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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Treatment of spinal cord ependymom as by surgery with or without postoperative radio therapy显示文摘 | Lin YH Huang CI Wong TT | 2005 | J Neurooncol2005，71，2： | 1 |
| 3 | Retinal microvasculature inacute lacunar stroke : a cross-sectional study 显示文摘 | Lindley RI Wang JJ Wong MC ci al | 2009 | Lancet Neurol2009，8，7： | 1 |
| 4 | Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy 显示文摘 | Lin YH Huang CI Wong TT | 2005 | J Neurooncol2005，71，2： | 1 |
| 5 | Clinical and histopathologicspectrum of cutaneous Rosai-Dorfman disease in Taiwan显示文摘 | Lu CI Kuo TT Wong WR | 2004 | J Am Acad Dermatol2004，51，6： | 1 |
| 6 | Clinical and histopathological spectrum of cutanous Rosai-Dorfman disease in Taiwan显示文摘 | Lu CI Kuo TT Wong WR | 2004 | J Am Acad Dermatol2004，51，6： | 1 |
| 7 | Clinical and histopathologic spec- trum of cutaneous Rosai-Dorfman disease in Taiwan 显示文摘 | Lu CI Kuo TT Wong WR | 2004 | J Am Acad Dermatol2004，51，： | 1 |
| 8 | Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotesto-sterone显示文摘 | Kemppainen JA Langley E Wong CI | 1999 | Mol Endocrinol1999，13，3： | 1 |
| 9 | Clinical effects of botulinum toxin a and phenol block on gait in Children with cerebral palsy显示文摘 | Wong AM Chen CI Chen CP | 2004 | Am J Phys Med Rehabil2004，83，： | 1 |
| 10 | The sensitivity and speci- ficity of guaiac and immunochemical fecal occult blood tests for the detection of advanced colonic adenomas and cancer 显示文摘 | Wong CK Fedorak RN Prosser CI | 2012 | Int J Colo- rectal Dis2012，27，12： | 1 |
| 11 | Clinical and histopathologic spectrum of cutaneous Rosai-Dorfman disease in Taiwan显示文摘 | Lu CI Kuo TT Wong WR | 2004 | J Am Acad Dermatol2004，51，6： | 1 |
| 12 | Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy显示文摘 | Lin YH Huang CI Wong TT | 2005 | J Neurooncol2005，71，2： | 1 |
| 13 | Clinical and histopathologic spectrum of eutaneous Rosai-Dorfman disease in Taiwan 显示文摘 | Lu CI Kuo TT Wong WR | 2004 | J Am Acad Derraatol2004，51，6： | 1 |
| 14 | Phase 1 and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor in patients with refractory solid malignancies显示文摘 | WONG CI KOH TS SOO R | 2009 | J Clin Oncol2009，27，28： | 1 |
| 15 | Treatment of spinalcord ependymomas by surgery with or without post-operative radiotherapy显示文摘 | Lin Huang CI Wong TT | 2005 | J Neurooncol2005，71，2： | 1 |
| 16 | Clinical and histopathologic spectrum of cutaneous Rosai-Dorfman disease in Taiwan显示文摘 | Lu CI Kuo TT Wong WR | 2004 | Journal of the American Academy of Dermatology2004，51，6： | 1 |
| 17 | Phase I and biomarker study of ABT-869,a multiple receptor tyrosine kinase inhibitor,in patients with refractory solid malignancies显示文摘 | Wong CI Koh TS Soo R | 2009 | J Clin Oncol2009，27，28： | 1 |
| 18 | Treatment of spinal cord ependymomas by surgery with or without postoper- ative radiotherapy 显示文摘 | Lin YH Huang CI Wong TF | 2005 | J Neurooncol2005，71，2： | 1 |
| 19 | Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy 显示文摘 | Lin YH Huang CI Wong TT | 2005 | JNeurooncol2005，71，： | 1 |
| 20 | 显示文摘 | Wong CI | 1995 | J Biol Chem1995，270，19： | 1 |
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