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| 1 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 2 | Optimal Energy-Efficient Transmission for Hybrid Spectrum Sharing in Cooperative Cognitive Radio Networks显示文摘In order to improve the energy efficiency(EE)in cognitive radio(CR),this paper investigates the joint design of cooperative spectrum sensing time and the power control optimization problem for the secondary user systems to achieve the maximum energy efficiency in a cognitive network based on hybrid spectrum sharing,meanwhile considering the maximum transmit power,user quality of service(QoS)requirements,interference limitations,and primary user protection.The optimization of energy efficient sensing time and power allocation is formulated as a non-convex optimization problem.The Dinkelbach’s method is adopted to solve this problem and to transform the non-convex optimization problem in fractional form into an equivalent optimization problem in the form of subtraction.Then,an iterative power allocation algorithm is proposed to solve the optimization problem.The simulation results show the effectiveness of the proposed algorithms for energy-efficient resource allocation in the cognitive network. | Linna Hu Rui Shi Minghe Mao Zhiyu Chen Hongxi Zhou Weiliang Li | 2019 | China Communications2019，16，6： | 9 |
| 3 | Flexible and transparent triboelectric nanogenerator based on high performance well-ordered porous PDMS dielectric film显示文摘灵活、透明的摩擦电 nanogenerator (FT-TENG ) 在自我动力的生物传感器系统,电子皮肤和便携电子设备为申请有大潜力。然而,与它的光性质的很少损坏改进输出性能是挑战性的。此处,我们开发了有秩序井然的像巢的多孔的 polydimethylsiloxane (NP-PDMS ) 的 FT-TENG 电影和 graphene 透明电极。有订的毛孔的 NP-PDMS 电影被 500 nm 的盐酸的酸的蚀刻制作用聚集的 nanoparticles 做的大小的 ZnO 范围,有 81.8% 的轻发射度和 118.62ichia coli 的一个水接触角度(E。coli ) ,肠球菌(ENT ) 和全部的大肠菌(TC ) 被分析。除了 EC 和没有 3, ,结果揭示了低 concentrati 吗?? | Xianming He Xiaojing Mu Quan Wen Zhiyu Wen Jun Yang Chenguo Hu Haofei Shi | 2016 | Nano Research2016，9，12： | 6 |
| 4 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
| 5 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 6 | Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis显示文摘Tetramethylpyrazine(TMP) is a traditional Chinese herbal medicine with strong antiinflammatory and cartilage protection activities, and thus a promising candidate for treating osteoarthritis. However, TMP is rapidly cleared from the joint cavity after intra-articular injection and requires multiple injections to maintain efficacy. The aim of this study was to encapsulate TMP into poly(lactic-co-glycolic acid)(PLGA) microspheres to enhance the TMP retention in the joint, reducing injection frequencies and decreasing dosage. TMP microspheres were prepared by emulsion/solvent evaporation method. The intra-articular retention of the drug was assessed by detecting the drug concentration distributed in the joint tissue at different time points. The therapeutic effect of TMP microspheres was evaluated by the swelling of knee joints and histologic analysis in papain-induced OA rat model. The prepared freezedried microspheres with a particle size of about 10 μm can effectively prolong the retention time of the drug in the articular cavity to 30 d, which is 4.7 times that of the TMP solution.Intra-articular injection of TMP microspheres efficiently relieved inflammatory symptoms,improved joint lesions and decreased the depletion of proteoglycan. In conclusion, intraarticular injection of TMP loaded microspheres was a promising therapeutic method in the treatment of OA. | Xiuping Zhang Yang Shi Zhiyue Zhang Zhenlei Yang Guihua Huang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，3： | 2 |
| 7 | Blue emitting CsPbBr3 perovskite quantum dot inks obtained from sustained release tablets显示文摘Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine(CsPbClxBr3-x,0 | Hewei Yang Yaqing Feng Zhiyu Tu Kuo Su Xiaozhi Fan Bingjie Liu Zhiping Shi Yuzhe Zhang Chenyang Zhao Bao Zhan | 2019 | Nano Research2019，12，12： | 2 |
| 8 | Anti-hypertensive and endothelia protective effects of Fufang Qima capsule(复方芪麻胶囊) on primary hypertension via adiponectin/adenosine monophosphate activated protein kinase pathway显示文摘OBJECTIVE:To investigate the potential mechanism of the vascular remodeling effect and provide additional information about anti-hypertension activity of Fufang Qima capsule(复方芪麻胶囊,QM).METHODS:Spontaneous hypertensive rats(SHRs)were used to study the underlying mechanism of the anti-hypertension activity of QM.In this study,SHRs were randomly divided into 5 groups:model group,Telmisartan group(7.2 mg/kg,p.o.),and three QM groups(0.9298,1.8596,and 3.7192 g/kg,p.o.).Wistar Kyoto rats(WKY)were used as normal control group.Blood pressure(BP),aorta,perivascular adipose tissue(PVAT)histology were investigated to evaluate the effect of QM.Nitric oxide(NO)and endothelial nitric oxide synthase(eNOS)phosphorylation were measured.Adiponectin(APN)secretion,as well as APN signal pathway proteins including APN,adiponectin receptors(R1 and R2)and adenosine 5’-monophosphate-activated protein kinase(AMPK)were all analyzed.RESULTS:QM significantly reduced BP and ameliorated the vascular pathological change,i.e.intima media thicken and collagen fiber hyperplasia.Meanwhile,QM increased concentration of NO and the phosphorylation of eNOS in the aorta.The anti-hypertensive and endothelia-protective effect of QM could be attributed to activating APN/AMPK pathway by up-regulating the expression of APN in PVAT and APN Receptor 2,AMPKαand phosphorylated AMPKαin the aorta.CONCLUSION:The QM alleviation effect mechanism for primary hypertension was via modulating the APN/AMPK signal pathway. | ZHAO Zhiyue SHI Zhenyu ZHANG Zhenzhen LI Yinghong ZENG Xiaohui CHEN Yuxing YAO Nan ZHOU Min SU Hui WANG Qinghai JIN LiLi | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 2 |
| 9 | MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population显示文摘 | Youchao Jia Aimin Zang Yanhong Shang Hua Yang Zizheng Song Zhiyu Wang Lili Ren Yaning Wei Ling Hu Hongyun Shi Hefei Li | 2014 | Medical Oncology2014，，： | 1 |
| 10 | Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats显示文摘 | Liang Xi Zhiyu Qian Guanglin Xu Shuguo Zheng Sai Sun Na Wen Liang Sheng Yun Shi Yabing Zhang | 2007 | The Journal of Nutritional Biochemistry2007，，1： | 1 |
| 11 | Programmable DNA tile self-assembly using a hierarchical sub-tile strategy显示文摘 | Shi Xiaolong Lu Wei Wang Zhiyu | 2014 | Nanotechnology2014，2，7： | 1 |
| 12 | Study on the intercalation and interlayer oxidation transformation of L cysteine in a confined region of layered double hydroxides 显示文摘 | Wei Min Shi Zhiyu Duan Xue | 2006 | J Mater Chem2006，16，21： | 1 |
| 13 | Structural damage localization from modal strain energy change显示文摘 | Shi Zhiyu Luo Shaoxiang | 1998 | Journal of Sound and Vibration1998，218，5： | 1 |
| 14 | Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model显示文摘Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of BD.In this study,we aimed to develop and validate a model of oxidative stress injury for predicting BD.Data were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid metabolism.Univariate analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable selection.Multivariable logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a nomogram.Internal validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the nomogram.The BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of 0.73.The discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of BD.For better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry. | Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang | 2022 | Neuroscience Bulletin2022，38，9： | 1 |
| 15 | Identifcation of linear time-varying systems using a wavelet-based state-space method显示文摘 | Xu Xin Shi Zhiyu | 2012 | Mechanical Systems and Signal Processing2012，26，： | 1 |
| 16 | Synthesis and crystal structure of the first Cu(I)-benzotrizolate complex [Cu 4 (bta) 3 (PPh 3 ) 4 ][Cu(PPh 3 ) 3 ](BF 4 ) 2 : a unique tetrametallic fragment like a reverse-umbrella显示文摘 | Dan Li Rongzhen Li Zhiyu Qi Xiaolong Feng Jiwen Cai Xuhua Shi | 2001 | Inorganic Chemistry Communications2001，，9： | 1 |
| 17 | A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer显示文摘Enzalutamide(ENZ) is a second-generation androgen receptor(AR) antagonist used for the treatment of castration-resistant prostate cancer(CRPC) and reportedly prolongs survival time within a year of starting therapy. However, CRPC patients can develop ENZ resistance(ENZR), mainly driven by abnormal reactivation of AR signaling, involving increased expression of the full-length AR(ARfl)or dominantly active androgen receptor splice variant 7(ARv7) and ARfl/ARv7 heterodimers. There is currently no efficient treatment for ENZR in CRPC. Herein, a small molecule LLU-206 was rationally designed based on the ENZ structure and exhibited potent inhibition of both ARfl and constitutively active ARv7 to inhibit PCa proliferation and suppress ENZR in CRPC. Mechanically, LLU-206 promoted ARfl/ARv7 protein degradation and decreased ARfl/ARv7 heterodimers through mouse double minute 2-mediated ubiquitination. Finally, LLU-206 exhibited favorable pharmacokinetic properties with poor permeability across the blood-brain barrier, leading to a lower prevalence of adverse effects, including seizure and neurotoxicity, than ENZ-based therapies. In a nutshell, our findings demonstrated that LLU-206 could effectively inhibit ARfl/ARv7-driven CRPC by dual-targeting of ARfl/ARv7 heterodimers and protein degradation, providing new insights for the design of new-generation AR inhibitors to overcome ARfl/ARv7-driven CRPC. | Yan Li Ya Chu Guangjiang Shi Xiaobin Wang Wanli Ye Chun Shan Dajia Wang Di Zhang Wei He Jingwei Jiang Shuqian Ma Yuhong Han Zhili Zhao Shijia Du Zhen Chen Zhiyu Li Yong Yang Chen Wang Xi Xu Hongxi Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 0 |
| 18 | Optimal Energy Efficiency Resource Allocation Strategy for Cognitive Clustering Network under PUEA Attack显示文摘5G has pushed the use of radio spectrum to a new level,and cognitive clustering network can effectively improve the utilization of radio spectrum,which is a feasible way to solve the growing demand for wireless communications.However,cognitive clustering network is vulnerable to PUEA attack,which will lead to the degradation of system detection performance,thereby reducing the energy efficiency.Aiming at these problems,this paper investigates the optimal energy efficiency resource allocation scheme for cognitive clustering network under PUEA attack.A cooperative user selection algorithm based on selection factor is proposed to effectively resist PUEA user attack and improve detection performance.We construct the energy efficiency optimization problem under multi-constraint conditions and transform the nonlinear programming problem into parametric programming problem,which is solved by Lagrangian function and Karush-Kuhn-Tucker condition.Then the sub-gradient iterative algorithm based on optimal energy efficiency under PUEA attack is proposed and its complexity is analyzed.Simulation results indicate that proposed method is effective when subjected to PUEA attacks,and the impact of different parameters on energy efficiency is analyzed. | Linna Hu Ning Cao Rui Shi Xue Cai Minghe Mao Zhiyu Chen | 2020 | China Communications2020，17，10： | 0 |
| 19 | Flexural wave bandgap properties of phononic crystal beams with interval parameters显示文摘Uncertainties are unavoidable in practical engineering,and phononic crystals are no exception.In this paper,the uncertainties are treated as the interval parameters,and an interval phononic crystal beam model is established.A perturbation-based interval finite element method(P-IFEM)and an affine-based interval finite element method(A-IFEM)are proposed to study the dynamic response of this interval phononic crystal beam,based on which an interval vibration transmission analysis can be easily implemented and the safe bandgap can be defined.Finally,two numerical examples are investigated to demonstrate the effectiveness and accuracy of the P-IFEM and A-IFEM.Results show that the safe bandgap range may even decrease by 10%compared with the deterministic bandgap without considering the uncertainties. | Feiyang HE Zhiyu SHI Denghui QIAN Y.K.LU Yujia XIANG Xuelei FENG | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，2： | 0 |
| 20 | In situ formed cross-linked polymer networks as dual-functional layers for high-stable lithium metal batteries显示文摘Lithium-metal anodes(LMAs)have been recognized as the ultimate anodes for next-generation batteries with high energy density,but stringent assembly-environment conditions derived from the poor moisture stability dramatically hinder the transformation of LMAs from laboratory to industry.Herein,an in situ formed cross-linked polymer layer on LMAs is designed and constructed by a facile thiol-acrylate click chemistry reaction between poly(ethylene glycol)diacrylate(PEGDA)and the crosslinker containing multi thiol groups under UV irradiation.Owing to the hydrophobic nature of the layer,the treated LMAs demonstrate remarkable humid stability for more than 3 h in ambient air(70%relative humidity).The coating humid-resistant protective layer also possesses a dual-functional characterization as solid polymer electrolytes by introducing lithium bis(trifluoromethanesulfonyl)imide in the system in advance.The intimate contact between the polymer layer and LMAs reduces interfacial resistance in the assembled Li/LiFePO_(4)or Li/LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)full cell effectively,and endows the cell with an outstanding cycle performance. | Lei Shi Wanhui Wang Chunjuan Wang Yang Zhou Yuezhan Feng Tiekun Jia Fang Wang Zhiyu Min Ji Hu Zhigang Xue | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
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