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| 1 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 2 | Determination of polyphenolic content and antioxidant activity of kudingcha made from Ilex kudingcha C.J. Tseng显示文摘 | Lixiang Liu Yi Sun Tanguy Laura Xingfei Liang Hong Ye Xiaoxiong Zeng | 2008 | Food Chemistry2008，，1： | 3 |
| 3 | TPC in the leaves of 116 sweet potato ( Ipomoea batatas L.) varieties and Pushu 53 leaf extracts显示文摘 | Wenqing Xu Lixiang Liu Bing Hu Yi Sun Hong Ye Daifu Ma Xiaoxiong Zeng | 2010 | Journal of Food Composition and Analysis2010，，6： | 1 |
| 4 | Frequency upconversion detection of rotational Doppler effect显示文摘We demonstrated an efficient scheme of measuring the angular velocity of a rotating object with the detection light working at the infrared regime.Our method benefits from the combination of second-harmonic generation(SHG)and rotational Doppler effect,i.e.,frequency upconversion detection of rotational Doppler effect.In our experiment,we use one infrared light as the fundamental wave(FW)to probe the rotating objects while preparing the other FW to carry the desired superpositions of orbital angular momentum.Then these two FWs are mixed collinearly in a potassium titanyl phosphate crystal via typeⅡphase matching,which produces the visible secondharmonic light wave.The experimental results show that both the angular velocity and geometric symmetry of rotating objects can be identified from the detected frequency-shift signals at the photon-count level.Our scheme will find potential applications in infrared monitoring. | HAOXU GUO XIAODONG QIU SONG QIU LING HONG FEI LIN YUAN REN LIXIANG CHEN | 2022 | Photonics Research2022，10，1： | 1 |
| 5 | Stability of the virus dynamics model with Beddington-DeAngelis functional response and delays 显示文摘 | XIANG Hong FENG Lixiang HUO Haifeng | 2013 | Appl Math Model2013，37，7： | 1 |
| 6 | Determination of polyphenolic content and antioxidant activity of kudingcha made from Ilex kudingcha C.J. Tseng显示文摘 | Lixiang Liu Yi Sun Tanguy Laura Xingfei Liang Hong Ye Xiaoxiong Zeng | 2008 | Food Chemistry2008，，1： | 1 |
| 7 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 8 | Oxygen vacancies with localized electrons direct a functionalized separator toward dendrite-free and high loading LiFePO_(4)for lithium metal batteries显示文摘The pursuit of high energy density has promoted the development of high-performance lithium metal batteries(LMBs).However,the underestimated but non-negligible dendrites of Li anode have been observed to shorten battery lifespan.Herein,a composite separator(TiO_(2-x)@PP),in which TiO_(2)with electron-localized oxygen vacancies(TiO_(2-x))is coated on a commercial PP separator,is fabricated to homogenize lithium ion transport and stabilize the lithium anode interface.With the utilization of TiO_(2-x)@PP separators,the symmetric lithium metal battery displays enhanced cycle stability over 800 h under a high current density of 8 m A cm^(-2).Moreover,the LMBs assembled with high-loading LiFePO_(4)(9.24 mg cm^(-2))deliver a stable cycling performance over 900 cycles at a rate of 0.5 C.Comprehensive theoretical studies based on density functional theory(DFT)further unveil the mechanism.The favorable TiO_(2-x)is beneficial for facilitating fast Li+migration and impeding anions transfer.In addressing the Li dendrite issues,the use of TiO_(2-x)@PP separator potentially provides a facile and attractive strategy for designing well-performing LMBs,which are expected to meet the application requirements of rechargeable batteries. | Qi An Qing Liu Shimin Wang Lixiang Liu Han Wang Yongjiang Sun Lingyan Duan Genfu Zhao Hong Guo | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 9 | Research Article Acetic acid-mediated rapid cubic-to-hexagonal(α-β)phase transformation for ultra-bright lanthanide-dopedβ-NaYF_(4)nanobioprobes显示文摘Hexagonal-phase NaYF_(4)(β-NaYF_(4))has been acknowledged to be one of the most efficient doping hosts to prepare bright lanthanide-doped luminescent nano-bioprobes for various biomedical applications.However,to date,it remains a great challenge to synthesize ultra-bright lanthanide-dopedβ-NaYF_(4)nano-bioprobes under a low reaction temperature by using conventional synthetic methods.Herein,we first develop an acetic acid(HAc)-mediated coprecipitation method for the preparation of ultrabright lanthanide-dopedβ-NaYF_(4)nanoprobes under a low reaction temperature at 200℃.Based on a series of comparative spectroscopic investigations,we show that the use of HAc in the reaction environment can not only promote the rapidα-βphase transformation of NaYF_(4)host at 200℃ within 1 h but also boost the absolute photoluminescence quantum yield(PLQY)of NaYF_(4)nanocrystals to 30.68%for near-infrared emission and to 3.79%for upconversion luminescence,both of which are amongst the highest values for diverse lanthanide-doped luminescent nanocrystals ever reported.By virtue of their superior nearinfrared luminescence,we achieve optical-guided dynamic vasculature imaging in vivo of the whole body at a high spatial resolution(23.8μm)under 980 nm excitation,indicating its potential for the diagnosis and treatment evaluation of vasculaturerelated diseases. | Shihui Jiang Jianxi Ke Guowei Li Aijun Liu Xiaohan Li Lixiang Ye Feilong Jiang Yongsheng Liu Maochun Hong | 2023 | Nano Research2023，16，7： | 0 |
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