwei Tang Rongrong Zhao Yueqiang Zhang Zhonghu He Chunqin Zou Ivan Ortiz-Monasterio | 2010 | Euphytica2010，，3： | 1 |
| 16 | Analysis ofwheel set longitudinal vibration and the correlateddynamic performance显示文摘 | MA Weihua LUO Shihui SONG Rongrong | 2011 | Applied Mechanics andMaterials2011，5254，： | 1 |
| 17 | Surface activated carbon nanospheres for fast adsorption of silver ions from aqueous solutions显示文摘 | Song Xianghua Gunawan P Jiang Rongrong | 2011 | Journal of Hazardous Materials2011，194，： | 1 |
| 18 | Study on im- proved fuzzy immune PID controller for maglev transporta- tion system with track irregularity 显示文摘 | Song Rongrong Ma Weihua Chen Zili | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 19 | Surface activated carbon nanospheres for fast adsorption of silver ions from aqueous solutions显示文摘 | Xianghua Song Poernomo Gunawan Rongrong Jiang Susanna Su Jan Leong Kean Wang Rong Xu | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 20 | FISH-based “pan” and “core” karyotypes reveal genetic diversification of Roegneria ciliaris显示文摘The genus Roegneria was firstly established with Roegneria caucasica C.Koch as the model species.Being the largest genera in the tribe Triticeae(Poaceae),Roegneria includes 130 species mainly distributed in the north temperate zone.There are 70 Roegneria species and 22 variants,which are widely distributed in different regions of China(Lei,2018).The diversified morphology of Roegneria species has caused controversy in their taxonomy.It has been argued whether Roegneria species should be included in the genus Elymus or considered as an independent genus(Lei et al.,2018).The investigation of the cytological and genomic feature would help to clarify the taxonomic placement of Roegneria. | Menghao Cheng Xingyue Li Huimin Cui Haojie Sun Tianshuo Deng Xinying Song Rongrong Song Tong Wang Zongkuan Wang Haiyan Wang Xiue Wang | 2023 | Journal of Genetics and Genomics2023，50，2： | 1 |
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