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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice 显示文摘 | Tang J Kozaki K Farr AG | 2005 | Am J Pathol2005，167，3： | 1 |
| 3 | Cognitive behaviour therapy for primary insomnia : can we rest yet? 显示文摘 | Harvey AG Tang NK | 2003 | Sleep Med Rev2003，7，3： | 1 |
| 4 | Aipway remodell in asthma:current understanding and implications for future therapies显示文摘 | Tang ML Wilson JW Stewart AG Royce SG | 2006 | Pharmacol Ther2006，112，2： | 1 |
| 5 | Airway remodelling in asthma: current understanding and implications for future therapies 显示文摘 | Tang LK Wilson JW Stewart AG | 2006 | Pharmacol Ther2006，112，2： | 1 |
| 6 | Cognitive approaches to insomnia显示文摘 | Harvey AG Tang NKY Browning L | 2005 | Clin Psychol Rev2005，25，5： | 1 |
| 7 | Relation of time since last birth and parity to survival of young women with breast cancer显示文摘 | Olson SH Zauber AG Tang J | 1998 | Epidemiology1998，9，6： | 1 |
| 8 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 9 | Primary Central Nervous Sys tem Lymphoma Involving the Optic Chiasm in AIDS显示文摘 | Lee AG Tang RA Roberts D | 2001 | J Neu roophthalmol2001，21，2： | 1 |
| 10 | Orbital presentations of giant cell arteritis 显示文摘 | Lee AG Tang RA Feldon SE | 2001 | Graefes Arch Clin Exp Ophthalmol2001，239，： | 1 |
| 11 | Cognitive approaches to insomnia显示文摘 | Harvey AG Tang NK Browning L | 2005 | Clin Psychol Rev2005，25，5： | 1 |
| 12 | The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/-mice显示文摘 | Tang J Kozaki K Farr AG | 2005 | Am J Pathol2005，167，： | 1 |
| 13 | Airway remodelling in asthma:current understanding and implications for future therapies显示文摘 | Tang ML Wilson JW Stewart AG | 2006 | Pharmacol Ther2006，112，2： | 1 |
| 14 | Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines显示文摘 | TANG CH ELIZABETH AG | 2004 | Biological chenmistry2004，279，1： | 1 |
| 15 | Cognitive approaches to insomnia显示文摘 | Harvey AG Tang NKY Browning L | 2005 | Clin Psychol Rev2005，25，5： | 1 |
| 16 | Modulation of neural connectivity during tongue movement and reading显示文摘 | He AG Tan LH Tang Y | 2003 | Human Brain Mapping2003，18，3： | 1 |
| 17 | More rapid and sensitive method for simultaneous determination of tryptophan and kynurenic acid by HPLC 显示文摘 | Pi LG Tang AG Mo XM | 2009 | Clin Biochem2009，40，45： | 1 |
| 18 | Determination of kynurenine in sertm by high-performance liquid chromatography with on-column fluorescence derivatization 显示文摘 | Luo XB Tang AG Pi LG | 2008 | Clin Chim Acta2008，389，12： | 1 |
| 19 | Cognitive approaches to insomnia显示文摘 | Harvey AG Tang NK Browning L | | 0，，05： | 1 |
| 20 | Modulation of neural connectivity during tongue movement and reading 显示文摘 | He AG Li Haitan Tang Yiyuan | 2003 | Hum Brain Mapp2003，18，3： | 1 |
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