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42篇 您的检索式:作者名="Shiping Zhou"
    题名 作者 年代 出处 被引量
1Anchoring mechanism and application of hydraulic expansion bolts used in soft rock roadway floor heave control显示文摘Comparing with the resin bolt, the hydraulic expansion bolt has different anchoring mechanism and application advantage. According to the working mechanism of the hydraulic expansion bolt, its anchoring force is expressed in four forms including support anchoring force, tension anchoring force, expansion anchoring force and tangent anchoring force, and their values can be obtained on the basis of each calculation formula. Among them, the expansion anchoring force, which is the unique anchoring force of the hydraulic expansion bolt, can provide confining pressure to increase the strength of rock. Aiming at solving the problem of stability control in the soft rock roadway in Jinbaotun Coal Mine which has a double layer of 40 U-type sheds and cannot provide enough resistance support to control floor heave, the study reveals the mechanism of floor heave in the soft rock roadway, and designs the reasonable support parameters of the hydraulic expansion bolts. The observed results of floor convergence indicate that the hydraulic expansion bolts can prevent the development and flow of the plastic zone in the floor rock to control floor heave. Research results enrich the control technology in the soft rock roadway.Chang Qingliang Zhou Huaqiang Xie Zhihong Shen Shiping 2013International Journal of Mining Science and Technology2013,23,3:20
2Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment.Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show 2020Cell Research2020,30,10:19
3Internet of Things to network smart devices for ecosystem monitoring显示文摘Smart, real-time, low-cost, and distributed ecosystem monitoring is essential for understanding and managing rapidly changing ecosystems. However, new techniques in the big data era have rarely been introduced into operational ecosystem monitoring, particularly for fragile ecosystems in remote areas.We introduce the Internet of Things(IoT) techniques to establish a prototype ecosystem monitoring system by developing innovative smart devices and using IoT technologies for ecosystem monitoring in isolated environments. The developed smart devices include four categories: large-scale and nonintrusive instruments to measure evapotranspiration and soil moisture, in situ observing systems for CO2 and d13 C associated with soil respiration, portable and distributed devices for monitoring vegetation variables, and Bi-CMOS cameras and pressure trigger sensors for terrestrial vertebrate monitoring. These new devices outperform conventional devices and are connected to each other via wireless communication networks. The breakthroughs in the ecosystem monitoring IoT include new data loggers and longdistance wireless sensor network technology that supports the rapid transmission of data from devices to wireless networks. The applicability of this ecosystem monitoring IoT is verified in three fragile ecosystems, including a karst rocky desertification area, the National Park for Amur Tigers, and the oasis-desert ecotone in China. By integrating these devices and technologies with an ecosystem monitoring information system, a seamless data acquisition, transmission, processing, and application IoT is created. The establishment of this ecosystem monitoring IoT will serve as a new paradigm for ecosystem monitoring and therefore provide a platform for ecosystem management and decision making in the era of big data.Xin Li Ning Zhao Rui Jin Shaomin Liu Xiaomin Sun Xuefa Wen Dongxiu Wu Yan Zhou Jianwen Guo Shiping Chen Ziwei Xu Mingguo Ma Tianming Wang Yonghua Qu Xinwei Wang Fangming Wu Yuke Zhou 2019Science Bulletin2019,64,17:10
4Synthesis and Luminescence of SrZnO_2∶Eu^(3+), Li^+ Phosphor by Long Wavelength UV Excitation显示文摘SrZnO2∶Eu 3+, Li+ phosphor powder by long wavelength UV excitation was synthesized by conventional solid-state reaction method. XRD and PL were employed to characterize their properties. The results show that Eu 3+ ions preferentially occupy Sr 2+ asymmetry cationic sites, thus emitting 612 nm red light originated from 5D0 to 7F2 transition. The luminescent intensity can be greatly enhanced with incorporation of Li+ ions. The excitation efficiency in range of 350~400 nm also increases greatly due to incorporating Li+ ions. SrZnO2∶Eu 3+, Li+ is a promising red-emitting phosphor by long wavelength UV excitation.Yu Xibin Yang Liangzhun Yang Shiping Zhou Chunlei Xu Xiaolin Tang Jingfen Peng Xiudong 2005Journal of Rare Earths2005,23,5:7
5Individual and combined toxic effects of cypermethrin and chlorpyrifos on earthworm显示文摘Toxicities were assessed for a pyrethroid (cypermethrin) and an organophosphate insecticide (chlorpyrifos) individually and in combination. A series of tests were conducted on different responses (acute, chronic, behavioral) of earthworms of species Eisenia fetida andrei in the ecological risk assessment of these pesticides. The results showed that the toxicity of the mixture of cypermethrin and chlorpyrifos was significantly higher than either of these pesticides individually, especially on the earthworm's chronic responses. At a concentration of 5 mg/kg, the mixture caused significant reductions on the growth and reproduction rates of earthworms, but did not cause any significant effect when the individual was tested. The increase in toxicity of the pesticide mixture means that the use of toxicity data obtained exclusively from single-pesticide experiments may underestimate the ecological risk of pesticides that actually present in the field.Shiping Zhou Changqun Duan Wong Hang Gi Michelle Fazhong Yang Xuehua Wang 2011Journal of Environmental Sciences2011,23,4:5
6Vaccination against Schistosoma japonicum Infection by DNA Vaccine Encoding Sj22.7 Antigen显示文摘在鼠标的效果, recombinant 原生质标志 pcDNA3-Sj22.7 与调停 liposome 的方法习惯于 transfectHeLa 房间, Sj22.7 mRNA 和蛋白质的表达式用反向的抄写聚合酶链反应,钠 dodecylsulfate-polyacrylamide 凝胶电泳和蛋白质印迹被检验。然后, pcDNA3-Sj22.7 的能力在鼠标的种痘以后根据蠕虫减小率和鸡蛋减小率被分析免于 Schistosomajaponicum 挑战感染。特定的 IgG 抗体和 T 淋巴细胞增长反应的浆液层次也是坚定的。在挑战感染以后,驾驶 Sj22.7 的干扰素(IFN )-gamma andinterleukin (IL )-4 也被确定。结果证明 pcDNA3-Sj22.7 能表示 Sj22.7 mRNAand 在 vitro.Immunization 的蛋白质导致了29.70%的蠕虫减小率;鸡蛋减小率of47.25%(肝)并且51.73%(肠),并且25.90%的鸡蛋减小率(鸡蛋每女性),在 连接group.Enzyme 的免疫吸着剂试金和蛋白质印迹分析显示了的 pcDNA3-Sj22.7 建议重要反肥沃的正式就职那使对从与 pcDNA3-Sj22.7 使免疫的鼠标的 Sj22.7.Tlymphocytes 的产生特定的 IgG 显示出的鼠标免疫怒气房间的一种重要增长反应 torSj22.7.The 文化证明 IFN-gamma 的那分泌物增加了但是 IL-4decreased.The 结果显示由 pcDNA3-Sj22.7 的 DNA 种痘对足够对 S.japonicum 感染得到保护的免疫的重要层次。DNA 疫苗能导致重要细胞、体液的有免疫力的反应,并且显示占优势的 T 助手房间类型 1 类型免疫者回答,它在鼠标对挑战感染贡献保护的免疫。Gan DAI Shiping WANG Junlong YU Shaorui XU Xianchu PENG Zhuo HE Xueqin LIU Songhua ZHOU and Fen LIU Institute of Schistosomiasis Research.Xiangya School of Medicine,Central South University,Changsha 410078 China 2007Acta Biochimica et Biophysica Sinica2007,39,1:5
7Cloning, expression and protective immunity evalua-tion of the full-length cDNA encoding succinate dehydrogenase iron-sulfur protein of Schistosoma japonicum显示文摘1071-bp fragment was obtained from the Schistosoma japonicum (Chinese strain) adult cDNA library after the 3′ and 5′ ends of the incomplete expression sequence tag (EST) of succinate dehydrogenase iron-sulfur protein of Schistosoma japonicum (SjSDISP) were amplified by the anchored PCR with 2 pairs of primers designed according to the EST of SjSDISP and the sequence of multiclone sites of the library vector. Sequence analysis indicated that the fragment was a full-length cDNA with a complete open reading frame (ORF), encoding 278 amino acid residues. The fragment was cloned into prokary- otic expression vector pQE30, and subsequently sequenced and expressed in Escherichia coli. SDS-PAGE and Western-blot analyses showed that the recombinant protein was about 32 kD and could be recognized by the polyclonal antisera from rabbits immunized with Schistosoma japonicum adult worm antigen. Compared with the FCA controls, mice vaccinated with rSjSDISP (test) or rSjGST (posi- tive control) all revealed high levels of specific antibody and significant reduction in worm burden, liver eggs per gram (LEPG), fecal eggs per gram (FEPG) and intrauterine eggs. These results suggest that SjSDISP may be a novel and partially protective vaccine candidate against schistosomiasis. In contrast to the worm burden reduction rate, the higher degree of egg reduction rate in the test group also sug- gested that SjSDISP vaccine may primarily play a role in anti-embryonation or anti-fecundity immunity.YU JunLong, WANG ShiPing, LI WenKai, DAI Gan, XU ShaoRui, HE Zhuo, PENG XianChu, ZHOU SongHua & LIU XueQin Department of Parasitology, Xiangya School of Medicine, Central South University, Changsha 410078, China 2007Science China(Life Sciences)2007,50,2:4
8Combined amendment reduces soil Cd availability and rice Cd accumulation in three consecutive rice planting seasons显示文摘The scientific application of stabilized materials has been considered an effective method for the in situ remediation of Cd-contaminated soil.This study aimed to investigate the persistence of the effect of a combined amendment of limestone and sepiolite(LS)on soil Cd availability and accumulation in rice grown in a mildly Cd-contaminated paddy field(0.45 mg/kg of Cd)over three consecutive rice seasons.1125–4500 kg/ha of LS was applied to the soil before the first rice planting season and 562.5–2250 kg/ha of LS was supplemented before the third rice planting season.The application of LS(1125–4500 kg/ha)increased the soil p H by 0.44–1.09,0.18–0.53,and 0.42–0.68 in the first,second,and third season,respectively,and decreased the soil acid-extractable Cd content by 18.2–36.4%,17.7–33.5%,and9.6–17.6%.LS application significantly decreased the Cd contents in the rice tissues.The application of 4500 kg/ha of LS decreased the Cd content in brown rice to below the National Food Limit Standard of 0.2 mg/kg(GB 2762-2017)in the three consecutive rice seasons.However,the effect of LS on the soil-rice system was significantly weakened in the third season.The supplementary application of 562.5–2250 kg/ha of LS further decreased the Cd content in brown rice by 26.1–56.5%and decreased the health risk index by 23.7–43.8%.Therefore,it was recommended to apply 4500 kg/ha of LS in the first season and to supplement2250 kg/ha of LS in the third season to effectively guarantee the clean production of rice in three consecutive rice seasons.Wenjun Yang Shilong Wang Hang Zhou Min Zeng Jingyi Zhang Fang Huang Shiping Shan Zhaohui Guo Hongwei Yi Zhiguang Sun Jiaofeng Gu Bohan Liao 2022Journal of Environmental Sciences2022,34,1:4
9printed electrode immunosensors for Schistosoma japonicum显示文摘ZENG Shaohua TIAN Zhi CHE Hongli YANG Huihui CHEN Xiuchun FENG Qimei ZHOU Yunfei ZHANG Shuju WU Zhaoyang WANG Shiping 2012中南大学学报(医学版)2012,37,6:3
10Vascular dementia has the highest hospitalisation rate in China:a nationwide hospital information system study显示文摘Background Although vascular dementia(VaD)is not uncommon in the hospital,most studies on VaD are community based.This study on VaD is the first to use a national hospital information system(HIS)in China.Methods This study was a hospital population-based cohort study,and data were acquired from the Hospital Quality Monitoring System,a Chinese national database that covers 1531 tertiary hospitals in China.The medical records in the HIS included demographic information,diagnoses,procedures,expenses,etc.VaD was diagnosed by hospital attending physicians and identified by the International Classification of Diseases(ICD)10 code(F01.0-F01.9).Results 1259(82.23%)tertiary hospitals were included in this study,and 274230 hospitalisation records of 123700 VaD patients from 2016 to 2018 were identified for analysis.VaD(51.27%)was the most common type of dementia in hospitalised patients.The age-adjusted and sex-adjusted hospital incidence of VaD was estimated to be 2.97 per 100000 person-years(95%CI 2.92 to 3.02).The mean age of VaD patients admitted to hospitals was 74.13±10.88,with more male(61.0%)patients.The main comorbidities were hypertension(67.2%),heart disease(63.6%)and cerebral infarction(55.5%).The mortality rate of VaD in hospital was 28.91‰(95%CI 28.0 to 29.9)between 2016 and 2018.The top 1 cause of death due to VaD was pneumonia and other respiratory disorders.Conclusions VaD is the most common form of dementia in hospitalised patients.It casts huge burdens on affected patients and their caregivers.Vascular risk factors are prevalent in VaD patients.Reducing these factors is essential to improve patient care.The leading causes of death by VaD are pneumonia and other respiratory disorders.Hospital care and the management of respiratory illness are critical for VaD care in the hospital.Yue Wang Shiping Li Qi Zhou Yongjun Wang Jiong Shi 2023Stroke & Vascular Neurology2023,8,1:2
11Optimum design and preliminary experiments of a novel parallel end traction apparatus for upper-limb rehabilitation显示文摘Robot-assisted technology has been increasingly employed in the therapy of post stroke patients to deliver high-quality treatment and alleviate therapists5 burden.This paper introduces a novel parallel end traction apparatus(PETA)to supplement equipment selection.Considering the appearance and performance of the PETA,two types of special five-bar linkage mechanisms are selected as the potential configurations of the actuation execution unit because of their compact arrangement and parallel structure.Kinematic analysis of each mechanism,i.e.,position solutions and Jacobian matrix,is carried out.Subsequently,a comparative study between the two mechanisms is conducted.In the established source of nondimensional parameter synthesis,the singularity,maximum continuous workspace,and performance variation trends are analyzed.Based on the evaluation results,the final scheme with determined configuration and corresponding near-optimized non-dimensional parameters is obtained.Then,a prototype is constructed.By adding a lockable translational degree of freedom in the vertical direction,the PETA can provide 2D planar exercise and 3D spatial exercise.Finally,a control system is developed for passive exercise mode based on the derived inverse position solution,and preliminary experiments are performed to verify the applicability of the PETA.Shiping ZUO Jianfeng LI Mingjie DONG Guotong LI Yu ZHOU 2021Frontiers of Mechanical Engineering2021,16,4:2
12An Enhanced Monte Carlo Localization Algorithm for Mobile Node in Wireless Sensor Networks 显示文摘Shiping Fan Yongiang Wen Lin Zhou 2013Applied Mechanics and Ma-terials2013,,:1
13增温和放牧对高寒草甸凋落物分解及其养分释放的影响不依赖于凋落物品质显示文摘在放牧生态系统中,增温、放牧和调落物品质共同决定着凋落物分解和养分释放。然而,在以往的研究中这些因子的效应通常被单独地研究。在本研究中,我们在青藏高原高寒草甸开展了一个昼夜非对称增温和中度放牧两因子的调落物分解试验。从每个处理中收集了调落物样品,这些调落物一部分放在它们的来源处理小区,另一部分放在其他处理小区以此来探究增温、放牧以及调落物品质对调落物分解和养分释放的影响。研究结果表明,增温而不是放牧显著增加了调落物质量的损失、单位面积全碳、全氮以及全磷含量的损失,这主要是因为增温增加了落物生物量和分解速率。然而,尽管同时增温放牧处理也加快了调落物分解速率,但由于降低了调落物生物量,所以增温放牧处理并没有显著影响单位面积的凋落物碳和养分释放量。相比木质素含量和碳氮比而言,季节性土壤平均温度能够更好地预测调落物分解速率。增温和放牧对调落物分解存在交互作用,但它们和调落物品质对调落物的影响均不存在交互作用。单位面积的总氮释放的温度敏感性要高于总磷。因此,我们的结果表明,增温对调落物分解以及养分释放的影响要显著大于调落物品质变化对其分解的影响。在高寒草甸,氮释放的增加可能会间接导致土壤磷有效性的缺乏。Bowen Li Wangwang Lv Jianping Sun Lirong Zhang Lili Jiang Yang Zhou Peipei Liu Huan Hong Qi Wang Wang A Suren Zhang Lu Xia Zongsong Wang Tsechoe Dorji Ailing Su Caiyun Luo Zhenhua Zhang Shiping Wang 2022Journal of Plant Ecology2022,15,5:1
14Synthesis and luminescent properties of SrZnO 2 :Eu 3+ ,M + (M显示文摘Xibin Yu Xiaolin Xu Chunlei Zhou Jinfeng Tang Xiudong Peng Shiping Yang 2006Materials Research Bulletin2006,,8:1
15Responses of the functional structure of soil microbial community to livestock grazing in the T ibetan alpine grassland显示文摘Yunfeng Yang Linwei Wu Qiaoyan Lin Mengting Yuan Depeng Xu Hao Yu Yigang Hu Jichuang Duan Xiangzhen Li Zhili He Kai Xue Joy van Nostrand Shiping Wang Jizhong Zhou 2012Glob Change Biol2012,,2:1
16An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors.Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou 2023Cell Research2023,33,8:1
17Effects of Compound Acidifier and Probiotics on Production Performance,Blood Biochemical Indexes,Antioxidant Indexes and Salmonella Infection of Laying Hens显示文摘This study evaluated the effects of compound acidifier and probiotics on production performance,blood biochemical indexes,antioxidant indexes and Salmonella infection of laying hens. A total of 600 50-week-old healthy laying hens with similar laying rate were randomly assigned to four groups,10 repeats each group,and each repeat contained 15 chickens. The laying hens in control group were fed a basal diet,and in the other three experimental groups were fed basal diets supplemented with 300 g/t probiotics,0. 1% compound acidifier in the drinking water every other day,and 300 g/t probiotics + 0. 1% compound acidifier in the drinking water every other day,respectively. After the feeding of 16 weeks,a total of 60 laying hens from control group were divided into four treatments as the same above for a 13-day long Salmonella challenge( 1. 3 × 10~8 CFU) trial. The results were shown as follows: no significant effects were observed on production performance,hemoglobin content,the superoxide dismutase activity and total antioxidant capacity of reproductive organ in compound acidifier and probiotics groups( P >0. 05). Dirty egg rate was significantly decreased in compound acidifier group,probiotics group and combination group of both( P <0. 05). Compared with the control group,white blood cell count in probiotics group was significantly decreased( P < 0. 05),and the immunoglobulin content in probiotics group tended to be increased( P = 0. 061). The malondialdehyde( MDA) content in oviduct isthmus of hens in compound acidifier group and combination group was significantly decreased compared with the control group( P < 0. 05). The Salmonella positive rate in oviduct of hens in compound acidifier group was significantly decreased at the 7^(th) and 14^(th) days( P < 0. 05),but that in probiotics group and combination group was not significantly different compared with control group( P > 0. 05). In conclusion,compound acidifier and probiotics can improve health status of laying hens through decreasing the dirty egg rate and increasing antioxidant capacity and immunity of them,thus reducing Salmonella infection of body and eggs.Zhou Ling Ding Xuemei Luo Yuheng Wang Jianping Bai Shiping Meng Huaiwang Zhang Keying 2017Animal Husbandry and Feed Science2017,9,3:1
18Generalized projective synchronization between two different chaotic systems using backstepping control 显示文摘Li Guohui Zhou Shiping Yang Kui 2006Phys Lett A2006,355,45:1
19Generalized projective synchronization between two different chaotic systems using baekstepping control 显示文摘Li Guohui Zhou Shiping Yang Kui 2006Phys Lett A2006,355,45:1
20Controllable synthesis of hydroxyapatite nanocrystals via a dendrimer-assisted hydrothermal process显示文摘Zhou Zhuohua Zhou Pingle Yang Shiping 2007Mater Res Bull2007,42,9:1
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