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| 1 | Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis显示文摘Acyl-CoA:cholesterol acyltransferase (ACAT ) 从胆固醇和长链的 fatty-acyl-coenzyme A 催化 cholesteryl 酉旨的形成。在单个房间的水平, ACAT 用作细胞内部的胆固醇动态平衡的一个管理者。另外, ACAT 在肝和小肠为脂蛋白汇编供应 cholesteryl 酉旨。在病理学的条件下面, ACAT 在巨噬细胞生产的 cholesteryl 酉旨的累积贡献泡沫房间形成,动脉粥样硬化的早阶段的一个特点。探讨 ACAT 和 ACAT 禁止者的各种各样的方面的几评论是可得到的。这评论简短在人的 ACAT 的生物化学的性质上构画出当前的知识,然后集中于对动脉粥样硬化为药品的干预作为一个药目标讨论 ACAT 的优点。 | Catherine CHANG Ruhong DONG Akira MIYAZAKI Naomi SAKASHITA Yi ZHANG Jay LIU Michael GUO Bo-Liang LI Ta-Yuan CHANG | 2006 | Acta Biochimica et Biophysica Sinica2006，38，3： | 13 |
| 2 | A closed-loop process for recycling LiNi_xCo_yMn_((1-x-y))O_2 from mixed cathode materials of lithium-ion batteries显示文摘With the rapid development of consumer electronics and electric vehicles(EV), a large number of spent lithium-ion batteries(LIBs) have been generated worldwide. Thus, effective recycling technologies to recapture a significant amount of valuable metals contained in spent LIBs are highly desirable to prevent the environmental pollution and resource depletion. In this work, a novel recycling technology to regenerate a LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2 cathode material from spent LIBs with different cathode chemistries has been developed. By dismantling, crushing,leaching and impurity removing, the LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2(selected as an example of LiNi_xCo_yMn_(1-x-y)O_2) powder can be directly prepared from the purified leaching solution via co-precipitation followed by solid-state synthesis. For comparison purposes, a fresh-synthesized sample with the same composition has also been prepared using the commercial raw materials via the same method. X-ray diffraction(XRD), scanning electron microscopy(SEM) and electrochemical measurements have been carried out to characterize these samples. The electrochemical test result suggests that the re-synthesized sample delivers cycle performance and low rate capability which are comparable to those of the freshsynthesized sample. This novel recycling technique can be of great value to the regeneration of a pure and marketable LiNi_xCo_yMn_(1-x-y)O_2 cathode material with low secondary pollution. | Rujuan Zheng Wenhui Wang Yunkun Dai Quanxin Ma Yuanlong Liu Deying Mu Ruhong Li Jie Rena Changsong Dai | 2017 | Green Energy & Environment2017，2，1： | 11 |
| 3 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 4 | Effect of Biodiesel Soot on Tribological Behavior of Liquid Paraffin显示文摘Biodiesel soot(BDS) was collected from the combustion of biodiesel using a self-made soot trap. The effect of BDS on the tribological behavior of liquid paraffin(LP) was investigated using a four-ball tribometer. A rotating viscometer was used to investigate the effect of BDS on the viscosity of LP. The morphology, composition, and tribological mechanism of BDS were studied by means of FETEM, XRD, XPS, SEM/EDS, and the 3D laser scanning microscopy. Test results showed that the BDS aggregates were chain-like, and the average diameter of BDS was 35 nm. The BDS existed in the form of graphitic layers and amorphous carbon. The oxygen-containing functional groups in BDS consisted of the(C-O-C) and(C-O-H). With an increasing BDS content, the dynamic viscosity of LP increased and the maximum non-seizure load increased initially and became stable later. In addition, the average wear scar diameter(AWSD) of LP increased and the average friction coefficient of LP decreased at first and then increased later. The tribological mechanisms could be ascribed to the variation in content of BDS: BDS could act as a friction modifier for a lower friction coefficient in case of low BDS content. However, the BDS aggregates could lead to increase of abrasive wear to influence the lubricating oil film at higher content of BDS, which would reduce the friction reduction ability and wear resistance of LP. | Li Chuan Wei Daozhu Zhuang Yuan Song Ruhong Hu Xianguo | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，3： | 3 |
| 5 | Surface characterization of steel/steel contact lubricated by PA06 with novel black phosphorus nanocomposites显示文摘In the present work,two types of novel nano additives,titanium sulfonate ligand/black phosphorus(TiLi/BP)and titanium dioxide/black phosphorus(TiCVBP)nanocomposites,were prepared.The tribological behavior of the steel/steel friction pairs lubricated by polyalphaolefins type 6(PA06)containing the nanocomposites under boundary lubrication was studied.The worn surfaces were analyzed using modem surface techniques.The experimental results show that the rubbed surfaces became smooth and showed little wear with the addition of the nanocomposites.TiO_(2)/BP nanocomposites can significantly improve the lubricity of BP nanosheets under high contact stress.The synergistic roles of the load-bearing abilities and rolling effect of TiO_(2) nanoparticles,the slip induced by the BP with its layered structure,and the establishment of a tribofilm on the sliding interface are the basis of the tribological mechanisms. | Zhiheng LUO Jingyuan YU Yufu XU He XI Gang CHENG Lulu YAO Ruhong SONG Karl D DEARN | 2021 | Friction2021，9，4： | 2 |
| 6 | Genome editing and animal models显示文摘Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal,and provides an extremely powerful tool to dissect the molecular mechanisms of disease.Transgenic mouse models made by microinjection of DNA into zygotic pronuclei in particular have been widely used by the genetics community for 30 years.However,it remains a rather crude approach:injected sequences randomly insert in multiple copies as concatamers,they can be mutagenic,and they have variable or silenced expression depending on the site of integration,a phenomenon called position effects.As a result,multiple lines are required in order to confirm appropriate transgene expression.This can be partially overcome by flanking transgenes with insulator sequences to protect the transgene from the influence of the surrounding regulatory elements.Large(\300 kb)BACbased transgenic vectors have also been shown to be more resistant to position effects.However,animals carrying extra copies of fairly large regions of the genome could have unpredictable phenotypes.The most effective method used to control for position effects is to target transgene insertion to specific genomic loci,the so-called targeted transgenesis;for instance,the fast,site-specific transgenic technology Targatt TM.The purpose of this review is to provide an overview on the current existing methods for making targeted transgenic mouse models. | Ruby Yanru Chen-Tsai Ruhong Jiang Luping Zhuang Junfeng Wu Lingsong Li Jiarui Wu | 2014 | Chinese Science Bulletin2014，59，1： | 2 |
| 7 | CHH methylation of genes associated with fatty acid and jasmonate biosynthesis contributes to cold tolerance in autotetraploids of Poncirus trifoliata显示文摘Polyploids have elevated stress tolerance,but the underlying mechanisms remain largely elusive.In this study,we showed that naturally occurring tetraploid plants of trifoliate orange(Poncirus trifoliata(L.) Raf.) exhibited enhanced cold tolerance relative to their diploid progenitors.Transcriptome analysis revealed that whole-genome duplication was associated with higher expression levels of a range of well-characterized cold stress-responsive genes.Global DNA methylation profiling demonstrated that the tetraploids underwent more extensive DNA demethylation in comparison with the diploids under cold stress.CHH methylation in the promoters was associated with up-regulation of related genes,whereas CG,CHG,and CHH methylation in the 3’-regions was relevant to gene down-regulation.Of note,genes involved in unsaturated fatty acids(UFAs) and jasmonate(JA)biosynthesis in the tetraploids displayed different CHH methylation in the gene flanking regions and were prominently up-regulated,consistent with greater accumulation of UFAs and JA when exposed to the cold stress.Collectively,our findings explored the difference in cold stress response between diploids and tetraploids at both transcriptional and epigenetic levels,and gained new insight into the molecular mechanisms underlying enhanced cold tolerance of the tetraploid.These results contribute to uncovering a novel regulatory role of DNA methylation in better cold tolerance of polyploids. | Yue Wang Lanlan Zuo Tonglu Wei Yu Zhang Yang Zhang Ruhong Ming Dahro Bachar Wei Xiao Khan Madiha Chuanwu Chen Qijun Fan Chunlong Li Ji-Hong Liu | 2022 | Journal of Integrative Plant Biology2022，64，12： | 2 |
| 8 | Effect of Diesel Soot on the Distribution,Composition and Mechanical Properties of ZDDP Tribofilm显示文摘To investigate the effect of diesel soot on the distribution,composition and mechanical properties of ZDDP tribofilm,a HFRR tribometer was applied to study the tribological performance.Worn surfaces lubricated with ZDDP and soot were analyzed by laser microscopy,SEM/EDS,Raman spectroscopy,XPS,and a nano-indentation equipment.Results show that soot scrapes off the ZDDP tribofilm and can be embedded into the worn surface,leading to the reduction of film thickness and non-uniform distribution of tribofim.The phosphate structure in ZDDP tribofilm changes from short chain pyrophosphate to long chain metaphosphate due to the increased contact stress caused by the soot abrasive wear,which can promote the cross-linking of ZDDP.The hardness(H)and elastic modulus(E)of the worn surfaces increase,while the ratio of hardness to elastic modulus,H/E,decreases,which indicates that the reduction of wear resistance is caused by the soot. | Feng Weimin Song Hui Song Ruhong Yang Bingxun Hu Xianguo | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 2 |
| 9 | Minimal enteral nutrient requirements for intestinal growth in neonatal piglets:how much is enough显示文摘 | Douglas G Burrin Barbara Stoll Ruhong Jiang | 2000 | Am J Clin Nutr2000，71，： | 1 |
| 10 | Biogasification of ricestraw with an anaerobic-phased solids digester system显示文摘 | Zhang Ruhong Zhang Zhiqin | 1999 | Bioresource Technology1999，68，3： | 1 |
| 11 | Reappraise role of lymph node status in patterns of recurrence following curative resection of gastric adenocarcinoma显示文摘Objective: To examine the association between lymph node status and recurrence patterns in completely resected gastric adenocarcinoma.Methods: We retrospectively assessed 1,694 patients who underwent curative gastrectomy from January 2010 to August 2014. Patients stratified according to lymph node status and recurrence patterns among different subgroups were compared.Results: Of all, 517(30.5%) patients developed recurrent disease, and complete data of recurrence could be obtained in 493(95.4%) patients. For p^(N0) patients, the patterns of recurrence were different according to p T stage: locoregional recurrence was most common in patients with p T1-2 disease(57.1%), distant recurrence was most common in patients with p T3 disease(57.1%), and peritoneal recurrence was most common in patients with p T4 a disease(66.7%). For p^(N+) patients, distant metastasis was most common pattern irrespective of p T stage. The site-specific trend of recurrence showed that locoregional recurrence increased within 5 years in patients with p^(N0)-2 disease but plateaued 3 years after surgery in patients with p N3 disease. Time to recurrence was significantly longer for the p^(N0) patients compared with the p^(N+) patients(median: 25 vs. 16 months, P=0.001).Moreover, post-recurrence survival was significantly better for the p^(N0) patients than for the p^(N+) patients(median:12 vs. 6 months, P<0.001), especially in patients with non-peritoneal recurrence, late recurrence, single recurrence,and receipt of potential curative treatment.Conclusions: Among clinicopathologic factors, lymph node status is the most important factor associated with recurrence patterns after curative gastrectomy. Lymph node status may be used as an adjunct in clinical decisionmaking about postoperative therapeutic and follow-up strategies. | Yihui Tang Jianxian Lin Junpeng Lin Jiabin Wang Jun Lu Qiyue Chen Longlong Caolj Mi Lin Ruhong Tu Changming Huang Ping Li Chaohui Zheng Jianwei Xie | 2021 | Chinese Journal of Cancer Research2021，33，3： | 1 |
| 12 | Cancer drug resistance:The central role of the karyotype显示文摘 | Peter D Ruhong L Rainer S | 2007 | Drug Resist Update2007，10，1： | 1 |
| 13 | Auricular reconstruction for microtia: personal 6-year experience based on 350 mierotia ear reconstruc- tions in China显示文摘 | Qun Zhang Ruhong Zhang | 2009 | Plast Reconstr Surg2009，123，3： | 1 |
| 14 | Auricular Reconstruction for Microtia: Personal 6-Year Experience Based on 350 Microtia Ear Reconstructions in China显示文摘 | Qun Zhang Ruhong Zhang Feng Xu Peihong Jin Yilin Cao | 2009 | Plastic and Reconstructive Surgery2009，，3： | 1 |
| 15 | Auricular Reconstruction for Microtia:personal 6-year experience based on 350 microtia ear reconstructions in China显示文摘 | Qun Zhang Ruhong Zhang Feng Xu | | 0，，03： | 1 |
| 16 | Firm elevation of the reconstructed auricle with a retroauricular fascial flap wrapping an EH (a mixture of epoxide acrylate malelic and hydroxyapatite) composite wedge显示文摘 | Qun Zhang Ruhong Zhang Feng Xu Peihong Jin Jinfang Wu Datao Li Wenshin Chin | 2009 | Journal of Plastic Reconstructive & Aesthetic Surgery2009，，9： | 1 |
| 17 | Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish显示文摘Folliculogenesis is essential for production of female gametes in vertebrates.However,the molecular mechanisms underlying follicle development,particularly apoptosis regulation in ovary,remain elusive.Here,we gen erated sox3 knockout zebrafish lines using CRISPR/Cas9.sox3 knockout led to follicle development retardation and a reduced fecundity in females.Comparative analysis of transcriptome between sox3^-/-and wild-type ovaries revealed that Sox3 was invoIved in pathways of ovarian steroidogenesis and apoptosis.Knockout of sox3 promoted follicle apoptosis and obvious apoptosis signals were detected in somatic cells of stages III and IV follicles of sox3^-/-ovaries.Moreover,Sox3 can bind to and activate the promoter of cyp19a1a.Up-regulation of Cyp19a1a expression promoted 17β-estradiol synthesis,which inhibited apoptosis in follicle development.Thus,Sox3 functions as a regulator of Cyp19a1a expression,via 17β-E2 linking apoptosis suppression,which is implicated in improving female fecundity. | Qiang Hong Cong Li Ruhong Ying Heming Lin Jingqiu Li Yu Zhao Hanhua Cheng Rongjia Zhou | 2019 | Protein & Cell2019，10，5： | 1 |
| 18 | Omicron adopts a different strategy from Delta and other variants to adapt to host显示文摘Dear Editor,With the ongoing of Corona Virus Disease 2019(COVID-19)epidemic,new strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)are continuously emerging.After Delta(B.1.617.2)identified in India,Lambda(C.37),Mu(B.1.621),and Omicron(B.1.1.529)were successively found in Peru,Colombia,and Botswana/South Africa,and subsequently defined as variant of interest(VOI)or variant of concern(VOC). | Xiaohong Du Haijun Tang Long Gao Zhao Wu Fang Meng Ruhong Yan Shigang Qiao Jianzhong An Chen Wang F.Xiao-Feng Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 19 | The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma显示文摘 | Chuanyu Wei Wenju Wang Wei Pang Mingyao Meng Lihong Jiang Sha Xue Yanhua Xie Ruhong Li Zongliu Hou | 2014 | Tumor Biology2014，，3： | 1 |
| 20 | Five-Stage Model of the Palaeozoic Crustal Evolution in Xinjiang显示文摘The great majority of the Palaeozoic orogenjc belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitional crust-oceanic crust-convergent transitional crust-new continental crust model. The stage for the extensional transitional crust is a pretty long, independent and inevitable phase. The dismembering mechanism of the basal continental crust becoming an extensional continental crust is delineated by the simple shear model put forward by Wernike (1981). The continental margins on the sides of a gently dipping detachment zone and moving along it are asymmetric: one side is of the nonmagmatic type and the other of the magmatic type with a typical bimodal volcanic formation. In the latter case, however, they were often confused with island arcs. This paper discusses the five-stage process of the crustal evolution of some typical orogenic belts in Xinjiang. | LIU Dequan TANG Yanling ZHOU Ruhong | 1998 | Acta Geologica Sinica(English Edition)1998，72，4： | 1 |
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