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| 1 | Interaction between the gut microbiome and mucosal immune system显示文摘The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development.The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses,influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies. | Na Shi Na Li Xinwang Duan Haitao Niu | 2017 | Military Medical Research2017，4，3： | 65 |
| 2 | Tapetum Degeneration Retardation is Critical for Aliphatic Metabolism and Gene Regulation during Rice Pollen Development显示文摘作为在 flowering 植物的一个复杂的墙系统,花粉外部墙主要包含脂肪族的 sporopollenin;然而,为综合的机制在花粉期间,开发仍然是不太好的这些油脂的先锋理解。这里,我们在米饭花粉开发期间在脂肪族的新陈代谢和它的规章的角色在米饭表示 tapetum TDR (Tapetum 退化延迟) 的功能上报导基因。电子显微镜学(TEM ) 和扫描电子显微镜学(SEM ) 分析的传播的观察建议那花粉墙形成显著地在 tdr 异种被改变。花药的脂肪族的作文的内容极大地在测试的 GCMS (煤气的 chromatographymass spectrometry ) 揭示的 tdr 异种被改变,特别地在丰满的酸,主要白酒,链烷和链烯积累的更少,和有到在 tdr 的 C35 的从 C29 的碳长度的第二等的白酒的反常增加。Microarray 数据表明通常认为地涉及类脂化合物运输和新陈代谢的一组基因显著地在 tdr 异种被改变,显示在花粉墙的形成的 TDR 的关键角色。另外,大量基因(236 在起来调整的 total154 并且 82 下面调整) 展出了之间的统计上重要的表现差别野类型并且 tdr。除了它在支持 tapetum PCD 的函数, TDR 可能在米饭花粉开发期间在几基本生物进程起关键规章的作用。 | Da-Sheng Zhang Wan-Qi Liang Zheng Yuan Na Li Jing Shi Jue Wang Yu-Min Liu Wen-Juan Yu Da-Bing Zhang | 2008 | Molecular Plant2008，1，4： | 38 |
| 3 | Facile Synthesis and Application of Ag-Chemically Converted Graphene Nanocomposite显示文摘An in situ chemical synthesis approach has been employed to prepare an Ag-chemically converted graphene (CCG) nanocomposite. The reduction of graphene oxide sheets was accompanied by generation of Ag nanoparticles. The structure and composition of the nanocomposites were confirmed by means of transmission electron microscopy (TEM), atomic force microscopy (AFM) and X-ray diffraction. TEM and AFM results suggest a homogeneous distribution of Ag nanoparticles (5-10 nm in size) on CCG sheets. The intensities of the Raman signals of CCG in such nanocomposites are greatly increased by the attached silver nanoparticles, i.e., there is surface-enhanced Raman scattering activity. In addition, it was found that the antibacterial activity of free Ag nanoparticles is retained in the nanocomposites, which suggests they can be used as graphene-based biomaterials. | Jianfeng Shen Min Shi Na Li Bo Yan Hongwei Ma Yizhe Hu Mingxin Ye | 2010 | Nano Research2010，3，5： | 29 |
| 4 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 5 | Ion Channel Genes and Epilepsy:Functional Alteration,Pathogenic Potential,and Mechanism of Epilepsy显示文摘Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations(funotypes), and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene. | Feng Wei Li-Min Yan Tao Su Na He Zhi-Jian Lin Jie Wang Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao | 2017 | Neuroscience Bulletin2017，33，4： | 21 |
| 6 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 7 | Pretreatment with a combination of ligustrazine and berberine improves cardiac function in rats with coronary microembolization显示文摘瞄准:我们证明了 ligustrazine 和 berberine 的联合在老鼠在血小板激活和煽动性的反应上生产更有效的抑制尖锐心肌的梗塞与也相比代理人独自一个。在我们评估了的这研究,在一只老鼠的 ligustrazine 和 berberine 的联合的有益的效果冠的 microembolization (CME ) 为 .Methods 建模:SD 老鼠与 ligustrazine, berberine, ligustrazine+berberine,或 clopidogrel 被对待 2 个星期。当处理完成了时, CME 被钠 laurate 的注射导致进左室,当妨碍上升主动脉时。所有老鼠为血液动力学的大小被把管子插进。血样品为生物化学的分析,流动 cytometry,和 ELISA 被收集。心纸巾为组织病理学说和随后的蛋白质 analyses.Results 被孤立:有 ligustrazine 的联合的预告的处理(27 mg· kg −1·d−1) 和 berberine (90 mg· kg −1·d−1) 显著地改善了心脏的功能,和减少的心肌的坏死,煽动性的房间渗入, microthrombosis 和浆液 CK-MB 在 CME 铺平老鼠。另外,这联合显著地减少了血浆 ET-1 层次和 von Willebrand 因素,禁止的导致自动数据处理的血小板激活,和减少的 TNFα, IL-1β,在浆液的 ICAM-1 和 RANTES 层次和心纸巾。这联合的保护的效果是比 ligustrazine 或 berberine 的那些更突出的到那些积极控制 clopidogrel 独自一个,却可比较(6.75 mg· kg −1·d−1).Conclusion:ligustrazine 和 berberine 的联合显著地经由包含 antiplatelet 和反煽动性的效果的机制在老鼠 CME 模型改进了心脏的功能。 | Ying ZHANG Xiao-juan MA Chun-yu GUO Ming-ming WANG Na KOU Hui-min MAO Da-zhuo SHI | 2016 | Acta Pharmacologica Sinica2016，37，4： | 19 |
| 8 | Ionic Liquid-Assisted One-Step Hydrothermal Synthesis of TiO2-Reduced Graphene Oxide Composites显示文摘我们为可溶的减少的 graphene 氧化物表(RGO ) 和钛氧化物(TiO2 ) 的准备的制造表明了灵巧、有效的策略用一出修改一步舞的 nanoparticle-RGO composites 热水的方法。graphene 氧化物能容易作为 reductant 与维生素酸在 solvothermal 条件下面被减少,这被发现,与 RGO 表面上的 TiO2 粒子的伴随物生长。TiO2-RGO 合成被 Fourier 变换彻底地描绘了红外线的光谱学,拉曼光谱学, X 光检查衍射, X 光检查光电子光谱学,和 thermogravimetric 分析。显微镜学技术(扫描电子显微镜学,原子力量显微镜学,和传播电子显微镜学) 被采用了探查词法特征以及调查 RGO 表的脱落。TiO2-RGO 氢的合成展出优秀光催化进化。 | Jianfeng Shen Min Shi Bo Yan Hongwei Ma Na Li Mingxin Ye | 2011 | Nano Research2011，4，8： | 18 |
| 9 | Combined Transplantation of Neural Stem Cells and Olfactory Ensheathing Cells Improves the Motor Function of Rats with Intracerebral Hemorrhage显示文摘Objective To investigate the effects of combined transplantation of neural stem cells (NSC) and olfactory ensheathing cells(OEC)on the motor function of rats with intracerebral hemorrhage.Methods In three days after a rat model of caudate nucleus hemorrhage was established,NSCs and OEC,NSC,OEC (from embryos of Wistar rats)or normal saline were injected into hematomas of rats in combined transplantation group,NSC group,OEC group,and control group,respectively.Damage of neural function was scored before and in 3,7,14,30 days after operation.Tissue after transplantation was observed by immunocytochemistry staining.Results The scores for the NSC,OEC and co-transplantation groups were significantly lower in 14 and 30 days after operation than in 3 days after operation(P<0.05).The scores for the NSC and OEC groups were significantly lower than those for the control group only in 30 days after operation(P<0.05),while the difference for the NSC-OEC group was significant in 14 days after operation(P<0.05).Immunocytochemistry staining revealed that the transplanted OEC and NSC could survive,migrate and differentiate into neurons,astrocytes,and oligodendrocytes.The number of neural precursor cells was greater in the NSC and combined transplantation groups than in the control group.The number of neurons differentiated from NSC was significantly greater in the co-transplantation group than in the NSC group.Conclusion Co-transplantation of NSC and OEC can promote the repair of injured tissue and improve the motor function of rats with intracerebral hemorrhage. | ZHOU-PING TANG XUE-WEI XIE YUAN-HONG SHI NA LIU SuI-QIANG ZHU ZAI-WANG LI YUN CHEN | 2010 | Biomedical and Environmental Sciences2010，23，1： | 17 |
| 10 | Identification, Genetic Analysis and Mapping of Resistance to Phytophthora sojae of Pm28 in Soybean显示文摘Phytophthora sojae Kanfman and Gerdemann (P. sojae) is one of the most prevalent pathogens and causes Phytophthora root rot, which limits soybean production worldwide. Development of resistant cultivars is a cost-effective approach to controlling this disease. In this study, 127 soybean germplasm were evaluated for their responses to Phytophthora sojae strain Pm28 using the hypocotyl inoculation technique, and 49 were found resistant to the strain. The hypocotyl of P1, P2, F1, and F2:3 of two crosses of Ludou 4 (resistant)×Youchu 4 (susceptible) and Cangdou 5 (resistant)×Williams (susceptible) were inoculated with Pm28, and were used to analyze the inheritance of resistance. The population derived from the cross of Ludou 4×Youchu 4 was used to map the resistance gene (designated as Rps9) to a linkage group. 932 pairs of SSR primers were used to detect polymorphism, and seven SSR markers were mapped near the resistance gene. The results showed that the resistance to Pm28 in Ludou 4 and Cangdou 5 was controlled by a single dominant gene Rps9, which was located on the molecular linkage group N between the SSR markers Satt631 (7.5 cM) and Sat_186 (4.3 cM). | WU Xiao-ling ZHANG Bao-qiang SUN Shi ZHAO Jin-ming YANG Feng GUO Na GAI Jun-yi XING Han | 2011 | Agricultural Sciences in China2011，10，10： | 13 |
| 11 | Fabrication,microstructures,and properties of copper matrix composites reinforced by molybdenum-coated carbon nanotubes显示文摘Multiwalled carbon nanotubes(CNTs) were coated by a molybdenum layer using carbonyl thermal decomposition process with a precursor of molybdenum hexacarbonyl.The Mo-coated CNTs(Mo-CNTs) were added into copper powders to fabricate Mo-CNT/Cu composites by means of mechanical milling followed by spark plasma sintering.The Mo-CNTs were uniform dispersion in the Cu matrix when their contents were 2.5 vol.%-7.5 vol.%,while some Mo-CNT clusters were clearly observed at additions of 10.0 vol.%-15.0 vol.% Mo-CNTs in the mixture.The mechanical,electrical,and thermal properties of the Mo-CNT/Cu composites were characterized,and the results showed that the tensile strength and hardness were 2.0 and 2.2 times higher than those of CNT-free specimens,respectively.Moreover,the Mo-CNT/Cu composites exhibited an enhanced thermal conductivity but inferior electrical conductivity compared with sintered pure Cu.The uncoated CNT/Cu composites were fabricated by the similar processes,and the measured tensile strength,hardness,thermal conductivity,and electrical conductivity of the CNT/Cu composites were lower than those of the Mo-CNT/Cu composites. | NIE Junhui JIA Chengchang JIA Xian ZHANG Yafeng SHI Na LI Yi | 2011 | Rare Metals2011，30，4： | 12 |
| 12 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 13 | ShikaniTM Seeing Optical Stylet-aided tracheal intubation in patients with a large epiglottic cyst显示文摘大 epiglottic 包囊能堵住声门,导致严肃的 consequences.This 状况以航线管理提出挑战因为麻醉学者在 anesthesia.We 的正式就职期间报导看见与 Macintosh 喉镜相结合与这种技术的大 epiglottic cysts.Use 在七个病人帮助气管的 intubation 的光锥刺能避免包囊破裂并且允许的 ShikaniTM 的使用光滑,安全 intubation 。 | LIN Na LI Mei SHI Song LI Tian-zuo ZHANG Bing-xi | 2011 | Chinese Medical Journal2011，，17： | 9 |
| 14 | Aluminum matrix composites reinforced by molybdenum-coated carbon nanotubes显示文摘To extend the application of carbon nanotubes (CNTs) and explore novel aluminum matrix composites,CNTs were coated by molybdenum layers using metal organic chemical vapor deposition,and then Mo-coated CNT (Mo-CNT)/Al composites were prepared by the combination processes of powder mixing and spark plasma sintering.The influences of powder mixing and Mo-CNT content on the mechanical properties and electrical conductivity of the composites were investigated.The results show that magnetic stirring is better than mechanical milling for mixing the Mo-CNTs and Al powders.The electrical conductivity of the composites decreases with increasing Mo-CNT content.When the Mo-CNT content is 0.5wt%,the tensile strength and hardness of Mo-CNT/Al reach their maximum values.The tensile strength of 0.5wt% Mo-CNT/Al increases by 29.9%,while the electrical conductivity only decreases by 7.1%,relative to sintered pure Al.The phase analysis of Mo-CNT/Al composites reveals that there is no formation of Al carbide in the composites. | Jun-hui Nie Cheng-chang Jia Na Shi Ya-feng Zhang Yi Li XianJia | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，6： | 9 |
| 15 | Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction显示文摘Objective To investigate whether recuperating lung decoction(RLD) can modulate the composition of gut microbiota in rats during asthma treatment.Methods Fifteen Sprague-Dawley rats were divided randomly and equally into control group,model group,dexamethasone(DEX) group,RLD medium-dose group,and RLD high-dose group.The asthma model was established in all groups,except for the control group.The rats in the DEX and RLD groups were treated orally with DEX and RLD,respectively.The rats in the control and model groups were treated orally with 0.9% saline.The intestinal bacterial communities were compared among groups using 16 S r RNA gene amplification and 454 pyrosequencing.Results The microbial flora differed between the control and model groups,but the flora in the RLD groups was similar to that in the control group.No significant differences were observed between the RLD high-dose and medium-dose groups.RLD treatment resulted in an increase in the level beneficial bacteria in the gut,such as Lactobacillus and Bifidobacterium spp.Conclusion Oral administration of RLD increased the number of intestinal lactic acid-producing bacteria,such as Lactobacillus and Bifidobacterium,in asthma model rats. | KONG Yan Hua SHI Qi HAN Na ZHANG Ling ZHANG Yuan Yuan GAO Tong Xin CHEN Chen LI You Lin | 2016 | Biomedical and Environmental Sciences2016，29，8： | 9 |
| 16 | Origin of the unusually high dibenzothiophene concentrations in Lower Ordovician oils from the Tazhong Uplift,Tarim Basin,China显示文摘The origin of the unusually high dibenzothiophene (DBT) concentrations in Lower Ordovician oils from the Tazhong Uplift,Tarim Basin was studied by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).The most abundant sulfur compounds in the oils are S 1 species with doublebond equivalent (DBE) values of 1-19 and 11-48 carbon atoms.The range of the number of carbon atoms in the sulfur compounds detected by the FT-ICR MS (S 1 species with DBE=9) is about ten times larger than that for sulfur compounds detected by GC/MS (DBTs).This suggests that FT-ICR MS is a much better approach than GC/MS for characterization of DBTs in crude oils.The abundance of S 1 species with DBE=1-8 decreased with increasing thermal maturity,while the abundance of S 1 species with DBE=9 (primarily DBTs) increased.Therefore,thermal maturity is an important factor in the formation of oils with high DBT concentrations.Unusually high abundances of S 1 species with low DBE values (1-8),which include sulfide,thiophene and benzothiophene,were observed in several oils,especially the TZ83 (O 1) oil with high or very high thermal maturity.Thermochemical sulfate reduction (TSR) was thought to be the reason for the high abundance of these low DBE compounds in deep reservoirs,and thermochemical sulfate reduction could affect the distribution and composition of DBTs in the oils.According to the results of FT-ICR MS analysis,there are no signs that TSR is occurring or has occurred recently for most of the Lower Ordovician oils. | Li Sumei Pang Xiongqi Shi Quan Zhang Baoshou Zhang Haizu Pan Na Zhao Ming | 2011 | Petroleum Science2011，8，4： | 9 |
| 17 | Updated review on immune factors in pathogenesis of Crohn's disease显示文摘Although the incidence of Crohn's disease(CD) in China is not as high as that in European and American countries, there has been a clear increasing trend in recent years. Little is known about its pathogenesis, cause of deferment, and the range of complications associated with the disease. Local and international scholars have presented many hypotheses about CD pathogenesis based on experimental and clinical studies, including genetic susceptibility, immune function defects, intestinal microflora disorders, delayed hypersensitivity, and food antigen stimulation. However, the specific mechanism leading to this immune imbalance, which causes persistent intestinal mucosal damage, and the source of the inflammatory cascade reaction are still unclear. So far, the results of research studies differ locally and internationally. This paper presents the most current research on immune factors in the pathogenesis of CD. | Na Li Rui-Hua Shi | 2018 | World Journal of Gastroenterology2018，24，1： | 9 |
| 18 | Analysis of a Cold Wave Weather Process in Chengdu in March 2010显示文摘[Objective] The aim was to analyze one cold wave weather process in Chengdu in March in 2010.[Method] Based on the NCEP 1°×1° 6 h interval reanalysis data and daily observation data,using synoptic analysis and diagnosis methods,and combining with the cold wave forecast index in spring of Sichuan,a cold wave event covering the whole region between March 21 and 24,2010 was analyzed from the aspects of circulation background,influencing weather systems and weather causation.[Result] Results showed that the 500 high-altitude cold vortex,700-850 hPa low layer shear,and ground cold front were the main systems that influenced this cold wave;there was a ridge from Lake Balkhash across Lake Baikal at 500 hPa.The early stage of the process was controlled by the high pressure ridge and the temperature was increasing obviously.The daily mean temperature was high.The range of cold high pressure was large and the central intensity was 1 043.0 hPa;the cold air was strong and deep which was in accordance with the strong surface temperature reduction center.The strong north airstream of Lake Balkhash to Lake Baikal,ground cold high pressure center intensity changes,north and south ocean pressure and temperature differences,850 hPa temperature changes,cold advection movement route and intensity were considered as reference factors for the forecast of cold wave intensity.[Conclusion] The study provided theoretical basis for improving the forecast ability of cold wave weather. | LI Xin-yi XIE Na SHI Juan LI Yu AN Xia | 2011 | Meteorological and Environmental Research2011，2，6： | 8 |
| 19 | Identifying Metabolite and Protein Biomarkers in Unstable Angina In-patients by Feature Selection Based Data Mining Method显示文摘Unstable angina(UA) is the most dangerous type of Coronary Heart Disease(CHD) to cause more and more mortal and morbid world wide. Identification of biomarkers for UA at the level of proteomics and metabolomics is a better avenue to understand the inner mechanism of it. Feature selection based data mining method is better suited to identify biomarkers of UA. In this study, we carried out clinical epidemiology to collect plasmas of UA in-patients and controls. Proteomics and metabolomics data were obtained via two-dimensional difference gel electrophoresis and gas chromatography techniques. We presented a novel computational strategy to select biomarkers as few as possible for UA in the two groups of data. Firstly, decision tree was used to select biomarkers for UA and 3-fold cross validation was used to evaluate computational performances for the three methods. Alternatively, we combined independent t test and classification based data mining method as well as backward elimination technique to select, as few as possible, protein and metabolite biomarkers with best classification performances. By the method, we selected 6 proteins and 5 metabolites for UA. The novel method presented here provides a better insight into the pathology of a disease. | SHI Cheng-he ZHAO Hui-hui HOU Na CHEN Jian-xin SHI Qi XU Xue-gong WANG Juan ZHENG Cheng-long ZHAO Ling-yan YANG Yi WANG Wei | 2011 | Chemical Research in Chinese Universities2011，27，1： | 8 |
| 20 | I_κB kinase-beta inhibitor attenuates hepatic fibrosis in mice显示文摘AIM: To investigate the anti-fibrosis effect of IκB kinase-beta inhibitor (IKK2 inhibitor IMD0354) in liver fibrosis. METHODS: Twenty male C57BL6 mice were divided into four groups. Five high-fat fed mice were injected with lipopolysaccharide (LPS, 10 mg/kg) intraperitoneally and five high-fat fed mice were without LPS injection to build models of liver injury, and the intervention group (five mice) was injected intraperitoneally with IKK2 inhibitor (IMD 30 mg/kg for 14 d), while the remaining five mice received a normal diet as controls. Hepatic function, pathological evaluation and liver interleukin-6 (IL-6) expression were examined. Western blotting and real-time polymerase chain reaction were used to detect the expressions of nuclear factor-κB (NF-κB), alpha-smooth muscle actin (α-SMA), tumor growth factor-beta1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), typeⅠand type Ⅲ collagen proteins and mRNA. RESULTS: A mouse model of liver injury was successfully established, and IMD decreased nuclear transloca-tion of NF-κB p65 in liver cells. In the IMD-treated group, the levels of alanine aminotransferase (103 ± 9.77 μ/L vs 62.4 ± 7.90 μ/L, P < 0.05) and aminotransferase (295.8 ± 38.56 μ/L vs 212 ± 25.10 μ/L, P < 0.05) were significantly decreased when compared with the model groups. The histological changes were significantly ameliorated. After treatment, the expressions of IL-6 (681 ± 45.96 vs 77 ± 7.79, P < 0.05), TGF-β1 (Western blotting 5.65% ± 0.017% vs 2.73% ± 0.005%, P < 0.05), TNF-α (11.58% ± 0.0063% vs 8.86% ± 0.0050%, P < 0.05), typeⅠcollagen (4.49% ± 0.014% vs 1.90% ± 0.0006%, P < 0.05) and type Ⅲ collagen (3.46% ± 0.008% vs 2.29% ± 0.0035%, P < 0.05) as well as α-SMA (6.19 ± 0.0036 μ/L vs 2.16 ± 0.0023 μ/L, P < 0.05) protein and mRNA were downregulated in the IMD group compared to the fibrosis control groups (P < 0.05). CONCLUSION: IKK2 inhibitor IMD markedly improved non-alcoholic fatty liver disease in mice by lowering NF-κB activation, which could become a remedial target for liver fibrosis. | Jue Wei Min Shi Wei-Qi Wu Hui Xu Ting Wang Na Wang Jia-Li Ma Yu-Gang Wang | 2011 | World Journal of Gastroenterology2011，17，47： | 8 |
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