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| 1 | Influence of desert sand on the mechanical properties of concrete subjected to impact loading显示文摘A74-mm-diameter Split Hopkinson pressure bar was used to carry out the dynamic compression experiment of concrete made of desert sand.The dynamic failure processes of concrete different in specimen size,impact velocity,desert sand replacement ratio,size and volume content of coarse aggregate were simulated.Research results showed that concrete made of desert sand had size-effect and was rate-dependent.The peak stress of concrete made of desert sand declined with the minimum size of coarse aggregate.However,the peak stress of concrete made of desert sand increased first,and then declined with the volume content and maximum size of coarse aggregate. | Liu Haifeng Ma Jurong Wang Yiying Ning Jianguo | 2017 | Acta Mechanica Solida Sinica2017，30，6： | 12 |
| 2 | Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms显示文摘Background Alzheimer’s disease is a neurodegenerative disorder.Therapeutically,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s disease.However,the relevant mechanism remains to be fully elucidated.Main body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,etc.The above mechanisms might play different roles at certain stages.It was revealed that the transplantation of BMMSCs could alter some gene levels.Moreover,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific patterns.Conclusions Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD models.Gene expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic effect.The transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease. | Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li | 2020 | Translational Neurodegeneration2020，9，2： | 9 |
| 3 | Restoration of rat calvarial defects by poly(lactide-co-glycolide)/hydroxyapatite scaffolds loaded with bone mesenchymal stem cells and DNA complexes显示文摘A composite construct comprising of a bone mesenchymal stem cell (BMSC) sheet, plasmid DNA, encoding human bone morphogenic protein-2 (hBMP-2), and poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) sponge was designed and employed in the restoration of rat calvarial defects. To improve gene transfection efficiency, a cationic chitosan derivative, N,N,N,-trimethyl chitosan chloride (TMC), was employed as the vector. The TMC/DNA complexes had a transfection efficiency of 13% in rat BMSCs, resulting in heterogeneous hBMP-2 expression in a 10-d culture period in vitro. In vivo culture of the composite constructs was performed by implantation into rat full-thickness calvarial defects, using constructs lacking pDNA-hBMP-2 or BMSC sheets as controls. Significantly higher heterogeneous expression of hBMP-2 was detected in vivo at 2 weeks for the cell sheet/DNA complex/scaffold constructs, compared with the constructs lacking pDNA-hBMP-2 or BMSC sheets. New bone formation was evident as early as 4 weeks in the experimental constructs. At 8 weeks, partial bridging of calvarial defects was observed in the experimental constructs, which was significantly better than the constructs lacking pDNA-hBMP-2 or BMSC sheets. Therefore, the combination of the PLGA/HA scaffold with BMSC sheets and gene therapy vectors is effective at enhancing bone formation. | LI Dan WANG Wei GUO Rui QI YiYing GOU ZhongRu GAO ChangYou | 2012 | Chinese Science Bulletin2012，57，5： | 9 |
| 4 | Intensifying Electron Utilization by Surface-Anchored Rh Complex for Enhanced Nicotinamide Cofactor Regeneration and Photoenzymatic CO_(2)Reduction显示文摘Solar-driven photocatalytic regeneration of cofactors,including reduced nicotinamide adenine dinucleotide(NADH),reduced nicotinamide adenine dinucleotide phosphate(NADPH),and reduced flavin adenine dinucleotide(FADH_(2)),could ensure the sustainable energy supply of enzymatic reactions catalyzed by oxidoreductases for the efficient synthesis of chemicals.However,the elevation of cofactor regeneration efficiency is severely hindered by the inefficient utilization of electrons transferred on the surface of photocatalysts.Inspired by the phenomenon of ferredoxin-NADP+reductase(FNR)anchoring on thylakoid membrane,herein,a homogeneous catalyst of rhodium(Rh)complex,[Cp_(∗)Rh(bpy)H_(2)O]^(2+),was anchored on polymeric carbon nitride(PCN)mediated by a tannic acid/polyethyleneimine(TA/PEI)adhesive layer,acquiring PCN@TA/PEI-Rh core@shell photocatalyst.Illuminated by visible light,electrons were excited from the PCN core,then transferred through the TA/PEI shell,and finally captured by the surface-anchored Rh for instant utilization during the regeneration of NADH.The TA/PEI-Rh shell could facilitate the electron transfer from the PCN core and,more importantly,achieved~1.3-fold elevation of electron utilization efficiency compared with PCN.Accordingly,the PCN@TA/PEI-Rh afforded the NADH regeneration efficiency of 37.8%after 20 min reaction under LED light(405 nm)illumination,over 1.5 times higher than PCN with free Rh.Coupling of the NADH regeneration system with formate dehydrogenase achieved continuous production of formate from carbon dioxide(CO_(2)).Our study may provide a generic and effective strategy to elevate the catalytic efficiency of a photocatalyst through intensifying the electron utilization. | Yuqing Cheng Jiafu Shi Yizhou Wu Xueying Wang Yiying Sun Ziyi Cai Yu Chen Zhongyi Jiang | 2021 | Research2021，，1： | 5 |
| 5 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 6 | 氨基甲酸酯类杀虫剂及其与阿维菌素的混配制剂对美洲斑潜蝇(Diptera:Agromyzidae)的防治效果显示文摘测定了扑蚜威、速灭威、灭蚜威、间乙威等9个氨基甲酸酯类化合物及其 与阿维菌素混剂对美洲斑潜蝇的田间药效,结果发现,当施用有效量075 kg/hm2时,氨 基甲酸酯类单剂对美洲斑潜蝇的防效在75%~92%之间,而扑蚜威、速灭威、灭蚜威与阿维菌 素混剂对该蝇的防效可达85%~92%。表明,氨基甲酸酯类化合物与阿维菌素混配对美洲斑潜 蝇田间防效、速效性均较好,且成本显著降低。 | 曾益良 秦小薇 严炳丽 任连奎 Ren Liankui Yan Bingli Wang Tongshun Zheng Yiying Zeng Yiliang Zhang Pingnan Qin Xiaowei Xie Lihua 张平南 解立华 王同顺 郑益英 | 2001 | 农药学学报2001，3，1： | 2 |
| 7 | Effect of aqueous extract of Sanweitanxiang powder on calcium homeostasis protein expression in ischemic-reperfusion injury rat heart显示文摘OBJECTIVE: To investigate the underlying mechanism of reduced myocardial ischemia-reperfusion (I/R) injury in rats using the traditionalTibetan medicine Sanweitanxiang powder (SWTX). METHODS: Rats were randomly divided into six groups (n=10) as follows: (a) propranolol dinitrate control group, given propranolol dinitrate 0.02 g/kg for 10 days before I/R, (b) SWTX with a high dose group, given SWTX 1.5 g/kg for 10 days before I/R, (c) SWTX with a medium dose group, given SWTX 1.25 g/kg for 10 days before I/R, (d) sham group (Sham), in which the rat heart was exposed by pericardiotomy but without I/R, (e) SWTX with a low dose group, given SWTX 1.0 g/kg for 10 days before I/R, and (f) I/R injury group. Rats were intragastrically pretreated with propranolol dinitrate orSWTX. After that, the operation to cause ischemia and reperfusion was conducted.The histopathologic changes of rat hearts were observed by hematoxylin and eosin staining and transmission electron microscopy. Ca2+ homeostasis protein expression was determined by western blot. RESULTS: After SWTX pretreatment, the development of ultrastructural pathological changes from IR injury was attenuated. A decrease in the expression of B-cell lymphoma 2 associated X protein, and an increase in the expression of B-cell lymphoma 2 were observed. An increased activation of extracellular signal regulated kinases were found. Compared with the sham group, the expression of sarcoplasmic reticulum calcium-ATPase, phospholamban, and calsequestrin were all up-regulated after pretreatment with SWTX. CONCLUSION: The protective mechanism of SWTX pretreatment on myocardial I/R injury might be related to its effect on maintaining the balance of calcium homeostasis in rat heart. | Mei Yang Shuna Zhang Shicun Ren Jinjun Wang Haixia Yun Sheng Yong Dejun Zhang Quanyu Yang Yiying Kou Dianxiang Lu Rili Ge | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 8 | Effect of the electro-acupuncture on senile plaques and its formation in APPD/PS1D double transgenic mice显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disease and its incidence will increase with age and is aggravating.The senile plaques(SPs)are one of three main pathological features in AD patients,which are formed by amyloid b-protein(Ab)overaccumulation.b-amyloid precursor protein(APP),b-site APP cleavage(BACE1),and insulin degrading enzyme(IDE)proteins participate in the process of Ab production and degradation.At present,the pathogenesis of AD is not yet clear and the current treatment methods can only relief the related symptoms of AD.The electro-acupuncture(EA)is a traditional Chinese medicine treatment combined the acupuncture and electrical stimulation and the treatment effect can also be controlled by transform the electrical frequency.Thus,in this experiment,we carried out behavioral test,immunohistochemistry(IHC),and Western Blot(WB)after different period treatments to the model mice by electro-acupuncturing“Baihui”and“Shenshu”acupoints in APPt/PS1t double transgenic mice.It was found that the EA therapy can improve the ability of learning,memory and spatial exploration,and reduce the deposition of SPs in brain of AD model mice,and reduce the expressions of APP and BACE1,increase the expression of IDE protein.These results prompt that EA can effectively alleviate the pathological process of AD.We speculate that EA may play a comprehensive role in preventing the development of AD,considering the previous data. | Qinghua Yang Shujuan Zhu Jin Xu Chenglin Tang Kaihui Wu Yanjun Wu Yiying Wang Huajun Sheng | 2019 | Genes & Diseases2019，6，3： | 2 |
| 9 | A Search on Sintering Characteristics and Mechanisms of Dried Sewage Sludge显示文摘 | WANG Xiagrun JIN Yiying WANG Zhingyu | 2008 | Journal of Hazardous Materials2008，，160： | 1 |
| 10 | 显示文摘 | Wang Xingrun Jing Yiying Wang Zhingyu | 2008 | Journal of Hazardous Materials2008，160，： | 1 |
| 11 | Development of light- weight aggregate from dry sewage sludge and coal ash 显示文摘 | Xingrun Wang Yiying Jin Zhiyu Wang | 2009 | WasteMan- agement2009，，29： | 1 |
| 12 | Modal space vibration control of a beam by using the feedforward and feedback control loop显示文摘 | Wang Der An Huang Yii Mei | 2002 | International Journal of Mechanical Sciences2002，44，1： | 1 |
| 13 | A search on sin- tering characteristics and mechanisms of dried sewage sludge显示文摘 | WANG Xingrun JIN Yiying WANG Zhingyu | 2008 | Jour- nal of Hazardous Materials2008，160，23： | 1 |
| 14 | Desertification and Blown Sand Disaster in China显示文摘 | Yanli Lyu Yanyan Yang Lanlan Guo Lianyou Liu Peijun Shi Guoming Zhang Zhiqiang Qu Xia Hu Jingpu Wang Yiying Xiong Haiming Wen Jie Lei Bo Liang Jiadong Dai | 2016 | Journal of Agricultural Science and Technology(A)2016，6，6： | 1 |
| 15 | PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling显示文摘Oral squamous cell carcinoma(OSCC)has a high incidence of metastasis.Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary;however,only a few patients with OSCC respond to this treatment.Therefore,it is essential to gain insights into the molecular mechanisms underlying the growth and metastasis of OSCC.In this study,we analysed the expression levels of protein kinase D3(PKD3)and PD-L1 and their correlation with the expression of mesenchymal and epithelial markers.We found that the expression of PKD3 and PD-L1 in OSCC cells and tissues was significantly increased,which correlated positively with that of mesenchymal markers but negatively with that of epithelial markers.Silencing PKD3 significantly inhibited the growth,metastasis and invasion of OSCC cells,while its overexpression promoted these processes.Our further analyses revealed that there was positive feedback regulation between PKD3 and PD-L1,which could drive EMT of OSCC cells via the ERK/STAT1/3 pathway,thereby promoting tumour growth and metastasis.Furthermore,silencing PKD3 significantly inhibited the expression of PD-L1,and lymph node metastasis of OSCC was investigated with a mouse footpad xenograft model.Thus,our findings provide a theoretical basis for targeting PKD3 as an alternative method to block EMT for regulating PD-L1 expression and inhibiting OSCC growth and metastasis. | Bomiao Cui Jiao Chen Min Luo Yiying Liu Hongli Chen Die Lü Liwei Wang Yingzhu Kang Yun Feng Libin Huang Ping Zhang | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 16 | Development of light-weight aggregate from dry sewage sludge and coal ash显示文摘 | Wang Xingren Jin Yiying Wang Zhiyu | 2009 | Waste Managernent2009，29，4： | 1 |
| 17 | A Bi-layer Composite Film Based on TiO_2 Hollow Spheres, P25,and Multi-walled Carbon Nanotubes for Efficient Photoanode of Dye-sensitized Solar Cell显示文摘A bi-layer photoanode for dye-sensitized solar cell(DSSC) was fabricated, in which TiO_2 hollow spheres(THSs) were designed as a scattering layer and P25/multi-walled carbon nanotubes(MWNTs) as an under-layer. The THSs were synthesized by a sacrifice template method and showed good light scattering ability as an over-layer of the photoanode. MWNTs were mixed with P25 to form an under-layer of the photoanode to improve the electron transmission ability of the photoanode. The power conversion efficiency of this kind of DSSC with bi-layer was enhanced to 5.13 %,which is 14.25 % higher than that of pure P25 DSSC.Graphical Abstract A bi-layer composite photoanode based on P25/MWNTs-THSs with improved light scattering and electron transmission, which will provide a new insight into fabrication and structure design of highly efficient dyesensitized solar cells. | Putao Zhang Zhiqiang Hu Yan Wang Yiying Qin Wenqin Li Jinmin Wang | 2016 | Nano-Micro Letters2016，8，3： | 1 |
| 18 | Recycling of municipal solid waste incineration fly ash for ordinary Portland cement production: a real-scale test显示文摘 | WANG Lei JIN Yiying NIE Yongfeng | 2010 | Resources Conservation and Recycling2010，54，12： | 1 |
| 19 | Three dimensional phytic acid-induced graphene as a solid-phase microextraction fiber coating and its analytical applications for nerolidol in tea显示文摘In this work, three dimensional phytic acid-induced graphene coating was prepared by hydrothermal synthesis and fabricated on a stainless-steel wire using physical coating method as a solid phase microextraction(SPME) coating. The graphene coating revealed high specific surface area, extraordinary electrical conductivity and excellent chemical stability. Coupled with gas chromatography-flame ionization detector(GC-FID), the home-made phytic acid-induced graphene SPME fiber exhibited excellent extraction efficiency for the analysis of nerolidol in tea samples. Under the optimized conditions, the linear range of working curve was found to be 1-1000 ng/g, and the limit of detection of nerolidol was 0.18 ng/g. The coefficient variation of repeatability for each single fiber and reproducibility for fiber to fiber was less than 3.9% and 8.3%, respectively. | Shujun Xia Jing Dong Yiying Chen Yiru Wang Xi Chen | 2018 | Chinese Chemical Letters2018，29，1： | 1 |
| 20 | Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine- N -Oxide in Patients With Heart Failure显示文摘 | W.H. Wilson Tang Zeneng Wang Yiying Fan Bruce Levison Jennie E. Hazen Lillian M. Donahue Yuping Wu Stanley L. Hazen | 2014 | Journal of the American College of Cardiology2014，，18： | 1 |
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