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| 1 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 2 | Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites显示文摘The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea flavors.However,there has been relatively little research on molecular markers related to these metabolites.Thus,we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three seasons.The theanine,caffeine,and catechin levels in Population 1 comprising 191 tea plant germplasms were examined,which revealed that their heritability exceeded 0.5 in the analyzed seasons,with the following rank order(highest to lowest heritabilities):(+)-catechin>(−)-gallocatechin gallate>caffeine=(−)-epicatechin>(−)-epigallocatechin-3-gallate>theanine>(−)-epigallocatechin>(−)-epicatechin-3-gallate>catechin gallate>(+)-gallocatechin.The SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven subgroups.An association analysis yielded 307 SNP markers related to theanine,caffeine,and catechins that were common to all three seasons.Some of the markers were pleiotropic.The functional annotation of 180 key genes at the SNP loci revealed that FLS,UGT,MYB,and WD40 domain-containing proteins,as well as ATP-binding cassette transporters,may be important for catechin synthesis.KEGG and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite biosynthesis.Moreover,in Population 2(98 tea plant germplasm resources),30 candidate SNPs were verified,including 17 SNPs that were significantly or extremely significantly associated with specific metabolite levels.These results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties. | Kaixing Fang Zhiqiang Xia Hongjian Li Xiaohui Jiang Dandan Qin Qiushuang Wang Qing Wang Chendong Pan Bo Li Hualing Wu | 2021 | Horticulture Research2021，8，1： | 10 |
| 3 | Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer显示文摘高活动性组蛋白质(HMG ) 是第二很丰富的染色质蛋白质并且在活跃或不活跃的染色质域的建立施加全球 genomic 函数。通过和 nucleosomes,抄写因素,改变 nucleosome 机器和 histones 的相互作用, HMG 家庭蛋白质贡献响应快速的环境变化抄写调节的罚款。哺乳动物的高活动性组 B (HMGB ) 被领域用一条长酸的尾巴跟随了的二个双人脚踏车 HMG 盒子描绘。最近的研究证明 HMGB 的那高表情在许多癌症被发现了,例如前列腺,肾,卵巢、胃的癌症。然而,他们在胰腺的癌症的角色很少被报导了。在这研究,我们估计了 HMGB 蛋白质的诊断、预示的值,包括 HMGB1, HMGB2,和 HMGB3,在从癌症染色体地图集(TCGA ) 数据集的胰腺的癌症。我们的结果证明 HMGB2 在胰腺的癌症预言了差的预后。在 vitro,研究证明 silencing HMGB2 禁止了房间增长和生存能力。机械学地,我们的结果证明 silencing HMGB2 减少了组织缺氧可诱导的因素 1 (HIF1 ) 蛋白质水平和禁止的调停 HIF1 的 glycolysis 处理。进一步的分析显示包括 GLUT1, HK2,和 LDHA,指向 HIF1 的 glycolytic 基因都是预示的因素并且断然与 HMGB2 表示相关。一起拿,我们为胰腺的癌症发现了新预示、预兆的标记,并且在癌症在 glycolytic 控制使 HMGB2 的新奇函数清楚些。 | Xin Cai Hongjian Ding Yanxia Liu Gaofeng Pan Qingguo Li Zhen Yang Weiyan Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 9 |
| 4 | Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction显示文摘The first paradigm of plant breeding involves direct selection-based phenotypic observation,followed by predictive breeding using statistical models for quantitative traits constructed based on genetic experimental design and,more recently,by incorporation of molecular marker genotypes.However,plant performance or phenotype(P)is determined by the combined effects of genotype(G),envirotype(E),and genotype by environment interaction(GEI).Phenotypes can be predicted more precisely by training a model using data collected from multiple sources,including spatiotemporal omics(genomics,phenomics,and enviromics across time and space).Integration of 3D information profiles(G-P-E),each with multidimensionality,provides predictive breeding with both tremendous opportunities and great challenges.Here,we first review innovative technologies for predictive breeding.We then evaluate multidimensional information profiles that can be integrated with a predictive breeding strategy,particularly envirotypic data,which have largely been neglected in data collection and are nearly untouched in model construction.We propose a smart breeding scheme,integrated genomic-enviromic prediction(iGEP),as an extension of genomic prediction,using integrated multiomics information,big data technology,and artificial intelligence(mainly focused on machine and deep learning).We discuss how to implement iGEP,including spatiotemporal models,environmental indices,factorial and spatiotemporal structure of plant breeding data,and cross-species prediction.A strategy is then proposed for prediction-based crop redesign at both the macro(individual,population,and species)and micro(gene,metabolism,and network)scales.Finally,we provide perspectives on translating smart breeding into genetic gain through integrative breeding platforms and open-source breeding initiatives.We call for coordinated efforts in smart breeding through iGEP,institutional partnerships,and innovative technological support. | Yunbi Xu Xingping Zhang Huihui Li Hongjian Zheng Jianan Zhang Michael S.Olsen Rajeev K.Varshney Boddupalli M.Prasanna Qian Qian | 2022 | Molecular Plant2022，15，11： | 7 |
| 5 | Dynamic analysis of granite rockburst based on the PIV technique显示文摘This paper describes the deep rockburst simulation system to reproduce the granite instantaneous rockburst process.Based on the PIV(Particle Image Velocimetry)technique,quantitative analysis of a rockburst,the images of tracer particle,displacement and strain fields can be obtained,and the debris trajectory described.According to the observation of on-site tests,the dynamic rockburst is actually a gas–solid high speed flow process,which is caused by the interaction of rock fragments and surrounding air.With the help of analysis on high speed video and PIV images,the granite rockburst failure process is composed of six stages of platey fragment spalling and debris ejection.Meanwhile,the elastic energy for these six stages has been calculated to study the energy variation.The results indicate that the rockburst process can be summarized as:an initiating stage,intensive developing stage and gradual decay stage.This research will be helpful for our further understanding of the rockburst mechanism. | Wang Hongjian Liu Da'an Gong Weili Li Liyun | 2015 | International Journal of Mining Science and Technology2015，25，2： | 6 |
| 6 | Genetic improvement of heat tolerance in wheat:Recent progress in understanding the underlying molecular mechanisms显示文摘As a cool season crop, wheat(Triticum aestivum L.) has an optimal daytime growing temperature of 15 ℃ during the reproductive stage. With global climate change, heat stress is becoming an increasingly severe constraint on wheat production. In this review, we summarize recent progress in understanding the molecular mechanisms of heat tolerance in wheat. We firstly describe the impact of heat tolerance on morphology and physiology and its potential effect on agronomic traits. We then review recent discoveries in determining the genetic and molecular factors affecting heat tolerance, including the effects of phytohormone signaling and epigenetic regulation. Finally, we discuss integrative strategies to improve heat tolerance by utilization of existing germplasm including modern cultivars, landraces and related species. | Zhongfu Ni Hongjian Li Yue Zhao Huiru Peng Zhaorong Hu Mingming Xin Qixin Sun | 2018 | The Crop Journal2018，6，1： | 4 |
| 7 | Expressed sequence tags analysis revealing the taxonomic position and fatty acid biosynthesis in an oleaginous green microalga,Myrmecia incisa Reisigl(Trebouxiophyceae,Chlorophyta)显示文摘cDNA library of Myrmecia incisa H4301 was constructed using λ phage vectors.The library consisted of 1.5×10 6 clones with a recombination rate of 90%,and 1942 clones were randomly sequenced.All 1854 readable expressed sequence tags(ESTs) were clustered into 596 non-redundant sequences(NRSs),among which 126 NRSs were from 1384 ESTs,showing a high redundancy.Among the 596 NRSs,30 were ribosomal RNA,and 152 significantly matched with those available in NCBI database and JGI Genome Portal,the latter were divided into nine subcategories.Overall,59 NRSs were involved in photosynthesis,the respiratory electron transport chain,ATP synthesis,oxidation reduction,fatty acid biosynthesis,glucose metabolism,protein metabolism,and small molecular metabolism,suggesting that these genes were abundantly transcribed during energy and substance metabolism.Acyl-carrier protein,ferrodoxin and fatty acid elongase genes obtained from this cDNA library enabled presumption of a possible biosynthesis pathway of ArA in M.incisa.Codon usage analysis of 142 NRSs with 17798 codons in the predicted coding regions showed that the average G+C content level of the total codons was 55.39%,and that of the third position in base trimers was 66.42%,indicating a strong bias toward cytosine and/or guanosine in this algal genome.Among all synonymous codons,NAG was most favored,while NUA was most avoided.Phylogenic trees inferred from ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit genes and the extra partial sequences of 18S rRNA obtained from this library demonstrated that M.incisa belonged to Trebouxiophyceae and was significantly clustered with M.incisa SAG 2007,Lobosphaera tirolensis,M.bisecta,and Parietochloris incisa,but was clearly distant from P.pseudoalveolaris and P.alveolar.Transmission electron microscopy revealed pyrenoids traversed by many parallel thylakoids membranes,while starch grains were only clearly observed when cells were grown under nitrogen stress.Based on combined investigation of the phylogeny and morphological characteristics,it is proposed that M.incisa be kept in the genus Myrmecia in which there might be two parallel groups,one living freely and another symbiotic species. | OUYANG LongLing DU DaoHai YU ShuiYan LI ChunYang ZHANG ChengWu GAO HongJian ZHOU ZhiGang | 2012 | Chinese Science Bulletin2012，57，25： | 4 |
| 8 | Electroluminescence efficiency in bilayer organic light-emitting devices with LiF/Al cathode显示文摘An analytical model to calculate electroluminescence (EL) efficiency of bilayer organic light-emitting devices, considering the influence of introducing LiF insulating buffer layer at metal/organic interface on the barrier height for electron injection, was presented. The relations of EL efficiency versus the applied voltage and injection barrier or internal interfacial barrier or the thickness of organic layer were discussed. The results indicate that: (1) when δ e/δ h < 2, metal/organic (M/O) interface is ohmic contact; when δ e/δ h > 2, M/O becomes contact limited; and when δ e/δ h = 2 (Φ h ~ 0.2 eV, Φ e ~ 0.3 eV), there is a transition from ohmic contact to contact limited; (2) η EL decreases with the increase of δ′e / δ′h; however, when δ′e / δ′h > 2.5 (H ′h~ 0.2 eV, H ′e~ 0.4 eV), the changes of η EL are very small, which shows that η EL is dominated by the carrier’s injection; (3) when increasing Lh/L, η R has a descending trend at low voltage and a rising one at higher voltage. For a given Lh/L, η EL first increases and then decreases with the increasing applied voltage, and as Lh/L further increases, the variation tendency of η EL is more obvious. These conclusions are in agreement with the reported theoretic and experimental results. | LI HongJian ZHU RuHui YAN LingLing ZHANG HaiYan | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，1： | 4 |
| 9 | Construction of molecule-selective mixed matrix membranes with confined mass transfer structure显示文摘Extraordinary mass transfer phenomenon is usually found when the small molecules pass through a confined structure, whose effective size is commensurate with the mean free path of the molecules. Small changes in the confined mass transfer structure(including size, morphology and properties) will lead to significant fluctuations of the mass transfer coefficient. The mass transfer of the penetrant molecules in the dense membranes for pervaporation, gas separation and so on, is located in the scope of confined mass transfer. Incorporating nanofillers into polymer matrix to construct mixed matrix membranes(MMMs) is an effective approach to tune the confined mass transfer structure and enhance the performance of the widely used polymeric membranes. This review focuses on the construction and manipulation of the confined structure in the polymeric membranes via incorporating one-dimensional(1D), two-dimensional(2D) and three-dimensional(3D) fillers.The comparison of the MMMs for pervaporation is summarized, and the research prospective of the MMMs is provided. | Weidong Li Fusheng Pan Yimeng Song Meidi Wang Hongjian Wang Shalik Walker Hong Wu Zhongyi Jiang | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 3 |
| 10 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 11 | Geochemistry of arsenic and selenium in a Ge-poor coal from the Wulantuga coal-hosted Ge ore deposit,Inner Mongolia,North China显示文摘This paper reports new data for arsenic(As)and selenium(Se)in a total of twelve bench samples of Ge-rich and Ge-poor coals in the No.6 coal seam from the Wulantuga ore deposit,Inner Mongolia,Northeastern China.The Gepoor coals are characterized by low-ash(with a weighted average ash yield 10.59%).The coal samples were digested using an UltraClave microwave high pressure reactor(milestone)and trace elements were detected by inductively coupled plasma mass spectrometry—collision/reaction cell technology,a reliable method for As and Se determination in coal samples.The contents of As and Se in the Ge-poor(with a weighted average content of 9.14 and 0.30 lg/g,respectively)and Ge-rich coal samples in the present study(varies from 16.88 to 17,776 lg/g and from 0.26 to 14.39 lg/g,respectively)are in a sharp contrast.The As in the Ge-poor coals is of both organic-and pyrite-associations,and its enrichment is attributed to the sediment source,and to a lesser extent,to hydrothermal fluids.Se is predominantly connected with organic matter in the Wulantuga Ge-poor coals. | Panpan Xie Qingqian Li Jingjing Liu Hongjian Song Jianpeng Wei | 2014 | International Journal of Coal Science & Technology2014，1，4： | 3 |
| 12 | Induced electric fields and plasmonic interactions between a metallic nanotube and a thin metallic film显示文摘We have numerically simulated the induced electric fields and the plasmonic interactions of a metallic nanotube near a thin metallic film. Our study shows that the energies and intensities of the plasmon resonances depend strongly on the aspect ratio (the ratio of the inner to outer radius) of the nanotube as well as the separation between the center of the nanotube and the upper surface of the metallic film and the thickness of the film. The enhancement of the induced electric field of this system reaches as high as 10 4 orders of magnitude and its field distribution is characterized by waveguide-mode resonance. The report proposes that these phenomena can be applied to designing surface enhanced spectroscopies such as surface enhanced Raman spectroscopy for efficient chemical and biological sensing. | LI HongJian 1,2 , FU ShaoLi 1 , XIE SuXia 1,2 , XU HaiQing 1 , ZHOU Xin 1,2 & WU JinJun 1 1 College of Physics Science and Technology, Central South University, Changsha 410083, China 2 College of Materials Science and Engineering, Central South University, Changsha 410083, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 3 |
| 13 | Computation of concentrations of characteristic atoms of alloys in BCC structure显示文摘In this paper,taking Nb-Mo alloy system as an example,the equations of concentration of characteristic atoms of alloys in BCC structure were obtained on the basis of the idea of systematic science of alloys and the number of coordination atoms.The concentrations of characteristic atoms in B2-NbMo type ordered alloys were calculated as functions of ordering degree(s) and composition xMo.When s=smax,the concentrations of characteristic atoms of stoichiometric B2-NbMo intermetallic compound are equal to that of alloys,that is,Nb 8 x0.5 at.,Mo 0 x0.5 at.As ordering degree decreases,characteristic atoms Nb 8A andM o 0A of B2-NbMo type ordered alloy split.And the degree of splitting of characteristic atoms increases with the ordering degree decreasing.Therefore,disordered alloys and various types of ordered alloys can be designed. | PENG HongJian WU Qing LI XiaoBo XIE YouQing | 2011 | Science China(Technological Sciences)2011，54，9： | 3 |
| 14 | KEY TECHNIQUES OF MULTI-BODY MODELING OF OCCUPANT RESTRAINT SYSTEM OF VEHICLE SIDE IMPACT显示文摘基于多身体动力学,汽车方面结构和占有人的模拟模型“ s 动态回答被建立,用占有人损害模拟软件 MADYMO3D.These,模型包括汽车身体结构,影响障碍,位子和哑巴。multi-bodyand 关节的定义和基于 FE,联合建模的关节的动力学性质,模型,安装被介绍。MADYMO 的凯尔文元素被介绍也显示出在 non-adjoiningrigid 身体之间的力量行动。然后,提及的方法的所有例子被给。由模拟和真实测试的比较,在为主要结构和哑巴的生物学力学性质的模拟和真实测试之间的合同曲线被获得。结果显示出模型的精确性和有效性。 | ZHANG Junyuan ZHANG Min DING Rufang QIU Shaobo ZHANG Yu LI Hongjian | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 3 |
| 15 | Effects of the local environment on plasmonic coupling of metallic nanotube arrays显示文摘We have theoretically investigated the effect of the dielectric core and the dielectric embedding medium separately on the transmission spectra and plasmonic properties of coupled metallic nanotube arrays.It is found that the plasmonic properties of the nanotube arrays are strongly influenced by the presence of the dielectric which induces additional screening charges.We show that instead of one single photonic bandgap for the hollow nanotube arrays placed in air,an additional photonic bandgap arises from the presence of dielectric media in the transmission spectra.Based on the localized nature of the electric field distributions,we also clearly show the presence of the local plasmonic resonant modes that originate from multipolar plasmon polaritons in the cross section of these nanotube arrays,and that a large amount of opposing surface charges are built up in the gap between adjacent nanotubes. | LI HongJian FU ShaoLi XIE SuXia XU HaiQing ZHOU Xin WU JinJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 2 |
| 16 | Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring显示文摘Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also adulthood.However,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely unknown.Therefore,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later life.Methods:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in plasma.The digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW pigs.Results:The rate of portal venous blood flow did not differ beween IUGR and NBW pigs.Plasma concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW pigs.The ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW pigs.IUGR increased hindgut microbial diversity and bacterial fermentation activity in the caecum.In vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal inocula.Conclusion:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing phase.These findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions. | Tiantian Li Shimeng Huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 17 | Recent advances of composite electrolytes for solid-state Li batteries显示文摘All-solid-state lithium batteries(ASSLBs)are recognized as high energy density batteries system without safety issues within the next generation of batteries.The development of solid electrolytes is the crucial step of ASSLBs.The composite electrolyte has stable physical and electrochemical characteristics,and its comprehensive performance surpasses the individual solid electrolyte,bringing unique vitality to the solid electrolyte.However,their intrinsic weakness limits the development of composite electrolytes.In this review,we provide a comprehensive and in-depth understanding of the challenges and opportunities of composite electrolytes,with special focus on mechanisms of ion transport,nanostructure design towards high ionic conductivity,interfacial issues within electrolytes and electrodes.Furthermore,future development is prospected,which can shed light on researchers in this field and accelerate the industrial production of composite electrolytes. | Laiqiang Xu Jiayang Li Honglei Shuai Zheng Luo Baowei Wang Susu Fang Guoqiang Zou Hongshuai Hou Hongjian Peng Xiaobo Ji | 2022 | Journal of Energy Chemistry2022，31，4： | 2 |
| 18 | Modeling multiple chemical equilibrium for reactive extraction of naproxen enantiomers with HP-β-CD as hydrophilic selector显示文摘Reactive extraction is an emerging technology for large-scale continuous resolution of drug enantiomers.The enantioselective extraction of R,S-naproxen by hydrophilic HP-β-CD in 1,2-dichloroethane was studied at 5 °C.The experimental data were described by a reactive extraction model with a homogeneous aqueous phase reaction of R,S-naproxen with HP-β-CD which couples a complete description of chemical equilibria in aqueous phase with the overall phase equilibria of the system.Important parameters of this model were determined experimentally.The physical distribution coefficients for molecular and ionic NAP were 0.041 and 1.730,respectively.Here we show that the efficiency of extraction depends strongly on two process variables including pH and HP-β-CD concentration.The model predictions are compared graphically with the results of previous experiments and there is a good agreement between each other.By the use of modeling and experiment,an optimized extraction condition with pH of 2.5 and HP-β-CD concentration of 0.1 mol/L was obtained with high enantioselectivity(α) of 1.59 and performance factor(pf) of 0.049.The model gives a good means of predicting enantiomers partitioning over a range of experimental conditions. | TANG KeWen ZHANG PanLiang PAN ChunYue LI HongJian | 2011 | Science China Chemistry2011，54，7： | 2 |
| 19 | A new long-acting GLP-1 derivative KTP ameliorates hyperglycemia and dyslipidemia and improves pancreas and fatty liver in db/db mice显示文摘Glucagon-like peptide-1 (GLP-1) is a polypeptide incretin hormone that glucose-dependently promotes the secretion and synthesis of insulin. However, its half-life is extremely short. To enhance its half-life, we developed a long-acting GLP-1 derivative KTP with controlled release, designed on the basis of another GLP-1 derivative GP62. The kinetics and bioactivity of KTP were evaluated in Sprague Dawley (SD) rats. Long-term treatment of KTP was performed in db/db mice. Mice were treated twice daily with subcutaneous injections of KTP (1.2 mg/kg body weight), Exendin-4 (0.1 mg/kg body weight) or vehicle (phosphate buffered saline (PBS), pH 7.4) for 60 d. KTP had a longer half-life, as well as further increasing the secretion and production of insulin and reducing blood glucose concentrations, than GP62. Long-term treatment with KTP also induced anorexia, decreased water and food intake, decreased weight gain, improved blood glucose and blood lipid and ameliorated pancreatic damage and fatty liver in db/db mice. | SANG YanXia ZHOU TianHong LI HongJian RAN YanHong JIANG DeQi ZHENG Fei CHEN Ying WANG CongFeng ZOU Xin | 2013 | Chinese Science Bulletin2013，58，20： | 2 |
| 20 | Variations in Both FTL1 and SP5G,Two Tomato FT Paralogs,Control Day-Neutral Flowering显示文摘Dear Editor,Selection for flowering time is a major goal of plant breeding efforts to spread cultivars far from their origin.Day-neutral tomato cultivars,which have reduced long-day(LD)and short-day(SD)flowering responses,have spread globally from the center of origin of tomato.Allelic variation of SELF-PRUNING 5G(SP5G),one of FLOWERING LOCUS T (FT) paralogs. | Jia Song Shuaibin Zhang Xiaotian Wang Shuai Sun Zhiqiang Liu Ketao Wang Hongjian Wan Guozhi Zhou Ren Li Hong Yu Xia Cui | 2020 | Molecular Plant2020，13，7： | 2 |
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