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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Mechanical behavior of coal under different mining rates:A case study from laboratory experiments to field testing显示文摘During the development of hot dry rock,the research on thermal fatigue damage caused by thermal shock of cold and heat cycles is the basis that ensures the long-term utilization of geothermal resources,but there are not enough relevant studies at present.Based on this,the thermal damage tests of granite at different temperatures(250,350,450°C)and quenching cycles(1,5,10,15 cycles)were carried out.Preliminary reveals the damage mechanism and heat transfer law of the quenching cycle effect on hot dry rock.The results show that with the increase of temperature and cycles,the uneven thermal expansion of minerals and the thermal shock caused by quenching promote the crack development of granite,resulting in the decrease of P-wave velocity,thermal conductivity and uniaxial compressive strength of granite.Meanwhile,the COMSOL was used to simulate the heat transfer of hot dry rock under different heat treatment conditions.It concluded that the increase in the number of quenching cycles reduced the heat transfer capacity of the granite,especially more than 10 quenching cycles,which also reflects that the thermal fatigue damage leads to a longer time for the temperature recovery of the hot dry rock mass.In addition,the three-dimensional nonlinear fitting relationship among thermal conductivity,temperature and cycle number was established for the first time,which can better reveal the change rule of thermal conductivity after quenching thermal fatigue effect of hot dry rock.The research results provide theoretical support for hot dry rock reservoir reconstruction and production efficiency evaluation. | Mingzhong Gao Jing Xie Yanan Gao Wenyong Wang Cong Li Bengao Yang Junjun Liu Heping Xie | 2021 | International Journal of Mining Science and Technology2021，31，5： | 39 |
| 3 | Study on Multi-Scale Blending Initial Condition Perturbations for a Regional Ensemble Prediction System显示文摘An initial conditions(ICs) perturbation method was developed with the aim to improve an operational regional ensemble prediction system(REPS). Three issues were identified and investigated:(1) the impacts of perturbation scale on the ensemble spread and forecast skill of the REPS;(2) the scale characteristic of the IC perturbations of the REPS; and(3) whether the REPS's skill could be improved by adding large-scale information to the IC perturbations. Numerical experiments were conducted to reveal the impact of perturbation scale on the ensemble spread and forecast skill. The scales of IC perturbations from the REPS and an operational global ensemble prediction system(GEPS) were analyzed. A 'multi-scale blending'(MSB) IC perturbation scheme was developed, and the main findings can be summarized as follows: The growth rates of the ensemble spread of the REPS are sensitive to the scale of the IC perturbations; the ensemble forecast skills can benefit from large-scale perturbations; the global ensemble IC perturbations exhibit more power at larger scales, while the regional ensemble IC perturbations contain more power at smaller scales; the MSB method can generate IC perturbations by combining the small-scale component from the REPS and the large-scale component from the GEPS; the energy norm growth of the MSB-generated perturbations can be appropriate at all forecast lead times; and the MSB-based REPS shows higher skill than the original system, as determined by ensemble forecast verification. | ZHANG Hanbin CHEN Jing ZHI Xiefei WANG Yi WANG Yanan | 2015 | Advances in Atmospheric Sciences2015，32，8： | 29 |
| 4 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 5 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 6 | Temporal variations and source apportionment of volatile organic compounds at an urban site in Shijiazhuang, China显示文摘Shijiazhuang,the city with the worst air quality in China,is suffering from severe ozone pollution in summer.As the key precursors of ozone generation,it is necessary to control the Volatile Organic Compounds(VOCs)pollution.To have a better understanding of the pollution status and source contribution,the concentrations of 117 ambient VOCs were analyzed from April to August 2018 in an urban site in Shijiazhuang.Results showed that the monthly average concentration of total VOCs was 66.27 ppbv,in which,the oxygenated VOCs(37.89%),alkanes(33.89%),and halogenated hydrocarbons(13.31%)were the main composite on.Eight major sources were identified using Positive Matrix Factorization modeling with an accurate VOCs emission inventory as inter-complementary methods revealed that the petrochemical industry(26.24%),other industrial sources(15.19%),and traffic source(12.24%)were the major sources for ambient VOCs in Shijiazhuang.The spatial distributions of major industrial activities emissions were identified by using geographic information statistics system,which illustrated the VOCs was mainly from the north and southeast of Shijiazhuang.The inverse trajectory analysis using Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)and Potential Source Contribution Function(PSCF)clearly demonstrated the features of pollutant transport to Shijiazhuang.These findings can provide references for local governments regarding control strategies to reduce VOCs emissions. | Yanan Guan Lei Wang Shujuan Wang Yihao Zhang Jieying Xiao Xiaoli Wang Erhong Duan Li'an Hou | 2020 | Journal of Environmental Sciences2020，32，11： | 19 |
| 7 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 8 | Effects of residual organics in municipal wastewater on hydrogenotrophic denitrifying microbial communities显示文摘Hydrogenotrophic denitrification is promising for tertiary nitrogen removal from municipal wastewater. To reveal the influence of residual organics in municipal wastewater on hydrogenotrophic denitrifiers, we adopted high-throughput 16 S r RNA gene amplicon sequencing to examine microbial communities in hydrogenotrophic denitrification enrichments. Using effluent from a municipal wastewater treatment plant as water source, COD,nitrate and p H were controlled the same except for a gradient of biodegradable carbon(i.e., primary effluent(PE), secondary effluent(SE), or combined primary and secondary effluent(CE)). Inorganic synthetic water(IW) was used as a control. Hydrogenophaga, a major facultative autotroph, accounted for 17.1%, 5.3%, 32.7% and 12.9% of the sequences in PE, CE,SE and IW, respectively, implicating that Hydrogenophaga grew well with or without organics.Thauera, which contains likely obligate autotrophic denitrifiers, appeared to be the most dominant genera(23.6%) in IW and accounted for 2.5%, 4.6% and 8.9% in PE, CE and SE,respectively. Thermomonas, which is related to heterotrophic denitrification, accounted for 4.2% and 7.9% in PE and CE fed with a higher content of labile organics, respectively.In contrast, Thermomonas was not detected in IW and accounted for only 0.6% in SE. Our results suggest that Thermomonas are more competitive than Thauera in hydrogenotrophic denitrification with biodegradable organics. Moreover, facultative autotrophic denitrifiers,Hydrogenophaga, are accommodating to residual organic in effluent wastewater, thus we propose that hydrogenotrophic denitrification is amenable for tertiary nitrogen removal. | Wei Xing Jinlong Li Peng Li Chong Wang Yanan Cao Desheng Li Yunfeng Yang Jizhong Zhou Jiane Zuo | 2018 | Journal of Environmental Sciences2018，30，3： | 16 |
| 9 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 10 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 11 | Energy metabolism disorders and potential therapeutic drugs in heart failure显示文摘Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy supply.This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of heart.Current HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the disease.Drugs aimed at cardiac energy metabolism have not yet been developed.In this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy metabolism.Finally,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF. | Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 11 |
| 12 | Preparation and properties of CMAS resistant bixbyite structured high-entropy oxides RE_(2)O_(3)(RE=Sm,Eu,Er,Lu,Y,and Yb):Promising environmental barrier coating materials for Al_(2)O_(3)f/Al_(2)O_(3) composites显示文摘Y_(2)O_(3) is regarded as one of the potential environmental barrier coating(EBC)materials for Al_(2)O_(3)f/Al_(2)O_(3)ceramic matrix composites owing to its high melting point and close thermal expansion coefficient to Al_(2)O_(3).However,the relatively high thermal conductivity and unsatisfactory calcium-magnesium-aluminosilicate(CMAS)resistance are the main obstacles for the practical application of Y_(2)O_(3).In order to reduce the thermal conductivity and increase the CMAS resistance,four cubic bixbyite structured high-entropy oxides RE_(2)O_(3),including(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3),(Sm_(0.2)Eu_(0.2)Er_(0.2)Y_(0.2)Yb_(0.2))2O_(3),and(Sm_(0.2)Eu_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)were designed and synthesized,among which(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)bulks were prepared by spark plasma sintering(SPS)to investigate their mechanical and thermal properties as well as CMAS resistance.The mechanical properties of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3)and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) are close to those of Y_(2)O_(3) but become more brittle than Y_(2)O_(3).The thermal conductivities of(Eu_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb_(0.2))2O_(3) and(Sm_(0.2)Er_(0.2)Lu_(0.2)Y_(0.2)Yb02)2O_(3)(5.1 and 4.6 W·m^(-1)·K^(-1))are only 23.8%and 21.5%respectively of that of Y_(2)O_(3)(21.4 W·m^(-1)·K^(-1)),while their thermal expansion coefficients are close to those of Y_(2)O_(3) and A12O_(3).Most importantly,HE RE_(2)O_(3) ceramics exhibit good CMAS resistance.After being attacked by CMAS at 1350℃for 4 h,the HE RE_(2)O_(3) ceramics maintain their original morphologies without forming pores or cracks,making them promising as EBC materials for Al_(2)O_(3)f/Al_(2)O_(3) composites. | Yanan SUN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Yan XING Xiaojun ZHAO Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 10 |
| 13 | High-speed image reconstruction for optically sectioned,super-resolution structured illumination microscopy显示文摘Super-resolution structured illumination microscopy(SR-SIM)is an outstanding method for visualizing the subcellular dynamics in living cells.To date,by using elaborately designed systems and algorithms,SR-SIM can achieve rapid,optically sectioned,SR observation with hundreds to thousands of time points.However,real-time observation is still out of reach for most SIM setups as conventional algorithms for image reconstruction involve a heavy computing burden.To address this limitation,an accelerated reconstruction algorithm was developed by implementing a simplified workflow for SR-SIM,termed joint space and frequency reconstruction.This algorithm results in an 80-fold improvement in reconstruction speed relative to the widely used Wiener-SIM.Critically,the increased processing speed does not come at the expense of spatial resolution or sectioning capability,as demonstrated by live imaging of microtubule dynamics and mitochondrial tubulation. | Zhaojun Wang Tianyu Zhao Huiwen Hao Yanan Cai Kun Feng Xue Yun Yansheng Liang Shaowei Wang Yujie Sun Piero RBianco Kwangsung Oh Ming Lei | 2022 | Advanced Photonics2022，4，2： | 9 |
| 14 | A New Species of the Genus Xenophrys(Amphibia: Anura: Megophryidae) from Libo County, Guizhou, China显示文摘A new species of the genus Xenophrys is described from a karst cave environment of Libo County, Guizhou Province, Southern China. The new species, Xenophrys liboensis sp. nov., is distinguished from its congeners by a combination of the following characters: 1) tympanum distinct; 2) vomerine teeth present; 3) the length of lower arm and hand larger than the half of snout-vent; 4) heels overlapped slightly when the flexed legs are held at right angles to the body axis; 5) toe tips with rudimentary webs and without grooves; 6) dermal fringes moderate; 7) tubercles on the dorsum forming an X-shaped weak ridge; 8) horn-like tubercle at the edge of the upper eyelid distinct; 9) color of the iris in life is brown. In Bayesian phylogenetic analysis of 22 species of Xenophrys, all the individuals of X. liboensis sp. nov. clustered into a monophyletic clade with high posterior probabilities. In addition, the ranges of genetic divergences of X. liboensis sp. nov. with other species were interspecific rather than intraspecific. Based on the above evidences, we consider that X. liboensis sp. nov. is a valid species in Xenophrys. | Yanan ZHANG Gang LI Ning XIAO Jiaqi LI Tao PAN Hui WANG Baowei ZHANG Jiang ZHOU | 2017 | Asian Herpetological Research2017，18，2： | 9 |
| 15 | Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling显示文摘Objective:Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of cancer.However,few anti-lymphangiogenic drugs have been approved for clinical use to date.Therefore,new therapies to block lymphangiogenesis are urgently required.Methods:Immunohistochemistry,immunofluorescence,Western blot,migration assays,and lymphangiogenesis and lymphatic metastasis assays were used.Results:Anlotinib,a receptor tyrosine kinase inhibitor,suppressed the rate of new metastatic lesions(31.82%in the placebo arm and 18.18%in the anlotinib arm)in patients with advanced lung adenocarcinoma who were enrolled in our ALTER-0303 study.D2-40+-lymphatic vessel density was strongly correlated with disease stage,metastasis,and poor prognosis in 144 Chinese patients with lung adenocarcinoma.In mice bearing A549EGFP tumors,tumor lymphatic vessel density,tumor cell migration to lymph nodes,and the number of distant metastatic lesions were lower in the anlotinib group than in the controls.Anlotinib inhibited the growth and migration of human lymphatic endothelial cells(hLECs)and lymphangiogenesisin vitro andin vivo.Treatment of hLECs with anlotinib downregulated phosphorylated vascular endothelial growth factor receptor 3(VEGFR-3).Conclusions:Anlotinib inhibits lymphangiogenesis and lymphatic metastasis,probably through inactivating VEGFR-3 phosphorylation.The results indicate that anlotinib may be beneficial for treatment in avoiding lymphangiogenesis and distant lymphatic metastasis in lung adenocarcinoma.(Trial registration:ALTER0303;NCT02388919;March 17,2015.) | Tingting Qin Zhujun Liu Jing Wang Junling Xia Shaochuan Liu Yanan Jia Hailin Liu Kai Li | 2020 | Cancer Biology & Medicine2020，17，3： | 9 |
| 16 | Genetic diversity,population structure,and relationships of apricot(Prunus)based on restriction site-associated DNA sequencing显示文摘Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversity,population structure,and relationships of apricot,which are important for germplasm conservation and molecular breeding.Restriction site-associated DNA sequencing(RAD-seq)was adopted to sequence 168 Prunus spp.accessions distributed in five ecological groups,including 74 accessions of cultivated Prunus armeniaca L.and 94 accessions of wild apricots(P.armeniaca L.and Prunus sibirica L.),which generated 417,961 high-quality SNPs.We used cluster,genetic structure,and principal component analyses to examine the genetic diversities and genetic relationships of the 168 accessions.The Dzhungar-Ili ecological group accessions showed the highest genetic diversity in terms of private allele number,observed heterozygosity,and nucleotide diversity.We speculate that the Central Asian ecological group accessions were domesticated from the Dzhungar-Ili ecological group accessions.The population structure and gene flow of the North China and European ecological group accessions suggested a genetic background of P.sibirica.We argue that the two groups should be considered hybrid swarms connected to P.sibirica by continuous and extensive gene flow.P.armeniaca originated in Northwest China(Ili Valley),subsequently spread throughout Central Asia,and eventually spread to Europe.In addition,selective sweep signatures in P.armeniaca during domestication from wild to cultivated apricots,combined with differentially expressed genes,underlie distinct fruit traits,including sugars,aromas,organic acids,and carotenoids.This study provides substantive and valuable genomic resources that will significantly advance apricot improvement and effective utilization. | Wenwen Li Liqiang Liu Yanan Wang Qiuping Zhang Guoquan Fan Shikui Zhang Yatong Wang Kang Liao | 2020 | Horticulture Research2020，7，1： | 9 |
| 17 | Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities显示文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. | Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 18 | From recollement of triangulated categories to recollement of abelian categories显示文摘In this paper,we prove that if a triangulated category D admits a recollement relative to triangulated categories D' and D″,then the abelian category D/T admits a recollement relative to abelian categories D'/i(T) and D″/j(T) where T is a cluster tilting subcategory of D and satisfies i i (T) T,j j (T) T. | LIN YaNan 1 & WANG MinXiong 1,2,1 School of Mathematical Sciences,Xiamen University,Xiamen 361005,China 2 School of Mathematical Sciences,Huaqiao University,Quanzhou 362021,China | 2010 | Science China Mathematics2010，53，4： | 8 |
| 19 | Power Allocation and Performance Analysis of the Collaborative NOMA Assisted Relaying Systems in 5G显示文摘Serving multiple cell-edge mobile terminals poses multifaceted challenges due to the increased transmission power and interferences, which could be overcome by relay communications. With the recent advancement of 5G technologies, non-orthogonal multiple access(NOMA) has been used at relay node to transmit multiple messages simultaneously to multiple cell-edge users. In this paper, a Collaborative NOMA Assisted Relaying(CNAR) system for 5G is proposed by enabling the collaboration of source-relay(S-R) and relay-destination(R-D) NOMA links. The relay node of the CNAR decodes the message for itself from S-R NOMA signal and transmits the remaining messages to the multiple cell-edge users in R-D link. A simplified-CNAR(S-CNAR) system is then developed to reduce the relay complexity. The outage probabilities for both systems are analyzed by considering outage behaviors in S-R and R-D links separately. To guarantee the data rate, the optimal power allocation among NOMA users is achieved by minimizing the outage probability. The ergodic sum capacity in high SNR regime is also approximated. Our mathematical analysis and simulation results show that CNAR system outperforms existing transmission strategies and S-CNAR reaches similar performance with much lower complexity. | Xin Liu Xianbin Wang Yanan Liu | 2017 | China Communications2017，14，1： | 8 |
| 20 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
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