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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer显示文摘 | Yang Yang Wei Huang Rongfang Qiu Ruiqiong Liu Yi Zeng Jie Gao Yu Zheng Yongqiang Hou Shuang Wang Wenqian Yu Shuai Leng Dandan Feng Yan Wang | 2018 | Journal of Molecular Cell Biology2018，10，4： | 10 |
| 3 | Research progress on properties of pre-gelatinized starch and its application in wheat flour products显示文摘Starch is the most abundant organic compound in nature,second only to cellulose.However,the conserved structure of native starches limits their properties and applications.Therefore,it is often necessary to modify them to obtain specific properties.As a common green and safe physical modification method,pre-gelatinization can improve the cold water solubility and swelling power of starch.The typical preparation methods of pre-gelatinized starch include spray drying,extrusion,and drum drying.Spray-dried pre-gelatinized starch still had good granule shape,but the increase of cold water solubility and cold paste viscosity was relatively small.Extruded and drum-dried pre-gelatinized starch showed serious structure destruction,significant increases in cold water solubility and cold paste viscosity,but relatively low hot paste viscosity.The properties of pre-gelatinized starch obtained by different methods are different,so do their effects on the quality of flour products.Wheat flour products,as one of the leading staple food for the people all over the world,play a vital role in people's daily life.With the improvement of people's living standards,more and more special flour products with unique features have received attentions of consumers and researchers.However,the sensory characteristics of special flour products are often inferior to traditional flour products,which limits its development.The unique functional characteristics of pre-gelatinized starch make it expected to play an essential role in the quality improvement of featured flour products.In this paper,the granule morphology,crystal structure,hydration and gelatinization properties of pre-gelatinized starch prepared by three common methods and their application in flour products were reviewed,which provides a theoretical basis for the application of pre-gelatinized starch in food industry. | Hao Ma Mei Liu Ying Liang Xueling Zheng Le Sun Wenqian Dang Jie Li Limin Li Chong Liu | 2022 | Grain & Oil Science and Technology2022，5，2： | 3 |
| 4 | Research on Distributed Cooperative Control Strategy of Microgrid Hybrid Energy Storage Based on Adaptive Event Triggering显示文摘Distributed collaborative control strategies for microgrids often use periodic time to trigger communication,which is likely to enhance the burden of communication and increase the frequency of controller updates,leading to greater waste of communication resources.In response to this problem,a distributed cooperative control strategy triggered by an adaptive event is proposed.By introducing an adaptive event triggering mechanism in the distributed controller,the triggering parameters are dynamically adjusted so that the distributed controller can communicate only at a certain time,the communication pressure is reduced,and the DC bus voltage deviation is effectively reduced,at the same time,the accuracy of power distribution is improved.The MATLAB/Simulink modeling and simulation results prove the correctness and effectiveness of the proposed control strategy. | Wenqian Zhang Jingwen Chen Saleem Riaz Naiwen Zheng Li Li | 2022 | Computer Modeling in Engineering & Sciences2022，，8： | 1 |
| 5 | An outbreak of Mycobacterium marinum infection associated with handling seabass in China显示文摘To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported. | Qing Zhao Fangfang Bao Zihao Mi Zhenzhen Wang Pengcheng Huai Qing Pan Zheng Pang Yaoming Li Nan Cao Xiaotong Xue Buyan Li Xuechao Chen Jinliang Wang Yanxia Cui Wenqian Chang Yuan Zhang Zhenhua Yue Yongxia Liu Zhenhua Wang Weiguo Yan Jinyong Li Hongqing Tian Xianmei Lu Guizhi Zhou Jianjun Liu Hong Liu Furen Zhang | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 6 | Impaired immunomodulatory ability of bone marrow mesenchymal stem cells on CD4 + T cells in aplastic anemia显示文摘 | Jianping Li Shihong Lu Shaoguang Yang Wen Xing Jianming Feng Wenqian Li Qinjun Zhao Hao Wu Meili Ge Fengxia Ma Hui Zhao Bin Liu Lei Zhang Yizhou Zheng Zhong Chao Han | 2012 | Results in Immunology2012，，： | 1 |
| 7 | bPermian, Lopingian, strontium isotopic ratio, conodont zone, marine carbonate, stable isotope chemostratigraphy显示文摘 | YE FaCheng LIU XinChun WANG Wei CHEN XiaoZheng LIU Jing SHEN ShuZhong WANG WenQian WANG XiangDong WANG Yue CAO ChangQun ZHENG QuanFeng ZHANG Hua ZHANG YiChun | 2015 | Science China Earth Sciences2015，58，11： | 0 |
| 8 | Instability Inception of a Single Rotor Embedded in a Transonic Stage with Partial Surge Inception显示文摘Partial surge is a type of instability inception discovered in our previous studies.It has been confirmed that partial surge is localized in the blade hub region,and the flow oscillation it caused will lead to the stall cells in the rotor tip.While since all information about partial surge is obtained from the compressor stage experiments,what will happen to the stall process after the stators are removed is also an issue that worth investigating.So,in this paper,a series of experiments are carried out on the single rotor embedded in the transonic compressor stage with partial surge inception.First,the experimental results under uniform inlet conditions show that,although partial surge appears at high rotor speed in the stage case,it does not occur at any speed in the single rotor case.Then,it is found by numerical simulation that the absence of partial surge may be due to the insufficient rotor hub loading,so an experiment with increased hub loading is carried out,but still fails to trigger partial surge.Finally,the reason why partial surge doesn’t occur in the single rotor is discussed.From these results,it can be concluded that partial surge cannot occur in the single rotor case,and the large-scale comer separation in the stator hub is considered to play an important role in the formation of partial surge. | PAN Tianyu WU Wenqian ZHENG Mengzong LI Qiushi | 2022 | Journal of Thermal Science2022，31，1： | 0 |
| 9 | GATA2^(−/−) human ESCs undergo attenuatedendothelial to hematopoietic transition andthereafter granulocyte commitment显示文摘Background: Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcriptionfactors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of hematopoiesisin mouse models. However, whether similar function of GATA2 is conserved in human hematopoiesis, especially duringearly embryonic development stage, is largely unknown.Results: To examine the role of GATA2 in human background, we generated homozygous GATA2 knockout humanembryonic stem cells (GATA2^(−/−) hESCs) and analyzed their blood differentiation potential. Our results demonstratedthat GATA2^(−/−) hESCs displayed attenuated generation of CD34^(+)CD43^(+) hematopoietic progenitor cells (HPCs), due tothe impairment of endothelial to hematopoietic transition (EHT). Interestingly, GATA2^(−/−) hESCs retained the potentialto generate erythroblasts and macrophages, but never granulocytes. We further identified that SPI1 downregulationwas partially responsible for the defects of GATA2^(−/−) hESCs in generation of CD34^(+)CD43^(+) HPCs and granulocytes.Furthermore, we found that GATA2^(−/−) hESCs restored the granulocyte potential in the presence of Notch signaling.Conclusion: Our findings revealed the essential roles of GATA2 in EHT and granulocyte development throughregulating SPI1, and uncovered a role of Notch signaling in granulocyte generation during hematopoiesis modeled byhuman ESCs. | Ke Huang Juan Du Ning Ma Jiajun Liu Pengfei Wu Xiaoya Dong Minghui Meng Wenqian Wang Xin Chen Xi Shi Qianyu Chen Zhongzhou Yang Shubin Chen Jian Zhang Yuhang Li Wei Li Yi Zheng Jinglei Cai Peng Li Xiaofang Sun Jinyong Wang Duanqing Pei Guangjin Pan | 2015 | Cell Regeneration2015，4，1： | 0 |
| 10 | Transcriptome Analysis and Genes Function Verification of Root Development of Paeonia suffruticosa under Sandy Loam Cultivation显示文摘Relatively poor in vitro rooting has limited the large-scale commercial production of tree peony.In this study,on the basis of transcriptome sequencing,differentially expressed genes and the associated metabolic pathways were identified in tree peony roots at different stages of root formation under sandy loam cultivation.A total of 31.63 Gb raw data were generated and 120,188 unigenes(mean length of 911.98 bp)were annotated according to six databases(NR,NT,GO,KEGG,COG,and Swiss-Prot).Analyses of the ungerminated root primordium period,induced root primordium period,and root formation period detected 8,232,6,907,and 10,687 differentially expressed genes related to 133,132,and 133 metabolic pathways,respectively.Two significantly differentially expressed genes(Unigene13430_All and CL10096.Contig1_All)were associated with the auxin pathway.The full-length Unigene13430_All coding sequence(843 bp)encoded 280 amino acids,whereas the full-length CL10096.Contig1_All coding sequence(1,470 bp)encoded 489 amino acids.Unigene13430_All and CL10096.Contig1_All were identified as IAA gene family members and were respectively named PsIAA27 and PsARF19.The qRT-PCR analysis and functional verification indicated that the expressions of PsARF19 and PsIAA27 in tree peony seedlings,cuttings and grafted seedlings were significant different.PsARF19 promoted root development,it might be a regulatory gene related to the formation of tree peony roots,while PsIAA27 inhibited lateral root development,and it might be involved in controlling auxin sensitivity during root formation.The results of this study may form the basis of future investigations on the mechanism mediating peony root formation.The transcriptome data will be an excellent resource for researchers interested in characterizing the rooting-related tree peony genes. | Yinglong Song Wenqian Shang Zheng Wang Songlin He Xinya Meng Liyun Shi Yuxiao Shen Dan He Xueyuan Lou Yuke Sun | 2022 | Phyton-International Journal of Experimental Botany2022，91，12： | 0 |
| 11 | MdVQ37 overexpression reduces basal thermotolerance in transgenic apple by affecting transcription factor activity and salicylic acid homeostasis显示文摘High temperature(HT)is one of the most important environmental stress factors and seriously threatens plant growth,development,and production.VQ motif-containing proteins are transcriptional regulators that have been reported to regulate plant growth and developmental processes,including responses to biotic and abiotic stresses.However,the relationships between VQ motif-containing proteins and HT stress have not been studied in depth in plants.In this study,transgenic apple(Malus domestica)plants overexpressing the apple VQ motif-containing protein-coding gene(MdVQ37)were exposed to HT stress,and the transgenic lines exhibited a heat-sensitive phenotype.In addition,physiological and biochemical studies revealed that,compared with WT plants,transgenic lines had lower enzymatic activity and photosynthetic capacity and lower amounts of nonenzymatic antioxidant system metabolites under HT stress.Transcriptome analysis revealed 1379 genes whose expression differed between the transgenic lines and WT plants.GO and KEGG pathway analyses showed that transcription factor activity and plant hormone signaling pathways were differentially influenced and enriched in the transgenic lines.Salicylic acid(SA)content analysis indicated that overexpression of MdVQ37 reduced the content of endogenous SA by regulating the expression of SA catabolism-related genes,which ultimately resulted in disruption of the SA-dependent signaling pathway under HT stress.The application of SA slightly increased the survival rate of the transgenic lines under HT stress.Taken together,our results indicate that apple MdVQ37 has a regulatory function in basal thermotolerance by modulating the activity of transcription factors and SA homeostasis.Overall,this study provides novel insights that improve our understanding of the various functions of VQ motif-containing proteins. | Qinglong Dong Dingyue Duan Wenqian Zheng Dong Huang Qian Wang Xiaoran Li Ke Mao Fengwang Ma | 2021 | Horticulture Research2021，8，1： | 0 |
| 12 | Statures in Han populations of China显示文摘Dear Editor,Shortly after initiating the'Physical Anthropological Research on Han Chinese'research project,we applied uniform sampling methods as well as methods and instruments of measurement to obtain a complete set of measurements of physical anthropological indicators among Han populations across China.Among these measurements,body stature was a key indicator.Currently,there should be | YE FaCheng LIU XinChun WANG Wei CHEN XiaoZheng LIU Jing SHEN ShuZhong WANG WenQian WANG XiangDong WANG Yue CAO ChangQun ZHENG QuanFeng ZHANG Hua ZHANG YiChun | 2015 | Science China(Life Sciences)2015，58，2： | 0 |
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