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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Regulation of glucose metabolism-related genes and VEGF by HIF-1 alpha and HIF-1 beta,but not HIF-2 alpha,in gastric cancer显示文摘 | Song IS Wang AG Yoon SY | 2009 | Exp Mol Med2009，41，1： | 1 |
| 3 | Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy显示文摘 | Song Q Schmidt AG Hahn HS | 2003 | J Clin Invest2003，111，6： | 1 |
| 4 | Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats显示文摘 | Song C Phillips AG Leonard BE | 2004 | Mol Psychiatry2004，9，6： | 1 |
| 5 | Regulation of glucose metabo-lism-related genes and VEGF by HIF-1alpha and HIF-1beta,but notHIF-2alpha,in gastric cancer显示文摘 | Song IS Wang AG Yoon SY | 2009 | Exp Mol Med2009，41，1： | 1 |
| 6 | Blood 25-hydroxy vitamin D lev- els and incident type 2 diabetes:a meta - analysis of prospectives- tudies 显示文摘 | Song Y Wang L Pittas AG | 2013 | Diabetes Care2013，36，5： | 1 |
| 7 | Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes A meta-analysis of prospective studies显示文摘 | Song Y Wang L Pittas AG | 2013 | DCP2013，36，5： | 1 |
| 8 | Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1 beta, but not HIF-2alpha, in gastric cancer 显示文摘 | Song IS Wang AG Yoon SY | 2009 | Exp Mol Med2009，41，1： | 1 |
| 9 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 10 | Blood 25-hydroxy vitamin D levels and incident type 2 diabetes:a meta-analysis of prospective studies显示文摘 | Song Y Wang L Pittas AG | 2013 | Diabetes Care2013，36，5： | 1 |
| 11 | Blood 25-hydroxy vitamin D levels and incident type 2 diabetes, a meta-analysis of prospective studies显示文摘 | Song Y Wang L Pittas AG | 2013 | Diabetes Oare2013，36，5： | 1 |
| 12 | Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy显示文摘 | Song Q Schmidt AG Hahn H | 2003 | J Clin Invest2003，111，： | 1 |
| 13 | Safety supervisory strategy for an upper-limb rehabilitation robot based on impedance con- trol 显示文摘 | Pan LZ Song AG Xu GZ | 2013 | Int JAdv Robot Sys2013，10，： | 1 |
| 14 | Clinical experimental research on adaptive robot aided therapy control methods for upper-limb rehabilita?tion显示文摘 | Xu GZ Song AG Pan LZ | 2014 | Robotica2014，32，7： | 1 |
| 15 | Regulation of glucose metabolism-related genes and VEGF by HIF-1 alpha and HIF-1 beta,but not HIF-2 alpha,in gastric cancer显示文摘 | Song IS Wang AG Yoon SY | | 0，，01： | 1 |
| 16 | Interleukin 1 beta enhances conditioned fear memory in rats; possible involvement of glucocorticoids显示文摘 | Song C Phillips AG Leonard B | 2003 | Eur J Neurosci2003，18，： | 1 |
| 17 | Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies显示文摘 | Song Y Wang L Pittas AG | 2013 | Diabetes Care2013，36，： | 1 |
| 18 | Impedance identification and adaptive control of rehabilitation robot for upper-limb passive training 显示文摘 | Song AG Pan LZ Xu GZ | 2014 | Found Appl Intel Sys2014，213，1： | 1 |
| 19 | CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells显示文摘 | Si W Kang Q Luu HH Park JK Luo Q Song WX Jiang W Luo X Li X Yin H Montag AG Haydon RC He TC | | 0，，8： | 1 |
| 20 | Blood 25-hydroxy vitamin D levels and incident type 2 diabetes显示文摘 | Song Y Wang L Pittas AG | 2013 | Diabetes Care2013，36，5： | 1 |
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