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| 1 | Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications显示文摘Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation.In the past decade,persistent luminescence nanoparticles(PLNPs)with intriguing optical properties have attracted a wide range of attention in various areas.Especially in recent years,the development and applications in biomedical fields have been widely explored.Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission,many researches have focused on the manipulation of PLNPs in biosensing,cell tracking,bioimaging and cancer therapy.These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions.In this review,we summarize the works on synthesis methods,bioapplications,biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing,imaging and imaging-guided therapy.We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications.Finally,the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications. | Shuqi Wu Yang Li Weihang Ding Letong Xu Yuan Ma Lianbing Zhang | 2020 | Nano-Micro Letters2020，12，6： | 8 |
| 2 | Preparation and properties of Nd,Yb:GGG polycrystalline nanopowders显示文摘Gadolinium gallium garnet(GGG)polycrystalline powders doped with Nd,Yb were prepared by co-precipitation method.The structure,phase and properties of powders were characterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS)and fluorescence spectroscopy.XRD analysis indicated that the crystallization of Nd,Yb:GGG powders occur at 900��.SEM analysis showed that the morphology of the powders was irregular and the average radius is 68.74 nm.FTIR analysis manifested that pure Nd,Yb:GGG powders were formed at 900��.The fluorescence spectrum revealed that the most strong emission of Nd,Yb:GGG powders was 1030 nm,which was attributed to 2F5/2��2F7/2 of Yb3+.The possible formation mechanism of Nd,Yb:GGG powders were preliminarily discussed. | Yanmin DONG Jing SUN Wensheng YU Weihang LI Fei TENG | 2012 | Journal of Advanced Ceramics2012，1，4： | 3 |
| 3 | A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis显示文摘The complex pathogenesis of osteoporosis includes excessive bone resorption,insufficient bone formation and inadequate vascularization,a combination which is difficult to completely address with conventional therapies.Engineered exosomes carrying curative molecules show promise as alternative osteoporosis therapies,but depend on specifically-functionalized vesicles and appropriate engineering strategies.Here,we developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells(MSCs)derived from human induced pluripotent stem cells(iPSCs).The engineered exosomes BT-Exo-siShn3,took advantage of the intrinsic anti-osteoporosis function of these special MSC-derived exosomes and collaborated with the loaded siRNA of the Shn3 gene to enhance the therapeutic effects.Modification of a bone-targeting peptide endowed the BT-Exo-siShn3 an ability to deliver siRNA to osteoblasts specifically.Silencing of the osteoblastic Shn3 gene enhanced osteogenic differentiation,decreased autologous RANKL expression and thereby inhibited osteoclast formation.Furthermore,Shn3 gene silencing increased production of SLIT3 and consequently facilitated vascularization,especially formation of type H vessels.Our study demonstrated that BT-Exo-siShn3 could serve as a promising therapy to kill three birds with one stone and implement comprehensive anti-osteoporosis effects. | Yongzhi Cui Yuanyuan Guo Li Kong Jingyu Shi Ping Liu Rui Li Yongtao Geng Weihang Gao Zhiping Zhang Dehao Fu | 2022 | Bioactive Materials2022，7，4： | 3 |
| 4 | Data-driven Optimal Control Strategy for Virtual Synchronous Generator via Deep Reinforcement Learning Approach显示文摘This paper aims at developing a data-driven optimal control strategy for virtual synchronous generator (VSG) in the scenario where no expert knowledge or requirement for system model is available. Firstly, the optimal and adaptive control problem for VSG is transformed into a reinforcement learning task. Specifically, the control variables, i.e., virtual inertia and damping factor, are defined as the actions. Meanwhile, the active power output, angular frequency and its derivative are considered as the observations. Moreover, the reward mechanism is designed based on three preset characteristic functions to quantify the control targets: ① maintaining the deviation of angular frequency within special limits;② preserving well-damped oscillations for both the angular frequency and active power output;③ obtaining slow frequency drop in the transient process. Next, to maximize the cumulative rewards, a decentralized deep policy gradient algorithm, which features model-free and faster convergence, is developed and employed to find the optimal control policy. With this effort, a data-driven adaptive VSG controller can be obtained. By using the proposed controller, the inverter-based distributed generator can adaptively adjust its control variables based on current observations to fulfill the expected targets in model-free fashion. Finally, simulation results validate the feasibility and effectiveness of the proposed approach. | Yushuai Li Wei Gao Weihang Yan Shuo Huang Rui Wang Vahan Gevorgian David Wenzhong Gao | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 2 |
| 5 | On the shakedown analysis of welded pipes显示文摘 | LI Tianbai CHEN Haofeng CHEN Weihang | 2011 | International Journal of Pressure Vessels and Piping2011，88，89： | 1 |
| 6 | Energy-efficient computing-in-memory architecture for AI processor: device, circuit, architecture perspective显示文摘An artificial intelligence(AI) processor is a promising solution for energy-efficient data processing, including health monitoring and image/voice recognition. However, data movements between compute part and memory induce memory wall and power wall challenges to the conventional computing architecture.Recently, the memory-centric architecture has been revised to solve the data movement issue, where the memory is equipped with the compute-capable memory technique, namely, computing-in-memory(CIM). In this paper, we analyze the requirement of AI algorithms on the data movement and low power requirement of AI processors. In addition, we introduce the story of CIM and implementation methodologies of CIM architecture. Furthermore, we present several novel solutions beyond traditional analog-digital mixed static random-access memory(SRAM)-based CIM architecture. Finally, recent CIM tape-out studies are listed and discussed. | Liang CHANG Chenglong LI Zhaomin ZHANG Jianbiao XIAO Qingsong LIU Zhen ZHU Weihang LI Zixuan ZHU Siqi YANG Jun ZHOU | 2021 | Science China(Information Sciences)2021，64，6： | 1 |
| 7 | Numerical Study of the Air Bleeding Caused Non-Uniformity in Axial Compressor显示文摘Bleeding in the compressor is getting more and more attractive because the increasing demand of bleeding rate as the temperature of the first stage of turbine gets higher and needs more cooling air.Though plenty of work has been done about bleeding,however,most of the work is studied with a single passage or ignoring the real structure of the bleeding system.In the present study,multi-passage calculation was used through ANSYS CFX to consider the finite duct holes in the whole blade row,and the effect of the axial location of bleeding slot on the non-uniformity of the blade passage was investigated,and the non-uniform could maintain a low level when bleeding at the front part of the blade passage and the non-uniformity would become large when moving the bleeding slot much further downstream.Afterward,the air bleeding mass flow rate was studied.It’s found that the non-uniformity of air bleeding mass flow is small when bleeding at a low mass flow rate in each passage and results in relatively uniform flow field in the passage.However,the non-uniformity increases significantly as the bleeding mass flow rate increases.Some flow field details were also given to study how the flow field changes when bleeding non-uniformly. | CHEN Shaowen GONG Yun LI Weihang WANG Songtao WANG Zhongqi | 2020 | Journal of Thermal Science2020，29，1： | 1 |
| 8 | Changes in intestinal micmflora in patients with chronic severe hepatitis 显示文摘 | Li lanjuan Wu zhongwen Ma weihang | 2001 | Chi-neseMedical Journal2001，114，8： | 1 |
| 9 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 10 | Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla显示文摘RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease(RNase)A superfamily,a gene family that is widely used as a model for molecular evolutionary studies.Here,we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this clade.Unexpectedly,RNase9experienced an evolutionary scenario of“birth and death”in Ruminantia,and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues(epididymis,vas deferens or prostate).This expression pattern combined with the estimate that these genes duplicated during the middle Eocene,a time when Ruminantia become a successful lineage,suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this period.In contrast,all RNase9 genes were lost in the Cetacean lineage,which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean resources.This study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla,providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment. | Datian Lang Xiaoping Wang Chunbing Liu Weihang Geng David M.Irwin Shanyuan Chen Chunqing Li Li Yu Heng Xiao | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
| 11 | Design and simulation of reverse-blocking Schottky-drain AlN/AlGaN HEMTs with drain field plate显示文摘In this paper,Schottky-drain reverse-blocking Al N/Al Ga N HEMTs with drain field plate(FP)have been investigated by Silvaco-ATLAS tools.For HEMTs without FP,with the increase of Al mole fraction in Al Ga N channel from 0 to 0.5,the reverse-blocking voltage increases from-158 V to-720 V.By using the drain field plate technique,a second electric field peak is introduced and the reverse-blocking voltage can be improved.Combined with the optimization of the Si N passivation thickness,optimal electric field management can be achieved to obtain the highest reverse-blocking voltage devices.Since HEMTs with different Al mole fractions possess different critical electric field values,the optimal Si N thickness are varied.With the increase of the Al mole fraction from 0 to 0.5,the reverse-blocking voltage increases from-510 V to-4500 V for HEMTs using drain FP and optimal Si N passivation thickness,and a high power figure-of-merit of 1.171 GW/cm^(2)is achieved.Al Ga N channel HEMTs with Al mole fraction demonstrate great potential for power applications. | Dujun ZHAO Zhaoxi WU Chao DUAN Bo MEI Zhongyang LI Zhongxu WANG Qing TANG Qing YANG Yinhe WU Weihang ZHANG Zhihong LIU Shenglei ZHAO Jincheng ZHANG Yue HAO | 2022 | Science China(Information Sciences)2022，65，2： | 1 |
| 12 | A multifunctional ribonuclease A-conjugated carbon dot cluster nanosystem for synchronous cancer imaging and therapy显示文摘 | Huiyang Liu Qin Wang Guangxia Shen Chunlei Zhang Chao Li Weihang Ji Chun Wang Daxiang Cui | 2014 | Nanoscale Research Letters2014，，1： | 1 |
| 13 | Influence of rainfall-induced diabatic heating on southern rainfall-northern haze over eastern China in early February 2023显示文摘In early February 2023,there was severe haze on the North China Plain(NCP)that was contemporaneous with heavy rainfall over southern China,which was known as southern rainfall-northern haze(SR-NH).Based on observational and reanalysis data,the meteorological causes of this SR-NH event are investigated in this study using correlation analysis,dynamic diagnostics and numerical experiments.The results show that the anticyclonic anomaly in the Pacific Northwest(also referred to as the northeast Asian anomalous anticyclone)is responsible for the SR-NH.On the one hand,this anticyclonic anomaly leads to persistent rainfall over southern China by causing strong ascending motion in conjunction with an anomalous cyclone over the Chinese mainland and transporting large amounts of water vapor there.On the other hand,it weakens the climatological northerly winds of the NCP through the southeasterly flow,worsening the horizontal diffusion conditions of pollutants.Additionally,the atmospheric stability and relative humidity over the NCP are significantly increased by this anticyclonic anomaly.These conditions result in higher PM2.5concentrations over the NCP.Additional results suggest that this anticyclonic anomaly is related to diabatic heating released by rainfall in southern China,which not only intensifies the rainfall process there(with a contribution of 11.5%)but also induces an anticyclonic anomaly in the upper troposphere of the Pacific Northwest(i.e.,200 hPa).The rainfall-related anticyclonic anomaly reinforces the anticyclonic anomaly in the Pacific Northwest caused by large-scale circulation(with a contribution of 27%)and thus affects haze over the NCP.This study provides a new reference for understanding the contribution of rainfall in southern China to haze over the NCP. | Xiadong AN Wen CHEN Chun LI Lifang SHENG Weihang ZHANG Shangfei HAI Peng HU | 2023 | Science China Earth Sciences2023，66，11： | 0 |
| 14 | Facile synthesis of defect-rich Fe-N-C hybrid from fullerene/ferrotetraphenylporphyrin as efficient oxygen reduction electrocatalyst for Zn-air battery显示文摘Exploring remarkable oxygen reduction reaction(ORR)electrocatalysts for regenerative fuel cells and metal-air batteries is highly essential.Herein,a novel non-noble metal-based heterogeneous electrocatalyst with rich defects were successfully synthesized by liquid-liquid interfacial precipitation(LLIP)of fullerene(C_(60))and ferrotetraphenylporphyrin(FeTPP)followed by one step pyrolysis.The obtained product annealed at 700℃(C_(60)/FeTPP-700),when employed as ORR electrocatalyst,revealed a positive halfwave potential(E_(1/2))of 0.877 V vs.reversible hydrogen electrode(RHE),which was superior to that of the commercial 25%Pt/C.Delightfully,the assembled Zn-air battery(ZAB)using C_(60)/FeTPP-700 as an air-electrode catalyst exhibited a high power density of 153 m W/cm^(2),specific capacity of 668 mAh/g and long-term cycling stability for more than 250 h.Experimental results proved that the excellent electrocatalytic ORR activity of C_(60)/FeTPP-700 would attribute to the synergistic effect between FeN_xsites,Fe_(3)C/Fe nanoparticles and the structure defects.This work provides a feasible and simple method to prepare nonnoble metal-based ORR electrocatalysts for the application of energy storage and conversion. | Hai Wang Liyun Cao Yongqiang Feng Junsheng Chen Weihang Feng Tianmi Luo Yuzhu Hu Chengke Yuan Yajuan Zhao Yong Zhao Koji Kajiyoshi Yijun Liu Zhenjiang Li Jianfeng Huang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 15 | Dielectric polymer grafted electrodes enhanced aqueous supercapacitors显示文摘Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long lifetimes.Aqueous SCs are promising for large-scale engineering applications because of their low cost and safety.However,the low operating voltage and low energy density of aqueous SCs severely limit their practical applications.In this study,a nanoscale dielectric layer is grafted onto a graphene electrode to achieve both a high operating voltage and enhanced capacitance.Compared with an SC without dielectric grafting,a dielectric-enhanced SC(DESC)shows a higher capacitance by 2200%.The mechanism of the capacitance enhancement can be attributed to three factors:the dielectric polarization,the ions desolvation by the dielectric,and the enhanced quantum capacitance from charge transfer and ion adsorption in the polymer molecules.In addition,a 2.5 V pouch DESC with a 1 M KCl electrolyte is confirmed to cycle up to 50,000 times with a capacitance retention of 87.5%.The DESC presents the optimal electrochemical properties after it is grafted with a 5 nm dielectric layer.This study provides new insights into the design of high-voltage and high-energy-density aqueous SCs. | Shian Dong Kunming Shi Jie Chen Yingke Zhu Hongfei Li Weihang Gao Zhenli Xu Qinglei Liu Xingyi Huang | 2024 | Nano Research2024，17，3： | 0 |
| 16 | Association of human cytomegalovirus viremia with human leukocyte antigens in liver transplantation recipients显示文摘人的 cytomegalovirus (HCMV ) 复活是在肝移植(副) 以后的普通复杂并发症。这里,我们调查了匹配的人的白血球抗原(HLA ) 是否在为肝炎 B 病毒肝硬化的副以后与 HCMV 感染和随后的接枝失败有关。这回顾的研究考察了 91 个副接受者。所有病人根据 HLA 被组织 -- A, HLA-B,并且 HLA 医生地点匹配。临床的数据是镇定的,包括 HCMV viremia 的完全的打 HLA, HCMV viremia,接枝失败,和时间。打字的 HLA 用一个顺序特定的教材聚合酶链反应工具包被执行。HCMV 被 pp65 antigenemia 用一个商业工具包检测。HCMV 感染的发生副以后是 81.32% 。接枝失败在 91 中的 16 个被观察(17.6%) 病人在 4 年的学习期间。HCMV viremia 的发生是 100%(5/5 ) , 91.4%(32/35 ) ,并且 72.5%(37/51 ) 在 HLA -- 二个地点,一个地点,和零地点相容性分别地。不过, HLA 的度 -- A, HLA-B,或 HLA 医生火柴没在 HCMV viremia 的诊断以后影响接枝失败的 HCMV viremia,接枝失败,或时间的时间(所有 P > 0.05 ) 。有趣的发现是 HCMV viremia 的风险趋于在有更好的 HLA 的病人更高 -- 相容性。接枝失败, HCMV viremia 的时间,和在 HCMV viremia 的诊断以后的接枝失败看起来独立于 HLA 等位基因相容性。 | Jianhua Hu Xueqin Meng Hong Zhao Xuan Zhang Hainv Gao Meifang Yang Yadan Ma Minhuan Li Weihang Ma Jun Fan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 0 |
| 17 | Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation显示文摘Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising neuromodulation.However,the invasive nature restricts its application.Traditional auricular acupuncture treatment has a long history.The auricular branch of the vagus nerve(ABVN) is a branch on the surface of the ear.Some studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i VNS.Ta VNS and i VNS share a common anatomical basis and acting mechanism.In this article,we made a comparison between i VNS and ta VNS in indications and efficacy.The recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i VNS.Highquality clinical evidences are needed before ta VNS become be an alternative of i VNS. | HE Jiakai ZHANG Jinling WANG Yu LI Shaoyuan FANG Jiliang ZHANG Shuai ZHAO Yanan ZHAI Weihang GAO Deqiang LI Ran JIANG Yuhang CHEN Zehao JIA Baohui RONG Peijing | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
| 18 | Impacts of application patterns and incorporation rates of dredged Yellow River sediment on structure and infiltration of saline-alkali soil显示文摘Soil salinization is an issue of global concern.Despite recent evidence indicates that application of sediments into saline-alkali soil in Yellow River Delta as an additive can increase crop yield,its effects on soil structure and infiltration remain uncertain.In this study,the comprehensively analyses were conducted on the soil infiltration and microstructure of the soil treated with three sediment application layers(surface layer at 0-15 cm,lower layer at 15-30 cm,and plough layer at 0-30 cm)and four sediment incorporation rates(0,2%,5%and 10%),using soil column simulation experiment.Results indicated that the dredged Yellow River sediments can improve the infiltration capacity of saline-alkali soil;and the infiltration capacity increased with the rising sediment incorporation rate under the given application pattern.Compared with the control,applying dredged Yellow River sediments at 10%rate at lower layer and plough layer significantly facilitated the soil infiltration of the saline-alkali soil.Soil macro-porosity for T2,T5 and T10 was 26%,52%and 158%more than that for the control,respectively.This phenomenon was attributed to the increased soil macro-porosity,due to the improved soil microstructure with the incorporation of sediment into the saline-alkali soil.Moreover,the cumulative infiltration was fitted better with Kostiakov infiltration model than Horton and Philip models. | Kesheng Li Weihang Kong Wenshuo Xu Chuanxiao Liu | 2022 | International Journal of Agricultural and Biological Engineering2022，15，4： | 0 |
| 19 | A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study显示文摘A new class of potent liver injury protective compounds,phychetins A-D(1-4)featuring an unique 6/6/5/6/5 pentacyclic framework,were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus franchetianus.Compounds 2-4 are three pairs of enantiomers that were initially obtained in a racemic manner,and were further separated by chiral HPLC preparation.Compounds 1-4 were proposed to be originated biosynthetically from a coexisting lignan via an intramolecular Friedel-Crafts reaction as the key step.A bioinspired total synthesis strategy was thus designated,and allowed the effective syntheses of compounds 2-4 in high yields.Some of compounds exhibited significant anti-inflammatory activities in vitro via suppressing the production of pro-inflammatory cytokine IL-1β.Notably,compound 4,the most active enantiomeric pair in vitro,displayed prominent potent protecting activity against liver injury at a low dose of 3 mg/kg in mice,which could serve as a promising lead for the development of acute liver injury therapeutic agent. | Kailong Ji Wei Liu Weihang Yin Xiangrong Kong Honghong Xu Zeng-Wei Lai Jing-Ya Li Jian-Min Yue | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
| 20 | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis显示文摘Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid peroxidation.The core organelle involved in ferroptosis is mitochondria.Mito-chondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology,biochemistry,gene expression,and energy metabolism.An increasing number of studies have shown that mitochondria and their associated metabolic pathways mediate ferroptosis in the development and progression of breast cancer.In this review,we discuss the relevant research about ferroptosis in breast cancer and provide a comprehensive summary of mitochondrial regulation in ferroptosis from the perspective of lipid metabolism,oxidative phosphorylation,ion metabolism,glycometabolism,and nucleotide metabolism.We also summarize the appli-cation of mitochondrial metabolism-related pathways as ferroptosis treatment targets.Here we provide new insights into the relationship between mitochondria,ferroptosis,and breast cancertreatment. | Xinrui Dong Ye Li Xiaonan Sheng Weihang Zhou Aijun Sun Huijuan Dai | 2024 | Genes & Diseases2024，11，1： | 0 |
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