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| 1 | A Novel Combinatorics-Based Reconfigurable Bit Permutation Network and Its Circuit Implementation显示文摘Bit permutation is an important operation in many applications. A novel reconfigurable N × N bit permutation network with a compact structure is presented. It is based on combinatorics theory by cascading two recursive N/2 × N/2 sub-networks, while each subnetwork is cascaded by two N/4 × N/4 sub-networks, and so on cascaded until reaching the elementary 4 × 4 seed networks. Its routing algorithm is also established to determine each multiplexor's status. Then the circuits of different sized permutation networks in a reconfigurable cipher co-processor were designed and implemented in 0.18μm CMOS process. The proposed circuit can achieve an arbitrary n × n permutation and support all types of bit permutations in many cryptographic algorithms. Plus, it consumes less multiplexors than commonly used BENES and OMFLIP networks. | SHAN Weiwei CHEN Xin LU Yinchao LI Jie | 2015 | Chinese Journal of Electronics2015，24，3： | 7 |
| 2 | Changes of Extreme Precipitation and its Associated Mechanisms in Northwest China显示文摘Characterized by scarce water resources and fragile ecosystems,Northwest China(NWC)has experienced a climate shift from warm-dry to warm-wet conditions since the 1980s that has garnered extensive concern in recent years.In this study,the variability in extreme precipitation(EP)during 1961-2016 in different climate zones of NWC and the possible mechanisms for this variation are investigated.The results show that the EP trends significantly increased in most of the westerly zone(WZ)and plateau zone(PZ),while the EP trends did not significantly decrease in the monsoon zone(MZ).The start dates of extreme precipitation(SDEP)and end dates of extreme precipitation(EDEP)advanced and were postponed,respectively,in the WZ and PZ,while the opposite occurred in the MZ.Summer atmospheric circulation,water vapor transport,and atmospheric instability over NWC varied greatly with the interdecadal shift in EP before and after 1986.During 1986-2016,upper-level divergence and lower-level convergence occurred in the MZ and PZ,which strengthened ascending flow.In addition,the summer water vapor and atmospheric instability increased in the WZ and PZ.These characteristics created favorable conditions for increased occurrences of EP in the WZ and PZ in summer.Conversely,the upper-level convergence and lower-level divergence in the MZ strengthened descending flow.Decreases in summer water vapor and atmospheric instability occurred in the MZ after 1986.Hence,the environmental conditions in the MZ may have prevented the occurrence and development of EP in summer during 1986-2016. | Shan LU Zeyong HU Haipeng YU Weiwei FAN Chunwei FU Di WU | 2021 | Advances in Atmospheric Sciences2021，38，10： | 4 |
| 3 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 4 | Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types显示文摘 | Yanan Cao Weiwei Zhou Lin Li Jiaqian Wang Zhibo Gao Yiran Jiang Xiuli Jiang Aijing Shan Matthew H. Bailey Kuan-lin Huang Sam Q. Sun Michael D. McLellan Beifang Niu Weiqing Wang Li Ding Guang Ning | 2018 | Cell Research2018，28，5： | 3 |
| 5 | Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway显示文摘We sought to assess the effect of progestin on the apoptosis of epithelial ovarian cancer cell line SKOV-3 and via regulation of phosphorylation signaling in.Epithelial ovarian cancer cell line SKOV-3 was treated with medroxyprogestogen,phosphatidylinositol 3-kinase inhibitor LY294002 and vehicle control.Akt,phospho-Akt,Bcl-2 and phospho-Bad proteins were examined by immunoblotting assays.Medroxyprogestogen-induced apoptosis was assessed by MTT assays and Annexin V apoptosis assay.We found no significant difference in Akt and Bad expression in both the medroxyprogestogen groups and the control group.The levels of phospho-Akt,Bcl-2 and phospho-Bad were decreased in all the medroxyprogestogen groups and significantly decreased in the high dose mitogen-activated protein (MAP) group (10 μmol/L).Viability of SKOV-3 was reduced and apparent apoptosis of SKOV-3 cells was observed with increased doses of MAP.The findings suggest that medroxyprogestogen can induce SKOV-3 cell apoptosis by inhibiting Akt phosphorylation. | Yan Li Yi Jiang Yicong Wan Lin Zhang Weiwei Tang Jingjing Ma Shan Wu Wenjun Cheng | 2013 | The Journal of Biomedical Research2013，27，1： | 2 |
| 6 | An Ultra Low Steady-State Current Power-on-Reset Circuit in 65nm CMOS Technology显示文摘A novel Power-on-reset(POR) circuit is proposed with ultra-low steady-state current consumption. A band-gap voltage comparator is used to generate a stable pull-up voltage. To eliminate the large current consumptions of the analog part, a power switch is adopted to cut the supply of band-gap voltage comparator, which gained ultra-low current consumption in steady-state after the POR rest process completed. The state of POR circuit is maintained through a state latch circuit. The whole circuit was designed and implemented in 65 nm CMOS technology with an active area of 120μm*160μm. Experimental results show that it has a steady pull-up voltage of 0.69 V and a brown-out voltage of 0.49 V under a 1.2V supply voltage rising from 0V, plus its steady-state current is only9 n A. The proposed circuit is suitable to be integrated in system on chip to provide a reliable POR signal. | SHAN Weiwei WANG Xuexiang LIU Xinning SUN Huafang | 2014 | Chinese Journal of Electronics2014，23，4： | 2 |
| 7 | lnfluenceof cutter geometric parameters on the stability of milling process of thin-walled blades 显示文摘 | Liu Weiwei Gao Xiaojuan Shan Chenwei | 2010 | 2nd international conference on intellectual technologyin industrial practice2010，，1： | 1 |
| 8 | Cache Power Optimization Based on Compare-Based Adaptive Clock Gating and Its 65nm SoC Implementation显示文摘In most embedded microprocessor based System on chips(So Cs), cache has become a ma jor source of power consumption due to its increasing size and high access rate. Power optimization of cache based on Compare-based adaptive clock gating(CACG) is proposed to reduce the power waste due to cache idle. By detecting the cache's working state, the CACG can automatically turn off its clock when it is in idle state, saving a large percentage of dynamic power. Measurements of a real So C chip fabricated under TSMC 65 nm CMOS process show that an average of 30.3% power reduction is gained in Dhrystone test benchmark at a cost of negligible area overhead and no virtually performance loss. | LI Jie WAN Xing WU Jianbing SHAN Weiwei | 2017 | Chinese Journal of Electronics2017，26，1： | 1 |
| 9 | Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers显示文摘 | Xiaohui Yan Zhongyi Hu Yi Feng Xiaowen Hu Jiao Yuan Sihai D. Zhao Youyou Zhang Lu Yang Weiwei Shan Qun He Lingling Fan Lana E. Kandalaft Janos L. Tanyi Chunsheng Li Chao-Xing Yuan Dongmei Zhang Huiqing Yuan Keqin Hua Yiling Lu Dionyssios Katsaros Qihong H | 2015 | Cancer Cell2015，，4： | 1 |
| 10 | Analog circuit implementation of a variable universe adaptive fuzzy logic controller显示文摘 | Shan Weiwei Ma Yuan Ncwcomb R W | 2008 | IEEE Trans on Circuits and Systems2008，55，10： | 1 |
| 11 | Mechanical behavior and microstructure during compression of semi-solid ZK60-RE magnesium alloy at high solid content 显示文摘 | Shan Weiwei Luo Shuojing | 2007 | Materials Science and Engineering2007，46，5： | 1 |
| 12 | Harmonic mixing of Bi_2Sr_2CaCu_2O_(8+x)intrinsic junction at millimeter waveband显示文摘Using intrinsic Josephson junctions in Ba2Sr2CaCu2O8+x single crystal, harmonic frequency mixing at 8 and 3 mm wavebands was successfully demonstrated at liquid nitrogen temperatures with harmonic numbers up to 68 and 50 respectively. The dependences of intermediate frequency output on the local oscillator power and dc bias were carefully studied. | XU Weiwei, ZHOU Gandong, SHAN Wenlei, YOU Lixing, YANG Senzu, Jl Zhengming, FENG Yijun, CHENG Qiheng and WU PeihengDepartment of Electronic Science and Engineering , Nanjing University , Nanjing 210093 , China | 1999 | Chinese Science Bulletin1999，44，13： | 0 |
| 13 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 14 | Near-Threshold Wide-Voltage Design Review显示文摘This paper presents a comprehensive review of near-threshold wide-voltage designs on memory,resilient logic designs,low voltage Radio Frequency(RF)circuits,and timing analysis.With the prosperous development of wearable applications,low power consumption has become one of the primary challenges for IC designs.To improve the power efficiency,the prefer scheme is to operate at an ultra low voltage of Near Threshold Voltage(NTV).For the performance variation and degradation,a self-adaptive margin assignment technique is proposed in the low voltage.The proposed technique tracks the circuit states in real time and dynamically allocates voltage margins,reducing the minimum supply voltage and achieving higher energy efficiency.The self-adaptive margin assignment technique can be used in Static Random Access Memory(SRAM),digital circuits,and analog/RF circuits.Based on the self-adaptive margin assignment technique,the minimum voltage in the 40 nm CMOS process is reduced to 0.6 V or even lower,and the energy efficiency is increased by 3–4 times. | Yan Zhao Jun Yang Chao Chen Weiwei Shan Peng Cao Yongliang Zhou Ziyu Li Tai Yang | 2023 | Tsinghua Science and Technology2023，28，4： | 0 |
| 15 | See the color,see the seed:GmW1 as a visual reporter for transgene and genome editing in soybean显示文摘A fast and efficient recognition method of transgenic lines will greatly improve detection efficiency and reduce cost.In this study,we successfully identified the transgenic soybean plants by the color.We isolated a GmW1 gene encoding a flavonoid 3'5'-hydroxylase from a soybean cultivar ZH42(purple flower).We found that purple flowers occurred in the overexpression lines in the Jack and Williams 82 backgrounds(white flower).All plants with purple flowers were positive,and this trait seems stably inherited in the offspring.We have also obtained the editing plants,which were classified into three types according to the different flower colors appeared.We analyzed the phenotype and the homozygous types of the T_1mutants.We also found that a correspondence between flower color and stem color.This study provides a visible color reporter on soybean transformation.It can be quickly and early to identify the transgenic soybean plants by stem color of seedlings,which substantially reduces the amount of labor and cost. | Li Chen Shan Yuan Yupeng Cai Weiwei Yao Qiang Su Yingying Chen Jialing Zhang Wensheng Hou | 2023 | The Crop Journal2023，11，1： | 0 |
| 16 | Morphological and molecular basis of ovarian serous carcinoma显示文摘Serous carcinoma is the most common type of epithelial ovarian cancer.In this review,we provide a comprehensive picture of ovarian serous cancers from multiple aspects:the first part of this review summarizes the morphological,histological,and immunological signatures of ovarian serous carcinoma;subsequently,we review the history of the evolvement of different grading systems used in ovarian serous cancer;in the end,we focus on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise:the low-grade and the high-grade pathways. | Daniel G Rosen Zhihong Zhang Weiwei Shan Jmsong Liu | 2010 | The Journal of Biomedical Research2010，24，4： | 0 |
| 17 | An Improved Path Delay Variability Model via Multi-Level Fan-Out-of-4 Metric for Wide-Voltage-Range Digital CMOS Circuits显示文摘In advanced CMOS technology,process,voltage,and temperature(PVT)variations increase the paths’latency in digital circuits,especially when operating at a low supply voltage.The fan-out-of-4 inverter chain(FO4 chain)metric has been proven to be a good metric to estimate the path’s delay variability,whereas the previous work ignored the non-independent characteristic between the adjacent cells in a path.In this study,an improved model of path delay variability is established to describe the relationship between the paths’max-delay variability and an FO4 chain,which is based on multilevel FO4 metric and circuit-level parameters knobs(i.e.,cell topology and driving strength)of the first few cells.We take the slew and load into account to improve the accuracy of this framework.Examples of 28 nm and 40 nm digital circuits show that our model conforms with Monte Carlo simulations as well as fabricated chips’measurements.It is able to model the delay variability effectively to speed up the design process with limited accuracy loss.It also provides a deeper understanding and quick estimation of the path delay variability from the near-threshold to nominal voltages. | CUI Yuqiang SHAN Weiwei DAI Wentao LIU Xinning GUO Jingjing CAO Peng | 2023 | Chinese Journal of Electronics2023，32，2： | 0 |
| 18 | A Novel Hybrid Fuzzification for Fuzzy Logic Controller and Its Circuit Implementation显示文摘 | CAI Zhikuang SHAN Weiwei LI Jie | 2013 | Chinese Journal of Electronics2013，22，1： | 0 |
| 19 | Forging Powerful Synergy for the Global Fight Against Covid-19显示文摘Just three decades into the new century,the world has been hit by the gravest global crisis since World War II.A novel coronavirus,which does not respect borders or distinguish between races,has spread to every corner of the globe with terrifying speed.By June 12,there were over 7.4 million confirmed cases of Covid-19,and more than 410,000 people had been killed by the virus. | Hao Weiwei Zheng Han’gen Shang Jing Chen Shan | 2020 | Qiu Shi2020，12，4： | 0 |
| 20 | Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice显示文摘SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread vaccination.However,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of concern.Here,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(Ad C68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of Ad C68-S.Notably,neutralizing antibodies were observed up to at least six months after vaccination,without substantial decline.Single or double doses Ad C68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of Ad C68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 infection.Taken together,this study demonstrates the efficacy and durability of the Ad C68-S vaccine and constitutes a promising candidate for clinical evaluation. | Mingqing Lu Kunpeng Liu Yun Peng Zhe Ding Yingwen Li Alexander Tendu Xue Hu Ge Gao Weiwei Guo Hang Liu Juhong Rao Jiaxuan Zhao Miaoyu Chen Zhiming Yuan Gary Wong Chao Shan Yanfeng Yao Jiaming Lan | 2022 | Virologica Sinica2022，37，4： | 0 |
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