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| 1 | Multi-energy Storage System Model Based on Electricity Heat and Hydrogen Coordinated Optimization for Power Grid Flexibility显示文摘Based on decreasing the flexibility of the power grid through the integration of large-scale renewable energy,a multi-energy storage system architectural model and its coor-dination operational strategy with the same flexibility as in the pumped storage power station and battery energy storage system(BESS)are studied.According to the new energy fluctuation characteristics and the different peak valley parameters in the power grid,this paper proposes a electricity heat hydrogen multi-energy storage system(EHH-MESS)and its coordination and optimization operational model to reduce the curtailment of wind power and photovoltaic(PV)to the power grid and improve the flexibility of the power grid.Finally,this paper studied the simulation model of an energy storage optimization control strategy after the multi-energy storage system is connected to the distribution networks,and analyzed three operational modes of the multi-energy storage system.The simulation results show that the EHH-MESS proposed in this paper has a better power grid regulation flexibility and economy,and can be used to replace the battery energy storage system based on MATLAB. | Yun Teng Zedi Wang Yan Li Qian Ma Qian Hui Shubin Li | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 38 |
| 2 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 3 | Pyrosequencing Reveals Significant Changes in Microbial Communities Along the Ecological Succession of Biological Soil Crustsin the Tengger Desert of China显示文摘Biological soil crusts(BSCs)have important ecological functions in arid and semiarid lands,but they remain poorly understood in terms of the changes in microbial communities during BSC succession under in situ field conditions.Here,454 pyrosequencing was used to assess the microbial community composition of four BSC types in the Tengger Desert of China:alga,lichen(cyanolichen and green alga-lichen),and moss crusts,representing early,middle,and final successional stages of BSCs,respectively.The results showed the highest diversity of microbial communities inhabiting lichen crusts,whereas the lowest diversity was observed in moss crusts.Five phyla,Proteobacteria,Actinobacteria,Cyanobacteria,Bacteroidetes,and Acidobacteria,accounted for about 72% to 87%of total prokaryotic sequences in different BSCs.The most abundant eukaryotic microorganism was Ascomycota,accounting for 47%to 93%of the total eukaryotic sequences.Along the succession of BSCs,the abundance of photoautotrophic Cyanobacteria,Chlorophyta,and Bacillariophyta declined,and that of heterotrophic microorganisms such as bacteria and fungi increased.Statistical analysis showed clear divergency of microbial taxa at the class level among the different successional stages of BSCs.The clustering results at class level showed that the moss crusts were the farthest from the rest in prokaryotic composition;the alga crusts were the most different in terms of eukaryotic microorganisms and the two kinds of lichen crusts were relatively closer in both compositions.Ordination analysis showed that the main variations of community structure among BSCs could be explained best by the abundance of Cyanobacteria and Ascomycota and by physiochemical properties of BSCs,including mechanical composition,moisture,and electrical conductivity.In conclusion,our results indicate that Cyanobacteria and Ascomycota likely play an important role in the evolution of BSC structure and functions and highlight the importance of environmental factors in shaping microbial community structures of BSCs in the Tengger Desert of China. | ZHANG Qingyi WANG Qiong OUYANG Hailong LAN Shubin HU Chunxiang | 2018 | Pedosphere2018，28，2： | 9 |
| 4 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 5 | Inheritance of Perpetual Blooming in Rosa chinensis ‘Old Blush'显示文摘Perpetual blooming is one of the most important biological and economical traits in modern rose, while the genetic basis underlining the control of this trait is poorly investigated. With an aim in dissecting the genetic determinism of perpetual blooming, we developed six rose populations(OB, W, F1, F2, BC1 OB and BC1W) derived from a WOB population [interspecific diploid hybridization between Rosa chinensis ‘Old Blush'(OB) and R. wichuriana ‘Basye's Thornless'(W)]. Perpetual blooming is absent both in a F1 population with 296 individuals and a BC1 W population(W as the backcross parent) with 150 individuals. However, the perpetual blooming trait showed a typical 3︰1 segregation in a backcross population BC1 OB with OB as the backcross parent. In this population with 300 individuals, 83 plants had the perpetual blooming phenotype while the other 217 featured non-perpetual blooming, indicating that the perpetual blooming trait is very likely controlled by two recessive genes in R. chinensis(rpb1 and rpb2). These genetic data suggest that the inheritance of rose perpetual blooming may be controlled by a complex mechanism. | LI Shubin ZHOU Ningning ZHOU Qing YAN Huijun JIAN Hongying WANG Qigang CHEN Min QIU Xianqin ZHANG Hao WANG Shufang LI Shufa TANG Kaixue | 2015 | Horticultural Plant Journal2015，1，2： | 9 |
| 6 | Large aperture N31 neodymium phosphate laser glass for use in a high power laser facility显示文摘Large aperture Nd:phosphate laser glass is a key optical element for an inertial confinement fusion(ICF) facility. N31,one type of neodymium doped phosphate glasses, was developed for high peak power laser facility applications in China. The composition and main properties of N31 glass are given, together with those of LHG-8, LG-770, and KGSS-0180 Nd:phosphate laser glasses, from Hoya and Schott, and from Russia. The technologies of pot melting, continuous melting, and edge cladding of large size N31 phosphate laser glass are briefly described. The small signal gain profiles of N31 glass slabs from both pot melting and continuous melting at various values of the pumping energy of the xenon lamp are presented. N31 glass is characterized by a stimulated emission cross section of 3.8 × 10-20cm2 at 1053 nm,an absorption coefficient of 0.10–0.15% cm-1at laser wavelength, small residual stress around the interface between the cladding glass and the laser glass, optical homogeneity of ~2 × 10-6in a 400 mm aperture, and laser damage threshold larger than 42 J/cm2 for a 3 ns pulse width at 1064 nm wavelength. | Lili Hu Shubin Chen Jingping Tang Biao Wang Tao Meng Wei Chen Lei Wen Junjiang Hu Shunguang Li Yongchun Xu Yasi Jiang Junzhou Zhang Zhonghong Jiang | 2014 | High Power Laser Science and Engineering2014，2，1： | 8 |
| 7 | Understanding the adsorption mechanism of Ni(II) on graphene oxides by batch experiments and density functional theory studies显示文摘The graphene oxides(GOs) have attracted multidisciplinary study because of their special physicochemical properties. The high surface area and large amounts of oxygen-containing functional groups make GOs suitable materials for the efficient elimination of heavy metal ions from aqueous solutions. Herein the sorption of Ni(II) on GOs was studied using batch experiments, and the results showed that the sorption of Ni(II) is strongly dependent on p H and ionic strength at pH<8, and independent of ionic strength at pH>8. The sorption of Ni(II) is mainly dominated by outer-sphere surface complexation and ion exchange at low p H, and by inner-sphere surface complexation at high p H. The interaction of Ni(II) with GOs was also investigated by theoretical density functional theory(DFT) calculations, and the results show that the sorption of Ni(II) on GOs is mainly attributed to the –COH and –COC groups and the DFT calculations show that Ni(II) forms stable GO_Ni_triplet structure with the binding energy of -39.44 kcal/mol, which is in good agreement with the batch sorption experimental results. The results are important for the application of GOs as adsorbents in the efficient removal of Ni(II) from wastewater in environmental pollution cleanup. | Yuantao Chen WeiZhang Shubin Yang Aatef Hobiny Ahmed Alsaedi Xiangke Wang | 2016 | Science China Chemistry2016，59，4： | 6 |
| 8 | An efficient and fast polarity optimization approach for mixed polarity Reed-Muller logic circuits显示文摘尽管基因算法广泛地在混合极性芦苇思考(MPRM ) 逻辑电路的极性优化被使用了,很少研究考虑了极性变换顺序。以便改进 MPRM 逻辑电路的极性优化的效率,我们就极性变换顺序而言建议一条有效、快的极性优化途径(FPOA ) 。第一,在 FPOA 后面的主要想法是那等评估的极性集合的最好的极性变换顺序被使用建议混合基因算法(HGA ) 获得;第二,每在极性集合的极性根据 HGA 获得的最好的极性变换顺序被变换。我们的建议 FPOA 在 C 被实现,比较分析为 MCNC 基准电路被介绍了。试验性的结果证明为有更多的变量的电路, FPOA 在与极性变换顺序和改进极性优化与启发式的技术接近疏忽的传统的极性优化途径相比改进 MPRM 逻辑电路的极性优化的效率是高度有效的。 | Zhenxue HE Limin XIAO Fei GU Tongsheng XIA Shubin SU Zhisheng HUO Rong ZHANG Longbing ZHANG Li RUAN Xiang WANG | 2017 | Frontiers of Computer Science2017，11，4： | 6 |
| 9 | Crustal structures of the Weihe graben and its surroundings from receiver functions显示文摘We use 15 seismic stations,crossing the Qinling orogen(QO),Weihe graben(WG)and Ordos block(OB),to study the crustal structures by receiver functions(RFs)methods.The results show quite a difference in crustal structures and materials of three tectonic units(orogenic belt,extentional basin and stable craton).The average crustal thickness in the northern QO is 37.8 km,and Poisson ratio is 0.247,which indicates the increase of felsic materials in QO.In the southern OB,the average crustal thickness is 39.2 km and Poisson ratio is 0.265.Comparatively high value of Poisson ratio is related with old crystallized base in the lower crust and shallow sediments.The artificial RFs reveal that low-velocity and thick sediments have a significant effect on phases of the Mohorovi i discontinuity(Moho).As a result,the Moho phases in WG are tangled.S-wave velocity(VS)inversion shows that there are shallow sediment layers with 4–8 km’s thickness and high velocity zones in the middle-lower crust in WG.Complex Moho structure and high velocity zone may have been induced by the activities of the Weihe faults series. | XU ShuBin MI Ning XU MingJie WANG LiangShu LI Hua YU DaYong | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 10 | MOF-derived ZnCo_2O_4/C wrapped on carbon fiber as anode materials for structural lithium-ion batteries显示文摘To meet the requirements for the mechanical and electrochemical performance for carbon fiber-based (CF-based) composites in the structural lithium ion batteries (SLIBs) application, better CF-Based composites are urgently needed. Herein, we report a novel composite metal organic framework (MOF)-derived ZnCo_2 O_4/C@carbon fiber via a facile method and subsequent annealing treatment. In this anode,the nano ZnCo_2 O_4/C coatings wrapped on the surface of CF provide more active sites for electrode reactions and the thin carbon layers give the additional protection. For this material, after 100 cycles, it exhibits excellent cycling stability including high reversible capacity of 463 mAh/g at 50 mA/g, which increases 201% than that of the CF. Thus, this structural anode material exhibits enhanced capacity, high initial columbic efficiency. | Huagen Li Shubin Wang Mengjie Feng Jiping Yang Boming Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 11 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 12 | Characterizing optical dipole trap via fluorescence of trapped cesium atoms显示文摘Optical dipole trap (ODT) is becoming an important tool of manipulating neu- tral atoms. In this paper ODT is realized with a far-off resonant laser beam strongly fo- cused in the magneto-optical trap (MOT) of cesium atoms. The light shift is measured by simply monitoring the fluorescence of the atoms in the magneto-optical trap and the opti- cal dipole trap simultaneously. The advantages of our experimental scheme are discussed, and the effect of the beam waist and power on the potential of dipole trap as well as heating rate is analyzed. | LIU Tao GENG Tao YAN Shubin LI Gang ZHANG Jing WANG Junmin PENG Kunchi ZHANG Tiancai | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，3： | 4 |
| 13 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 14 | Congenital bifurcation of tympanic segment of facial nerve显示文摘Congenital aural atresia is usually associated with facial nerve (the seventh cranial nerve,CN7) anomalies with an incidence rate of 60%-75%.These anomalies include facial nerve displacement,facial nerve component overlying the oval window,bony canal dehiscence,and bifurcation,which increase the risk of surgical facial nerve injuries.Among all these anomalies,congenital bifurcation of the tympanic segment of facial nerve is the most confusing situation that significantly increases the surgical risk during hearing reconstruction. | Wang Danni Zhao Shouqin Zhao Yanling Chen Shubin Yang Lin | 2014 | Chinese Medical Journal2014，，9： | 3 |
| 15 | Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response显示文摘The breakthrough development of induced pluripotent stem cells(iPSCs)raises the prospect of patient-specific treatment for many diseases through the replacement of affected cells.However,whether iPSC-derived functional cell lineages generate a deleterious immune response upon auto-transplantation remains unclear.In this study,we differentiated five human iPSC lines from skin fibroblasts and urine cells into neural progenitor cells(NPCs)and analyzed their immunogenicity.Through co-culture with autogenous peripheral blood mononuclear cells(PBMCs),we showed that both somatic cells and iPSC-derived NPCs do not stimulate significant autogenous PBMC proliferation.However,a significant immune reaction was detected when these cells were co-cultured with allogenous PBMCs.Furthermore,no significant expression of perforin or granzyme B was detected following stimulation of autogenous immune effector cells(CD3+CD8 T cells,CD3+CD8+T cells or CD3 CD56+NK cells)by NPCs in both PBMC and T cell co-culture systems.These results suggest that human iPSC-derived NPCs may not initiate an immune response in autogenous transplants,and thus set a base for further preclinical evaluation of human iPSCs. | HUANG Ke LIU PengFei LI Xiang CHEN ShuBin WANG LiHui QIN Li SU ZhengHui HUANG WenHao LIU JuLi JIA Bei LIU Jie CAI JingLei PEI DuanQing PAN GuangJin | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 16 | Preparation and properties of ^(117m)Sn(Ⅳ)-TTHMP in in-vitro and in small animals显示文摘In this work,TTHMP was synthesized and labelled with ^(117m)Sn.The preparation conditions,stability and lipophilicity of ^(117m)Sn(Ⅳ)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the preparation solution had vital effects on the labeling yield of ^(117m)Sn(Ⅳ)-TTHMP.It was also found that ^(117)Sn(Ⅳ)-TTHMP was hydrophilic and stable at room tempera- ture and 37℃in open air.^(117m)Sn(Ⅳ)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals.This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors. | HE Jiaheng LUO Shunzhong JIANG Shubin YANG Yuqing WANG Guanquan | 2007 | Nuclear Science and Techniques2007，18，6： | 3 |
| 17 | Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing mortality.Currently,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed. | Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang | 2017 | Science China(Life Sciences)2017，60，9： | 2 |
| 18 | Numerical simulation of profile control by clay particles after polymer flooding显示文摘A three-dimensional,two-phase,five-component mathematical model has been developed to describe flow characteristics of clay particles and flocs in the profile control process,in which the clay particle suspension is injected into the formation to react with residual polymer.This model considers the reaction of clay particles with residual polymer,apparent viscosity of the mixture,retention of clay particles and flocs,as well as the decline in porosity and permeability caused by the retention of clay particles and flocs.A finite difference method is used to discretize the equation for each component in the model.The Runge-Kutta method is used to solve the polymer flow equation,and operator splitting algorithms are used to split the flow equation for clay particles into a hyperbolic equation for convection and a parabolic equation for diffusion,which effectively ensures excellent precision,high speed and good stability.The numerical simulation had been applied successfully in the 4-P1920 unit of the Lamadian Oilfield to forecast the blocking capacity of clay particle suspension and to optimize the injection parameters. | Feng Qihong Shi Shubin Wang Sen Zheng Lu | 2010 | Petroleum Science2010，7，4： | 2 |
| 19 | Dislocation glide and mechanical twinning in a ductile VNbTi medium entropy alloy显示文摘An equiatomic VNbTi medium-entropy alloy with outstanding tensile properties and unique deformation behavior is reported.The screw dislocation glide,deformation twinning,and dislocation accumulation induced kink bands are identified as three deformation mechanisms that contribute to a large elongation above 20%.The{112}<111>twins are activated at the beginning of the yield stage accompanied by sudden stress-drop and pronounced acoustic emission.Dislocations dominate subsequent tensile deformation,and the prevalent multiplanar dislocation slip promotes the formation of complex dislocation configurations(e.g.,debris,dipoles,and loops)and dense dislocation networks.The twin bands and kink bands can further impede the dislocation motion meanwhile effectively alleviate stress concentration.The synergistic activation of these deformation mechanisms provides new opportunities to design ductile refractory medium-and high-entropy alloys. | Mingxu Wu Shubin Wang Fei Xiao Guoliang Zhu Chao Yang Da Shu Baode Sun | 2022 | Journal of Materials Science & Technology2022，，15： | 2 |
| 20 | Clinical characteristics and prognosis of triple-negative breast cancer显示文摘客观我们调查了临床的特征,和三元组否定的乳癌的预示的因素。130 个三元组否定的乳癌病人在临床的特征和预后上被考察的方法。所有情况是免疫组织化学决定的雌激素受体,孕酮受体,和 HER2/neu 的表示的缺乏。结果 17.1% 所有乳癌病人(774 个案例) 是三元组否定的乳癌,并且 68.9% 三元组否定的乳癌病人(91 个案例) 是绝经前的。53.8% 病人(71 个案例) 与 T2 尺寸有肿瘤,并且(52 个病人) 他们中的 39.4% 个有淋巴节点转移。没有淋巴节点转移,在有淋巴节点转移的病人的恶化的率在病人显然比那高(P = 0.001 ) 。后续的中部的时间是 63 个月。33 案例 relapsed 和 20 个病人死了。23 个病人有至少二机关转移。5 年的没有疾病、全面的幸存率是 73.8% 和 85.7% 。结论三元组否定的乳癌病人通常在治疗以后在 2 3 年里有多重远转移的高率。淋巴节点的地位是最重要的预示的因素。有淋巴节点转移的三元组否定的胸 caner 病人有差的预后。 | Hua Cao Maosheng Yan Shubin Wang Tao Zheng Ruilian Xu Yixin Chen Yajie Liu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 2 |
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