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| 1 | Concentrations and gas-particle partitioning of PCDD/Fs in the urban air of Dalian,China显示文摘PCDD/Fs in the urban air of Dalian,China were monitored with high-volume active sampler from November 2009 to October 2010.The concentration of Cl 4-8 DD/Fs ranged from 3065 to 49538 fg m-3,with an average of 10249 fg m-3.The international toxic equivalents(I-TEQ) value of that was 61.8 1182 fg m-3,with an average of 235 fg m-3,which was comparable to those in the other urban locations around the world.It was found that the Cl 4 8 DD/Fs appeared to be present mainly in the particle phase during winter,spring and autumn,while during summer which were dominantly in gas phase.The ratio of Cl 4-8 DD/Fs present in particle phase increased with the increasing level of chlorination.The concentrations of PCDFs and PCDDs decreased with the increase of chlorinated level,while the concentrations of 2,3,7,8-PCDDs congeners increased with the increase of chlorination level.The homolog profiles of the concentrations of PCDFs presented were higher than those of the PCDDs,which indicated the PCDD/Fs pollution source of the air in Dalian was characteristic for thermal source pollution.The correlation analysis of meteorological parameters with the concentrations of Cl 4-8 CDD/Fs was conducted using SPSS packages,and it was found that the ambient temperature and atmospheric pressure were important factors influence the concentration of PCDD/Fs in the air.The respiratory risk and intake dioxins of the residents around the sampling sites were studied in the paper.It was found that Junge-Pankow model was much more accurate in predicting the gas-particle partitioning behavior of PCDD/Fs homologues during winter,while the Harner-Bidleman model shows better agreement with the measured data during winter and summer. | QIN SongTao ZHU XiuHua WANG Wei CHEN JiPing NI YuWen LI XiaoXiao MU Jun Xu Qian SCHRAMM Karl-Werner | 2012 | Chinese Science Bulletin2012，57，26： | 10 |
| 2 | TNF-αTNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms显示文摘Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha(TNF-a) and its receptors TNF receptor subtype-1(TNFR1) and TNFR2 in acute and chronic itch in mice.Compared to wild-type(WT) mice, TNFR1-knockout(TNFR1-KO) and TNFR1/R2 double-KO(DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine(CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-αantagonist etanercept dose-dependently suppressed acute itch. Intradermal injection of TNF-α was not sufficient to evoke scratching, but potentiated itch induced by compound 48/80, but not CQ. In addition, compound 48/80 induced TNF-α mRNA expression in the skin, while CQ induced its expression in the dorsal root ganglia(DRG) and spinal cord. Furthermore, chronic itch induced by dry skin was reduced by administration of thalidomide and etanercept and in TNFR1/R2 DKO mice. Dry skin induced TNF-α expression in the skin, DRG, and spinal cord and TNFR1 expression only in the spinal cord. Thus, our findings suggest that TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch via peripheral and central mechanisms, and targeting TNFR1 may be beneficial for chronic itch treatment. | Xiuhua Miao Ya Huang Teng-Teng Liu Ran Guo Bing Wang Xue-Long Wang Li-Hua Chen Yan Zhou Ru-Rong Ji Tong Liu | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 3 | Simultaneous monitoring of PCB profiles in the urban air of Dalian,China with active and passive samplings显示文摘The concentration of polychlorinated biphenyls (PCBs) in the urban air of Dalian, China was monitored from November 2009 to October 2010 with active high-volume sampler and semipermeable membrane device (SPMD) passive sampler. The concentration of PCBs (particle + gas) ( ∑ PCBs) ranged from 18.6 to 91.0 pg/m 3 , with an average of 50.9 pg/m 3 , and the most abundant dioxin-like PCB (DL-PCBs) was PCB118. The WHO-TEQ values of DL-PCBs were 3.6-22.1 fg/m3 , with an average of 8.5 fg/m 3 , and PCB126 was the maximum contributor to ∑ TEQ. There was a much larger amount of PCBs in the gas phase than in the particulate phase. The dominant PCB components were lower and middle molecular weight PCBs. With increasing chlorination level, the concentration of the PCB congeners in the air decreased. The gas-particulate partitioning of PCBs was different for the four seasons. The gas- particulate partitioning coefficients (logK p ) vs. subcooled liquid vapor pressures (logP L 0 ) of PCBs had reasonable correlations for different sampling sites and seasons. The absorption mechanism contributed more to the gas-particulate partitioning process than adsorption. Correlation analysis of meteorological parameters with the concentration of PCBs was conducted using SPSS packages. The ambient temperature and atmospheric pressure were important factors influencing the concentration of PCBs in the air. The distribution pattern of the congeners of PCBs and the dominant contributors to DL-PCBs and TEQ in active samples and SPMDs passive samples were similar. SPMD mainly sequestrated gas phase PCBs. | Qian Xu Xiuhua Zhu Bernhard Henkelmann Karl-Werner Schramm Jiping Chen Yuwen Ni Wei Wang Gerd Pfister Jun Mu Songtao Qin Yan Li | 2013 | Journal of Environmental Sciences2013，25，1： | 8 |
| 4 | A novel deletion mutation, c.1296delT in the BCOR gene, is associated with oculo-facio-cardio-dental syndrome显示文摘The purpose of the present study was to analyze the clinical phenotypes of a girl with oculo-facio-cardio-dental(OFCD)syndrome and to identify the potential pathogenic mutation responsible for her disease. The patient underwent detailed clinical examinations and phenotype data were collected over a follow-up period of 9 years. Mutation analysis of the candidate gene BCOR was performed with polymerase chain reaction and Sanger sequencing. BCOR of 60 unrelated normal individuals were also sequenced as a control group. Clinical phenotyping and follow-up study results indicate that this patient had multiple system anomalies including ocular, facial, cardiac, dental, and limb malformations. In addition, papilloma of the choroid plexus was identified, which represents the first report of this phenotype in an OFCD patient. A novel deletion mutation, c.1296 delT in exon4 of the BCOR gene, was identified in this patient and was not found in her parents or in 60 normal unrelated individuals. This deletion was a frameshift mutation and is proposed to encode a premature stop codon, thus producing a truncated protein. Our patient fitted the diagnostic criteria for OFCD syndrome and we report the first papilloma of the choroid plexus in an OFCD patient, expanding the recognized phenotypic spectrum of this disease. Meanwhile, we identified a novel deletion mutation that may cause OFCD syndrome. | Jingshang Zhang Hongyan Jia Jinda Wang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Xiaohui Zhang Qisheng You Guyu Zhu Frank F.Tsai Mark Espina Xiuhua Wan | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 5 | A lattice-based signcryption scheme without random oracles显示文摘 | Xiuhua LU Qiaoyan WEN Zhengping JIN Licheng WANG Chunli YANG | 2014 | Frontiers of Computer Science2014，8，4： | 5 |
| 6 | Introduction of antisense waxy gene into main parent lines of indica hybrid rice显示文摘Amylose content in rice endosperm is one of the key determinants of rice eating and cooking quality, and the poor quality of indica hybrid rice is closely related to the high amylose level in rice grains. In order to improve the grain quality of the indica hybrid rice by genetic engineering, an antisense fragment of rice waxy gene, driven by the 5’-franking sequences of the rice waxy gene, was successfully introduced into three major parent lines of indica hybrid rice, all contain a high amylose level in the grains, via Agrobacte-rium, and more than 100 hygromycin-resistant plants were regenerated. The analysis of PCR amplification and Southern blots indicated that the T-DNA containing the antisense waxy gene had been integrated into the genome of transgenic rice plants. Most of the primary transgenic rice plants grew normally, and the mature seeds from these transgenic plants were performed for analysis of the amylose content. The results showed that the amylose content in the endosperm of some grains | CHEN Xiuhua LIU Qiaoquan WANG Zongyang WANG Xingwen CAI Xiuling ZHANG Jingliu GU Minghong | 2002 | Chinese Science Bulletin2002，47，14： | 5 |
| 7 | In-situ Chemical Age of the Sandstone-hosted Uranium Deposit in Ningdong Area on the Western Margin of the Ordos Basin, North China显示文摘Objective The Ordos Basin located in the western part of the North China Craton bears various energy resources such as oil,gas,coal and uranium.It is one of the richest uranium-bearing basins in China.Since the discovery of the large-scale Dongsheng,Hangjinqi and Daying uranium deposits in the north of the Ordos Basin,a | WANG Feifei LIU Chiyang NIU Haiqing ZHOU Ningchao LI Xiuhua LUO Wei ZHANG Dongdong ZHAO Yan | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 8 | Effects of fertilization and container-type on nutrient uptake and utilization by four subtropical tree seedlings显示文摘Seedling quality is important for subtropical tree species endangered by the degradation of natural habitats in southern China.At present,the cultural regime for raising these seedlings involving fertilizer levels and size of container is not clear.In this study,seedlings of three endangered species,red-seed tree(Ormosia hosiei),Zhejiang phoebe(Phoebe chekian gensis),and Zhejiang camphor(Cinnamomum japonicum)were evaluated along with red-bark oak(Cyclobalanopsis gilva)as a reference,a species which is not endangered.Seedlings were raised in 2.8,3.6,5.1,and 6.3 L containers and fertilizer applied at 1.0,2.0,3.0 and 4.0 kg m-3.Seedling height and leaf biomass increased in response to higher fertilizer levels while larger containers resulted in greater stem and root biomass.Root biomass of endangered species seedlings did not respond to neither treatments.Zhejiang phoebe seedlings responded to nitrogen and phosphorus uptake but red-seed tree seedlings were unaffected by any nutrient levels.Red-bark oak seedlings had high nitrogen-use efficiency.Based on the results,it is recommended using at least 5.1 L containers to culture Zhejiang phoebe and Zhejiang camphor seedlings with fertilizer at 3.0 kg m-3.Red-bark oak and red-seed tree seedlings should be cultured with 2.0 kg m-3 in smaller containers. | Xiuli Chu Xiuhua Wang Dongbei Zhang Xiaolin Wu Zhichun Zhou | 2020 | Journal of Forestry Research2020，31，4： | 4 |
| 9 | Traditional Chinese Medicines alleviated myocardial ischemia by regulating Qi and promoting blood circulation显示文摘OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sham operation(Sham),(b)myocardial ischemia(Model),(c)treatment that regulates Qi(Qi),(d)treatment that promotes blood circulation(Blood),(e)treatment that both regulates Qi and promotes blood circulation(QB).The rat model was established via activities restriction for 6 h followed by tail clamp stimulation for 5 mins every day for 7 d and occlusion left coronary anterior descending artery.Afterwards rats were treated with medicines that regulate Qi and/or promote blood circulation via gavage for 14 d.Behavioral parameters were evaluated using open field and elevated plus-maze tests.The tongue color and sublingual vein were visually examined.Blood flow perfusion of tongue and auricle were detected using PIMⅡ.The mesenteric microcirculation was examined via capillaroscopy,and hemodynamics was assessed using a polygraph system.Serum homocysteine(Hcy),creatine kinase isoenzyme(CKMB)levels and endothelin-1(ET-1)were measured.Hematoxylin and eosin staining and transmission electron microscopy were employed to detect the myocardial morphology and ultrastructure,respectively.RESULTS:Compared with findings in Sham group,rats in model group had coarse hair,dark mucosa of the lips and claw,low activity,and increased anxiety.Compared with findings in Model group,rats in the three treatment groups exhibited a lighter tongue color without an extended and varicose sublingual vein.There were significant increases of auricle blood flow perfusion in the Qi group and tongue bottom blood flow perfusion in the QB group.Compared with findings in Model rats,rats in Blood group exhibited improved mesenteric microcirculation associated with increased mesenteric blood flow and a larger arteriole diameter.Moreover,compared with findings in Model rats,Qi and QB rats exhibited increased left ventricular±dp/dtmax,decreased serum CKMB,Hcy,ET-1 levels,and reduced myocardial ultrastructural damage.CONCLUSION:Myocardial ischemia damage was suppressed by Traditional Chinese Medicines that regulate Qi and promote blood circulation. | Wang Chen Wang Xiaoreng Tao Tianqi Song Dandan Wang Jianli Wang You Liu Xiuhua Wu Xudong | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 10 | Microwave-assisted pyrolysis of vegetable oil soapstock:Comparative study of rapeseed,sunflower,corn,soybean,rice,and peanut oil soapstock显示文摘In this study,the effects of catalytic temperature and the type of soapstock on products from microwave-assisted pyrolysis were investigated.HZSM-5 was used as the catalyst to study the pyrolysis of six different soapstocks at 200℃,300℃,and 400℃ catalytic temperature.Results showed that the bio-oil yields initially increased and then decreased with the increase in catalytic temperature.When the catalytic temperature was 300℃,the bio-oil reached up to the maximum value(65.8 wt.%).Findings indicated that the composition of bio-oil was related to the degree of unsaturation of fatty acids sodium in the soapstocks.In the case of saturated fatty acid sodium,a series of alkanes was formed,whereas the pyrolysis of monounsaturated fatty acid sodium resulted mainly in cycloalkanes,the cycloalkenes obtained from bio-oil was produced by polyunsaturated fatty acid sodium. | Yunpu Wang Shumei Zhang Qiuhao Wu Dengle Duan Yuhuan Liu Roger Ruan Guiming Fu Leilei Dai Lin Jiang Zhenting Yu Zihong Zeng Xiaojie Tian Xiuhua Yang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 11 | Aβ inhibits mesenchymal stem cell-pericyte transition through MAPK pathway显示文摘 | Lixia Xu Jialin Li Zhongqiu Luo Qiaoli Wu Weijia Fan Xiuhua Yao Qingguo Li Hua Yan Jinhuan Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 12 | Comparison of ocular modulation transfer function determined by a ray-tracing aberrometer and a double-pass system in early cataract patients显示文摘 | Qiao Liya Wan Xiuhua Cai Xiaogu Balamurali Vasudevan Xiong Ying Tan Jiaxuan Guan Zheng David A Atchison Wang Ningli | 2014 | Chinese Medical Journal2014，，19： | 3 |
| 13 | TGF-β regulation of microRNA miR-497-5p and ocular lens epithelial cell mesenchymal transition显示文摘The purpose of this study was to investigate the role of a human lens microRNA(miR-497-5p) in regulating epithelialmesenchymal transition(EMT) under the control of transforming growth factor beta(TGF-β). A microRNA array was used to evaluate the microRNA profiles of untreated and TGF-β-treated human lens epithelial cells in culture. This showed that TGF-βtreatment led to the upregulation of 96 microRNAs and downregulation of 39 microRNAs. Thirteen microRNAs were predicted to be involved in the pathogenesis of posterior capsule opacification(PCO). Meanwhile, overexpression of miR-497-5p suppressed cell proliferation and EMT 48 h post-transfection, and inhibition of miR-497-5p accelerated cell proliferation and EMT.Treatment with TGF-β inhibited the expression of miR-497-5p, but not cell proliferation. miR-497-5p was also found to regulate the level of CCNE1 and FGF7, which are reported to be actively involved in EMT. CCNE1 and FGF7 were bona fide targets of miR-497-5p. The results suggest that miR-497-5p participates in the direct regulation of lens epithelial cell EMTand is regulated by TGF-β. miR-497-5p may be a novel target for PCO therapy. | Jinda Wang Jingshang Zhang Ying Xiong Jing Li Xiaoxia Li Jing Zhao Guyu Zhu Hailong He Yusufu Mayinuer Xiuhua Wan | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 14 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 15 | INFLUENCE OF ANTIDROM IC ELECTRIC STIM ULATI ON ONPREPROTACHYKININ m RNA EXPRESSION IN ADJACENT DORSAL ROOT GANGLIA OF RATS显示文摘By in situ hybridization histochemistry, the changes of preprotachykinin (PPT) mRNA expression were examined in the neurons of adjacent thoracal dorsal root ganglion (DRG) after a strong electric stimulation to an intact dorsal cutaneous branch and the cut distal part of left T 9 thoracal spinal nerve of rat. There was a significant increase of the number of neurons expressing PPT mRNA in the ipsilateral T 8, T 9 and T 10 DRG of the animals given electric stimulation to intact spinal nerve branch 24 h after the electric stimulation. The same increase was found in the ipsilateral T 8 and T 10 DRG of the animals given electric stimulation to the distal part of spinal nerve branch. While no change was found in the DRG of the contralateral side of these animals. The present results showed that the antidromic electric stimulation strengthened the biosynthesis of PPT mRNA in adjacent DRG. These findings suggested that there was information transmission across segments between two sensory nerve endings and some bioactive substances such as SP might play important roles in the information transmission across segments of spinal cord. | Li Xiuhua,Zhao Yan,Shi Wenchun,Li XinminFirst Affiliated Hospital,Wang Huisheng Research Center of Neurobiology, Xi′an Medical University, Xi′an 710061 | 1999 | Journal of Pharmaceutical Analysis1999，13，2： | 2 |
| 16 | Effects of dry dietary protein on digestibility, nitrogen-balance and growth performance of young male mink显示文摘The experiment was to study the nutrient digestibility and metabolism performance of male minks,which were fed different protein level diets during growth period. Effects of protein quantity on growth and development of minks and feed conversion ratio(FCR) were also investigated. Sixty healthy male minks of 45 d were randomly allocated into six groups with ten replicates, which was one sable for each replicate. The minks in six groups were fed diets in which protein levels were 28, 30,32, 34, 36 and 38%,respectively. The six groups were denoted as P28, P30, P32, P34, P36 and P38. After 2 wk, all minks were weighed, average daily gains(ADG) were calculated, and the digestibility values of nutrients were determined. The results indicated that digestibility of calcium, nitrogen of fence, nitrogen deposition, net protein utilization(NPU), and biological value of protein(BV) were similar(P > 0.05), however, nitrogen intake greatly varied among groups(P < 0.01). Compared with group P28, groups of P34, P36 and P38 showed significant difference(P < 0.01) in ADG and FCR. In conclusion, it was recommended that adding34% protein to mink diet would optimize production parameters including ADG, digestibility of nutrition,and FCR, and negative result was observed when diet protein was lower than 28%. | Tietao Zhang Haihua Zhang Xuezhuang Wu Qiang Guo Zhi Liu Wang Qian Xiuhua Gao Fuhe Yang Guangyu Li | 2015 | Animal Nutrition2015，，2： | 2 |
| 17 | Modulating intestinal mucus barrier for nanoparticles penetration by surfactants显示文摘Improving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However,intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore,in this study,taking fluorescent labeled PLGA(poly(lactic-co-glycolic acid)) nanoparticles as a tool,the influence of anionic and nonionic surfactants on mucus penetration ability of nanoparticles and their mucus barrier regulating ability were studied. The movement of PLGA nanoparticles in mucus was tracked by multiple particles tracking method(MPT).Alteration of mucus properties by addition of surfactants was evaluated by rheology and morphology study. Rat intestinal villus penetration study was used to further evaluate penetration enhancement of nanoparticles. The effective diffusivities of the nanoparticles in surfactants pretreated mucus were increased by 2–3 times and the mucus barrier regulating capacity was also surfactant type dependent. Sodium dodecyl sulfate(SDS) increased the complex viscosity and viscoelastic properties of mucus,but poloxamer presented a decreased trend. Tween 80 maintained the rheological property of the mucus. With the mucus barrier regulated by surfactants,the penetration of nanoparticles in intestinal villus was obviously increased. In summary,the mucus penetration ability of nanoparticles could be enhanced by altering mucus microenvironment with surfactants. Tween 80 which largely retains the original mucus rheology and morphology properties may be a promising candidate for facilitating nanoparticle penetration through the mucus barrier with good safety profile. | Xin Zhang Wei Dong Hongbo Cheng Meixia Zhang Yongqiang Kou Jian Guan Qiaoyu Liu Mingyue Gao Xiuhua Wang ShiruiMao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 2 |
| 18 | Monitoring gas-and particulate-phase short-chain polychlorinated paraffins in the urban air of Dalian by a self-developed passive sampler显示文摘The concentration of short-chain polychlorinated paraffins(SCCPs) in the urban air of Dalian,China was monitored from September 2016 to August 2017 with a self-developed passive sampler(PAS1) and an active high-volume sampler, simultaneously. PAS1 successfully collected the entire target SCCPs in the ambient air. Air SCCPs sampled by PAS1 were found be in the linear uptake stage during 181 days of sampling. Passive and active samples showed comparable congener profiles, and the dominant contributors of SCCPs in the two kinds of samples were similar. A significant linear correlation was observed between the total concentration of SCCPs sampled by PAS1 and active sampler in the four seasons. The passive sampling rates of the PAS1 for the gas and particulate phases of SCCPs were measured. The quantitative structure–property relationship of the sampling rate of PAS1(Rair) for gas-phase SCCPs was studied. From the molecular point of view, Rairwas mainly affected by the molecular weight and sub-cooled liquid vapor pressure of SCCPs. In general, SCCPs in the urban air of Dalian mainly existed in gas phase,lower molecular weight SCCPs primarily occurred in the gas phase, whereas higher molecular weight SCCPs were predominately adsorbed or absorbed on airborne particles. The air concentration of SCCPs in the four seasons were different, the correlation of the concentration of SCCPs in the air with the meteorology parameters was conducted. The exposure risk by intake air SCCPs of the residents around the sampling sites was evaluated according to the European risk assessment standards. | Yifan Wang Xiuhua Zhu Yuan Gao Hao Bai Pengyuan Wang Jiping Chen Heping Yuan Longxing Wang Xiaoxiao Li Wei Wang | 2019 | Journal of Environmental Sciences2019，31，6： | 2 |
| 19 | Effect of Ti-enriched Carbonitride on Microstructure and Mechanical Properties of X80 Pipeline Steel显示文摘In this study,two API X80 pipeline steels were fabricated by varying Ti additions,and their microstructures and fracture characteristics were analyzed to investigate the effects of Ti-enriched carbonitride on the tensile properties and Charpy impact properties.Lathy bainite,a mass of matensite/austenite(M/A),coarse cubic Ti-enriched inclusions,chain-typed Ti-enriched precipitations,weak toughness and high tensile strength were found as consequences of higher amount of Ti content.Those large scale and chain-typed Ti-enriched carbonitrides are one kind of crack sources during fracture.The negative effect of higher amount of Ti on the impact properties is increased with decreased temperature. | Wei Deng,Xiuhua Gao,Dewen Zhao,Linxiu Du,Di Wu and Guodong Wang State key laboratory of rolling and automation,Northeastern University,Shenyang 110819,China | 2010 | Journal of Materials Science & Technology2010，26，9： | 2 |
| 20 | The open-close mechanism of M2 channel protein in influenza A virus:A computational study on the hydrogen bonds and cation-π interactions among His37 and Trp41显示文摘The M2 protein from influenza A virus is a tetrameric ion channel. It was reported that the permeation of the ion channel is correlated with the hydrogen bond network among His37 residues and the cation-π interactions between His37 and Trp41. In the present study,the hydrogen bonding network of 4-methyl-imidazoles was built to mimic the hydrogen bonds between His37 residues,and the cation-π interactions between 4-methyl-imidazolium and indole systems were selected to represent the interac-tions between His37 and Trp41. Then,quantum chemistry calculations at the MP2/6-311G level were carried out to explore the properties of the hydrogen bonds and the cation-π interactions. The calcula-tion results indicate that the binding strength of the N-H···N hydrogen bond between imidazole rings is up to -6.22 kcal·mol-1,and the binding strength of the strongest cation-π interaction is up to -18.8 kcal·mol-1(T-shaped interaction) or -12.3 kcal·mol-1(parallel stacking interaction). Thus,the calcu-lated binding energies indicate that it is possible to control the permeation of the M2 ion channel through the hydrogen bond network and the cation-π interactions by altering the pH values. | CHENG JiaGao ZHU WeiLiang WANG YanLi YAN XiuHua LI Zhong TANG Yun JIANG HuaLiang | 2008 | Science China Chemistry2008，51，8： | 2 |
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