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| 1 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 2 | Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts显示文摘Multiple regulatory mechanisms control osteoblast differentiation and function to ensure unperturbed skeletal formation and remodeling. In this study we identify histone lysine-specific demethylase 1(LSD1/KDM1 A) as a key epigenetic regulator of osteoblast differentiation. Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells(hMSCs)in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. Mechanistic in vitro studies revealed that LSD1 epigenetically regulates the expression of WNT7 B and BMP2. LSD1 deficiency resulted in increased BMP2 and WNT7 B expression in osteoblasts and enhanced bone formation, while downregulation of WNT7 B-and BMP2-related signaling using genetic mouse model or small-molecule inhibitors attenuated bone phenotype in vivo. Furthermore, the LSD1 inhibitor tranylcypromine(TCP) could increase bone mass in mice. These data identify LSD1 as a novel regulator of osteoblast activity and suggest LSD1 inhibition as a potential therapeutic target for treatment of osteoporosis. | Jun Sun Joerg Ermann Ningning Niu Guang Yan Yang Yang Yujiang Shi Weiguo Zou | 2018 | Bone Research2018，6，3： | 5 |
| 3 | EQUIVALENT NORMAL CURVATURE APPROACH MILLING MODEL OF MACHINING FREEFORM SURFACES显示文摘A new milling methodology with the equivalent normal curvature milling model machining freeform surfaces is proposed based on the normal curvature theorems on differential geometry. Moreover,a specialized whirlwind milling tool and a 5-axis CNC horizontal milling machine are introduced.This new milling model can efficiently enlarge the material removal volume at the tip of the whirlwind milling tool and improve the producing capacity.The machining strategy of this model is to regulate the orientation of the whirlwind milling tool relatively to the principal directions of the workpiece surface at the point of contact,so as to create a full match with collision avoidance between the workpiece surface and the symmetric rotational surface of the milling tool.The practical results show that this new milling model is an effective method in machining complex three- dimensional surfaces.This model has a good improvement on finishing machining time and scallop height in machining the freeform surfaces over other milling processes.Some actual examples for manufacturing the freeform surfaces with this new model are given. | YI Xianzhong MA Weiguo QIHaiying YAN Zesheng GAO Deli | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 5 |
| 4 | In Situ Loading of Cu_(2)O Nanoparticles on a Hydroxyl Group Rich TiO_(2) Precursor as an Excellent Catalyst for the Ullmann Reaction显示文摘An in situ method has been used to load Cu_(2)O nanoparticles on the surface of a hydroxyl group rich TiO_(2)precursor.Cu_(2)O nanoparticles are formed by in situ reduction of Cu(OH)_(2) with Sn^(2+)ions linked to the surface of the TiO_(2)precursor.The initial Cu_(2)O nanoparticles serve as seeds for subsequent particle growth.The resulting Cu_(2)O nanoparticles are evenly dispersed on the surface of the TiO_(2)precursor,and are heat and air stable.The as-prepared composite is an excellent catalyst for Ullmann type cross coupling reactions of aryl halides with phenol.The composite catalyst also showed good stability,remaining highly active after five consecutive runs. | Fang Niu Yan Jiang Weiguo Song | 2010 | Nano Research2010，3，11： | 4 |
| 5 | Distribution of branched glycerol dialkyl glycerol tetraethers in soils on the Northeastern Qinghai-Tibetan Plateau and possible production by nitrite-reducing bacteria显示文摘Branched glycerol dialkyl glycerol tetraethers(b GDGTs) are ubiquitous and abundant in soils, but their sources remain elusive. Recent studies demonstrate that the distributions of b GDGTs are sensitive to various environmental factors. In an effort to understand how and to what extent soil moisture(expressed as soil water content(SWC) or mean annual precipitation(MAP), p H and temperature may impact the distribution of b GDGTs, and to shed more light on the biological sources of b GDGTs in cold and arid regions, we investigated the distribution of b GDGTs as well as bacterial 16 S r RNA gene and functional genes involved in the N cycle(including amo A, nir S and nir K) in 41 surface soil samples from around Lake Qinghai and east of Qaidam Basin on the Northeastern Qinghai-Tibetan Plateau. We found that lower soil moisture reduced the fractional concentrations of cyclic b GDGTs and thus the cyclisation ratio of branched tetraethers(CBT) index correlated negatively with SWC and MAP, suggesting that soil moisture is an important factor controlling b GDGT distributions in soils in this arid and semi-arid region. Two subgroups of b GDGTs were assigned on the basis of cluster analysis, and b GDGT indices behaved differently in the two groups, hinting at different biosynthetic mechanisms for b GDGTs under different environmental conditions. Real time PCR results showed that nir S and nir K genes correlated significantly with the concentration of b GDGTs, suggesting that the nir S- or nir K-encoding bacteria involved in denitrification might potentially be an additional biological source for soil b GDGTs(besides Acidobacteria). Moreover, our results also support the application of new indices based on 5-methyl b GDGTs and 6-methyl b GDGTs in reconstructing past temperature and p H variations in this region. | SUN ChiJun ZHANG ChuanLun LI Fu Yan WANG HuanYe LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，9： | 3 |
| 6 | Preparation and analysis of active rat model of rheumatoid arthritis with features of TCM toxic heat-stasis painful obstruction显示文摘Objective:To establish a collagen type II-induced rat model of rheumatoid arthritis(RA)presenting characteristics of the human form of the traditional Chinese syndrome pattern of toxic heat-stasis painful obstruction(bi zheng;arthromyodynia)as well as pathologic features of active RA.The Chinese herbal medicine Tengmei decoction was used to validate the animal model.Methods:Ninety specific pathogen free Sprague-Dawley rats were randomly divided into a normal group of 6 rats and a model group of 84 rats.To establish the rat model of collageninduced arthritis(CIA),bovine type II collagen in complete Freund’s adjuvant was injected into the model group rats as a priming dose(Day 0)and boosting dose(Day 9).Changes in arthritic index(AI)scores,including limb swelling,were monitored.Thereafter,24 successfullyestablished CIA rats were randomly assigned to 4 groups with 6 animals each:model,positive control drug,high-dose traditional Chinese herbal medicine,and traditional Chinese herbal medicine.A blank control group of 6 rats was included.After 12 weeks of intervention with Tengmei decoction,articular synovial tissue and serum specimens were collected to detect interleukin-2(IL-2)and IL-17 transcription and protein expression levels. | Yanan Wang Yan Lu Jie Wang Zhiming Shen Hui Liu Weiguo Ma Jisheng Zhang Xuehong Ma Kang Wang Fengxian Meng | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 3 |
| 7 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 8 | Effects of heat treatment and Re-content on the TCP-phase in two Ni-Mo-Cr-Re superalloys显示文摘The volume fraction and morphology of the TCP-phase formed in two kinds of Ni-Mo-Cr-Re superalloys under different heat treatment conditions were investigated in this paper. In Re-5% alloy, with increasing of the heat treatment temperature and prolonging the holding time, the volume fraction of TCP-phase decreased and the TCP-phase size increased. At relatively lower temperature, the TCP-phase prefers to present in the dendrite cores. In Re-10% alloy, the volume fraction and size have the same change tendency as that of in Re-5% alloy, but the morphology will change from needle-like and block-like to sphere when the temperature increases. The TCP-phases formed in these two Ni-Mo-Cr-Re alloys are σ and P phase. | Pingli MAO Yan XIN Ke HAN Weiguo JIANG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，5： | 3 |
| 9 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Yong Dai Weiguo Sui Huijuan Lan Qiang Yan He Huang YuanShuai Huang | 2009 | Rheumatology International2009，，7： | 3 |
| 10 | Impact of photosynthesis and transpiration on nitrogen removal in constructed wetlands显示文摘To determine the impact of photosynthesis and transpiration on nitrogen removal in wetlands,an artificial wetland planted with reeds was constructed to treat highly concentrated domestic wastewater.Under different meteoro-logical and hydraulic conditions,the daily changes of photo-synthesis and transpiration of reeds,as well as nitrogen removal efficiency were measured.It was found that net pho-tosynthesis rate per unit leaf area was maintained on a high level(average 19.0μmol CO_(2)/(m^(2)·s))from 10:00 to 14:00 in July 2004 and reached a peak of 21.1μmol CO2/(m2·s)when Photon Flux Density was high during the day.Meanwhile,TN and NH_(4)^(+)-N removal efficiency rose to 79.6%and 89.6%,respectively-the maximum values observed in the test.Correlation coefficient analysis demonstrated a positive cor-relation among photon flux density,net photosynthetic rate,transpiration rate,and TN and NH_(4)^(+)-N removal efficiency.In contrast,there was a negative correlation between stomatal conductance and TN and NH_(4)^(+)-N removal efficiency.Results suggest that the photosynthesis and transpiration of wetland plants have a great impact on nitrogen removal efficiency of wetlands,which can be enhanced by an increase in the photo-synthesis and transpiration rate.In addition,the efficiency of water usage by reeds and nitrogen removal efficiency could be affected by the water level in wetlands;a higher level boosts nitrogen removal efficiency. | LUO Weiguo WANG Shihe HUANG Juan YAN Lu HUANG Jun | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 2 |
| 11 | Role of Integrin-linked Kinase (ILK) in Interstitial Fibrosis in Renal Allograft显示文摘 | Qiang Yan Weiguo Sui Shuiyong Xie Huaizhou Chen Shenping Xie Guimina Zou Hequn Zou | 2009 | 器官移植内科学杂志2009，4，3： | 2 |
| 12 | Cdhl regulates craniofacial development via APC- dependent ubiquitination and activation of Goosecoid显示文摘 | Rui Shao Jia Liu Guang Yan Jinfang Zhang Yujiao Han Jianfeng Guo Zhan Xu Zhu Yuan Jiankang Liu Marcos Malumbres Lixin Wan Wenyi Wei Weiguo Zou | 2016 | Cell Research2016，26，6： | 2 |
| 13 | Clinical Study of Incidence and Pathogenesis of Metabolic Syndrome after Kidney Transplantation显示文摘 | Weiguo Sui Huaizhou Chen Hequn Zou Qiang Yan Wenti Che Guimian Zou Shenping Xie | 2008 | 器官移植内科学杂志2008，3，2： | 2 |
| 14 | Efficacy of 40-O-(2-hydroxyethyl)-Rapamycin in Treating Chronic Allograft Nephropathy in Rats显示文摘 | Hequn Zou Weiguo Sui Qiang Yan Wenti Che Guimian Zou | 2008 | 器官移植内科学杂志2008，3，4： | 2 |
| 15 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 16 | A limit theorem for partial sums of random variables and its applications显示文摘 | Liu Wen Yan Jiaan Yang Weiguo | 2003 | Statistics and Probability Letters2003，62，： | 1 |
| 17 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 18 | The joint moderating role of trust propensity and gender on consumers ' online shopping behavior显示文摘 | Chen Yue Yan Xiangbin Fan Weiguo | 2015 | Computers in Human Behavior2015，43，2： | 1 |
| 19 | Determinants in the forecast of the gross national income of China and India from 1952 to 2015显示文摘In 2015,China and India's population represented approximately 35.74%of the total number of people living in the world.Due to the historical context and behavior of the most relevant indicators,this study proposes to utilize a wide variety of demographic,economic,and production indicators from 1952 to 2015 to assess their impact on the GNI in China and India.A comprehensive and new fangled modeling process with stepwise,regularization and distributed lag regression approaches is presented.Accordingly,theoretical results were corroborated through extensive diagnostic tests and an empirical check of the models'predictive capacity.The findings show that GNI in China is most influenced by variables such as reserves in foreign currency and the dependency ratio;whereas,variables of energy production and birth rate were generated for India.Therefore,it's the timing for China to relax the universal two-child policy.Due to the current value below the substitution rate,a gloomy outlook for China's future population and economy is predicted.Conversely,a positive outlook is forecasted for India,given the low price in the future of oil-India's primary raw material. | Angel Colmenares Xu Yan Weiguo Wang | 2021 | Journal of Management Science and Engineering2021，6，3： | 1 |
| 20 | Mutation and expression of the p53 gene during chemical hepatocarcinogenesis in F344 rats显示文摘 | Yan F Weiguo D Yoshihiko K | 2003 | Biochimica et Biophysica Acta2003，1628，1： | 1 |
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