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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Electronic Skin from High-Throughput Fabrication of Intrinsically Stretchable Lead Zirconate Titanate Elastomer显示文摘Electronic skin made of thin,soft,stretchable devices that can mimic the human skin and reconstruct the tactile sensation and perception offers great opportunities for prosthesis sensing,robotics controlling,and human-machine interfaces.Advanced materials and mechanics engineering of thin film devices has proven to be an efficient route to enable and enhance flexibility and stretchability of various electronic skins;however,the density of devices is still low owing to the limitation in existing fabrication techniques.Here,we report a high-throughput one-step process to fabricate large tactile sensing arrays with a sensor density of 25 sensors/cm^(2) for electronic skin,where the sensors are based on intrinsically stretchable piezoelectric lead zirconate titanate(PZT)elastomer.The PZT elastomer sensor arrays with great uniformity and passive-driven manner enable highresolution tactile sensing,simplify the data acquisition process,and lower the manufacturing cost.The high-throughput fabrication process provides a general platform for integrating intrinsically stretchable materials into large area,high device density soft electronics for the next-generation electronic skin. | Yiming Liu Huanxi Zheng Ling Zhao Shiyuan Liu Kuanming Yao Dengfeng Li Chunki Yiu Shenghan Gao Raudel Avila Pakpong Chirarattananon Lingqian Chang Zuankai Wang Xian Huang Zhaoqian Xie Zhengbao Yang Xinge Yu | 2020 | Research2020，，1： | 11 |
| 3 | The apricot(Prunus armeniaca L.)genome elucidates Rosaceae evolution and beta-carotenoid synthesis显示文摘Apricots,scientifically known as Prunus armeniaca L,are drupes that resemble and are closely related to peaches or plums.As one of the top consumed fruits,apricots are widely grown worldwide except in Antarctica.A high-quality reference genome for apricot is still unavailable,which has become a handicap that has dramatically limited the elucidation of the associations of phenotypes with the genetic background,evolutionary diversity,and population diversity in apricot.DNA from P.armeniaca was used to generate a standard,size-selected library with an average DNA fragment size of~20 kb.The library was run on Sequel SMRT Cells,generating a total of 16.54 Gb of PacBio subreads(N50=13.55 kb).The high-quality P.armeniaca reference genome presented here was assembled using long-read single-molecule sequencing at approximately 70×coverage and 171×Illumina reads(40.46 Gb),combined with a genetic map for chromosome scaffolding.The assembled genome size was 221.9 Mb,with a contig NG50 size of 1.02 Mb.Scaffolds covering 92.88%of the assembled genome were anchored on eight chromosomes.Benchmarking Universal Single-Copy Orthologs analysis showed 98.0%complete genes.We predicted 30,436 protein-coding genes,and 38.28%of the genome was predicted to be repetitive.We found 981 contracted gene families,1324 expanded gene families and 2300 apricot-specific genes.The differentially expressed gene(DEG)analysis indicated that a change in the expression of the 9-cis-epoxycarotenoid dioxygenase(NCED)gene but not lycopene beta-cyclase(LcyB)gene results in a lowβ-carotenoid content in the white cultivar“Dabaixing”.This complete and highly contiguous P.armeniaca reference genome will be of help for future studies of resistance to plum pox virus(PPV)and the identification and characterization of important agronomic genes and breeding strategies in apricot. | Fengchao Jiang Junhuan Zhang Sen Wang Li Yang Yingfeng Luo Shenghan Gao Meiling Zhang Shuangyang Wu Songnian Hu Haoyuan Sun Yuzhu Wang | 2019 | Horticulture Research2019，6，1： | 9 |
| 4 | Preference of subpicosecond laser pulses for terahertz wave generation from liquids显示文摘Terahertz(THz)wave generation from laser-induced air plasma generally requires a short temporal laser pulse.In contrast,it was observed that THz radiation from ionized liquid water prefers a longer pulse,wherein the mechanism remains unclear.We attribute the preference for longer pulse duration to the process of ionization and plasma formation in water,which is supported by a numerical simulation result showing that the highest electron density is achieved with a subpicosecond pulse.The explanation is further verified by the coincidence of our experimental result and simulation when the thickness of the water is varied.Other liquids are also tested to assure the preference for such a pulse is not exclusive to water. | Qi Jin Yiwen E Shenghan Gao Xi-Cheng Zhang | 2020 | Advanced Photonics2020，2，1： | 6 |
| 5 | High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads显示文摘Arabidopsis thaliana is an important and long-established model species for plant molecular biology,genetics,epigenetics,and genomics.However,the latest version of reference genome still contains a significant number of missing segments.Here,we reported a high-quality and almost complete Col-0 genome assembly with two gaps(named Col-XJTU)by combining the Oxford Nanopore Technologies ultra-long reads,Pacific Biosciences high-fidelity long reads,and Hi-C data.The total genome assembly size is 133,725,193 bp,introducing 14.6 Mb of novel sequences compared to the TAIR10.1 reference genome.All five chromosomes of the Col-XJTU assembly are highly accurate with consensus quality(QV)scores>60(ranging from 62 to 68),which are higher than those of the TAIR10.1 reference(ranging from 45 to 52).We completely resolved chromosome(Chr)3 and Chr5 in a telomere-to-telomere manner.Chr4 was completely resolved except the nucleolar organizing regions,which comprise long repetitive DNA fragments.The Chrl centromere(CEN1),reportedly around 9 Mb in length,is particularly challenging to assemble due to the presence of tens of thousands of CEN180 satellite repeats.Using the cutting-edge sequencing data and novel computational approaches,we assembled a 3.8-Mb-long CEN1 and a 3.5-Mb-long CEN2.We also investigated the structure and epigenetics of centromeres.Four clusters of CEN180 monomers were detected,and the centromere-specific histone H3-like protein(CENH3)exhibited a strong preference for CEN180 Cluster 3.Moreover,we observed hypomethylation patterns in CENH3-enriched regions.We believe that this high-quality genome assembly,Col-XJTU,would serve as a valuable reference to better understand the global pattern of centromeric polymorphisms,as well as the genetic and epigenetic features in plants. | Bo Wang Xiaofei Yang Yanyan Jia Yu Xu Peng Jia Ningxin Dang Songbo Wang Tun Xu Xixi Zhao Shenghan Gao Quanbin Dong Kai Ye | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 6 |
| 6 | Metal-Organic Frameworks Derived Porous Carbons: Syntheses, Porosity and Gas Sorption Properties显示文摘从金属器官的框架(MOF ) 导出的多孔的碳材料由于象高孔和可定制的结构差异那样的 MOF 的内在的优点被带进舞台,它可能在与多样的结构和各种各样的装饰生产多孔的碳提供无限的可能性。从 MOF 继承了,在碳材料的孔是一个重要因素评估多孔的碳的表演(例如煤气的吸着性质,电气化学、催化的行为) 。影响多孔的碳材料的孔的因素主要集中于太古的 MOF,添加剂和进行的条件的孔。然而,在过去的十年期间,仍然在 MOF 的孔的影响因素上没有系统的报告导出的多孔的碳材料和相应煤气的吸着性质。在这评论,我们将总结 导出MOF 的碳材料的表演(即非做的多孔的碳, heteroatoms 做了多孔的碳,金属/金属氧化物装饰了多孔的碳)并且关于在性质和四主要效果之间的连接给详细讨论(锻烧温度,另外的先锋装载,象 MOF 的内在的性质一样的synthetic以后处理)。 | Xiaokun Pei Yifa Chen Siqing Li Shenghan Zhang Xiao Feng Junwen Zhou Bo Wang | 2016 | Chinese Journal of Chemistry2016，34，2： | 5 |
| 7 | Water Purification: Adsorption over Metal-Organic Frameworks显示文摘关于人的健康的水污染是越过社区社会的一个通用问题。高度有效、经济地可行、容易可完成的途径为水纯化是长追求的。有多孔的材料的吸附过程(例如沸石,激活的碳,硅石胶化,金属器官的框架(MOF )) 在过去的十年期间在这块地里引起了许多注意。在它,有众多的活跃地点,一致的孔和可定制的结构差异的 MOF 正在产生是为水纯化的最有希望的吸附物之一。在吸附进程期间,决定或影响 MOF 的可用性和表演的影响因素主要集中于 MOF,他们为沾染物的亲密关系和进行的条件的稳定性(pH,沾染物的起始的集中) 。在这评论,我们将系统地介绍 MOF 的表演(主要集中了于晶体, MOF nanomaterial 或 MOF composites 将在这评论的范围以外的 MOF )为沾染物纯化(无机、器官的沾染物)在在他们的表演之中关于连接浇并且给详细讨论,进行条件因素和潜在的相互作用机制(例如静电的相互作用,协作或 p-p 相互作用)。我们希望这评论将对 MOF 吸附物的设计,新生和复用有益并且为水纯化支持 MOF 的发展。 | Siqing Li Yifa Chen Xiaokun Pei Shenghan Zhang Xiao Feng Junwen Zhou Bo Wang | 2016 | Chinese Journal of Chemistry2016，34，2： | 5 |
| 8 | Genome Assembly and Pathway Analysis of Edible Mushroom Agrocybe cylindracea显示文摘Agrocybe cylindracea,an edible mushroom,is widely cultivated for its abundance of nutrients and flavor,and many of its metabolites are reported to have beneficial roles,such as medicinal effects on tumors and chronical illnesses.However,the lack of genomic information has hindered further molecular studies on this fungus.Here,we present a genome assembly of A.cylindracea together with comparative genomics and pathway analyses of Agaricales species.The draft,generated from both next-generation sequencing(NGS)and single-molecule real-time(SMRT)sequencing platforms to overcome high genetic heterozygosity,is composed of a56.5 Mb sequence and 15,384 predicted genes.This mushroom possesses a complex reproductive system,including tetrapolar heterothallic and secondary homothallic mechanisms,and harbors several hydrolases and peptidases for gradual and effective degradation of various carbon sources.Our pathway analysis reveals complex processes involved in the biosynthesis of polysaccharides and other active substances,including B vitamins,unsaturated fatty acids,and N-acetylglucosamine.RNA-seq data show that A.cylindracea stipes tend to synthesize carbohydrate for carbon sequestration and energy storage,whereas pilei are more active in carbon utilization and unsaturated fatty acid biosynthesis.These results reflect diverse functions of the two anatomical structures of the fruiting body.Our comprehensive genomic and transcriptomic data,as well as preliminary comparative analyses,provide insights into the molecular details of the medicinal effects in terms of active compounds and nutrient components. | Yuan Liang Dengxue Lu Sen Wang Yuhui Zhao Shenghan Gao Rongbing Han Jun Yu Weili Zheng Jianing Geng Songnian Hu | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 2 |
| 9 | Chlorophyll-based organic solar cells with improved power conversion efficiency显示文摘Chlorophylls(Chls), and associated chlorophyll derivatives, are one of the oldest, most versatile organic semiconductors found in nature. Herein, we present two easily semi-synthesized chlorophyll derivatives, namely, chlorin e6 trimethyl ester(Ce6Me3) and its copper complex(Cu–Ce6 Me3), as the p-type dopants for organic semiconductors and their impact in organic solar cells(OSCs). In our study, both Chls showed intense Soret and Q y bands in the UV-visible spectra, leading to an effect means for capturing solar light and energy. Chls also exhibited high carrier mobility owing to the partial formation of aggregates through the spin-coating process. Using Chls, we fabricated OSCs in both planar-heterojunction(PHJ) and bulkheterojunction(BHJ) solar cell configurations, together with C70/PC70 BM as electron acceptors. In PHJ solar cells, we received solar power conversion efficiencies(PCEs) of only 0.85% and 0.93% for Cu–Ce6 Me 3-and Ce6Me3-based devices, respectively, with the thickness of the donor layer at 5 nm. In BHJ cells, we achieved much higher PCEs of 1.53% and 2.05% for Cu–Ce6Me3 :PC 70 BM and Ce6Me3 :PC 70 BM respectively, where both blending ratios were set to 1:8. The improvement on PCE in BHJ cells may be attributed to the better charge separation increase at the donor–acceptor interface. | Shenghan Wang Shengnan Duan Yuwei Wang Chenglin Sun Xiao-Feng Wang Shin-ichi Sasaki | 2019 | Journal of Energy Chemistry2019，28，11： | 1 |
| 10 | Combination of Organic and Inorganic Electrolytes for Composite Membranes Toward Applicable Solid Lithium Batteries显示文摘To meet the demand for long-range electric vehicles with high-energy-density batteries,the solid-state batteries(SSBs)have attracted ever-increasing attention due to their enormous potential in affording the energy density greater than 400 W·h/kg.As the key materials,the solid electrolytes can be classified as inorganic electrolyte and organic electrolyte.The former usually has high ionic conductivity,good stability and mechanical properties,whereas being heavy and brittle.The latter is usually flexible,light and easy to mass produce,nevertheless has poor ionic conductivity and stability.Thus,the combination of the organic and the inorganic electrolytes for the composite membranes has become the inevitable trend to achieve the high energy density and safety of lithium batteries.From the perspective of practical application,this paper discusses how to construct the ideal organic-inorganic composite solid electrolyte with low areal specific resistance,thin texture,wide electrochemical window and high safety for applicable SSBs.Furthermore,the critical challenges and future development directions are prospected for the composite solid electrolytes. | MU Shuang BI Zhijie GAO Shenghan GUO Xiangxins | 2021 | Chemical Research in Chinese Universities2021，37，2： | 1 |
| 11 | AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism显示文摘Type 2 diabetes mellitus(T2 DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2 DM and found that rs3743121, located 1 kb downstream of AQR,was a novel susceptibility SNP associated with T2 DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2 DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2,increased the phosphorylation of GSK-3β, and restored the insulin sensitivity. Furthermore, the suppression of AQR inhibited the mTOR pathway and the protein ubiquitination process. Our study suggests that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. | Chun Song Han Yan Hanming Wang Yan Zhang Huiqing Cao Yiqi Wan Lingbao Kong Shenghan Chen Hong Xu Bingxing Pan Jin Zhang Guohuang Fan Hongbo Xin Zicai Liang Weiping Jia Xiao-Li Tian | 2018 | Journal of Genetics and Genomics2018，45，2： | 1 |
| 12 | HIV,HCV,and HBV Co-Infections in a Rural Area of Shanxi Province with a History of Commercial Blood Donation显示文摘Background:Unhygienic blood collection in the early 1990s led to blood‐borne infections in Central China.This study aimed to estimate human immunodeficiency virus (HIV) co‐infection with hepatitis C and B viruses (HCV and HBV) and their risk factors in a rural area of Shanxi Province with a history of commercial blood donation.Methods:A cross‐sectional study was conducted in 2004.All adult residents in the target area were invited to participate in the study.Face‐to‐face interviews were completed and blood specimens were tested for HIV,HCV,and HBV surface antigen (HBsAg).Results:Prevalence rates of HIV,HCV,and HBsAg were 1.3% (40/3 062),12.7% (389/3 062),and 3.5% (103/2982),respectively.Of the 40 HIV‐positive specimens,85% were HCV positive and 2.5% were HBsAg positive.The history of commercial blood donation was positively associated with HIV,HCV,and HIV/HCV co‐infections,but was negatively associated with HBsAg seropositivity.Migration for employment in the last 5 years was positively related to HIV,HBsAg,and HIV/HCV co‐infections.Univariate logistic analysis showed that illegal drug use,number of sex partners,extramarital sex behavior,commercial sex behavior,and condom use rate were not related to anti‐HIV,anti‐HCV,HBsAg seropositivity or their co‐infections.Conclusion:The history of commercial blood donation was the main risk factor for HIV,HCV,and HIV/HCV co‐infections in this former commercial blood donation area.HIV and HCV prevention and treatment interventions are important in this area. | DONG RuiLing QIAO Xiao Chun JIA WangQian WONG Michelle QIAN HanZhu ZHENG XiWen XING WenGe LAI ShengHan WU ZhengLai JIANG Yan WANG Ning | 2011 | Biomedical and Environmental Sciences2011，24，3： | 1 |
| 13 | An Intra-and Inter-industry Analysis of E-business Effectiveness显示文摘 | Motiwalla Luvai Khan M Riaz Xu Shenghan | 2005 | Informaiton & Management2005，42，： | 1 |
| 14 | High-performance organic thin-film transistors with metal oxide/metal bilayer electrode显示文摘 | CHU Chilwei LI Shenghan CHEN Chiehwei | 2005 | Appl Phys Lett2005，87，19： | 1 |
| 15 | Effects of carbon fiber/Al interface on mechanical properties of carbon-fiber-reinforced aluminum -matrix composites 显示文摘 | LI Shenghan CHAO Chuenguang | 2004 | Metallurgical and Materials Transactions A2004，35，7： | 1 |
| 16 | Hing risk of HIV related mortality is associated with selenium deficiency显示文摘 | Baum MK Shor-Posner G Shenghan L | | 0，，05： | 1 |
| 17 | Embodied Environmental Burdens of Wood Structure in Taiwan Compared with Reinsforced Concrete and Steel Structures with Various Recovery Rates显示文摘 | LI Shenghan | 2012 | Applied Mechanics and Materials2012，174，： | 1 |
| 18 | RGAAT: A Reference-based Genome Assembly and Annotation Tool for New Genomes and Upgrade of Known Genomes显示文摘The rapid development of high-throughput sequencing technologies has led to a dramatic decrease in the money and time required for de novo genome sequencing or genome resequencing projects, with new genome sequences constantly released every week. Among such projects, the plethora of updated genome assemblies induces the requirement of versiondependent annotation files and other compatible public dataset for downstream analysis. To handlethese tasks in an efficient manner, we developed the reference-based genome assembly and annotation tool(RGAAT), a flexible toolkit for resequencing-based consensus building and annotation update. RGAAT can detect sequence variants with comparable precision, specificity, and sensitivity to GATK and with higher precision and specificity than Freebayes and SAMtools on four DNAseq datasets tested in this study. RGAAT can also identify sequence variants based on cross-cultivar or cross-version genomic alignments. Unlike GATK and SAMtools/BCFtools, RGAAT builds the consensus sequence by taking into account the true allele frequency. Finally, RGAAT generates a coordinate conversion file between the reference and query genomes using sequence variants and supports annotation file transfer. Compared to the rapid annotation transfer tool(RATT),RGAAT displays better performance characteristics for annotation transfer between different genome assemblies, strains, and species. In addition, RGAAT can be used for genome modification,genome comparison, and coordinate conversion. RGAAT is available at https://sourceforge.net/projects/rgaat/and https://github.com/wushyer/RGAAT_v2 at no cost. | Wanfei Liu Shuangyang Wu Qiang Lin Shenghan Gao Feng Ding Xiaowei Zhang Hasan Awad Aljohi Jun Yu Songnian Hu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，5： | 1 |
| 19 | Improving point selection in cubature by a new discrepancy 显示文摘 | CHEN Jianbing ZHANG Shenghan | 2013 | SIAM Journal on Scientific Computing2013，35，5： | 1 |
| 20 | Acupuncture and endorphins显示文摘 | Ji Shenghan | 2004 | Neuroscience Letters2004，361，： | 1 |
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