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| 1 | Strontium and boron isotopic constraint on the marine origin of the Khammuane potash deposits in southeastern Laos显示文摘Since 2006,we have conducted a geological exploration of the Khammuane area in southeastern Laos.Several thick sequences of potash deposits containing sylvite and carnallite were discovered from drilling Paleocene strata of the Thangon Formation(E1tg).To constrain the origin of the brine that formed thick sequences of salt mineral deposits,we measured the strontium and boron isotope composition of some salt minerals in the potash deposit.Boron isotope composition of halite-and potash-associated minerals in the Khammuane potash deposit varied from 19.91%to 31.01‰,which differs significantly from continental evaporates(-6.83‰--5.79‰)but is very close to that of salts precipitated from evapo-concentrated seawater(10‰-36‰).The 87Sr/86Sr ratios(0.707542 to 0.709461)of salts were also close to the values of Paleocene seawater(0.70772 to 0.707830).The content of Br-(0.01%-0.25%)and Br×103/Cl ratios(0.10-0.52)of halite were>10 times higher than that of common continental salts.These characteristics indicate clearly that the Laos potash deposits were deposited from seawater.The small variation in boron and strontium isotopes in all salt sedimentary sequences(gypsum-halite-potash-halite)also suggests that the recharge source should be stable and the effects of other continental water mixing are negligible.Large-scale potash deposits are commonly precipitated from seawater.Hence,the results of recent regional drilling work and geochemical research suggest extensive potash resources could occur in the Thangon Formation of southeastern Laos. | TAN HongBing MA HaiZhou LI BinKai ZHANG XiYing XIAO YingKai | 2010 | Chinese Science Bulletin2010，55，27： | 37 |
| 2 | Typical Geochemical Elements in Loess Deposit in the Northeastern Tibetan Plateau and Its Paleoclimatic Implication显示文摘Widespread and thick loess deposit in the northeastern Tibetan Plateau records paleoclimatic changes over the Quaternary period. In this study, we investigate a loess section located in a high terrace of the Huangshui River in the Xining Basin, and collect samples at 20-cm intervals by digging a well of 16-m depth (including paleosol S1 and S0 and several loess interlayers over the last glacial-interglacial cycle and the Holocene). Concentration of some active elements (Sr and Ca) and inert elements (Rb, Zr, Ti) in these loess samples are measured. The results show that ratios of those elements (oxide), such as Rb/Sr, Ti/Sr, and Zr/CaO ratios, would indicate sensitively paleoclimatic changes, especially the history of precipitation over the last glacial-interglacial and the Holocene. Moreover, the curves of Rb/Sr, Ti/Sr, and Zr/CaO ratios had almost the same variable trends from the bottom to the top and also closely correlated with values of magnetic susceptibility and the global marine δ18O record. But compared with the curves of magnetic susceptibility, the changes of ratios of these elements (oxide) are clearer and easy to understand. Therefore, the ratios of these typical chemical elements in the loess deposit may be used as an excellent index to investigate the history of paleoclimate, particularly precipitation changes in the northeastern Tibetan Plateau. | TAN Hongbing MA Haizhou ZHANG Xiying LU Huayu WANG Jianguo | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 10 |
| 3 | Chemical and Isotopic Approach to Groundwater Cycle in Western Qaidam Basin,China显示文摘Due to the extremely arid climate in the western Qaidam Basin,the groundwater almost becomes the single water source for local residents and industrial production.It is necessary to know the reliable information on the groundwater cycle in this region for reasonable and sustainable exploitation of the groundwater resources with the further execution of recycling economy policies.This study focused on the recharge,the flow rate and the discharge of groundwater in the western Qaidam Basin through investigations on water chemistry and isotopes.Hydrological,chemical and isotopic characteristics show that the groundwater in the western Qaidam Basin was recharged by meltwater from new surface snow and old bottom glaciers on the northern slope of the Kunlun Mountains.In addition,the results also prove that the source water is enough and stable,and the rates of the circulation and renewal of the groundwater are relatively quick.Therefore,it can be concluded that the groundwater resources would guarantee the regional requirement if the meltwater volume of the mountains has not a great changes in future,moreover,water exploitation should be limited to the renewable amount of the groundwater reservoir in the western Qaidam Basin. | TAN Hongbing RAO Wenbo CHEN Jiansheng SU Zhiguo SUN Xiaoxu LIU Xiaoyan | 2009 | Chinese Geographical Science2009，19，4： | 10 |
| 4 | Origin and evolution of oilfield brines from Tertiary strata in western Qaidam Basin:Constraints from ^(87)Sr/^(86)Sr,δD,δ^(18)O,δ^(34)S and water chemistry显示文摘Chemistry of major and minor elements,87Sr/86Sr,δD,δ18O and δ34S of brines were measured from Tertiary strata and Quaternary salt lakes in the western Qaidam Basin.The water chemistry data show that all oilfield brines are CaCl2 type.They were enriched in Ca2+,B3+,Li+,Sr2+,Br-,and were depleted in Mg2+,SO42-,which indicated that these brines had the characteristics of deeply circulated water.The relationship between δD and δ18O shows that all data of these brines decline towards the Global Meteoric Water Line(GWL) and Qaidam Meteoric Water Line(QWL),and that the intersection between oilfield brines and Meteoric Water Lines was close to the local spring and fresh water in the piedmont in the western Qaidam Basin.The results suggest that oilfield brines has initially originated from meteoric water,and then might be affected by water-rock metamorphose,because most oilfield brines distribute in the range of metamorphosing water.The 87Sr/86Sr values of most oilfield brines range from 0.71121 to 0.71194,and was less than that in salt lake water(>0.712),but close to that of halite in the study area.These imply that salt dissolution occurred in the process of migration.In addition,all oilfield brines have obviously much positive δ34S values(ranging from 26.46‰ to 54.57‰) than that of salt lake brines,which was caused by bacterial sulfate reduction resulting in positive shift of δ34S value and depleteed SO42-in oilfield brines.Combined with water chemical data and δD,δ18O,87Sr/86Sr,δ34S values,we concluded that oilfield brines mainly originate from the deeply circulated meteoric waters,and then are affected by salt dissolution,water-rock metamorphose,sulfate reduction and dolomitization during the process of migration.These processes alter the chemical compositions of oilfield brines and accumulate rich elements(such as B,Li,Sr,Br,K and so on) for sustainable utilization of salt lake resources in the Qaidam Basin. | FAN Qishun MA Haizhou LAI Zhongping TAN Hongbing LI Tingwei | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 10 |
| 5 | Identity Based Encryption and Biometric Authentication Scheme for Secure Data Access in Cloud Computing显示文摘 | CHENG Hongbing RONG Chunming TAN Zhenghua ZENG Qingkai | 2012 | Chinese Journal of Electronics2012，21，2： | 10 |
| 6 | Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia显示文摘Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stochastic dynamic causal modeling(s DCM) to quantify connections among the left dorsolateral prefrontal cortex(inner speech monitoring), auditory cortex(auditory processing), hippocampus(memory retrieval), thalamus(information filtering), and Broca's area(language production) in 17 first-episode drug-na?¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic(ROC) analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence. | Baojuan Li Long-Biao Cui Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu | 2017 | Neuroscience Bulletin2017，33，3： | 8 |
| 7 | Study on the mechanism of isotope fractionation in soil water during the evaporation process under equilibrium condition显示文摘In this study, with the method of vacuum extraction, two evaporative processes of soil water and free water under equilibrium condition were simulated. For each sample,water vapor was condensed by liquid nitrogen and was collected in four time intervals. From the analysis of hydrogen and oxygen isotopic compositions of the water collected at different times, it was discovered that the isotope fractionation of soil water also follows the mode, which is just the same as the evaporative process of free water. The relationship between the stable hydrogen and oxygen isotopes in residual water showed that the simulative evaporation line was close to the global meteoric water line (GMWL) under the equilibrium condition at about 20℃. Comparison of the two types of evaporative processes indicated that the isotope fractionation and evaporation velocity of soil water were only slightly modified by the Van der Waals force. | SUN Xiaoxu CHEN Jiansheng TAN Hongbing RAO Wenbo WANG Yongsen LIU Xiaoyan SU Zhiguo | 2009 | Chinese Journal Of Geochemistry2009，28，4： | 4 |
| 8 | Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways显示文摘 | Chengbo Sun Chun Liang Yusheng Ren Yi Zhen Zhiqing He Hua Wang Hongbing Tan Xiaoming Pan Prof. Dr. Zonggui Wu | 2009 | Basic Research in Cardiology2009，，1： | 1 |
| 9 | New lakes in the Taklamakan Desert显示文摘 | CHEN Jiansheng WANG Chiyue TAN Hongbing | 2012 | Geophysical Research Letters2012，39，22： | 1 |
| 10 | New lakes in the Taklamakan Desert显示文摘 | CHEN Jiansheng WANG Qiyong TAN Hongbing | 2012 | Geophysical Research Letters2012，39，22： | 1 |
| 11 | Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population显示文摘 | Jiang Chang Ying Huang Lixuan Wei Baoshan Ma Xiaoping Miao Yun Li Zhibin Hu Dianke Yu Weihua Jia Yu Liu Wen Tan Zhonghu He Yang Ke Tangchun Wu Hongbing Shen Yixin Zeng Chen Wu Dongxin Lin | 2013 | Carcinogenesis2013，，8： | 1 |
| 12 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations显示文摘 | Hu Zhibin Jin Guangfu Liang Jie Zhang Mingfeng Shen Hongbing Wu Chen Yu Dianke Huang Liming Tan Wen Lin Dongxin Guo Huan Wu Tangchun Qian Ji Lu Daru | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 1 |
| 13 | Geothermal constraints on enrichment of boron and lithium in salt lakes: An example from a river-salt lake system on the northern slope of the eastern Kunlun Mountains, China显示文摘 | Hongbing Tan Jun Chen Wenbo Rao Wenjie Zhang Huifang Zhou | 2012 | Journal of Asian Earth Sciences2012，，： | 1 |
| 14 | Hydrogen, oxygen, helium and strontium isotopic constraints on the formation of oilfield waters in the western Qaidam Basin, China显示文摘 | Hongbing Tan Wenbo Rao Haizhou Ma Jiansheng Chen Tingwei Li | 2010 | Journal of Asian Earth Sciences2010，，2： | 1 |
| 15 | Geothermal constraints on enrichment of boron and lithium in salt lakes: An example from a river-salt lake system on the northern slope of the eastern Kunlun Mountains, China显示文摘 | Hongbing Tan Jun Chen Wenbo Rao Wenjie Zhang Huifang Zhou | 2012 | Journal of Asian Earth Sciences2012，，： | 1 |
| 16 | PPAR gamma protects cardiomyocytes against oxidative stress and apoptosis via Bcl-2 upregulation显示文摘 | Yusheng Ren Chengbo Sun Yan Sun Hongbing Tan Yuechun Wu Bo Cui Zonggui Wu | 2009 | Vascular Pharmacology2009，，2： | 1 |
| 17 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 18 | New lakes in the Taklamakan desert显示文摘 | CHEN Jiansheng WANG Chiyuen TAN Hongbing | 2012 | Geophysical Research Letters2012，39，22： | 1 |
| 19 | A nomogram predicting clinical pregnancy in the first fresh embryo transfer for women undergoing in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI) treatments显示文摘The extent to which factors affect the probability of clinical pregnancy in the first fresh embryo transfer after assisted conception is unknown.In order to examine the predictors of clinical pregnancy,a retrospective cohort study was launched between January 1,2013 and December 31,2016 in four infertility clinics including 19837 in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI)fresh cycles with known outcomes and relevant records.A multivariable logistic regression was used to select the most significant predictors in the final nomogram for predicting clinical pregnancy.Furthermore,the model was validated by an independent validation set and the performance of the model was evaluated by the receiver operating characteristic(ROC)curves along with the area under the ROC curve(AUC)and calibration plots.In a training set including 17854 participants,we identified that female age,tubal factor,number of embryos transferred,endometrial thickness and number of good-quality embryos were independent predictors for clinical pregnancy.We developed a nomogram using these five factors and the predictive ability was 0.66 for AUC(95%CI=0.64−0.68),which was independently validated in the validation set(AUC=0.66,95%CI=0.65−0.68).Our results show that some specific factors can be used to provide infertile couples with an accurate assessment of clinical pregnancy following assisted conception and facilitate to guide couples and clinicians. | Fang Wu Feng Liu Yichun Guan Jiangbo Du Jichun Tan Hong Lv Qun Lu Shiyao Tao Lei Huang Kun Zhou Yankai Xia Xinru Wang Hongbing Shen Xiufeng Ling Feiyang Diao Zhibin Hu Guangfu Jin | 2019 | The Journal of Biomedical Research2019，33，6： | 1 |
| 20 | TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case–control analysis in a Chinese population显示文摘 | Guangfu Jin Yimei Deng Ruifen Miao Zhibin Hu Yan Zhou Yongfei Tan Jianming Wang Zhaolai Hua Weiliang Ding Lina Wang Wensen Chen Jing Shen Xinru Wang Yaochu Xu Hongbing Shen | 2008 | Journal of Cancer Research and Clinical Oncology2008，，： | 1 |
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