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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Contributions of climate change and human activities to ET and GPP trends over North China Plain from 2000 to 2014显示文摘确定土壤水分蒸发蒸腾损失总量(et ) 和粗野主要生产率(GPP ) 改变的生态系统的气候变化和人的活动的贡献为改编评价和持续开发是重要的。et 和 GPP 的空间与时间的模式与一个物理、遥远的基于感觉的模型一起在诺思中国平原(NCP ) 上从 2000 ~ 2014 被估计。et 和 GPP 趋势的气候变化和人的活动的贡献被第一个差别趋势 de 方法和 multivariate 回归分开并且确定。结果显示出那年度 et , GPP 微弱地增加了,与气候变化和人的活动贡献 0.188 公里 yr-2 和 0.466 公里年-2到 0.654 公里年-2,的 et 趋势 and-1.321 g C m -2年-2和 7.542 g C m -2年-2到 GPP 6.221 的趋势 g C m -2年-2,分别地。在农田,增加的趋势主要在种舞台的小麦发生了;小麦和玉米的气候变化的贡献两个都是否定的。降水和阳光持续时间是调整 et 和 GPP 趋势的主要气候的因素。人的活动在 NCP 是到水消费和粗野主要生产率的长期的趋势的主要司机,这被结束。 | CHEN Xuejuan MO Xingguo HU Shi LIU Suxia | 2017 | Journal of Geographical Sciences2017，27，6： | 11 |
| 3 | Effects of annealing treatment on the microstructure and electrochemical properties of low-Co hydrogen storage alloys containing Cu and Fe显示文摘The effects of annealing treatment on the microstructure and electrochemical properties of low-Co LaNi 3.55 Mn 0.35 Co 0.20 Al 0.20 Cu 0.75 Fe 0.10 hydrogen storage alloys were investigated. X-ray diffraction (XRD) analysis indicated that annealing treatment remarkably reduced the lattice strain and defects, and increased the unit-cell volume. The optical microscope analysis showed that the as-cast alloy had a crass dendrite microstructure with noticeable composition segregation, which gradually disappeared with increasing annealing temperature, and the micro-structure changed to an equiaxed structure after annealing the alloy at 1233 K. The electrochemical tests indicated that the annealed alloys demonstrated much better cycling stability compared with the as-cast one. The capacity retention at the 100th cycle increased from 90.0% (as-cast) to 94.7% (1273 K). The annealing treatment also improved the discharge capacity. However, the high rate dischargeability (HRD) value of the annealed alloy slightly dropped, which was believed to be ascribed to the decreased exchange current density and the hydrogen diffusion coefficient in alloy bulk. | YANG Suxia LIU Zhiping HAN Shumin ZHANG Wei SONG Jianzheng | 2011 | Rare Metals2011，30，5： | 10 |
| 4 | Virus-induced Phytoene Desaturase(PDS) Gene Silencing Using Tobacco Rattle Virus in Lilium × formolongi显示文摘Gene function analysis is challenging for Lilium due to the lack of an efficient method for stable genetic transformation. Virus-induced gene silencing(VIGS) is an attractive tool for determining gene function in plants. This study reported that Tobacco rattle virus(TRV)-based VIGS of a PHYTOENE DESATURASE(PDS) ortholog(LhPDS) can be achieved in Lilium × formolongi seedlings, with a survival rate of 92%, using the inoculation method of rubbing plus injection. Compared with untreated and mock-treated seedlings, the photobleached leaf phenotype of silenced plants significantly correlates with down-regulation of endogenous LhPDS(P ≤ 0.05). In addition, the silencing phenomenon can be observed in the growing points of plants, indicating that systemic viral infection was achieved using the protocol. The results indicate that TRV-based VIGS can be used to characterize gene function in Lilium × formolongi. This work lays the foundation for gene function analysis and molecular breeding in Lilium spp. | Hua Xu Leifeng Xu Panpan Yang Yuwei Cao Yuchao Tang Guoren He Suxia Yuan Jingyi Lei Jun Ming | 2019 | Horticultural Plant Journal2019，5，1： | 6 |
| 5 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 6 | Bone marrow mesenchymal stem cells with Nogo-66 receptor gene silencing for repair of spinal cord injury显示文摘We hypothesized that RNA interference to silence Nogo-66 receptor gene expression in bone marrow mesenchymal stem cells before transplantation might further improve neurological function in rats with spinal cord transection injury. After 2 weeks, the number of neurons and BrdU-positive cells in the Nogo-66 receptor gene silencing group was higher than in the bone marrow mesenchymal stem cell group, and significantly greater compared with the model group. After 4 weeks, behavioral performance was significantly enhanced in the model group. After 8 weeks, the number of horseradish peroxidase-labeled nerve fibers was higher in the Nogo-66 receptor gene silencing group than in the bone marrow mesenchymal stem cell group, and significantly higher than in the model group. The newly formed nerve fibers and myelinated ner ve fibers were detectable in the central transverse plane section in the bone marrow mesenchymal stem cell group and in the Nogo-66 receptor gene silencing group. | Zhiyuan Li Zhanxiu Zhang Lili Zhao Hui Li Suxia Wang Yong Shen | 2014 | Neural Regeneration Research2014，9，8： | 5 |
| 7 | Assessing the impact of climate change on potential evapotranspiration in Aksu River Basin显示文摘土壤水分蒸发蒸腾损失总量是水文学过程的关键部件之一。在土壤水分蒸发蒸腾损失总量上估计气候因素的影响在在水文学过程上理解气候变化的影响是有用的。在这份报纸,基于从 1960 ~ 2007 的每天气象学的数据在以内并且在 Aksu 河盆附近,引用土壤水分蒸发蒸腾损失总量(沤) 与 FAO Penman-Monteith 方法被估计。时间、空间的变化沤被使用 ARCGIS 和 Mann-Kendall 方法分析。多重回归分析被采用归因空气温度,太阳的放射,相对湿度,蒸汽压力和风速度的变化的效果在上沤。结果显示出那一般水准年度在 Aksu 河盆的东方平凡区域沤在西方的多山的区域像那一样将近是大约 1100 公里,它是两次。趋势年度沤有的重要空间可变性。年度沤在东南的绿洲区域和西南的平凡区域显著地被减少并且在山区稍微增加了。变化的振幅沤到达在夏天最高,年度变化的作出贡献的大多数沤。除了在相对湿度支配了 RET 的变化的一些高举起区域,风速度的变化支配了变化几乎在整个盆沤。作为一个例子拿 Kuqa 和 Ulugqat 车站,风速度的变化占了超过 50% 变化沤。 | ZHANG Shouhong LIU Suxia MO Xingguo SHU Chang SUN Yang ZHANG Chun | 2011 | Journal of Geographical Sciences2011，21，4： | 5 |
| 8 | Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter显示文摘肾调整雄激素的蛋白质(Kap ) 基因是由雄激素在老鼠肾特定、调整的织物近似小管房间(PTC ) 。在现在的学习,我们试图识别最小的 PTC 特定的调整雄激素的 Kap 倡导者并且分析它的雄激素反应元素(AREs ) 。Kap1542 倡导者 / 酶构造的一个删除系列是 assayed 在里面鼠肾(好) PTC 当面或 15 nM dihydrotestosterone (DHT ) 的缺席。Kap1542 和 Kap637 举办了低活动和没有雄激素正式就职;Kap224 举办了比 Kap1542 的高是到 5 褶层的 4- 的一项基础活动,但是被 DHT 仅仅稍微导致。Kap147 举办了比 Kap1542 的高是到 3 褶层的 2- 并且被 DHT 4- 导致到 6 褶层的一项基础活动。Kap77 废除了基础倡导者活动,但是被 DHT 仍然导致。结果证明在 vitro, Kap147 是一个最小的调整雄激素的倡导者。在不同房间的短暂 transfection 证明 Kap147 明确地在 PTC 开始了记者基因表示。顺序分析揭示了在位置 −124 和 Kap147 的 −39 定位的二潜在的 AREs。Mutational 试金证明仅仅在 −124 的 ARE 在好房间涉及雄激素反应。Electrophoretic 活动性移动试金也证实 −124 雄激素受体明确地一定。在结论,我们定义可以是为肾的学习的一个好模型的最小的 Kap147 倡导者在 vivo 导致一只雄激素特定的应答的海角的 PTC 特定的表示和分子的机制。 | Liqiang Fan Dianne O Hardy James F Catteral Jian Zhao Suxia Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 4 |
| 9 | Induced electric fields and plasmonic interactions between a metallic nanotube and a thin metallic film显示文摘We have numerically simulated the induced electric fields and the plasmonic interactions of a metallic nanotube near a thin metallic film. Our study shows that the energies and intensities of the plasmon resonances depend strongly on the aspect ratio (the ratio of the inner to outer radius) of the nanotube as well as the separation between the center of the nanotube and the upper surface of the metallic film and the thickness of the film. The enhancement of the induced electric field of this system reaches as high as 10 4 orders of magnitude and its field distribution is characterized by waveguide-mode resonance. The report proposes that these phenomena can be applied to designing surface enhanced spectroscopies such as surface enhanced Raman spectroscopy for efficient chemical and biological sensing. | LI HongJian 1,2 , FU ShaoLi 1 , XIE SuXia 1,2 , XU HaiQing 1 , ZHOU Xin 1,2 & WU JinJun 1 1 College of Physics Science and Technology, Central South University, Changsha 410083, China 2 College of Materials Science and Engineering, Central South University, Changsha 410083, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 3 |
| 10 | Towards smart optical focusing:deep learningempowered dynamic wavefront shaping through nonstationary scattering media显示文摘Optical focusing through scattering media is of great significance yet challenging in lots of scenarios,including biomedical imaging,optical communication,cybersecurity,three-dimensional displays,etc.Wavefront shaping is a promising approach to solve this problem,but most implementations thus far have only dealt with static media,which,however,deviates from realistic applications.Herein,we put forward a deep learning-empowered adaptive framework,which is specifically implemented by a proposed Timely-Focusing-Optical-Transformation-Net(TFOTNet),and it effectively tackles the grand challenge of real-time light focusing and refocusing through time-variant media without complicated computation.The introduction of recursive fine-tuning allows timely focusing recovery,and the adaptive adjustment of hyperparameters of TFOTNet on the basis of medium changing speed efficiently handles the spatiotemporal non-stationarity of the medium.Simulation and experimental results demonstrate that the adaptive recursive algorithm with the proposed network significantly improves light focusing and tracking performance over traditional methods,permitting rapid recovery of an optical focus from degradation.It is believed that the proposed deep learning-empowered framework delivers a promising platform towards smart optical focusing implementations requiring dynamic wavefront control. | YUNQI Luo SUxIA YAN HUANHAO LI PUXIANG LAI YUANJIN ZHENG | 2021 | Photonics Research2021，9，8： | 3 |
| 11 | Estimating the minimum in-stream flow requirements via wetted perimeter method based on curvature and slope techniques显示文摘Under the assumptions of triangular cross section channel and uniform stable flow, an analytical solution of the minimum ecological in-stream flow requirement (MEIFR) is deduced. Based on the analytical solution, the uncertainty of the wetted perimeter method is analyzed by comparing the two techniques for the determination of the critical point on the relationship curve between wetted perimeter, P and discharge, Q. It is clearly shown that the results of MEIFR based on curvature technique (corresponding to the maximum curvature) and slope technique (slope being 1) are significantly different. On the P-Q curve, the slope of the critical point with the maximum curvature is 0.39 and the MEIFR varied prominently with the change of the slope threshold. This indicates that if a certain value of the slope threshold is not available for slope technique, curvature technique may be a better choice. By applying the analytical solution of MEIFR in the losing rivers of the Western Route South-to-North Water Transfer Project in China, the MEIFR value via curvature technique is 2.5%-23.7% of the multi-year average annual discharge, while that for slope technique is 11%-105.7%. General conclusions would rely on the more detailed research for all kinds of cross-sections. | LIU Suxia' MO Xingguo XIA Jun LIU Changming LINZhonghui MEN Baohui JI Lina | 2006 | Journal of Geographical Sciences2006，16，2： | 2 |
| 12 | Multiple active components synergistically driven heteroatom-doped porous carbon as high-performance counter electrode in dye-sensitized solar cells显示文摘A facile template-free in situ self-activation approach for the multiple active components synergistically driven porous carbon was presented via a feasible annealing process.The biomass-derived carbon without additional activation reagents was fabricated using K-rich pomelo peel(PP)as the carbon source,which possesses a high electric conductivity where abundant functional hetero-metal atoms are doped into the carbon framework that playing the role of catalytic graphitization.The K^+that exists within the biomass can induce self-activation during pyrolysis apart from the activating gases during the pyrolysis process.The resulting electrocatalyst of PP-850(PP was pyrolyzed at 850°C in an N_2atmosphere)with abundant heteroatoms possesses a higher power conversion efficiency(PCE)of 7.81%as the counter electrode(CE)of dye-sensitized solar cells(DSCs)compared with the CEs calcinated at other temperatures and a similar PCE with Pt counterpart(8.24%)based on the liquid I_3^-/I^-electrolyte.The better electrocatalytic performance is attributed to the synergistic effect between self-activation and the co-doping of nitrogen,sulfur and phosphorus all together in a carbon matrix.Due to the feasibility of large-scale production,rich heteroatom doping,the PP-derived carbon,which simplifies the procedure and decreases the cost,has a potential application for an alternative electrocatalyst for high-performance photovoltaic devices. | Hongyu Jing Danyang Wu Suxia Liang Xuedan Song Yonglin An Ce Hao Yantao Shi | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 13 | Simulation Research on Stress Intensity Factors of Different Crack Aspect Ratios on Hollow Axles显示文摘Because of the wicked service environment of the high speed train,it is possible that the hollow axle of the train may encounter the foreign object damage and form a sharp notch.Under the fatigue loading a crack can initiate from the notch and propagate to failure.It is noted that the stress intensity factor is the control parameter of the crack propagating,for the purpose of getting the more exact propagation characteristics,the stress intensity factor is studied mainly.The service loads of hollow axles are defined,and the stress distribution of hollow axles is obtained according to the load spectrum.The semi-ellipse crack configuration is defined with three parameters:the aspect ratio,the relative depth and the relative location along the crack front.Quarter point 20-node isoparametric degenerate singular elements are used for the region near the crack tip.The finite element model of crack extension of hollow axle is created,and the crack front is dispersed which can realize orthogonal extension.Based on this the stress intensity factors of crack front were calculated,and the distribution rules of the stress intensity factors of different initial crack shapes are obtained.The conclusions are compared with that of the analytic method and they agree with each other very well,and the calculating results show that there is a close relationship between the stress intensity factor and the initial crack shape.For a round crack the stress intensity factor at the surface point increases faster than the one at the center point with the crack propagation.However,for a narrow crack,the results are in contrast with that of a round one.So,all the cracks with different shapes propagate toward to a similar shape,and they grow at this shape to end.The study may contribute to the crack propagate characteristics research. | ZHOU Suxia XIE Jilong | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 2 |
| 14 | Effects of the local environment on plasmonic coupling of metallic nanotube arrays显示文摘We have theoretically investigated the effect of the dielectric core and the dielectric embedding medium separately on the transmission spectra and plasmonic properties of coupled metallic nanotube arrays.It is found that the plasmonic properties of the nanotube arrays are strongly influenced by the presence of the dielectric which induces additional screening charges.We show that instead of one single photonic bandgap for the hollow nanotube arrays placed in air,an additional photonic bandgap arises from the presence of dielectric media in the transmission spectra.Based on the localized nature of the electric field distributions,we also clearly show the presence of the local plasmonic resonant modes that originate from multipolar plasmon polaritons in the cross section of these nanotube arrays,and that a large amount of opposing surface charges are built up in the gap between adjacent nanotubes. | LI HongJian FU ShaoLi XIE SuXia XU HaiQing ZHOU Xin WU JinJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 2 |
| 15 | DAMAGE TOLERANCE ANALYSIS ON HOLLOW AXLES OF HIGH SPEED MOTOR TRAINS显示文摘According to the rules of UIC515-3,the service loads of the axles arc defined,which include some different loads cases as follows:the static loads;the impact loads resulted from running through the rail joints and unevenness rails;the loads through curves and fi'om braking.Through the calculating and analysis,the stress distribution of the hollow axles is obtained for 200 km/h high speed motor trains used in China.At the same time,the fatigue crack growth of hollow axles is studied,and the initial surface cracks of 2 mm depth caused by hard objects strike or the other causes are discussed.On the basis of the linear elastic fracture mechanics theory,the stress intensity factor of the crack of the geometry transition outside the wheel scat is also studied.Associated with fatigue crack propagation equation and the corresponding crack propagation threshold,the crack propagation characteristics under different shapes are calculated.Then the running distances arc educed with different shapes propagating to the critical length,and the estimation of the residual lives about hollow axles which are the reference values of examine and repair limit of the hollow axle is given. | ZHOU Suxia XIE Jilong YANG Guangxue XIAO Nan | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 2 |
| 16 | Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is characterized by the highest mortality among carcinomas.The pathogenesis of PDAC requires elevated autophagy,inhibition of which using hydroxychloroquine has shown promise.However,current realization is impeded by its suboptimal use and unpredictable toxicity.Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid and accessible approach.Here,using a patient-derived organoid model,we performed a comparative analysis of therapeutic responses among various antimalarial/fungal/parasitic/viral agents,through which econazole(ECON),an antifungal compound,emerged as the top candidate.Further testing in cell-line and xenograft models of PDAC validated this activity,which occurred as a direct consequence of dysfunctional autophagy.More specifically,ECON boosted autophagy initiation but blocked lysosome biogenesis.RNA sequencing analysis revealed that this autophagic induction was largely attributed to the altered expression of activation transcription factor 3(ATF3).Increased nuclear import of ATF3 and its transcriptional repression of inhibitor of differentiation-1(ID-1)led to inactivation of the AKT/mammalian target of rapamycin(m TOR)pathway,thus giving rise to autophagosome accumulation in PDAC cells.The magnitude of the increase in autophagosomes was sufficient to elicit ER stress-mediated apoptosis.Furthermore,ECON,as an autophagy inhibitor,exhibited synergistic effects with trametinib on PDAC.This study provides direct preclinical and experimental evidence for the therapeutic efficacy of ECON in PDAC treatment and reveals a mechanism whereby ECON inhibits PDAC growth. | Ningna Weng Siyuan Qin Jiayang Liu Xing Huang Jingwen Jiang Li Zhou Zhe Zhang Na Xie Kui Wang Ping Jin Maochao Luo Liyuan Peng Edouard C.Nice Ajay Goel Suxia Han Canhua Huang Qing Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 17 | Comparative study on the effect of integrin αvβ3 on secretion of matrix metalloproteinases in human normal and carcinoma trophoblasts显示文摘进母亲的子宫内膜的 cytotrophoblast 房间的侵略在胚胎的培植期间很类似于癌房间的转移。然而,重要差别是前者是一个高度控制的过程。在这份报告, integrin 高山的效果哈在矩阵 metalloproteinase (MMP ) 的分泌物上的 v 贝它 3 被 RT-PCR 在正常 cytotrophoblast 房间和 chorio 癌房间之间比较,明胶 zymography andimmunocytochemistry。结果表明两个正常 cytotrophoblast 房间和 choriocarcinomacells 能表示 integrin 高山哈 v 贝它 3。在由 anti-alpha v 贝它 3 抗体调整 isup 的正常 cytotrophoblast 房间的 MMP 的分泌物,而,在 choriocarcinoma 房间减少了。它被建议那座高山哈 v 贝它 3 能在 trophoblasts 调制 MMP 的表示,并且这个行动在正常和癌 cytotrophoblast 房间通过不同机制被执行。 | BAI Suxia FU Yayuan KONG Gang WANG Yanling | 2005 | Progress in Natural Science:Materials International2005，15，11： | 2 |
| 18 | Simultaneous determination of 5-nitroimidazoles and nitrofurans in pork by high-performance liquid chromatography–tandem mass spectrometry显示文摘 | Xi Xia Xiaowei Li Suxia Zhang Shuangyang Ding Haiyang Jiang Jiancheng Li Jianzhong Shen | 2008 | Journal of Chromatography A2008，，1： | 2 |
| 19 | Relationship between Expression of CEA,E-cadherin and Liver Metastasis in Colorectal Cancer显示文摘OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver metastasis.METHODS CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal cancer.Immunohistochemical analysis was used to evaluate theexpression of E-cadherin.RESULTS In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver metastasisgroup.The difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N stage.Liver metastatic rate innegative expression was higher than that in positive expression.And the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer. | Ning Li Xiaobing Chen Xiangbin Wan Suxia Luo Lili Han Mengqiang Zhou Dengwen Yin Li Zhang | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 20 | Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples显示文摘Here we report the codon bias and the mRNA secondary structural features of the hemagglutinin(HA)cleavage site basic amino acid regions of avian influenza virus H5N1 subtypes.We have developed a dynamic extended folding strategy to predict RNA secondary structure with RNAstructure 4.1 program in an iterative extension process.Statistical analysis of the sequences showed that the HA cleavage site basic amino acids favor the adenine-rich codons,and the corresponding mRNA fragments are mainly in the folding states of single-stranded loops.Our sequential and structural analyses showed that to prevent and control these highly pathogenic viruses,that is,to inhibit the gene expression of avian influenza virus H5N1 subtypes,we should consider the single-stranded loop regions of the HA cleavage site-coding sequences as the targets of RNA interference. | ZHANG SuXia WANG Xin CHEN XueFeng CAO Huai ZHANG Wen LIU CiQuan | 2008 | Chinese Science Bulletin2008，53，3： | 2 |
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