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| 1 | Effects of dietary Clostridium butyricum supplementation on growth performance,intestinal development,and immune response of weaned piglets challenged with lipopolysaccharide显示文摘Background: Weanling pigs, with immature immune system and physiological function, usually experience postweaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, and immunity of weaned pigs challenged with lipopolysaccharide(LPS).Methods: In Experiment(Exp.) 1,144 weaned piglets were weaned at 21 d and randomly assigned to six groups,with six replicates per group and four pigs per replicate, receiving a control diet(CON) or diet supplemented with antibiotics(AB) or C. butyricum(CB)(0.1%, 0.2%, 0.4%, or 0.8%), respectively. All diets in Exp. 1 were a highly digestible basal diet, with 3,000 mg/kg zinc oxide supplied in the first 2 wk only. In Exp. 2, 180 piglets were weaned at 21 d and randomly assigned to five groups, with six replicates per group and six pigs per replicate, receiving CON, AB, or CB(0.2%, 0.4%, or 0.6%) diets. The digestibility of diets was lower than those in Exp. 1, and did not include zinc oxide. At 36 d of Exp. 2, 12 piglets were selected from each of the CON and 0.4% CB groups, six piglets were intraperitoneally injected with LPS(50 μg/kg body weight) and the other six piglets with normal saline;animals were killed at 4 h after injection to collect blood, intestine, and digesta samples for biochemical analysis.Results: In Exp. 1, CB and AB diets had no effect on growth performance of piglets. In Exp. 2, 0.4% CB decreased feed-gain ratio(P < 0.1), diarrhea score(P < 0.05), and increased duodenal, jejunal, and ileal villus height and jejunal villus height/crypt depth(P < 0.05). The 0.4% CB decreased the plasma tumor necrosis factor(TNF) α(P < 0.05) but increased ileal mucosa IL-10 and TLR2 mRNA expression(P < 0.05). Furthermore, 0.4% CB altered the microbial profile, with Bacillus and Ruminococcaceae UGG-003 at genus level and Lactobacillus casei and Parasutterella secunda at species level were higher than CON in colonic content(P < 0.05).Conclusions: Dietary C. butyricum supplementation had positive effects on growth of weaned piglets with less digestible diets. There was a tendency to reduce the feed-gain ratio, which could reduce feed costs in pig production. Moreover, C. butyricum decreased post-weaning diarrhea by improving the intestinal morphology,intestinal microflora profile, and immune function. | Ling Chen Shuang Li Jie Zheng Wentao Li Xuemei Jiang Xilun Zhao Jian Li Lianqiang Che Yan Lin Shengyu Xu Bin Feng Zhengfeng Fang De Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 26 |
| 2 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 3 | The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine显示文摘The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hippocampi of rats with post-stroke depression, and exert antidepressant effects. | Yongmei Yan Wentao Fan Li Liu Ru Yang Wenjia Yang | 2013 | Neural Regeneration Research2013，8，19： | 13 |
| 4 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 5 | Phase-field modeling of grain evolutions in additive manufacturing from nucleation,growth,to coarsening显示文摘A three-dimensional phase-field model is developed to simulate grain evolutions during powder-bed-fusion(PBF)additive manufacturing,while the physically-informed temperature profile is implemented from a thermal-fluid flow model.The phase-field model incorporates a nucleation model based on classical nucleation theory,as well as the initial grain structures of powder particles and substrate.The grain evolutions during the three-layer three-track PBF process are comprehensively reproduced,including grain nucleation and growth in molten pools,epitaxial growth from powder particles,substrate and previous tracks,grain re-melting and re-growth in overlapping zones,and grain coarsening in heat-affected zones.A validation experiment has been carried out,showing that the simulation results are consistent with the experimental results in the molten pool and grain morphologies.Furthermore,the grain refinement by adding nanoparticles is preliminarily reproduced and compared against the experimental result in literature. | Min Yang Lu Wang Wentao Yan | 2021 | npj Computational Materials2021，，1： | 8 |
| 6 | Performance and microbial diversity of an expanded granular sludge bed reactor for high sulfate and nitrate waste brine treatment显示文摘The disposal of waste brines has become a major challenge that hinders the wide application of ionexchange resins in the water industry in recent decades. In this study, high sulfate removal efficiency(80%–90%) was achieved at the influent sulfate concentration of 3600 mg/L and 3% NaCl after 145 days in an expanded granular sludge bed(EGSB) reactor. Furthermore, the feasibility of treating synthetic waste brine containing high levels of sulfate and nitrate was investigated in a single EGSB reactor during an operation period of 261 days. The highest nitrate and sulfate loading rate reached 6.38 and 5.78 kg/(m3·day) at SO2-4-S/NO-3-N mass ratio of 4/3, and the corresponding removal efficiency was 99.97% and 82.26% at 3% NaCl, respectively. Meanwhile, 454-pyrosequencing technology was used to analyze the bacterial diversity of the sludge on the 240th day for stable operation of phase X. Results showed that a total of 9194 sequences were obtained, which could be affiliated to 14 phyla, including Proteobacteria, Firmicutes, Chlorobi, Bacteroidetes, Synergistetes and so on. Proteobacteria(77.66%) was the dominant microbial population, followed by Firmicutes(12.23%) and Chlorobi(2.71%). | Runhua Liao Yan Li Xuemin Yu Peng Shi Zhu Wang Ke Shen Qianqian Shi Yu Miao Wentao Li Aimin Li | 2014 | Journal of Environmental Sciences2014，26，4： | 7 |
| 7 | Detection of quantitative trait loci and heterotic loci for plant height using an immortalized F_2 population in maize显示文摘A set of recombinant inbred lines (RIL) derived from Yuyu22, an elite hybrid widespread in China, was used to construct an immortalized F2 (IF2) population comprising 441 different crosses. Genetic linkage maps were constructed containing 10 linkages groups with 263 simple sequence repeat (SSR) molecular markers. Twelve and ten quantitative trait loci (QTL) were detected for plant height in the IF2 and RIL populations respectively, using the composite interval mapping method, and six same QTL were identified in the two populations. In addition, ten unique heterotic loci (HL) located on seven different chromosomes were revealed for plant height using the mid-parent heterosis as the input data. These HL explained 1.26%―8.41% of the genotypic variance in plant height heterosis and most expressed overdominant effects. Only three QTL and HL were located in the same chromosomal region, it implied that plant height and its heterosis might be controlled by two types of genetic mechanisms. | TANG JiHua MA XiQing TENG WenTao YAN JianBing WU WeiRen DAI JingRui LI JianSheng | 2007 | Chinese Science Bulletin2007，52，4： | 5 |
| 8 | Modeling and Experimental Validation of the Electron Beam Selective Melting Process显示文摘 | Wentao Yan Ya Qian Weixin Ma Bin Zhou Yongxing Shen Feng Lin | 2017 | Engineering2017，3，5： | 5 |
| 9 | Complications and risk factors for complications of implanted subcutaneous ports for intraperitoneal chemotherapy in gastric cancer with peritoneal metastasis显示文摘Objective:Intraperitoneal(IP)chemotherapy through subcutaneous port is an effective treatment for gastric cancer(GC)patients with peritoneal metastasis(PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods:In retrospective screening of 301 patients with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results:Of the 249 analyzed patients,57(22.9%)experienced port complications.Subcutaneous liquid accumulation(42.1%)and infection(28.1%)were the main complications,and other complications included port rotation(14.1%),wound dehiscence(12.3%),inflow obstruction(1.7%)and subcutaneous metastasis(1.7%).The median interval between port implantation and occurrence of complications was 3.0 months.Eastern Cooperative Oncology Group(ECOG)performance status[odds ratio(OR),1.74;95%confidence interval(95%CI),1.12-2.69],albumin(OR,3.67;95%CI,1.96-6.86),implantation procedure optimization(OR,0.33;95%CI,0.18-0.61)and implantation groups(OR,0.37;95%CI,0.20-0.69)were independent risk factors for port complications(P<0.05).ECOG performance status was the only factor that related to the grades of port complications(P=0.016).Conclusions:Port complications in GC patients who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM. | Zhongyin Yang Chen Li Wentao Liu Yanan Zheng Zhenglun Zhu Ziehen Hua Zhentian Ni Sheng Lu Min Yan Chao Yan Zhenggang Zhu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 10 | Lanthanum-doped Cu-Mn composite oxide catalysts for catalytic oxidation of toluene显示文摘CuMn mixed oxides catalysts doped with La were prepared following a co-precipitation method and used for the catalytic oxidation of toluene. Catalysts properties of the catalysts were investigated by X-ray diffraction, N_2 adsorption/desorption,scanning electron microscopy, H_2-temperature-programmed reduction(H_2-TPR), O_2-temperature-programmed desorption(O_2-TPD) and X-ray photoelectron spectroscopy techniques. Characterization data reveal that the phase change and decrease in crystallinity of the La-doped catalysts increase the number of oxygen vacancies. Improvements in reducibility and an increase in the amount of chemisorbed oxygen of the La-doped catalysts were also verified by H_2-TPR and O_2-TPD. The activity of the CuMn mixed oxides catalysts is significantly improved by the addition of a nominal amount of La. The CuMn/La-4 mol% catalyst exhibits the best catalytic activity, with a 90%conversion temperature of 255 ℃,attributed to a high Mn^(3+)ratio, superficial chemisorbed oxygen,and high surface area. This study indicates La to be a promising dopant for Cu-Mn catalysts toward toluene oxidation. | Jing Pan Wentao Du Yongjun Liu Yan Cheng Shandong Yuan | 2019 | Journal of Rare Earths2019，37，6： | 5 |
| 11 | Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene显示文摘A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of acetylene.Characterization indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 crystals.In addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of Cu.Reaction results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction activity.This should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal particles.Moreover,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved. | Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.Jang Jong K.Keum Karren More Changjun Liu Xiaoliang Yan | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 4 |
| 12 | Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China显示文摘 | Wentao Zhao Ying Guo Shuguang Lu Pingping Yan Qian Sui | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 4 |
| 13 | Environmental pollution by persistent toxic substances and health risk in an industrial area of China显示文摘Soil is an important environmental medium that is closely associated with humans and their health.Despite this,very few studies have measured toxicants in soils,and associated them with health risks in humans.An assessment of health effects from exposure to contaminants in soils surrounding industrial areas of chemical production and storage is important.This article aims at determining pollution characteristics of persistent toxic substances (PTS) in an industrial area in China to unravel the relationship between soil pollution by PTS and human health.One hundred and five soil samples were collected and 742 questionnaires were handed out to residents living in and around an industrial area around Bohai Bay,Tianjin in Northern China.Concentrations of organochlorine pesticides and polycyclic aromatic hydrocarbons (PAHs) were determined in soil.Mann-Whitney U and binary multivariate non-conditional logistic regression models were employed to analyze the relationship between health indicators of local residents and contaminant levels.Odds ratio (OR) and a 95% confidence interval (CI) for health incidences were also calculated.The average concentrations of DDT (73.9 ng/g),HCH (654 ng/g) and PAHs (1225 ng/g) were relatively high in the industrial area.Residents living in the chemical industry parks were exposed to a higher levels of PTS than those living outside the chemical industry parks.This exposure was associated with a higher risk of breast cancer (OR 1.87,95% CI 0.12-30.06),stomach cancer (OR 1.87,95% CI 0.26-13.41),dermatitis (OR 1.72,95% CI 1.05-2.80),gastroenteritis (OR 1.59,95% CI 0.94-2.68),and pneumonia (OR 1.05,95% CI 0.58-1.89). | Jing Li Yonglong Lu Yajuan Shi Tieyu Wang Guang Wang Wei Luo Wentao Jiao Chunli Chen Feng Yan | 2011 | Journal of Environmental Sciences2011，23，8： | 3 |
| 14 | Thermodynamics of strange quark matter with the density-dependent bag constant显示文摘The thermodynamics of strange quark matter with density dependent bag constant are studied self-consistently in the framework of the general ensemble theory and the MIT bag model.In our treatment,an additional term is found in the expression of pressure.With the additional term,the zero pressure locates exactly at the lowest energy state,indicating that our treatment is a self-consistently thermodynamic treatment.The self-consistent equations of state of strange quark matter in both the normal and color-flavor-locked phase are derived.They are both softer than the inconsistent ones.Strange stars in both the normal and color-flavor locked phase have smaller masses and radii in our treatment.It is also interesting to find that the energy density at a star surface in our treatment is much higher than that in the inconsistent treatment for both phases.Consequently,the surface properties and the corresponding observational properties of strange stars in our treatment are different from those in the inconsistent treatment. | ZHU MingFeng LIU GuangZhou YU Zi XU Yan SONG WenTao | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 3 |
| 15 | Mechanism of keyhole pore formation in metal additive manufacturing显示文摘During metal additive manufacturing,the porosity of the as-built part deteriorates the mechanical property and even hinders the further application of metal additive manufacturing.Particularly,the mechanisms of keyhole pores associated with the keyhole fluctuation are not fully understood.To reveal the mechanisms of the keyhole pores formation,we adopt a multiphysics thermal-fluid flow model incorporating heat transfer,liquid flow,metal evaporation,Marangoni effect,and Darcy’s law to simulate the keyhole pore formation process,and the results are validated with the in situ X-ray images.The simulation results present the instant bubble formation due to the keyhole instability and motion of the instant bubble pinning on the solidification front.Furthermore,comparing the keyhole pore formation under different laser scanning speeds shows that the keyhole pore is sensitive to the manufacturing parameters.Additionally,the simulation under a low ambient pressure shows the feasibility of improving the keyhole stability to reduce and even avoid the formation of keyhole pores. | Lu Wang Yanming Zhang Hou Yi Chia Wentao Yan | 2022 | npj Computational Materials2022，，1： | 3 |
| 16 | Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression显示文摘The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac. | Wentao Fan Qian Wang Yongmei Yan | 2012 | Neural Regeneration Research2012，7，3： | 3 |
| 17 | Selective laser melting of dense and crack-free AlCoCrFeNi_(2.1) eutectic high entropy alloy: Synergizing strength and ductility显示文摘Additively manufactured high-entropy alloys generally suffer from low strength and/or poor ductility.In this work,by leveraging the good castability of eutectic high entropy alloys and high cooling rate of selective laser melting(SLM),we report a nearly fully dense and crack-free as-SLM AlCoCrFeNi_(2.1) eutectic high entropy alloy with an exceptional strength-ductility synergy,showing an ultrahigh yield strength of 982.1±35.2 MPa and an ultimate tensile strength of 1322.8±54.9 MPa together with an elongation to fracture of 12.3±0.5%.Such strength-ductility enhancement is owing to the heterogeneous eutectic microstructure consisting of the columnar,equiaxed,and“L-shape”cells with much refined sizes down to nanoscales.The morphology of cells in the transition zone is related to the misorientation between the growth direction of adjacent layers.This heterogeneous eutectic microstructure is the result of the graingrowth behavior dominated by the mechanisms of the epitaxial growth and growth of heterogeneous nuclei in SLM.Our current results provide a new methodology for the future design of ultrahigh-strength and ductile SLM-fabricated metallic materials including HEAs,and other printable alloys for various structural applications. | Lin He Shiwei Wu Anping Dong Haibin Tang Dafan Du Guoliang Zhu Baode Sun Wentao Yan | 2022 | Journal of Materials Science & Technology2022，，22： | 2 |
| 18 | BDS satellite clock offset prediction based on a semiparametric adjustment model considering model errors显示文摘In view of the influence of model errors in conventional BeiDou prediction models for clock offsets,a semiparametric adjustment model for BeiDou Navigation Satellite System(BDS)clock offset prediction that considers model errors is proposed in this paper.First,the model errors of the conventional BeiDou clock offset prediction model are analyzed.Additionally,the relationship among the polynomial model,polynomial model with additional periodic term correction,and its periodic correction terms is explored in detail.Second,considering the model errors,combined with the physical relationship between phase,frequency,frequency drift,and its period in the clock sequence,the conventional clock offset prediction model is improved.Using kernel estimation and comprehensive least squares,the corresponding parameter solutions of the prediction model and the estimation of its model error are derived,and the dynamic error correction of the clock sequence model is realized.Finally,the BDS satellite precision clock data provided by the IGS Center of Wuhan University with a sampling interval of 5 min are used to compare the proposed prediction method with commonly used methods.Experimental results show that the proposed prediction method can better correct the model errors of BDS satellite clock offsets,and it can effectively overcome the inaccuracies of clock offset correction.The average forecast accuracies of the BeiDou satellites at 6,12,and 24 h are 27.13%,37.71%,and 45.08%higher than those of the conventional BeiDou clock offset forecast models;the average model improvement rates are 16.92%,20.96%,and 28.48%,respectively.In addition,the proposed method enhances the existing BDS satellite prediction method for clock offsets to a certain extent. | Xiong Yan Wentao Li Yufeng Yang Xiong Pan | 2020 | Satellite Navigation2020，1，1： | 2 |
| 19 | Biodegradation of bezafibrate by the activated sludge under aerobic condition:Effect of initial concentration,temperature and pH显示文摘Lab-scale experiments were conducted to investigate the effect of initial concentration,temperature and pH on the removal of bezafibrate(BF)by activated sludge under aerobic condition.The results showed that adsorption of BF onto activated sludge was negligible,and biodegradation was the main removal mechanism of BF.The removal of BF in the aqueous phase by the activated sludge can be described by a pseudo-first-order reaction.The reaction rate constants had a negative relationship with the initial concentration of BF,and dramatically reduced from 0.050 to 0.007 h^-1,when the temperature dropped from 20℃to 10℃.Variation of pH between 5.0 and 9.0 did not have significant influence on the removal of BF,indicating a high adaptation of microorganism in the activated sludge responsible for BF degradation to a wide pH range.The findings of this study are helpful to improve the removal of pharmaceuticals during the wastewater treatment plants by selecting the appropriate process variables,and eventually eliminate their release to the environment. | Qian Sui Pingping Yan Xuqi Cao Shuguang Lu Wentao Zhao Maozhe Chen | 2016 | Emerging Contaminants2016，2，4： | 2 |
| 20 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
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