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| 1 | Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty显示文摘在维生素 D 缺乏和自发的中央早熟的发身(ICPP ) 之间的关系最近被记录了。在这研究, 280 个女孩与 ICPP 诊断了,类似的年龄的 188 个正常发身控制女孩被注册并且回顾地学习了。有的 ICPP 组显著地降低浆液 25-hydroxyvitamin D (25 [哦] D ) 层次比控制组。而且,一种非线性的关系在浆液 25 之间被发现[哦] D 和 ICPP,和为浆液 25 的一个截止的点[哦] D 有或没有调整不同惊讶因素为 ICPP 在 31.8 ng/ml 被发现。有浆液 25 的女孩[哦] D31.8 ng/ml 有更低的机会比率(unadjusted:或 0.36, 95% CI 0.15 到 0.83, P < 0.05;调整的高度和重量:或 0.44, 95% CI 0.18 到 1.08, P = 0.072;BMI 调整了:或 0.36, 95% CI 0.16 到 0.84, P < 0.05 ) 。有 25 的 ICPP 题目[哦] D 缺乏从二另外的亚群比这些题目有一个更高的身体团索引(BMI ) 。关联分析证明那维生素 D 水平在 ICPP 组与 BMI 和一些新陈代谢的参数被相关。我们的学习建议那维生素 D 地位可以与 ICPP 风险被联系并且可以在 ICPP 上有阀值效果。 | Yue Zhao Wenjun Long Caiqi Du Huanhuan Yang Shimin Wu Qin Ning Xiaoping Luo | 2018 | Frontiers of Medicine2018，12，2： | 16 |
| 2 | Metabolic changes in cancer: beyond the Warburg effect显示文摘改变的新陈代谢是癌症房间的特点之一。在癌症房间的最著名的新陈代谢的反常是 Warburg 效果,它甚至面对氧表明增加的 glycolysis。然而,肿瘤相关的新陈代谢的畸形没被限制到在葡萄糖发酵和氧化 phosphorylation 之间的改变的平衡。象 p53 和 c-myc 那样的关键肿瘤基因被发现是新陈代谢的主人管理者。象 succinate 脱氢酶, fumarate hydratase, pyruvate kinase,和 isocitrate 脱氢酶变化或表示水平改变那样的新陈代谢的酶都被连接到 tumorigenesis。在这评论,我们介绍一些联系癌症的新陈代谢的混乱和他们的分子的 tumorigenic 机制的当前的理解。 | Weihua Wu Shimin Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，1： | 15 |
| 3 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 4 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010，，2： | 5 |
| 5 | Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts显示文摘In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical application.The[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular efflux.Compared to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo.Micro-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node metastases.These results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical evaluation.The feasibility of FAP imaging was demonstrated using PET studies. | Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 6 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010，，2： | 3 |
| 7 | Distribution and identification of the low-velocity layer in the northern South China Sea显示文摘低速度的层(LVL ) ,与构造活动和动态背景密切相关,总是是在深外壳的结构研究的一个热话题。深地震(OBS/OBH ) 并且自从 1990 年代,向陆近海的实验广泛地在北华南海(SCS ) 被实现了。六地震侧面被国内、国际的合作在 SCS 的北边缘上完成。外壳的结构的特征被揭示,五速度倒置层被发现。在他们之中,有 3.0-3.5 km · s -1 速度的三 LVL 位于 Yinggehai 盆和珀尔河嘴盆的沉积结构(深入地的 2.0-6.0km 和在厚度的 2.0-4.6 km ) 。他们被反射、折射的阶段为他们的浅深度识别。有 5.5-6.0 km · s -1 速度的另外的二 LVL 通常在东北、西北的 SCS 的过渡外壳的结构与大约 2.5-6.0 km 厚度在中间的外壳(深入地的 7.0-18.0 km ) 中存在。他们被折射阶段检测从他们的覆盖并且内在的层。我们探索了与以前报导的结果结合的可能的构造形成机制,它为 SCS 的形成和进化提供了证据。 | Zhao Minghui Qiu Xuelin Xu Huilong Shi Xiaobin Wu Shimin Ye Chunming Xia Shaohong | 2007 | Progress in Natural Science:Materials International2007，17，5： | 3 |
| 8 | Active and stable Cu doped NiMgAlO catalysts for upgrading ethanol to n-butanol显示文摘Upgrading ethanol to n-butanol is an attractive way for renewable n-butanol production. Herein, Cu was selected to modify NiMgAlO catalysts for improving ethanol conversion and n-butanol selectivity. Over the optimized 2%Cu-NiMgAlO catalyst, ethanol conversion and n-butanol selectivity were enhanced to 30.0% and 64.2%, respectively, in 200 h time on stream at 523 K. According to physicochemical characterizations and theoretical calculations, the key role of multiple active sites in this reaction was extensively investigated. The plate-like structure of hydrotalcite was maintained over 2%Cu-NiMgAlO catalysts, with an average Ni particle size of ca. 5.4 nm. The presence of Cu species created CuNi alloy sites and Lewis acid-base pairs, and increased hydrogen transfer and condensation reactions, resulting in elevated ethanol conversion and n-butanol selectivity. Additionally, CuNi alloy had a strong interaction with CuNiMgAl oxides, forming homogeneous boundary due to their close ionic radius and lattice matching, and afforded the long time stability in the ethanol to n-butanol reaction. | Zhinuo Wang Ming Yin Jifeng Pang Xianquan Li Yanan Xing Yang Su Shimin Liu Xiaoyan Liu Pengfei Wu Mingyuan Zheng Tao Zhang | 2022 | Journal of Energy Chemistry2022，31，9： | 2 |
| 9 | Client importance,institutional improvements,and audit quali-ty in China:An office and individual auditor analysis显示文摘 | Shimin Chen Sunny Y.J.Sun DongHui Wu | | 0，，： | 1 |
| 10 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010，，2： | 1 |
| 11 | Trace determination of nine haloacetic acids in drinking water by liquid chromatography–electrospray tandem mass spectrometry显示文摘 | Liping Meng Shimin Wu Fujun Ma Ai Jia Jianying Hu | 2010 | Journal of Chromatography A2010，，29： | 1 |
| 12 | Client Importance,Institutional Improvements,and Audit Quality in China:An Office and Individual Auditor Level Analysis显示文摘 | Chen Shimin Sunny Y J Sun Donghui Wu | 2010 | The Accounting Review2010，85，1： | 1 |
| 13 | Single wall carbon nanotubes and their electrical properties显示文摘 | Zengquan Xue Weimin Liu Shimin Hou Zujin Shi Zhennan Gu Hongwen Liu Xingyu Zhao Zhaoxiang Zhang Mianlei Wu Lianmao Peng Quande Wu | 2000 | Science in China Series A: Mathematics2000，，11： | 1 |
| 14 | Clinicopathologic Significance of HIF-1 α , CXCR4, and VEGF Expression in Colon Cancer显示文摘 | Yugang Wu Min Jin Huanbai Xu Zhang Shimin Songbing He Liang Wang Yanyun Zhang Silvano Sozzani | 2010 | Clinical and Developmental Immunology2010，，： | 1 |
| 15 | Effects of Rhynchophylline on Learning and Memory of Alzheimer's Disease Zebrafish显示文摘[Objectives]To investigate the effect of rhynchophylline on the behavior of Alzheimer's disease zebrafish induced by aluminum trichloride(AlCl3),to provide theoretical basis for the development and application of rhynchophylline in the field of Alzheimer's disease.[Methods]The video recording was made on zebrafish before training,so as to judge whether zebrafish training was successful or not.After training zebrafish for 7 d,60 zebrafish were randomly divided into 6 groups:blank group,model group,positive group,low-dose rhynchophylline group,medium-dose rhynchophylline group and high-dose rhynchophylline group.The blank group was video-recorded,while the model group,positive group,low-dose group,medium-dose group and high-dose group were exposed to AlCl3 for modelling.After the end,the model group was video-recorded,and the other groups were given drug intervention.Both the positive group and the rhynchophylline group were given drug for 6 d,and finally all the groups were video-recorded.After all the videos were finished,the behavioral analysis was carried out by using the behavioral record analysis software smart3.0,and the conclusion was drawn by analyzing the data.[Results]The data of length of stay of zebrafish in red short arm area of 6 groups were compared and analyzed:there was a significant difference between blank group and model group(P<0.05),and there was a significant difference between model group and positive group,medium-dose group or high-dose group(P<0.05).The percentage of time spent in the red short arm area of 6 groups of zebrafish was compared and analyzed:there was a significant difference between blank group and model group(P<0.05),and there was a significant difference between model group and positive group,medium-dose group or high-dose group(P<0.05).The data of swimming distance of 6 groups of zebrafish in red short arm area were compared and analyzed:there was no significant difference between the blank group and the model group(P>0.05),but there was only significant difference between the model group and the high-dose group(P<0.05).The percentage of swimming distance of zebrafish in the red short arm area of the six groups was compared and analyzed:there was a significant difference between the blank group and the model group(P<0.05),and there were significant differences between model group and positive group,medium-dose group or high-dose group(P<0.05).[Conclusions]Rhynchophylline can improve the behavior of Alzheimer's disease zebrafish. | Kaifei LIU Yao HUANG Guokai GUAN Shimin WU Xunyi LI Linglin CHEN Yifei CHEN | 2021 | Medicinal Plant2021，12，4： | 1 |
| 16 | Divergent responses of soil carbon and nitrogen pools to short-term nitrogen addition between two plantations in Northeast China显示文摘Nitrogen(N)deposition has a profound influence on forest soil carbon(C)and N pools,but there was no consensus on the responses of different C and N components in different forest types.In this study,a two-year simulated N deposition experiment with four levels of N(NH4NO3)-addition treatments(0,50,100,and 150 kg N/hm^(2)·a)were conducted in Larix gmelinii(LG)and Quercus mongolica(QM)plantation in Northeast China,in order to investigate the C and N pool dynamics under continuously enhanced N deposition.Soil organic carbon(SOC),soil total N(STN)and their active components(readily oxidizable C,ROC;dissolved organic C,DOC;microbial biomass C,MBC,dissolved organic N,DON;microbial biomass N,MBN)of the forest soil were measured monthly from May to October 2017.C and N contents in LG were observed higher than in QM.N addition had no effect on SOC and STN of LG,but significantly increased SOC and STN of QM at low N addition level.Low N addition generally raised active C components(ROC,DOC,and MBC)in both plantations,whereas high N addition did not significantly affect these components,or even decreased ROC in LG soil.Low N addition also increased STN and MBN of QM,while no significant change in STN and MBN of LG was observed.DON was directly affected by N addition and increased significantly with elevated N addition levels.The results indicated that N addition,especially of low rate,might enhance the C sequestration capacity of the forest soils and mitigate climate change. | Yedong Li Bo Wang Sen Dou Haoyue Shen Liyong Mei Yang Zhang Ximing Zeng Yaya Zhang Yameng Pei Haoye Ren Shimin Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 1 |
| 17 | Supercritical fluid extraction and determination of lutein in heterotrophi- cally cultivated Chlorella pyrenoidosa 显示文摘 | WU Zhengyun WU Shimin SHI Xianming | 2007 | J Food Process Eng2007，30，2： | 1 |
| 18 | Crustal structure across the Xisha Trough, northwestern South China Sea 显示文摘 | Qiu Xuelin Ye Sanyu Wu Shimin | 2001 | Tectonophysics2001，341，： | 1 |
| 19 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010，，2： | 1 |
| 20 | Client Importance,Institutional Improvements,and Audit Quality in China:An Office and Individual Auditor Level Analysis显示文摘 | Chen Shimin Sunny Y.J.Sun Donghui Wu | | 0，，： | 1 |
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