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| 1 | Restraining effect of nitrogen on coal oxidation in different stages:Non-isothermal TG-DSC and EPR research显示文摘Nitrogen is widely used to prevent the spontaneous combustion of coal in underground coal mines. A spontaneous combustion-prone coal seam was studied to investigate the restraining effect of nitrogen on coal oxidation in different oxidation stages, based on non-isothermal thermogravimetry-differential scanning calorimetry(TG-DSC) and electron paramagnetic resonance(EPR) experiments. We found that the key feature temperatures grow steadily with increasing nitrogen in the oxidation environment,resulting in longer oxidation stages. The most significant finding is that there is a stagnation of the inhibitory effect of nitrogen on coal oxidation in the range of 85.0–95.0% nitrogen in the slow and the rapid oxidation stages, owing to the competitive adsorption of coal by nitrogen and oxygen. However, the restraining effect cannot be reflected by the kinetic parameters of the coal before it reaches the thermal decomposition and combustion stage. Nitrogen can also affect free radical types and free radical concentrations during coal oxidation: the higher the concentration of nitrogen in the oxidation environment, the greater the number of free radical types and the lower the free radical concentration. This experimental study improves the understanding of the restraining effect of nitrogen on coal oxidation in different oxidation stages and provides an important reference for coal fire prevention in spontaneous combustionprone coal seams. | Tongyu Zhao Shengqiang Yang Xincheng Hu Wanxin Song Jiawen Cai Qin Xu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 9 |
| 2 | A high-surface-area silicoaluminophosphate material rich in Brnsted acid sites as a matrix in catalytic cracking显示文摘A transparent gel-like mesoporous silicoaluminophosphate material (SAP) with a Si/Al molar ratio of 20 was synthesized by hydrothermal method. The physicochemical features of SAP were characterized by XRD, XRF, BET, SEM and FT-IR spectroscopy of pyridine adsorption techniques. The results indicated that incorporation of phosphorus (P) into aluminasilica system altered the basic textural characteristics of aluminasilica. Especially after hydrothermal treatment, the material with large special surface area (up to 492 m 2 /g) exhibited a good performance on hydrothermal stability. Moreover, the phosphorus modifier can not only increase the amount of Bro¨nsted acidic sites (up to 48.44 μmol/g) and the percentage of weak acidic sites in total acidic sites, but also regulate the acid type, such as the ratio of B/L (Bro¨nsted acid/Lewis acid) increases to 1.15. The performances of samples as matrices for the catalytic cracking of heavy vacuum gas oil (VGO) were investigated. At 520 C, the catalysts showed much higher gasoline and diesel oil yields achieving to 45.59 wt% and 19.20 wt%, respectively, and lower coke selectivity (2.86%) than conventional FCC matrices, such as kaolin and amorphous silica-alumina. | Shaoiun Xu Qiang Zhang Zhaoxuan Feng Xiaojing Meng Tongyu Zhao Chunyi Li Chaohe Yang Honghong Shan | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 8 |
| 3 | Radiative transfer models(RTMs)for field phenotyping inversion of rice based on UAV hyperspectral remote sensing显示文摘The nondestructive and rapid acquisition of rice field phenotyping information is very important for the precision management of the rice growth process.In this research,the phenotyping information LAI(leaf area index),leaf chlorophyll content(C_(ab)),canopy water content(C_(w)),and dry matter content(C_(dm))of rice was inversed based on the hyperspectral remote sensing technology of an unmanned aerial vehicle(UAV).The improved Sobol global sensitivity analysis(GSA)method was used to analyze the input parameters of the PROSAIL model in the spectral band range of 400-1100 nm,which was obtained by hyperspectral remote sensing by the UAV.The results show that C_(ab) mainly affects the spectrum on 400-780 nm band,C_(dm) on 760-1000 nm band,C_(w) on 900-1100 nm band,and LAI on the entire band.The hyperspectral data of the 400-1100 nm band of the rice canopy were acquired by using the M600 UAV remote sensing platform,and the radiance calibration was converted to the canopy emission rate.In combination with the PROSAIL model,the particle swarm optimization algorithm was used to retrieve rice phenotyping information by constructing the cost function.The results showed the following:(1)an accuracy of R^(2)=0.833 and RMSE=0.0969,where RMSE denotes root-mean-square error,was obtained for C_(ab) retrieval;R^(2)=0.816 and RMSE=0.1012 for LAI inversion;R^(2)=0.793 and RMSE=0.1084 for C_(dm);and R^(2)=0.665 and RMSE=0.1325 for C_(w).The C_(w) inversion accuracy was not particularly high.(2)The same band will be affected by multiple parameters at the same time.(3)This study adopted the rice phenotyping information inversion method to expand the rice hyperspectral information acquisition field of a UAV based on the phenotypic information retrieval accuracy using a high level of field spectral radiometric accuracy.The inversion method featured a good mechanism,high universality,and easy implementation,which can provide a reference for nondestructive and rapid inversion of rice biochemical parameters using UAV hyperspectral remote sensing. | Yu Fenghua Xu Tongyu Du Wen Ma Hang Zhang Guosheng Chen Chunling | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 8 |
| 4 | Combining long-term and short-term user interest for personalized hashtag recommendation显示文摘 | Jianjun YU Tongyu ZHU | 2015 | Frontiers of Computer Science2015，9，4： | 8 |
| 5 | ANALYSIS OF PARTICULATE MASS CONCENTRATION,AEROSOL NUMBER CONCENTRATION AND VISIBILITY IN BEIJING显示文摘Particulate mass concentration (PM10, PM2.5), aerosol number concentration (Nopc), aerosol size distribution and atmospheric visibility were simultaneously measured in Beijing in the summer and winter of 2001. From the profuse data collected, the following conclusions can be drown: (1) there are two peaks for the average diurnal variations of PM10 and Nopc in the summer, an obvious valley can be seen between 12:30 and 15:00 for their average diurnal variation in the winter; (2) there is one single peak for the average diurnal variation of atmospheric visibility in the summer,while there are two peaks in the winter; (3) PM10 and Nopc are usually smaller in the summer than those in the winter; (4)the average visibility is much lower during 00:00-09:00 in the summer than that in the winter, because of the very high relative humidity and higher concentration of the large particles (t>1.25μm) in the summer during the period; (5) aerosol size distributions usually depend closely on season and relative humidity at the same place. | FengqiYan HuanlingHu TongYu | 2004 | China Particuology2004，2，1： | 7 |
| 6 | Cultivation Mode of Innovative Talents in Architecture under the Cooperation of Production, Teaching and Research显示文摘In current training of architectural talents, there are a series of problems, such as separation of teaching, scientific research and production, rigid teaching mode and lack of practice and innovative ability, which make it hard to achieve the goal of training the idealized innovative talents. In order to solve these problems and the confusion of architecture in the cultivation of innovative talents, a production-teachingresearch integrated iterative platform was built at the levels of teacher and student. In the platform, the 32 modules involving teaching, researching and producing can be linked according to the logical relationship and teaching needs, thus helping the development of teaching by scientific research and production achievements. The teaching system under this kind of mutual assistance has positive significance to the training of innovative talents in architecture. | WANG Jiang WANG Tongyu | 2018 | Journal of Landscape Research2018，10，2： | 6 |
| 7 | Models for estimating the leaf NDVI of japonica rice on a canopy scale by combining canopy NDVI and multisource environmental data in Northeast China显示文摘Remote sensing of rice traits has advanced significantly with regard to the capacity to retrieve useful plant biochemical,physiological and structural quantities across spatial scales.The rice leaf NDVI(normalized difference vegetation index)has been developed and applied in monitoring rice growth,yield prediction and disease status to guide agricultural management practices.This study combined rice canopy NDVI and environmental data to estimate rice leaf NDVI.The test site was a japonica rice experiment located in the eastern city of Shenyang,Liaoning Province,China.This paper describes(1)the use of multiple linear regression to establish four periods of rice leaf NDVI models with good accuracy(R2=0.782–0.903),and(2)how the key point of the rice growth period based on these models was determined.The techniques for modeling leaf NDVI at the point of remote canopy sensing were also presented.The results indicate that the rice leaf NDVI has a high correlation with the canopy NDVI and multisource environmental data.This research can provide an efficient method to detect rice leaf growth at the canopy scale in the future. | Yu Fenghua Xu Tongyu Cao Yingli Yang Guijun Du Wen Wang Shu | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 6 |
| 8 | Broadband near-infrared luminescence and energy transfer of Cr^(3+),Ce^(3+) co-doped Ca_(2)LuHf_(2)Al_(3)O_(12) phosphors显示文摘Broadband near-infrared phosphors are highly desirable for food testing.Targeted Ca_(2)LuHf_(2)Al_(3)O_(12):Cr^(3+)(CLHA:Cr^(3+)) and Ca_(2)LuHf_(2)Al_(3)O_(12):Ce^(3+),Cr^(3+)(CLHA:Ce^(3+),Cr^(^(3+))) phosphors were synthesized by the conventional high-temperature solid state reaction.The CLHA:Cr^(3+)phosphor,with a good thermal stability,shows a red shift owing to radiation reabsorption and non-radiative transition with increasing Cr^(3+)content.For co-doped sample,the emission intensity of Cr^(3+)can be enhanced by three times due to the energy transfer from Ce^(3+)to Cr^(3+),which can be evidenced by a significant overlap between the PLE of Cr^(3+)single-doped phosphor and the PL of Ce^(3+)single-doped phosphor.In addition,the mechanism of energy transfer is identified as a quadrupole-quadrupole interaction according to decay Lifetime and Dexter’s energy transfer formula.The broadband NIR emission peaked at 775 nm of CLHA:Cr^(3+),Ce^(3+)phosphor shows a bright prospect in nondestructive quality-control analysis systems for food. | Jinpin Wu Weidong Zhuang Ronghui Liu Yuanhong Liu Tongyu Gao Chunpei Yan Min Cao Junhang Tian Xiaoxia Chen | 2021 | Journal of Rare Earths2021，39，3： | 6 |
| 9 | Research on the Surface Subsidence Monitoring Technology Based on Fiber Bragg Grating Sensing显示文摘 | Jinyu WANG Long JIANG Zengrong SUN Binxin HU Faxiang ZHANG Guangdong SONG Tongyu LIU Junfeng QI Longping ZHANG | 2017 | Photonic Sensors2017，7，1： | 5 |
| 10 | Ridge subduction, magmatism, and metallogenesis显示文摘Modern oceans contain large bathymetric highs(spreading oceanic ridges,aseismic ridges or oceanic plateaus and inactive arc ridges)that,in total,constitute more than 20–30%of the total area of the world’s ocean floor.These bathymetric highs may be subducted,and such processes are commonly referred to as ridge subduction.Such ridge subduction events are not only very common and important geodynamic processes in modern oceanic plate tectonics,they also play an important role in the generation of arc magmatism,material recycling,the growth and evolution of continental crust,the deformation and modification of the overlying plates,and metallogenesis at convergent plate boundaries.Therefore,these events have attracted widespread attention.The perpendicular or high-angle subduction of mid-ocean spreading ridges is commonly characterized by the occurrence of a slab window,and the formation of a distinctive adakite–high-Mg andesite–Nb-enriched basalt-oceanic island basalt(OIB)or a mid-oceanic ridge basalt(MORB)-type rock suite,and is closely associated with Au mineralization.Aseismic ridges or oceanic plateaus are traditionally considered to be difficult to subduct,to typically collide with arcs or continents or to induce flat subduction(low angle of less than 10°)due to the thickness of their underlying normal oceanic crust(>6–7 km)and high topography.However,the subduction of aseismic ridges and oceanic plateaus occurred on both the western and eastern sides of the Pacific Ocean during the Cenozoic.On the eastern side of the Pacific Ocean,aseismic ridges or oceanic plateaus are being subducted flatly or at low angles beneath South and Central American continents,which may cause a magmatic gap.But slab melting can occur and adakites,or an adakite–high-Mg andesite–adakitic andesite–Nb-enriched basalt suite may be formed during the slab rollback or tearing.Cu-Au mineralization is commonly associated with such flat subduction events.On the western side of the Pacific Ocean,however,aseismic ridges and oceanic plateaus are subducted at relatively high angles(>30°).These subduction processes can generate large scale eruptions of basalts,basaltic andesites and andesites,which may be derived from fractional crystallization of magmas originating from the subduction zone fluid-metasomatized mantle wedge.In addition,some inactive arc ridges are subducted beneath Southwest Japan,and these subduction processes are commonly associated with the production of basalts,high-Mg andesites and adakites and Au mineralization.Besides magmatism and Cu-Au mineralization,ridge subduction may also trigger subduction erosion in subduction zones.Future frontiers of research will include characterizing the spatial and temporal patterns of ridge subduction events,clarifying the associated geodynamic mechanisms,quantifying subduction zone material recycling,establishing the associated deep crustal and mantle events that generate or influence magmatism and Cu-Au mineralization,establishing criteria to recognize pre-Cenozoic ridge subduction,the onset of modernstyle plate tectonics and the growth mechanisms for Archean continental crust. | Qiang WANG Gongjian TANG Lulu HAO Derek WYMAN Lin MA Wei DAN Xiuzheng ZHANG Jinheng LIU Tongyu HUANG Chuanbing XU | 2020 | Science China Earth Sciences2020，63，10： | 3 |
| 11 | Fiber Bragg Grating (FBG) Sensors Used in Coal Mines显示文摘纤维布拉格栅栏(FBG ) 紧张传感器被用于在在 Dongtan 矿沿着号码 3203 煤采矿脸的废矿保留的网关的衬里的墙的压力变化的联机监视。结果证明有宽测量范围的 FBG 紧张传感器能在沿着废矿保留的网关的支持过程期间精确地测量压力变化并且能提供基础进一步优化支持结构并且决定沿着废矿保留的网关的支持计划。FBG 微地震的传感器在 Xinglong 矿被使用检测微地震的信号。信号受到欢迎并且分析了决定地点和微地震的事件警告的来源的精力水平。FBG 传感器和检测系统为微地震的察觉和地质的灾难察觉显示出一个重要潜力。 | Jinyu WANG Tongyu LIU Guangdong SONG Hongjing XIE Lianqing LI Xiaolin DENG Zhijie GONG | 2014 | Photonic Sensors2014，4，2： | 3 |
| 12 | Chemical Synthesis of Proteins Containing 300 Amino Acids显示文摘Chemical synthesis of proteins containing up to 300 amino acids may cover 30%—50%of all the proteins encountered in biomedical studies and may provide an alternate approach to the usually used recombinant expression teclmology,vastly expanding the chemical space of the latter.In the present review article,we tried to survey the recent progresses made for more rapid synthesis of increasingly long peptides and more efficient ligation of multiple peptide segments.The developments of seminal methods by many research groups have greatly contributed to the recent breakthroughs in the successful total synthesis of a number of functionally important proteins,such as oligoubiquitins,bacterial GroEL/ES chaperones,and mirror-image DNA polymerases.Through these studies,a potential bottleneck has also been recognized for the chemical synthesis of large proteins,namely,how to ensure that each peptide segment from a large protein avoids unfavorable aggregation when dissolved in aqueous solution.Many new methods,such as removable backbone modification(RBM)strategy have been developed to overcome this bottleneck,while more studies need to be carried out to develop more effective and less costly methods that ultimately,may lead to fully automatable chemical synthesis of customized proteins of 300 amino acids bearing any artificial designs. | ZHANG Baochang LI Yulei SHI Weiwei WANG Tongyue ZHANG Feng LIU Lei | 2020 | Chemical Research in Chinese Universities2020，36，5： | 3 |
| 13 | Low molecular weight heparin reduces arterial blood lactic acid content and increases estimated glomerular filtration rate in patients with moderate Covid-19 pneumonia显示文摘Background:Coronavirus disease 2019(Covid-19)remains a serious health threat worldwide.We aimed to investigate whether low molecular weight heparin(LMWH)can promote organ function recovery in moderate Covid-19 pneumonia patients.Methods:We initiated an LMWH protocol in Covid-19 patients with increased D-dimer,body mass index>30 kg/m^(2) or a history of diabetes from January 18,2020 at Shanghai Public Health Clinical Center.In this retrospective study,we assigned moderate Covid-19 pneumonia patients admitted between January 18th and April 18,2020 receiving the LMWH protocol to the LMWH group.Moderate patients who met the inclusion criteria but did not receive LMWH protocol were included in the control group by 1:2 propensity score matching.General clinical information,indicators for renal function,arterial blood gas analyses,arterial blood lactic acid content(mmol/L),and coagulation indexes at 0 day,3 days,7 days,and 11 days after admission were recorded and compared between the two groups.Results:There were 41 patients in the LMWH group and 82 patients in the control group.General information in both groups were similar.Compared to the control group,the arterial blood lactic acid content(mmol/L)at day 11(1.3[1.1,1.7]vs.1.2[0.9,1.3],P=0.016)was reduced in the LMWH group.The estimated glomerular filtration rate(eGFR)in the LMWH group was higher than that in the control group at day 7(108.54[89.11,128.17]vs.116.85[103.39,133.47],P=0.039)and day 11(113.74[94.49,126.34]vs.128.31[112.75,144.12],P=0.003).The serum creatinine levels(Scr)in the LMWH group were lower than that in the control group at day 7(62.13[51.47,77.64]vs.55.49[49.50,65.75],P=0.038)and day 11(63.35[50.17,75.73]vs.51.62[44.62,61.24],P=0.005).Conclusions:LMWH treatment can reduce arterial blood lactic acid levels and improve eGFR in moderate Covid-19 pneumonia patients.Randomized controlled trials are warranted to further investigate this issue. | Li Ma Yigang Zeng Bing ZhaoL ili Xu Jian Li Tongyu Zhu Enqiang Mao | 2022 | Chinese Medical Journal2022，，6： | 3 |
| 14 | A Coal Mine Multi-Point Fiber Ethylene Gas Concentration Sensor显示文摘煤矿废矿的自燃是在煤矿的主要灾难之一。察觉技术基于符号的气体是主要工具认识到煤矿废矿的自燃预言,并且乙烯气体是在煤的自燃的重要标志气体加速的氧化舞台。以便克服当前的煤乙烯察觉的问题,纸论述一个矿光纤维多点的乙烯集中传感器基于悦耳的二极管激光吸收光谱学。基于乙烯的在红外线附近的光谱的实验和分析,采用的系统联合的 1.62 m (DFB ) 波长纤维作为轻来源散布了反馈激光。由使用扫描技术并且发展中的波长,稳定的纤维长联合了 Herriot 类型路径气体吸收房间, ppm 水平高度为乙烯气体的集中的敏感检测系统被认识到,它能满足煤矿火预防废矿的需要预言。 | Yubin WEI Jun CHANG Jie LIAN Tongyu LIU | 2015 | Photonic Sensors2015，5，1： | 3 |
| 15 | A Precision Fiber Bragg Grating Interrogation System Using Long-Wavelength Vertical-Cavity Surface-Emitting Laser显示文摘这份报纸论述一个划算的精确纤维布拉格栅栏(FBG ) 的发展用长波长的垂直洞的射出表面的激光(VCSEL ) 的讯问系统。调节长波长的 VCSEL 的性质试验性地被学习了。它注射水流上的波长的近似二次的依赖被观察了。全面设计和包括紧张正规化,山峰察觉,和二次的曲线试穿的这个系统的关键操作详细被介绍。结果证明系统与 3 nm 的一个调节范围和 1 kHz 的调节的率完成 1.2 下午的精确性。这个系统由实际、有效,这被表明在监视的 FBG 变压器温度适用。 | Binxin HU Guangxian JIN Tongyu LIU Jinyu WANG | 2016 | Photonic Sensors2016，6，4： | 3 |
| 16 | Research on a New Fiber-Optic Axial Pressure Sensor of Transformer Winding Based on Fiber Bragg Grating显示文摘基于纤维布拉格栅栏的原则,为变压器弯屈的轴的力量测量的光纤的压力传感器的一种新类型被设计,它与把板横梁,包装过程的优化,和传感器的材料弄弯的结构被设计。通过刻度试验校准传感器, Taikai 变压器工厂的地测试结果证明传感器的敏感是 0.133 pm/kPa,重覆性错误是 2.7% FS。在不同位置的光纤的压力传感器的数据维持一致、可重复,它能满足变压器弯屈的轴的力量的即时监视的要求。 | Yuan LIU Lianqing LI Lin ZHAO Jiqiang WANG Tongyu LIU | 2017 | Photonic Sensors2017，7，4： | 2 |
| 17 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 18 | A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer显示文摘Drug resistance,accounting for therapeutic failure in the clinic,remains a major challenge to effectively manage cancer.Cyclosporin A(CsA)can reverse multidrug resistance(MDR),especially resistance to epidermal growth factor receptor tyrosine kinase inhibitors.However,the application of both drugs in cancer therapies is hampered by their poor aqueous solubility and low bioavailability due to oral administration.CsA augments the potency of gefitinib(Gef)in both Gef-sensitive and Gef-resistant cell lines.Here,we show that the simultaneous encapsulation of CsA and Gef within polyethylene glycol-block-poly(D,L-lactic acid)(PEG-PLA)produced a stable and systemically injectable nanomedicine,which exhibited a sub-50-nm diameter and spherical structures.Impressively,the co-delivery of therapeutics via single nanoparticles(NPs)outperformed the oral administration of the free drug combination at suppressing tumor growth.Furthermore,in vivo results indicated that CsA formulated in NPs sensitized Gef-resistant cells and Gefresistant tumors to Gef treatment by inactivating the STAT3/Bcl-2 signaling pathway.Collectively,our nanomedicine approach not only provides an alternative administration route for the drugs of choice but also effectively reverses MDR,facilitating the development of effective therapeutic modalities for cancer. | Weidong Han Linlin Shi Lulu Ren Liqian Zhou Tongyu Li Yiting Qiao Hangxiang Wang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 19 | Oxaliplatin,Fluorouracil and Leucovorin (FOLFOX) as First-line Chemotherapy for Metastatic or Recurrent Colorectal Cancer Patients显示文摘OBJECTIVE To investigate the efficiency and safety of the oxaliplatin, fluorouracil(5-FU)and leucovorin regimen(FOLFOX)in previously untreated patients with metastatic or recurrent colorectal cancer. METHODS Previously untreated patients with metastatic or recurrent colorectal cancer received 100 mg/m2 of oxaliplatin intravenously(IV)over 2 h on day 1,and IV 400 mg/m2 of leucovorin over 2 h followed by a bolus of 400 mg/m2 of 5-FU.Then 2,600~3,000 mg/m2 of 5-FU was administered by continuous infusion over 46 h. RESULTS An evaluated response rate was determined for 97 of 105 treated patients.The overal response rate was 35.1%,9 patients(9.3%) had a complete response and 25 patients(25.8%)a partial response.Thirty-two patients(33.0%)developed stable disease and 32.0%of the patients progressed.The median time to progression(TTP)was 7.7 months and the median overal survival 20.5 months.One and 2-year survival rates were 68%and 32%.Toxic effects based on the National Cancer Institute-Common Toxicity Criteria(NCI-CTC),reaching grade 3/4 were:neutropenia 12.3%, anemia 11.3%,vomiting 4.1%and diarrhea 7.2%.Grade 3 neuropathy was 5.1%.The overall survival rate of patients who had received a radical resection was superior to the patients who had not received a operation,or had received a pal iative resection(P=0.0658).The serum levels of CEA,ALP and LDH had no relationship with survival(P>0.05). CONCLUSION The FOLFOX regimen containing oxaliplatin,5-FU plus leucovorin was an efficacious regimen with good tolerability in previously untreated metastatic or recurrent colorectal cancer patients. | Bing Han Ruihua Xu Yanxia Shi Huiyan Luo Xiaojuan Xiang Yuhong Li Li Zhang Tongyu Lin Youjian He | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 2 |
| 20 | Study of stability mechanism and kinetics of dispersion polymerization 显示文摘 | CAO TONGYU DAIBING DM JUN - YAN | 1995 | Polymer Communication1995，，3： | 1 |
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