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| 1 | Thiolactone copolymer donor gifts organic solar cells a 16.72% efficiency显示文摘Since 1995,bulk-heterojunction organic solar cells consisting of one or two organic donors and one or two organic acceptors have been fighting for high power conversion efficiencies(PCEs)and good stability[1].Until recent years,this next-generation photovoltaic technology starts to offer decent PCEs,shedding the light on commercialization,and attracting great attention again[2-14].Compared w让h the continuously emerging highperformance nonfullerene acceptors,high-performance donors are rare. | Ji Xiong Ke Jin Yufan Jiang Jianqiang Qin Tan Wang Jinfeng Liu Qishi Liu Haili Peng Xiongfeng Li Anxin Sun Xianyi Meng Lixiu Zhang Ling Liu Wenting Li Zhimin Fang Xue Jia Zuo Xiao Yaqing Feng Xiaotao Zhang Kuan Sun Shangfeng Yang Shengwei Shi Liming Ding | 2019 | Science Bulletin2019，64，21： | 17 |
| 2 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 3 | Epigenetics in the pathogenesis of diabetic nephropathy显示文摘Diabetic nephropathy(DN),which is a common microvascular complication with a high incidence in diabetic patients,greatly increases the mortality of patients.With further study on DN,it is found that epigenetics plays a crucial role in the pathophysiological process of DN.Epigenetics has an important impact on the development of DN through a variety of mechanisms,and promotes the generation and maintenance of metabolic memory,thus ultimately leading to a poor prognosis.In this review we discuss the methylation of DNA,modification of histone,and regulation of non-coding RNA involved in the progress of cell dysfunction,inflammation and fibrosis in the kidney,which ultimately lead to the deterioration of DN. | Xue Li Lihong Lu Wenting Hou Ting Huang Xiangyuan Chen Jie Qi Yanjun Zhao Minmin Zhu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 6 |
| 4 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 5 | Live cell single molecule-guided Bayesian localization super resolution microscopy显示文摘 | Xu, Fan Zhang, Mingshu He, Wenting Han, Renmin Xue, Fudong Liu, Zhiyong Zhang, Fa Lippincott-Schwartz, Jennifer Xu, Pingyong | 2017 | Cell Research2017，27，5： | 6 |
| 6 | DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells显示文摘superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests. | Wenting Xue Zhenghan Di Ya Zhao Aiping Zhang Lele Li | 2019 | Chinese Chemical Letters2019，30，4： | 4 |
| 7 | Hessian single-molecule localization microscopy using sCMOS camera显示文摘 | Fudong Xue Wenting He Fan Xu Mingshu Zhang Liangyi Chen Pingyong Xu | 2018 | Biophysics Reports2018，4，4： | 2 |
| 8 | Strong and Injectable Hydrogels Based on Multivalent Metal Ion-Peptide Cross-linking显示文摘Injectable hydrogels are ideal biomaterials tor delivering cells,growth tactors and dmgs specifically to localized lesions and subsequent controlled release.Many factors can a fleet the efficacy of injectable hydrogels.To avoid potential damage to encapsulated cells or dmgs,injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly refonn after injection.However,dynamic hydrogels are often mechanically weak,leading to the leakage of encapsulated cells or drugs.Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds.We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not atlected by the fonnation of multivalent binding.Yet,the mechanical stability of the hydrogels was significantly improved due to the increased themiodynamic stability of the crosslinkers.We turthcr showed that the drug release rates were slowed down by the formation of multivalent crosslinkers.Our results highlight the importance of ligand valency to themechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels. | YU Wenting XUE Bin ZHU Zhenshu SHEN Ziqin QIN Meng WANG Wei CAO Yi | 2020 | Chemical Research in Chinese Universities2020，36，5： | 1 |
| 9 | Experimental and numerical study on hysteretic performance of SMA spring-friction bearings显示文摘This paper presents an experimental and numerical study to investigate the hysteretic performance of a new type of isolator consisting of shape memory alloy springs and friction bearing called an SMA spring-friction bearing(SFB). The SFB is a sliding-type isolator with SMA devices used for the seismic protection of engineering structures. The principle of operation of the isolation bearing is introduced. In order to explore the possibility of applying SMA elements in passive seismic control devices, large diameter superelastic tension/compression Ni Ti SMA helical springs used in the SFB isolator were developed. Mechanical experiments of the SMA helical spring were carried out to understand its superelastic characteristics. After that, a series of quasi-static tests on a single SFB isolator prototype were conducted to measure its force-displacement relationships for different loading conditions and study the corresponding variation law of its mechanical performance. The experimental results demonstrate that the SFB exhibits full hysteretic curves, excellent energy dissipation capacity, and moderate recentering ability. Finally, a theoretical model capable of emulating the hysteretic behavior of the SMA-based isolator was then established and implemented in MATLAB software. The comparison of the numerical results with the experimental results shows the efficacy of the proposed model for simulating the response of the SFB. | Zhuang Peng Xue Suduo Nie Pan Wang Wenting | 2016 | Earthquake Engineering and Engineering Vibration2016，15，4： | 1 |
| 10 | Preparation of biomimetic gene hydrogel via polymerase chain reaction for cell-free protein expression显示文摘Deoxyribonucleic acid(DNA)hydrogels,a three-dimensional(3 D)network made from DNA chains,have attracted great attention because of its molecular programmability,excellent biocompatibility and wide biomedical applications.Construction of hydrogel incorporating genetic function is still a challenge because of the limitations in available preparation methods.Herein,we develop a polymerase chain reaction(PCR)based strategy to construct gene integrated hydrogel to mimic the biofunction of nucleus zone.DNA primers were chemically modified by methacrylamide,which were used as modular primers in PCR to hybridize with template plasmid DNA,yielding methacrylamide functionalized gene(Acry-gene).Afterwards,Acry-gene was chemically cross-linked and compressed via free radical polymerization of terminal group methacrylamide to form a threedimensional gene network,namely gene hydrogel.The gene hydrogel retained the genetic function and expressed protein successfully in a cell free protein expression system.This work provides a general approach for the construction of biofunctional gene hydrogel which mimics bioprocesses,showing great potential in biomedicine and biomimetic fields. | Feng Li Wenting Yu Xue Zhang Xiaocui Guo Xihan Xu Xiaolei Sun Dayong Yang | 2020 | Science China Chemistry2020，63，1： | 1 |
| 11 | Mesenchymal stromal cells in hepatic fibrosis/cirrhosis:from pathogenesis to treatment显示文摘Hepatic fibrosis/cirrhosis is a significant health burden worldwide,resulting in liver failure or hepatocellular carcinoma(HCC)and accounting for many deaths each year.The pathogenesis of hepatic fibrosis/cirrhosis is very complex,which makes treatment challenging.Endogenous mesenchymal stromal cells(MsCs)have been shown to play pivotal roles in the pathogenesis of hepatic fibrosis.Paradoxically,exogenous MsCs have also been used in clinical trials for liver cirrhosis,and their effectiveness has been observed in most completed clinical trials.There are still many issues to be resolved to promote the use of MsCs in the clinic in the future.In this review,we will examine the controversial role of MsCs in the pathogenesis and treatment of hepatic fibrosis/cirrhosis.We also investigated the clinical trials involving MsCs in liver cirrhosis,summarized the parameters that need to be standardized,and discussed how to promote the use of MsCs from a clinical perspective. | Xue Yang Qing Li Wenting Liu Chen Zong Lixin Wei Yufang Shi Zhipeng Han | 2023 | Cellular & Molecular Immunology2023，20，6： | 1 |
| 12 | Preparation,characterization and photodegradation of methylene blue based on TiO_2 microparticles modified with thiophene substituents显示文摘The new microparticles,2-formylthiophene(FT)/TiO2 and(E)-1,2-bis(5-formyl-2-thienyl) ethylene(EBFTE)/TiO2 were synthesized with a silane coupling agent.The prepared TiO2 composites were characterized using Ultraviolet-Vis absorption(UV-Vis),X-ray diffraction(XRD),scanning electron microscope(SEM) and thermogravimetric analyzer(TGA).Methylene blue was used as a model material to examine the photocatalytic activities of the prepared catalysts under both Ultraviolet-Vis(UV) and visible(Vis) light.The enhanced photocatalytic activities were observed in the presence of(FT)/TiO2 and EBFTE/TiO2 under Vis light.It suggests that FT or EBFTE plays a block or active role in the photodegradation mechanisms under UV and Vis light irradiation,respectively. | LIU Pei ZHANG Peng CAO DongLiang XUE WenTing | 2012 | Chinese Science Bulletin2012，57，33： | 0 |
| 13 | The First Detection of Echinococcus Granulosus DNA in Residents’Hands,Dogs’Hair,and Soil in Highly Endemic Region of Echinococcosis-Naqu City,Xizang Autonomous Region,China,2020显示文摘Summary What is already known about this topic?Echinococcosis is a serious zoonotic parasitic disease that predominantly infects humans;domestic animals like cattle or sheep;as well as wild animals such as small rodents.To date,there is a lack of comprehensive information about all potential environmental transmission routes for Echinococcus.What is added by this report?This study assesses the importance of under-researched environmental factors for the transmission of Echinococcus.It concludes that hand hygiene is an important factor in the robust environmental transmission of Echinococcus granulosus.What are the implications for public health practice?This study suggests that residents are at risk of catching echinococcosis through hand-oral transmission routes.Health education given to local residents is thus a key intervention,as well as avoiding close contact with dogs and ensuring proper hand-washing practices are followed. | Baixue Liu Chuizhao Xue Xu Wang Wenting Wu Shuai Han Weiping Wu | 2022 | China CDC weekly2022，4，44： | 0 |
| 14 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 15 | Amorphous Se species anchored into enclosed carbon skeleton bridged by chemical bonding toward advanced K-Se batteries显示文摘Potassium-selenium(K-Se)batteries have attracted significant attention as one of the most promising alternatives of lithium-ion storage systems owing to high energy density and low cost.In the design of Se-based cathode materials,however,the low utilization rate of active Se and the rapid dissolution of polyselenides seriously weaken the capacity and cycle stability.Therefore,how to make full use of Se species without loss during the charge and discharge process is the key to design high-performance Se-based cathode.In this paper,a 3 D'water cube'-like Se/C hybrid(denoted as Se-O-PCS)is constructed with the assistance of Na_(2)CO_(3) templates.Thanks to the abundant carbonate groups(CO_(3)^(2-))originated from the Na_(2)CO_(3) templates,the molten Se species are firmly anchored into the pore of carbon skeleton by strong C-O-Se bonding.Thus,this unique Se-O-PCS model not only improves the utilization of active Se species,but also can reduce the contact with the electrolyte to inhibit the shuttle effect of polyselenides.Moreover,flexible carbon skeleton gives Se-O-PCS hybrid a good electrical conductivity and excellent structural robustness.Consequently,the resultant Se-O-PCS hybrid is endowed with an obviously enhanced K-ions storage property. | Li Zhou Yongpeng Cui Dongqing Kong Wenting Feng Xiuli Gao Youguo Yan Hao Ren Han Hu Qingzhong Xue Zifeng Yan Wei Xing | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 16 | Mahuang Xixin Fuzi decoction protects against ovalbumin-induced allergic rhinitis by inhibiting type 2 innate lymphoid cells in mice显示文摘Objective:As a traditional herbal formula,Mahuang Xixin Fuzi decoction(MXFD)has been used to treat allergic rhinitis(AR).It regulates the transcription factor GATA3 in T cells,blocks Th2 skewing and rebalances the Th1/Th2 immunity.Type 2 innate lymphoid cells(ILC2s)are closely associated with GATA3.However,it remains unknown whether ILC2s could be one mechanism through which MXFD acts.We sought to elucidate the efficacy and mechanism of action of this decoction in AR treatment.Methods:Forty C57BL/6J female mice were equally divided into control,model,loratadine-and MXFDtreated groups in random.AR was induced by ovalbumin(OVA),and then treatment with loratadine or MXFD was administered.AR scores were evaluated and compared before and after treatment.Pathological changes in the nasal mucosa and lung were observed using hematoxylin-eosin staining of tissue samples.Activation of ILC2 in nasal mucosa was assessed by immunofluorescence and quantitative polymerase chain reaction analysis.ILC2 cell count in lungs was measured by flow cytometry and levels of interleukin-(IL)4,IL-5 and IL-13 in serum were detected by ELISA.Results:The decoction alleviated the symptoms of AR in mice,improved vascular congestion and expansion,glandular hyperplasia and inflammatory cell infiltration in mouse nasal mucosa and slowly improved the interstitial pneumonia and lesions.Meanwhile,MXFD reduced the number and percentage of ILC2s in the nasal mucosa and lungs,downregulated the expression of GATA3 mRNA and RORa mRNA,and reduced the related inflammatory cytokine levels,including IL-4,IL-5 and IL-13.Conclusion:These data suggest that inhibition of ILC2s by MXFD may be an important means by which to treat AR. | Hong Ren Wenting Ji Xue Yu Dongyu Ge Ruijuan Dong Qingguo Wang Min Liu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 0 |
| 17 | Construction of Frame-Structured Flexible MXene Film Electrode to Achieve High Areal Capacitance Micro-Supercapacitor显示文摘Two-dimensional MXene-based film materials as flexible electrodes have been widely studied in wearable microsupercapacitors(MSCs).However,the existence of strong van derWaals interactions leads to serious self-stacking ofMXene layers,resulting in poor ionic dynamics and loss of active sites,which causes MXene film electrodes to exhibit low capacitance and poor rate performance in practical studies.To solve this,a frame-structured hybrid film(labeled as CN-MX hybrid film)is constructed by introducing intercalating agents(nanometer g-C_(3)N_(4))into MXene layers.In this unique hybrid film,the g-C_(3)N_(4)nanoparticles rationally occupy the interspace between MXene layers so as to alleviate layer stacking,thus effectively expanding the electrochemically active surface and promoting proton transfer.Synergistic pseudocapacitance inducted by g-C_(3)N_(4)surface groups,consequently,the CN-MX hybrid film electrode achieves an enhanced capacitive capability.In the three-electrode system,this frame-structured film electrode exhibits an ultra-high areal capacitance of 1932.8 mF cm^(−2).The assembled symmetry flexible MSC device based on CN-MX hybrid film can achieve an energy density of 2.28μWh cm^(−2)at 0.075 mW cm^(−2),as well as a superior cyclic stability with 90.4%retention after 700 cycles in alternating 90o bending and releasing states,revealing its potential in practical applications. | Yesheng Wang Yongpeng Cui Dongqing Kong Xiaoning Wang Wenting Feng Pengyun Liu Tonghui Cai Xuejin Li Lianming Zhao Debin Kong Linjie Zhi Qingzhong Xue Zifeng Yan Wei Xing | 2023 | Renewables2023，1，2： | 0 |
| 18 | Tissue Culture of Calla Lily (Zantedeschia spreng.): An Updated Review on the Present Scenario and Future Prospects显示文摘The calla lily(Zantedeschia spreng.)is a bulbousflower native to the tropical regions of Africa.Calla lily has gained significant popularity in the international market owing to its intricate morphology and prolonged flowering duration.Despite such advantages,for two sub-groups of calla lily,known as group Zantedeschia and group Aestivae,there are challenges in terms of hybrid production due to the‘plastome-genome incompatibility’there-between.Tissue culture is a fundamental biotechnological tool used in gene editing research,with a focus on disease resistance andflower color in calla lily breeding programs.The present review provides a brief background on the history and development of the calla lily,as well as a comprehensive and critical summary of calla lily tissue culture research.The regeneration pathways for both group Zantedeschia and group Aestivae can be divided into de novo organogenesis and somatic embryogenesis.Both groups are capable of obtaining replants through such means.However,only some species in group Aestivae have been reported to be successful in the somatic embryogenesis pathway.In the present review,special attention was paid to the influence of explant types,plant growth regulators,and culture conditions on both de novo organogenesis and somatic embryogenesis in calla lily tissue culture.Ultimately,future research prospects were determined based on integrated analysis of recent progress in calla lily tissue culture research. | Xuan Sun Xue Wang Bijaya Sharma Subedi Yin Jiang Di Wang Rongxin Gou Guojun Zhang Wenting Xu Zunzheng Wei | 2023 | Phyton-International Journal of Experimental Botany2023，92，8： | 0 |
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